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Extract from the Register of European Patents

EP About this file: EP1594889

EP1594889 - NELL PEPTIDE EXPRESSION SYSTEMS AND BONE FORMATION ACTIVITY OF NELL PEPTIDE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.02.2012
Database last updated on 25.09.2024
Most recent event   Tooltip18.07.2014Lapse of the patent in a contracting state
New state(s): HU		published on 20.08.2014  [2014/34]
Applicant(s)For all designated states
The Regents of the University of California
1111 Franklin Street, 12th Floor
Oakland, CA 94607 / US
[N/P]
Former [2011/14]For all designated states
The Regents of The University of California
12th Floor 1111 Franklin Street
Oakland, CA 94607-5200 / US
Former [2005/46]For all designated states
The Regents of the University of California
12th Floor, 1111 Franklin Street Oakland
California 94607-5200 / US
Inventor(s)01 / TING, Kang
115 N. Doheny Drive
Beverly Hills, CA 90211 / US
02 / KURODA, Shunichi
Osaka University, 8-1 Mihogaoka
Ibaraki, Osaka 567-0047 / JP
03 / WU, Ben
2253 Selby Avenue
Los Angeles, CA 90064 / US
 [2005/46]
Representative(s)Gervasi, Gemma
Notarbartolo & Gervasi GmbH
Bavariaring 21
80336 München / DE
[N/P]
Former [2005/46]Gervasi, Gemma
Notarbartolo & Gervasi GmbH, Bavariaring 21
80336 München / DE
Application number, filing date04709500.509.02.2004
[2005/46]
WO2004US03808
Priority number, dateUS20030445672P07.02.2003         Original published format: US 445672 P
WO2003US2928115.09.2003         Original published format: PCT/US0329/281
[2007/36]
Former [2005/46]US20030445672P07.02.2003
WO2003US2828115.09.2003
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2004072100
Date:26.08.2004
Language:EN
[2004/35]
Type: A2 Application without search report 
No.:EP1594889
Date:16.11.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 26.08.2004 takes the place of the publication of the European patent application.
[2005/46]
Type: B1 Patent specification 
No.:EP1594889
Date:06.04.2011
Language:EN
[2011/14]
Search report(s)International search report - published on:US15.03.2007
(Supplementary) European search report - dispatched on:EP20.02.2008
ClassificationIPC:C12N15/12, C12N15/62, C12N15/86, C07K14/435, C07K14/51, A61K38/18
[2010/38]
CPC:
C07K14/51 (EP,US); A61P19/00 (EP); A61P19/08 (EP);
A61P43/00 (EP)
Former IPC [2008/12]C12N15/12, C12N15/63, C07K14/51, A61K38/17
Former IPC [2007/20]A61K38/16, C12N15/00, C12N15/12, C12N15/63, C07K14/435
Former IPC [2005/46]C07K1/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/46]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:NELL-PEPTIDEXPRESSIONSSYSTEME UND KNOCHENBILDENDE AKTIVITÄT DES NELL-PEPTIDS[2005/46]
English:NELL PEPTIDE EXPRESSION SYSTEMS AND BONE FORMATION ACTIVITY OF NELL PEPTIDE[2005/46]
French:SYSTEMES D'EXPRESSION DE PEPTIDES NELL ET ACTIVITE DE FORMATION OSSEUSE DE PEPTIDE NELL[2005/46]
Entry into regional phase06.09.2005National basic fee paid 
06.09.2005Search fee paid 
06.09.2005Designation fee(s) paid 
06.09.2005Examination fee paid 
Examination procedure06.09.2005Examination requested  [2005/46]
29.05.2007Amendment by applicant (claims and/or description)
07.07.2008Despatch of a communication from the examining division (Time limit: M04)
11.11.2008Reply to a communication from the examining division
22.01.2009Despatch of a communication from the examining division (Time limit: M04)
20.05.2009Reply to a communication from the examining division
22.06.2009Despatch of a communication from the examining division (Time limit: M04)
21.10.2009Reply to a communication from the examining division
23.11.2009Despatch of a communication from the examining division (Time limit: M04)
23.03.2010Reply to a communication from the examining division
01.04.2010Despatch of a communication from the examining division (Time limit: M04)
02.08.2010Reply to a communication from the examining division
15.09.2010Communication of intention to grant the patent
12.01.2011Fee for grant paid
12.01.2011Fee for publishing/printing paid
Opposition(s)10.01.2012No opposition filed within time limit [2012/11]
Fees paidRenewal fee
27.02.2006Renewal fee patent year 03
27.02.2007Renewal fee patent year 04
25.02.2008Renewal fee patent year 05
26.02.2009Renewal fee patent year 06
24.02.2010Renewal fee patent year 07
23.02.2011Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU09.02.2004
AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
IT06.04.2011
NL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
TR06.04.2011
BG06.07.2011
GR07.07.2011
PT08.08.2011
[2014/34]
Former [2014/32]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
IT06.04.2011
NL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
TR06.04.2011
BG06.07.2011
GR07.07.2011
PT08.08.2011
Former [2014/21]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
TR06.04.2011
BG06.07.2011
GR07.07.2011
PT08.08.2011
Former [2013/29]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
BG06.07.2011
GR07.07.2011
PT08.08.2011
Former [2012/10]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
GR07.07.2011
PT08.08.2011
Former [2012/09]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
SE06.04.2011
SI06.04.2011
GR07.07.2011
PT08.08.2011
Former [2012/02]AT06.04.2011
BE06.04.2011
CY06.04.2011
FI06.04.2011
NL06.04.2011
SE06.04.2011
SI06.04.2011
GR07.07.2011
PT08.08.2011
Former [2012/01]AT06.04.2011
BE06.04.2011
CY06.04.2011
FI06.04.2011
SE06.04.2011
SI06.04.2011
GR07.07.2011
PT08.08.2011
Former [2011/49]CY06.04.2011
FI06.04.2011
SE06.04.2011
SI06.04.2011
GR07.07.2011
PT08.08.2011
Former [2011/47]SI06.04.2011
PT08.08.2011
Former [2011/41]SI06.04.2011
Documents cited:Search[A]EP0796913  (OTSUKA PHARMA CO LTD [JP]) [A] 1-18 * claims 19-24; sequences 34-39 *;
 [Y]WO0124821  (UNIV CALIFORNIA [US]) [Y] 1-18 * the whole document *;
 [Y]WO03006483  (APPLERA CORP [US], et al) [Y] 1-18 * page 41, line 18 - line 21 * * page 43, line 3 - line 6 * * claims 1-23 *;
 [Y]  - TESSIER D C ET AL, "Enhanced secretion from insect cells of a foreign protein fused to the honeybee melittin signal peptide.", GENE 15 FEB 1991, (19910215), vol. 98, no. 2, ISSN 0378-1119, pages 177 - 183, XP002467777 [Y] 1-18 * the whole document *

