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Extract from the Register of European Patents

EP About this file: EP1511852

EP1511852 - USE OF FLUORINE NMR FOR HIGH THROUGHPUT SCREENING [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.04.2011
Database last updated on 02.11.2024
Most recent event   Tooltip13.09.2013Lapse of the patent in a contracting state
Updated state(s): BG		published on 16.10.2013  [2013/42]
Applicant(s)For all designated states
NERVIANO MEDICAL SCIENCES S.R.L.
Viale Pasteur, 10
20014 Nerviano (MI) / IT
[N/P]
Former [2008/30]For all designated states
NERVIANO MEDICAL SCIENCES S.r.l.
Viale Pasteur, 10
20014 Nerviano (MI) / IT
Former [2007/04]For all designated states
Pharmacia & Upjohn Company LLC
7000 Portage Road
Kalamazoo, MI 49001 / US
Former [2005/22]For all designated states
Pharmacia & Upjohn Company LLC
301 Henrietta Street
Kalamazoo, MI 49001 / US
Former [2005/10]For all designated states
PHARMACIA & UPJOHN COMPANY
301 Henrietta Street
Kalamazoo, Michigan 49001 / US
Inventor(s)01 / DALVIT, Claudio
Via G.C. Procaccini, 23
I-20154 Milano / IT
02 / STOCKMAN, Brian, J.
2140 Waite Avenue
Kalamazoo, MI 49008 / US
03 / FLOCCO, Maria
Piazza Conciliazone 4
20123 Milano / IT
04 / VERONESI, Marina
Via Faravelli, 8
I-20149 Milano / IT
 [2010/21]
Former [2005/10]01 / DALVIT, Claudio
Via G.C. Procaccini, 23
I-20154 Milan / IT
02 / STOCKMAN, Brian, J.
2140 Waite Avenue
Kalamazoo, MI 49008 / US
03 / FLOCCO, Maria
Piazza Concilliazone 4
20123 Milano / IT
04 / VERONESI, Marina
Via Faravelli, 8
I-20149 Milano / IT
Representative(s)Modiano, Micaela Nadia
Modiano Josif Pisanty & Staub Ltd
Thierschstrasse 11
80538 München / DE
[N/P]
Former [2005/45]Modiano, Micaela Nadia
Modiano, Josif, Pisanty & Staub Ltd., Baaderstrasse 3
80469 München / DE
Former [2005/10]Modiano, Guido, Dr.-Ing., et al
Modiano, Josif, Pisanty & Staub, Baaderstrasse 3
80469 München / DE
Application number, filing date03812412.905.06.2003
[2005/10]
WO2003US17729
Priority number, dateUS20020386897P05.06.2002         Original published format: US 386897 P
US20020389252P17.06.2002         Original published format: US 389252 P
US20020398875P26.07.2002         Original published format: US 398875 P
US20030454766P14.03.2003         Original published format: US 454766 P
US20030454765P14.03.2003         Original published format: US 454765 P
[2005/10]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2004051214
Date:17.06.2004
Language:EN
[2004/25]
Type: A2 Application without search report 
No.:EP1511852
Date:09.03.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 17.06.2004 takes the place of the publication of the European patent application.
[2005/10]
Type: B1 Patent specification 
No.:EP1511852
Date:26.05.2010
Language:EN
[2010/21]
Search report(s)International search report - published on:US10.09.2004
(Supplementary) European search report - dispatched on:EP17.06.2008
ClassificationIPC:C12Q1/00, G01N33/566, G01N35/00, G01N24/00
[2005/10]
CPC:
G01N24/088 (EP,US); C12Q1/00 (KR); G01N21/64 (KR);
G01N24/00 (KR); G01N24/08 (EP,US); G01R33/465 (EP,US);
G01R33/4625 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/10]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:VERWENDUNG VON FLUOR-NMR ZUM SCREENING MIT HOHEM DURCHSATZ[2005/10]
English:USE OF FLUORINE NMR FOR HIGH THROUGHPUT SCREENING[2005/10]
French:MISE EN OEUVRE D'UNE IRM AU FLUOR POUR UN DEPISTAGE A HAUT RENDEMENT[2005/10]
Entry into regional phase21.12.2004National basic fee paid 
21.12.2004Search fee paid 
21.12.2004Designation fee(s) paid 
21.12.2004Examination fee paid 
Examination procedure05.01.2004Request for preliminary examination filed
International Preliminary Examining Authority: US
