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EP1627046
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EP About this file: EP1627046
| EP1627046 - DOMAIN-EXCHANGED BINDING MOLECULES, METHODS OF USE AND METHODS OF PRODUCTION [Right-click to bookmark this link] | Status | The application has been refused Status updated on 08.06.2012 Database last updated on 03.09.2024 | Most recent event Tooltip | 08.06.2012 | Refusal of application | published on 11.07.2012 [2012/28] | Applicant(s) | For all designated states THE SCRIPPS RESEARCH INSTITUTE 10550 North Torrey Pines Road La Jolla, CA 92037 / US | [2006/08] | Inventor(s) | 01 /
CALARESE, Daniel 5033 Clairemont Mesa Boulevard, 6 San Diego, CA 92112 / US | 02 /
BURTON, Dennis 6044 Beaumont Ave. La Jolla, CA 92037 / US | 03 /
WILSON, Ian, A. 1025 Newkirk Drive La Jolla, CA 92037 / US | [2006/08] | Representative(s) | Cornish, Kristina Victoria Joy Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | [N/P] |
| Former [2006/08] | Cornish, Kristina Victoria Joy Kilburn & Strode, 20 Red Lion Street London WC1R 4PJ / GB | Application number, filing date | 04750977.3 | 30.04.2004 | [2006/08] | WO2004US13349 | Priority number, date | US20030468503P | 06.05.2003 Original published format: US 468503 P | [2006/08] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2004101738 | Date: | 25.11.2004 | Language: | EN | [2004/48] | Type: | A2 Application without search report | No.: | EP1627046 | Date: | 22.02.2006 | Language: | EN | The application published by WIPO in one of the EPO official languages on 25.11.2004 takes the place of the publication of the European patent application. | [2006/08] | Search report(s) | International search report - published on: | US | 22.06.2006 | (Supplementary) European search report - dispatched on: | EP | 15.01.2008 | Classification | IPC: | A61K39/395, A61K39/21, C07K16/00 | [2008/07] | CPC: |
G01N33/56988 (EP,US);
A61P31/00 (EP);
A61P31/18 (EP);
A61P35/00 (EP);
A61P37/02 (EP);
C07K16/00 (EP,US);
C07K16/1063 (EP,US);
G01N33/53 (EP,US);
G01N33/531 (EP,US);
G01N33/574 (EP,US);
G01N33/6845 (EP,US);
C07K2317/55 (EP,US);
C07K2317/56 (EP,US)
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|
| Former IPC [2006/36] | A61K39/395, A61K39/21 | ||
| Former IPC [2006/08] | C12N1/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR [2006/08] | Extension states | AL | Not yet paid | HR | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | Title | German: | BINDUNGSMOLEKÜLE MIT DOMÄNENAUSTAUSCH, VERWENDUNGSVERFAHREN UND HERSTELLUNGSVERFAHREN | [2006/08] | English: | DOMAIN-EXCHANGED BINDING MOLECULES, METHODS OF USE AND METHODS OF PRODUCTION | [2006/08] | French: | MOLECULES DE LIAISON A ECHANGE DE DOMAINE, PROCEDES D'UTILISATION ET PROCEDES DE PRODUCTION | [2006/08] | Entry into regional phase | 06.12.2005 | National basic fee paid | 06.12.2005 | Search fee paid | 06.12.2005 | Designation fee(s) paid | 06.12.2005 | Examination fee paid | Examination procedure | 06.12.2005 | Amendment by applicant (claims and/or description) | 06.12.2005 | Examination requested [2006/08] | 19.03.2008 | Despatch of a communication from the examining division (Time limit: M06) | 03.11.2008 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 09.01.2009 | Reply to a communication from the examining division | 29.07.2010 | Despatch of a communication from the examining division (Time limit: M06) | 01.02.2011 | Reply to a communication from the examining division | 10.02.2012 | Cancellation of oral proceeding that was planned for 13.02.2012 | 13.02.2012 | Date of oral proceedings (cancelled) | 24.02.2012 | Despatch of communication that the application is refused, reason: substantive examination [2012/28] | 05.03.2012 | Application refused, date of legal effect [2012/28] | Divisional application(s) | EP10184208.6 Application withdrawn : 11.01.2011 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 