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Extract from the Register of European Patents

EP About this file: EP1635821

EP1635821 - 4-BROMO-5-(2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID (PHENYL)AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.05.2010
Database last updated on 15.03.2025
Most recent event   Tooltip19.10.2012Lapse of the patent in a contracting state
New state(s): TR		published on 21.11.2012  [2012/47]
Applicant(s)For all designated states
ELAN PHARMACEUTICALS, INC.
800 Gateway Boulevard
South San Francisco, CA 94080 / US
[2006/12]
Inventor(s)01 / GAROFALO, Albert, W.
128 Adrian Avenue
South San Francisco, CA 94080 / US
02 / TUNG, Jay, S.
224 Semeria Avenue
Belmont, CA 94002 / US
03 / PLEISS, Michael, A.
848 Stella Court
Sunnyvale, CA 94086 / US
04 / WU, Jing
524 Shorebird Circle, Unit 15204
Redwood City, CA 94065 / US
05 / WONE, David, W., G.
6170 Honeysuckle Drive
Newark, CA 94560 / US
06 / GUINN, Ashley C.
1404 Ocean Park Boulevard
Santa Monica, CA 90405 / US
07 / DRESSEN, Darren, B.
3110 Casa de Campo, 2
San Mateo, CA 94403 / US
08 / MARUGG, Jennifer
6305 Paso Los Ceritos
San Jose, CA 95120 / US
09 / NEITZEL, Martin
316 Seaside Drive
Pacifica, CA 94044 / US
 [2006/20]
Former [2006/12]01 / GAROFALO, Albert, W.
128 Adrian Avenue
South San Francisco, CA 94080 / US
02 / TUNG, Jay, S.
224 Semeria Avenue
Belmont, CA 94002 / US
03 / PLEISS, Michael, A.
848 Stella Court
Sunnyvale, CA 94086 / US
04 / WU, Jing
524 Shorebird Circle, Unit 15204
Redwood City, CA 94065 / US
05 / WONE, David, W., G.
6170 Honeysuckle Drive
Newark, CA 94560 / US
06 / GUINN, Ashley C.
335 Talbot Avenue, Apt. 102 A
Pacifica, CA 94044 / US
07 / DRESSEN, Darren, B.
3110 Casa de Campo, 2
San Mateo, CA 94403 / US
08 / MARUGG, Jennifer
2094 Carlton Avenue
San Jose, CA 95124 / US
09 / NEITZEL, Martin
3048 Ponderosa Drive
Concord, CA 94520 / US
Representative(s)Wytenburg, Wilhelmus Johannes, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
[N/P]
Former [2009/36]Wytenburg, Wilhelmus Johannes, et al
Mewburn Ellis LLP 33 Gutter Lane London
EC2V 8AS / GB
Former [2006/12]Wytenburg, Wilhelmus Johannes, et al
Mewburn Ellis LLP York House 23 Kingsway
GB-London WC2B 6HP / GB
Application number, filing date04751178.730.04.2004
[2006/12]
WO2004US13655
Priority number, dateUS20030467695P02.05.2003         Original published format: US 467695 P
US20030503652P17.09.2003         Original published format: US 503652 P
[2006/12]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2004099155
Date:18.11.2004
Language:EN
[2004/47]
Type: A2 Application without search report 
No.:EP1635821
Date:22.03.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 18.11.2004 takes the place of the publication of the European patent application.
[2006/12]
Type: B1 Patent specification 
No.:EP1635821
Date:08.07.2009
Language:EN
[2009/28]
Search report(s)International search report - published on:EP10.11.2005
ClassificationIPC:A61K31/415, A61K31/4155, C07D231/40, A61P29/00
[2006/12]
CPC:
C07D401/12 (EP,US); A61P1/04 (EP); A61P11/02 (EP);
A61P11/06 (EP); A61P15/06 (EP); A61P17/02 (EP);
A61P19/02 (EP); A61P25/00 (EP); A61P25/04 (EP);
A61P25/06 (EP); A61P29/00 (EP); A61P31/04 (EP);
A61P43/00 (EP); C07D231/16 (EP,US); C07D231/40 (EP,US);
C07D403/12 (EP,US); C07D417/12 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/12]
Extension statesAL24.11.2005
HR24.11.2005
LT24.11.2005
LV24.11.2005
MK24.11.2005
TitleGerman:4-BROM-5-(2-CHLOR-BENZOYLAMINO)-1H-PYRAZOL-3-CARBONSÄURE(PHENYL)AMID-DERIVATE UND VERWANDTE VERBINDUNGEN ALS BRADYKININ B1 RECEPTOR ANTAGONISTEN ZUR BEHANDLUNG VON ENTZÜNDLICHEN ERKRANKUNGEN[2006/12]
English:4-BROMO-5-(2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID (PHENYL)AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES[2006/12]
French:DERIVES PHENYLAMIDE DU 4-BROMO-5-(3-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-ACIDE CARBOXYLIQUE ET COMPOSES SIMILAIRES POUR L'UTILISATION COMME ANTAGONISTS DU RECEPTEUR BRADYKININ B1 POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES[2006/12]
Entry into regional phase24.11.2005National basic fee paid 
24.11.2005Designation fee(s) paid 
24.11.2005Examination fee paid 
Examination procedure02.12.2004Request for preliminary examination filed
International Preliminary Examining Authority: US
24.11.2005Amendment by applicant (claims and/or description)
24.11.2005Examination requested  [2006/12]
30.04.2007Despatch of a communication from the examining division (Time limit: M04)