21.12.2004Examination requested  [2005/10]
16.01.2009Despatch of a communication from the examining division (Time limit: M04)
26.05.2009Reply to a communication from the examining division
11.12.2009Communication of intention to grant the patent
09.04.2010Fee for grant paid
09.04.2010Fee for publishing/printing paid
Opposition(s)01.03.2011No opposition filed within time limit [2011/18]
Fees paidRenewal fee
21.06.2005Renewal fee patent year 03
28.06.2006Renewal fee patent year 04
27.06.2007Renewal fee patent year 05
25.06.2008Renewal fee patent year 06
26.06.2009Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY26.05.2010
CZ26.05.2010
DK26.05.2010
EE26.05.2010
FI26.05.2010
RO26.05.2010
SI26.05.2010
SK26.05.2010
TR26.05.2010
LU05.06.2010
MC30.06.2010
BG26.08.2010
GR27.08.2010
PT27.09.2010
HU27.11.2010
[2013/42]
Former [2012/47]BG26.05.2010
CY26.05.2010
CZ26.05.2010
DK26.05.2010
EE26.05.2010
FI26.05.2010
RO26.05.2010
SI26.05.2010
SK26.05.2010
TR26.05.2010
LU05.06.2010
MC30.06.2010
GR27.08.2010
PT27.09.2010
HU27.11.2010
Former [2012/43]BG26.05.2010
CY26.05.2010
CZ26.05.2010
DK26.05.2010
EE26.05.2010
FI26.05.2010
RO26.05.2010
SI26.05.2010
SK26.05.2010
LU05.06.2010
MC30.06.2010
GR27.08.2010
PT27.09.2010
HU27.11.2010
Former [2012/42]BG26.05.2010
CY26.05.2010
CZ26.05.2010
DK26.05.2010
EE26.05.2010
FI26.05.2010
RO26.05.2010
SI26.05.2010
SK26.05.2010
MC30.06.2010
GR27.08.2010
PT27.09.2010
HU27.11.2010
Former [2012/41]BG26.05.2010
CY26.05.2010
CZ26.05.2010
DK26.05.2010
EE26.05.2010
FI26.05.2010
RO26.05.2010
SI26.05.2010
SK26.05.2010
MC30.06.2010
GR27.08.2010
PT27.09.2010
Former [2011/10]CY26.05.2010
CZ26.05.2010
DK26.05.2010
EE26.05.2010
FI26.05.2010
RO26.05.2010
SI26.05.2010
SK26.05.2010
MC30.06.2010
GR27.08.2010
PT27.09.2010
Former [2011/08]CY26.05.2010
DK26.05.2010
EE26.05.2010
FI26.05.2010
SI26.05.2010
MC30.06.2010
GR27.08.2010
PT27.09.2010
Former [2011/07]CY26.05.2010
DK26.05.2010
FI26.05.2010
SI26.05.2010
MC30.06.2010
GR27.08.2010
Former [2011/05]CY26.05.2010
FI26.05.2010
SI26.05.2010
GR27.08.2010
Former [2011/01]FI26.05.2010
SI26.05.2010
GR27.08.2010
Former [2010/52]FI26.05.2010
SI26.05.2010
Former [2010/50]FI26.05.2010
Documents cited:Search[X]WO0123889  (SMITHKLINE BEECHAM CORP [GB], et al) [X] 19,20* page 9, line 31 - page 10, line 15 *
International search[X]  - CLAUDIO DALVIT ET AL, "Fluorine-NMR Competition Binding Experiments for High- Throughput Screening of Large Compound Mixtures", COMBINATORIAL CHEMISTRY AND HIGH THROUGHPUT SCREENING, (200212), vol. 5, no. 8, pages 605 - 611, XP008039096
 [Y]  - DALVIT ET AL, "NMR-bases screening with competition water-ligand observed via gradient spectroscopy experiments: detection of high-affinity ligands", J. MED. CHEM., (200206), vol. 45, no. 12, pages 2610 - 2614, XP002968313

DOI:   http://dx.doi.org/10.1021/jm011122k
 [Y]  - AKOKA ET AL, "Concentration measurement by proton NMR using the ERETIC method", ANAL. CHEM., (199907), vol. 71, no. 13, pages 2554 - 2557, XP002271269

DOI:   http://dx.doi.org/10.1021/ac981422i
 [Y]  - JENKINS ET AL, "Detection of site-specific binding and co-binding of ligands to human serum albumin using 19F NMR", MOLECULAR PHARMACOLOGY, (1990), vol. 37, no. 1, pages 111 - 118, XP009096286
 [Y]  - SUN ET AL, "A (19)F-NMR study of the membrane-binding region of D-lactate dehydrogenase of Escherichia coli", PROTEIN SCIENCE, (1993), vol. 2, pages 1938 - 1947, XP002978106
 [Y]  - JENKINS B.G., "Detection of site-specific binding and co-binding of ligands to macromolecules using 19F NMR", LIFE SCI, (1991), vol. 48, no. 13, pages 1227 - 1240, XP002978107

DOI:   http://dx.doi.org/10.1016/0024-3205(91)90517-F
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.