19.03.2008 | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 12.01.2009 | Request for further processing filed | 12.01.2009 | Full payment received (date of receipt of payment) | Fees paid | Renewal fee | 05.05.2006 | Renewal fee patent year 03 | 27.04.2007 | Renewal fee patent year 04 | 07.04.2008 | Renewal fee patent year 05 | 16.04.2009 | Renewal fee patent year 06 | 25.03.2010 | Renewal fee patent year 07 | 11.05.2011 | Renewal fee patent year 08 | Penalty fee | Additional fee for renewal fee | 30.04.2006 | 03 M06 Fee paid on 05.05.2006 | 30.04.2011 | 08 M06 Fee paid on 11.05.2011 | 30.04.2012 | 09 M06 Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [A] - WU A M ET AL, "Multimerization of a chimeric anti-CD20 single-chain Fv-Fc fusion protein is mediated through variable domain exchange", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, (2001), vol. 14, no. 12, ISSN 0269-2139, pages 1025 - 1033, XP002982160 [A] * the whole document * DOI: http://dx.doi.org/10.1093/protein/14.12.1025 | [A] - LEE Y C ET AL, "Reversible Dimer Formation and Stability of the Anti-tumour Single-chain Fv Antibody MFE-23 by Neutron Scattering, Analytical Ultracentrifugation, and NMR and FT-IR Spectroscopy", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, (20020628), vol. 320, no. 1, ISSN 0022-2836, pages 107 - 127, XP004449713 [A] * the whole document * DOI: http://dx.doi.org/10.1016/S0022-2836(02)00403-5 | [A] - PERISIC O ET AL, "CRYSTAL STRUCTURE OF A DIABODY, A BIVALENT ANTIBODY FRAGMENT", STRUCTURE, CURRENT BIOLOGY LTD., PHILADELPHIA, PA, US, (19941215), vol. 2, no. 12, ISSN 0969-2126, pages 1217 - 1226, XP000563854 [A] * the whole document * DOI: http://dx.doi.org/10.1016/S0969-2126(94)00123-5 | [A] - ROUX KENNETH H ET AL, "Characterization of biosynthetic IgG oligomers resulting from light chain variable domain duplication", MOLECULAR IMMUNOLOGY, (1994), vol. 31, no. 12, ISSN 0161-5890, pages 933 - 942, XP002461980 [A] * the whole document * DOI: http://dx.doi.org/10.1016/0161-5890(94)90013-2 | [A] - PEI XUE Y ET AL, "The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate V-H-V-L domain pairs shows a rearrangement of V-H CDR3", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1997), vol. 94, no. 18, ISSN 0027-8424, pages 9637 - 9642, XP002461981 [A] * the whole document * DOI: http://dx.doi.org/10.1073/pnas.94.18.9637 | [A] - LIU YANSHUN ET AL, "3D domain swapping: As domains continue to swap", PROTEIN SCIENCE, (200206), vol. 11, no. 6, ISSN 0961-8368, pages 1285 - 1299, XP002461982 [A] * the whole document * DOI: http://dx.doi.org/10.1110/ps.0201402 | [T] - BURTON DENNIS R ET AL, "Antibody vs. HIV in a clash of evolutionary titans", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (200510), vol. 102, no. 42, ISSN 0027-8424, pages 14943 - 14948, XP002461983 [T] * the whole document * DOI: http://dx.doi.org/10.1073/pnas.0505126102 | [T] - ROUX K H ET AL, "Electron microscopic and immunochemical analysis of the broadly neutralizing HIV-1-specific, anti-carbohydrate antibody, 2G12", MOLECULAR IMMUNOLOGY, (200408), vol. 41, no. 10, ISSN 0161-5890, pages 1001 - 1011, XP009093536 [T] * the whole document * | International search | [A] - TRKOLA A. ET AL., "Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG", J. VIROLOGY, (199511), vol. 69, no. 11, pages 6609 - 6617, XP002220278 | [A] - SANDERS R.W. ET AL., "The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120", J. VIROLOGY, (200207), vol. 76, no. 14, pages 7293 - 7305, XP002306711 DOI: http://dx.doi.org/10.1128/JVI.76.14.7293-7305-2002 | [A] - CALARESE D.A. ET AL., "Antibody Domain Exchange is an Immunological Solution to Carbohydrate Cluster Recognition", SCIENCE, (200306), vol. 300, no. 5628, pages 2065 - 2071, XP002995532 DOI: http://dx.doi.org/10.1126/science.1083182 | by applicant | - J. BIOL. CHEM., (1969), vol. 243, pages 3552 - 59 |