24.08.2007Reply to a communication from the examining division
02.02.2009Communication of intention to grant the patent
25.05.2009Fee for grant paid
25.05.2009Fee for publishing/printing paid
Opposition(s)09.04.2010No opposition filed within time limit [2010/24]
Fees paidRenewal fee
30.03.2006Renewal fee patent year 03
11.04.2007Renewal fee patent year 04
25.03.2008Renewal fee patent year 05
16.04.2009Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT08.07.2009
BE08.07.2009
CY08.07.2009
CZ08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
IT08.07.2009
NL08.07.2009
PL08.07.2009
RO08.07.2009
SE08.07.2009
SI08.07.2009
SK08.07.2009
TR08.07.2009
BG08.10.2009
GR09.10.2009
ES19.10.2009
PT09.11.2009
HU09.01.2010
[2012/47]
Former [2012/42]AT08.07.2009
BE08.07.2009
CY08.07.2009
CZ08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
IT08.07.2009
NL08.07.2009
PL08.07.2009
RO08.07.2009
SE08.07.2009
SI08.07.2009
SK08.07.2009
BG08.10.2009
GR09.10.2009
ES19.10.2009
PT09.11.2009
HU09.01.2010
Former [2012/41]AT08.07.2009
BE08.07.2009
CY08.07.2009
CZ08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
IT08.07.2009
NL08.07.2009
PL08.07.2009
RO08.07.2009
SE08.07.2009
SI08.07.2009
SK08.07.2009
BG08.10.2009
GR09.10.2009
ES19.10.2009
PT09.11.2009
Former [2012/37]AT08.07.2009
BE08.07.2009
CY08.07.2009
CZ08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
IT08.07.2009
NL08.07.2009
PL08.07.2009
RO08.07.2009
SI08.07.2009
SK08.07.2009
BG08.10.2009
GR09.10.2009
ES19.10.2009
PT09.11.2009
Former [2011/15]AT08.07.2009
BE08.07.2009
CZ08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
IT08.07.2009
NL08.07.2009
PL08.07.2009
RO08.07.2009
SI08.07.2009
SK08.07.2009
BG08.10.2009
GR09.10.2009
ES19.10.2009
PT09.11.2009
Former [2010/50]AT08.07.2009
BE08.07.2009
CZ08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
NL08.07.2009
PL08.07.2009
RO08.07.2009
SI08.07.2009
SK08.07.2009
BG08.10.2009
GR09.10.2009
ES19.10.2009
PT09.11.2009
Former [2010/25]AT08.07.2009
BE08.07.2009
CZ08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
NL08.07.2009
PL08.07.2009
RO08.07.2009
SI08.07.2009
SK08.07.2009
BG08.10.2009
ES19.10.2009
PT09.11.2009
Former [2010/23]AT08.07.2009
CZ08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
NL08.07.2009
PL08.07.2009
RO08.07.2009
SI08.07.2009
SK08.07.2009
BG08.10.2009
ES19.10.2009
PT09.11.2009
Former [2010/22]AT08.07.2009
CZ08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
NL08.07.2009
PL08.07.2009
RO08.07.2009
SI08.07.2009
BG08.10.2009
ES19.10.2009
PT09.11.2009
Former [2010/20]AT08.07.2009
DK08.07.2009
EE08.07.2009
FI08.07.2009
NL08.07.2009
PL08.07.2009
SI08.07.2009
BG08.10.2009
ES19.10.2009
PT09.11.2009
Former [2010/17]AT08.07.2009
FI08.07.2009
NL08.07.2009
PL08.07.2009
SI08.07.2009
BG08.10.2009
ES19.10.2009
PT09.11.2009
Former [2010/10]AT08.07.2009
FI08.07.2009
NL08.07.2009
PL08.07.2009
SI08.07.2009
ES19.10.2009
Former [2009/51]SI08.07.2009
Cited inInternational search[A]DE3421386  (NATTERMANN A & CIE [DE]) [A] 1-13,15,17,18,20,21 * claim 1 * * page 4, line 33 *;
 [X]WO9605196  (PHARMACIA SPA [IT], et al) [X] 1-13 * page 6 - page 18; compounds 1-81 * * example - * * claim - *;
 [X]GB2310207  (PHARMACIA SPA [IT], et al) [X] 1-13,15,17,18,20,21 * page 14, line 27 * * example -; claim - *;
 [X]WO9811101  (CANCER SOC AUCKLAND DIV NZ INC [NZ], et al) [X] 1-13 * examples S,T *;
 [X]WO9927939  (US HEALTH [US], et al) [X] 1-13,15,17,18,20,21 * page 4, line 11 * * compound, page 8, line 9 * * claim 1 *;
 [A]WO0050418  (FOURNIER IND & SANTE [FR], et al) [A] 1-23 * page 1, lines 10,11 * * claim 1 *;
 [A]WO0187888  (SK CHEMICALS CO LTD [KR], et al) [A] 1-23 * page 3, lines 3,10,11 *;
 [X]WO0202523  (PHARMACIA & UPJOHN SPA [IT], et al) [X] 1-13 * page 2 - page 3; compounds 1-7 * * compounds of formulae (I)-(V), (VII) *;
 [X]WO0222655  (PHARMACIA & UPJOHN SPA [IT], et al) [X] 1-13 * compounds 3,9,10,14-18,21,22 * * claims 2,6,10,11,13 *;
 [X]WO03015774  (ASTRAZENECA AB [SE], et al) [X] 1-13 * page 89; example GG5 * * claims 1,7,8,10 *;
 [PX]WO03095429  (TRANSMIT TECHNOLOGIETRANSFER [DE], et al) [PX] 1-13 * page 13; example -; compound 1 * * page 17; example -; compounds 1,2 * * page 31; example 3 * * page 34; example 4 * * page 38; example 6 ** reference examples, pages 21-39 *;
 [X]  - BARALDI ET AL, "Benzoyl Nitrogen Mustard Derivatives of Benzoheterocyclic Analogues of Netropsin: Synthesis and Biological Activity", BIOORGANIC MEDICINAL CHEMISTRY, (20030410), vol. 11, page 2381-2388, XP002301176 [X] 1-13 * compound 3 *

