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Extract from the Register of European Patents

EP About this file: EP1615955

EP1615955 - ALTERATION OF FCRN BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  02.08.2013
Database last updated on 31.08.2024
Most recent event   Tooltip02.08.2013No opposition filed within time limitpublished on 04.09.2013  [2013/36]
Applicant(s)For all designated states
AbbVie Biotherapeutics Inc.
1500 Seaport Boulevard
Redwood City, CA 94063 / US
[2013/12]
Former [2012/39]For all designated states
Abbott Biotherapeutics Corp.
1500 Seaport Boulevard
Redwood City, CA 94063 / US
Former [2010/52]For all designated states
Abbott Biotherapeutics Corp.
1500 Seaport Boulevard
Redwood City CA 94063 / US
Former [2009/35]For all designated states
Facet Biotech Corporation
1500 Seaport Boulevard
Redwood City, CA 94063 / US
Former [2007/52]For all designated states
PDL BioPharma, Inc.
1400 Seaport Blvd.
Redwood City, CA 94063 / US
Former [2006/30]For all designated states
PDL BioPharma, Inc.
34801 Campus Drive
Fremont, CA 94555 / US
Former [2006/03]For all designated states
PROTEIN DESIGN LABS, INC.
34801 Campus Drive
Fremont, CA 94555 / US
Inventor(s)01 / HINTON, Paul R.
321 Dunsmuir Terrace 4
Sunnyvale, CA 94085 / US
02 / TSURUSHITA, Naoya
3719 Redwood Circle
Palo Alto, CA 94306 / US
03 / TSO, J. Yun
445 Oakgrove Avenue No16
Menlo Park, CA 94025 / US
04 / VASQUEZ, Maximiliano
3813 Louis Road
Palo Alto, CA 94303 / US
 [2006/14]
Former [2006/03]01 / HINTON, Paul R.
321 Dunsmuir Terrace 4
Sunnyvale, CA 94085 / US
02 / TSURUSHITA, Naoya
3719 Redwood Circle
Palo Alto, CA 94306 / US
03 / TSO, J. Yun
445 Oakgrove Avenue 6
Menlo Park, CA 94025 / US
04 / VASQUEZ, Maximiliano
3813 Louis Road
Palo Alto, CA 94303 / US
Representative(s)Bizley, Richard Edward, et al
Avidity IP
Broers Building
Hauser Forum
21 J J Thomson Ave
Cambridge CB3 0FA / GB
[N/P]
Former [2012/39]Bizley, Richard Edward, et al
avidity IP
Merlin House
Falconry Court
Baker's Lane
Epping, Essex CM16 5DQ / GB
Former [2006/03]Bizley, Richard Edward, et al
HLBBshaw Merlin House Falconry Court Baker's Lane
Epping, Essex CM16 5DQ / GB
Application number, filing date04759444.509.04.2004
[2006/03]
WO2004US11213
Priority number, dateUS20030462014P10.04.2003         Original published format: US 462014 P
US20030475762P03.06.2003         Original published format: US 475762 P
US20030499048P29.08.2003         Original published format: US 499048 P
US2003068711815.10.2003         Original published format: US 687118
[2006/03]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2004092219
Date:28.10.2004
Language:EN
[2004/44]
Type: A2 Application without search report 
No.:EP1615955
Date:18.01.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 28.10.2004 takes the place of the publication of the European patent application.
[2006/03]
Type: B1 Patent specification 
No.:EP1615955
Date:26.09.2012
Language:EN
[2012/39]
Search report(s)International search report - published on:EP24.02.2005
ClassificationIPC:C07K16/00, // (C07K16/28, 16:24)
[2012/39]
CPC:
C07K16/082 (EP,US); C07K16/00 (EP,KR,US); C07H21/04 (KR);
C07K14/00 (KR); C07K16/249 (EP,US); C07K16/2809 (EP,US);
C07K16/2833 (EP,US); C07K16/2866 (EP,US); C12N15/00 (KR);
C07K2317/21 (EP,US); C07K2317/52 (EP,US); C07K2317/732 (EP,US) (-)
Former IPC [2006/03]C07K16/00, // C07K16/28, C07K16/24
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/03]
TitleGerman:ÄNDERUNG DER FCRN-BINDUNDSAFFINITÄTEN ODER DER SERUM-HALBWERTZEITEN VON ANTIKÖRPERN DURCH MUTAGENESE[2006/03]
English:ALTERATION OF FCRN BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS[2006/03]
French:MODIFICATION D'AFFINITES DE LIAISON POUR FCRN OU DE DEMI-VIES DE SERUM D'ANTICORPS PAR MUTAGENESE[2006/03]
Entry into regional phase04.11.2005National basic fee paid 
04.11.2005Designation fee(s) paid 
04.11.2005Examination fee paid 
Examination procedure04.11.2005Amendment by applicant (claims and/or description)
04.11.2005Examination requested  [2006/03]
15.01.2009Despatch of a communication from the examining division (Time limit: M04)
21.05.2009Reply to a communication from the examining division
21.08.2009Despatch of a communication from the examining division (Time limit: M04)
24.12.2009Reply to a communication from the examining division
21.01.2011Despatch of a communication from the examining division (Time limit: M02)
31.03.2011Reply to a communication from the examining division
16.05.2012Communication of intention to grant the patent
20.08.2012Fee for grant paid
20.08.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.01.2009
Opposition(s)27.06.2013No opposition filed within time limit [2013/36]
Fees paidRenewal fee
26.04.2006Renewal fee patent year 03
27.04.2007Renewal fee patent year 04
25.04.2008Renewal fee patent year 05
29.04.2009Renewal fee patent year 06
26.04.2010Renewal fee patent year 07
25.04.2011Renewal fee patent year 08
25.04.2012Renewal fee patent year 09
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Cited inInternational search[AD]US5530101  (QUEEN CARY L [US], et al) [AD] 15-18 * the whole document *;
 [A]US5834597  (TSO J YUN [US], et al) [A] 22-24 * column 9, line 30 - line 52 * * figures 1c,1d,2,4 * * claims 6,11 *;
 [AD]US6329511  (VASQUEZ MAXIMILIANO [US], et al) [AD] 19-21 * the whole document *;
 [XDI]WO02060919  (MEDIMMUNE INC [US], et al) [XD] 1-5,7,9-11,13-15 * page 5, line 8 - page 7, line 11 * * page 14, line 4 - page 17, line 36 * * page 24, line 20 - page 25, line 12 * * claims 1-3,9-11,15 * [I] 16-27;
 [X]  - HE X-Y ET AL, "Humanization and pharmacokinetics of a monoclonal antibody with specificity for both E- and P-selectin", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, (19980115), vol. 160, no. 2, ISSN 0022-1767, pages 1029 - 1035, XP002959848 [X] 9,13 * abstract * * table 1 * * figure 5 *
 [ID]  - GHETIE V ET AL, "INCREASING THE SERUM PERSISTENCE OF AN IGG FRAGMENT BY RANDOM MUTAGENESIS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, (1997), vol. 15, no. 7, ISSN 1087-0156, pages 637 - 640, XP000876642 [ID] 9,13 * abstract * * page 638, column L, paragraph 2 - column R, paragraph 4 * * table 1 *