DOI:   http://dx.doi.org/10.1016/0378-1119(91)90171-7
 [Y]  - LI Y ET AL, "Control of expression, glycosylation, and secretion of HIV-1 gp120 by homologous and heterologous signal sequences.", VIROLOGY OCT 1994, (199410), vol. 204, no. 1, ISSN 0042-6822, pages 266 - 278, XP002467778 [Y] 1-18 * the whole document *

DOI:   http://dx.doi.org/10.1006/viro.1994.1531
 [Y]  - SARKAR M ET AL, "Removal of 106 amino acids from the N-terminus of UDP-GlcNAc: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I does not inactivate the enzyme.", GLYCOCONJUGATE JOURNAL FEB 1998, (199802), vol. 15, no. 2, ISSN 0282-0080, pages 193 - 197, XP002467779 [Y] 1-18 * the whole document *

DOI:   http://dx.doi.org/10.1023/A:1006928624913
 [Y]  - SHUN'ICHI KURODA ET AL, "BIOCHEMICAL CHARACTERIZATION AND EXPRESSION ANALYSIS OF NEURAL THROMBOSPONDIN-1-LIKE PROTEINS NELL1 AND NELL2", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (199911), vol. 265, no. 1, ISSN 0006-291X, pages 79 - 86, XP001051695 [Y] 1-18 * the whole document *

DOI:   http://dx.doi.org/10.1006/bbrc.1999.1638
 [Y]  - ELKINS D.A., ROSSI, J.,, "Protein kinase C-binding protein NELL2 precursor (NEL-like protein) (Mouse)", EMBL, EMBL Hinxton UK, (19971101), Database accession no. Q61220, URL: EBI, XP002467817 [Y] 1-18 * column A *
 [A]  - WATANABE T K ET AL, "CLONING AND CHARACTERIZATION OF TWO NOVEL HUMAN CDNAS (NELL1 AND NELL2) ENCODING PROTEINS WITH SIX EGF-LIKE REPEATS", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, (19961215), vol. 38, no. 3, ISSN 0888-7543, pages 273 - 276, XP002064052 [A] 1-18 * the whole document *

DOI:   http://dx.doi.org/10.1006/geno.1996.0628
 [A]  - KURODA S ET AL, "Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (1999), vol. 265, no. 3, ISSN 0006-291X, pages 752 - 757, XP003007039 [A] 1-18 * the whole document *

DOI:   http://dx.doi.org/10.1006/bbrc.1999.1753
International search[A]  - LUCE M.J. AND BURROWS P.D., "The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage", GENE, (1999), vol. 231, pages 121 - 126, XP004166785

DOI:   http://dx.doi.org/10.1016/S0378-1119(99)00093-1
 [A]  - TING K. ET AL., "Human NELL-1 expressed in unilateral coronal synostosis", JOURNAL OF BONE AND MINERAL RESEARCH, (1999), vol. 14, no. 1, pages 80 - 89, XP002937149

DOI:   http://dx.doi.org/10.1359/jbmr.1999.14.1.80
by applicantWO0124821
 WO03006483
    - TESSIER D.C. ET AL., GENE, (1991), vol. 98, no. 2, pages 177 - 183
    - LI, Y. ET AL., VIROLOGY, (1994), vol. 204, no. 1, pages 266 - 278
    - SARKAR M. ET AL., GLYCOCONJUGATE J., (1998), vol. 15, no. 2, pages 193 - 197
    - WATANABE, T.K. ET AL., Genomics, ACADEMIC PRESS, (1996), vol. 38, pages 273 - 276
    - KURODA, S. ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (1999), vol. 265, no. 3, pages 752 - 757
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.