DOI:   http://dx.doi.org/10.1016/S0968-0896(03)00144-5
 [X]  - BARALDI ET AL, "Synthesis and Antitumor Activity of New Benzoheterocyclic Derivatives of Distamycin A", JOURNAL OF MEDICINAL CHEMISTRY, (2000), vol. 43, pages 2675 - 2684, XP002301177 [X] 1-13 * compounds 9,10 *

DOI:   http://dx.doi.org/10.1021/jm9911229
 [X]  - BARALDI ET AL, "Novel Benzoyl Nitrogen Mustard Derivatives of Pyrazole Analogues of Distamycin A: Synthesis and Antileukemic Activity", BIOORGANIC AND MEDICINAL CHEMISTRY, (1999), vol. 7, pages 251 - 262, XP002301178 [X] 1-13 * compounds 3-11, 23-35, 38-40 *

DOI:   http://dx.doi.org/10.1016/S0968-0896(98)00205-3
 [X]  - BARALDI ET AL, "Structure-Activity Relationship of Novel Tallimustine Derivatives: Synthesis and Antitumor Activity", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, (1996), vol. 6, no. 11, pages 1247 - 1252, XP002301179 [X] 1-13 * compounds 1,2,10,11,12,14,16 *

DOI:   http://dx.doi.org/10.1016/0960-894X(96)00205-3
 [X]  - BARALDI ET AL, "Synthesis and Antitumor Activity of Novel Distamycin Derivatives", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, (1996), vol. 6, no. 11, pages 1241 - 1246, XP002301246 [X] 1-13 * compounds 1-4, 10, 13, *

DOI:   http://dx.doi.org/10.1016/0960-894X(96)00204-1
 [X]  - ATWELL ET AL, "5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[eindoles:", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (1999), vol. 42, no. 17, ISSN 0022-2623, pages 3400 - 3411, XP002294767 [X] 1-13 * page 3402; compound D * * page 3403; compounds 33, 34 *

DOI:   http://dx.doi.org/10.1021/jm990136b
 [X]  - MARCHINI, S. ET AL, "Sequence-specific DNA alkylation of novel tallimustine derivatives", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1998), Database accession no. 1998:302076, URL: STN, XP002301180 [X] 1-13 * abstract *
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 [X]  - LEE, H. H. ET AL, "Pyrazole analogs of the bispyrrolecarboxamide anti-tumor antibiotics: synthesis, DNA binding and anti-tumor properties", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1992), Database accession no. 1992:173857, URL: STN, XP002301181 [X] 1-13 * abstract *
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.