DOI:   http://dx.doi.org/10.1038/nbt0797-637
 [AD]  - MARTIN W LANCE ET AL, "Crystal structure at 2.8 ANG of an FcRn/heterodimeric Fc complex: Mechanism of pH-dependent binding", MOLECULAR CELL, (200104), vol. 7, no. 4, ISSN 1097-2765, pages 867 - 877, XP002305812 [AD] 1-27 * abstract * * page 874, column R, paragraph 1 - page 875, column L, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/S1097-2765(01)00230-1
 [PXI]  - HINTON PAUL R ET AL, "Engineered human IgG antibodies with longer serum half-lives in primates.", JOURNAL OF BIOLOGICAL CHEMISTRY, (20040220), vol. 279, no. 8, ISSN 0021-9258, pages 6213 - 6216, XP002305813 [PX] 1,3,5-10,12-14 * the whole document * [PI] 2,4,11,16-27

DOI:   http://dx.doi.org/10.1074/jbc.C300470200
Examination   - WARHAM LANCE MARTIN, "PROTEIN-PROTEIN RECOGNITION: The Neonatal Fc Receptor and Immunoglobulin G", THESIS, XX, XX, (20010101), page 248pp, XP009095293
by applicant   - SIJMONS ET AL., BIO/TECHNOLOGY, (1990), vol. 8, pages 217 - 221
    - PUTLITZ ET AL., BIO/TECHNOLOGY, (1990), vol. 8, pages 651 - 654
    - QUEEN ET AL., IMMUNOL. REV., (1986), vol. 89, pages 49 - 68
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.