Extract from the Register of European Patents

EP About this file: EP1656132

EP1656132 - NOVEL PYRROLE-BASED HMG-COA REDUCTASE INHIBITORS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  26.06.2009
Database last updated on 11.04.2026
Most recent event   Tooltip26.06.2009Application deemed to be withdrawnpublished on 29.07.2009  [2009/31]
Applicant(s)For all designated states
Warner-Lambert Company LLC
235 East 42nd Street
New York, NY 10017 / US
[2007/08]
Former [2006/20]For all designated states
Warner-Lambert Company LLC
201 Tabor Road Morris Plains
New Jersey 07950 / US
Inventor(s)01 / KENNEDY, Robert M., Pfizer Global Res.&Development
2800 Plymouth Road
Ann Arbor, MI 48105 / US
02 / PARK, William K.-Ch., Pfizer Global Res.&Developm.
2800 Plymouth Road
Ann Arbor, MI 48105 / US
03 / ROTH, Bruce David, Pfizer Global Res.&Development
2800 Plymouth Road
Ann Arbor, MI 48105 / US
04 / SONG, Yuntao, Pfizer Global Res.&Development
2800 Plymouth Road
Ann Arbor, MI 48105 / US
05 / TRIVEDI, Bharat K., Pfizer Global Res.&Development
2800 Plymouth Road
Ann Arbor, MI 48105 / US
 [2006/20]
Representative(s)Hayles, James Richard
Pfizer
ATTENTION: ADDRESS INACTIVE - USE ASS-NR - CDR / FR
[N/P]
Former [2006/20]Hayles, James Richard
Pfizer Limited, Patents Department, Ramsgate Road Sandwich
Kent CT13 9NJ / GB
Application number, filing date04769110.030.07.2004
[2006/20]
WO2004IB02540
Priority number, dateUS20030494216P11.08.2003         Original published format: US 494216 P
[2006/20]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005014539
Date:17.02.2005
Language:EN
[2005/07]
Type: A2 Application without search report 
No.:EP1656132
Date:17.05.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 17.02.2005 takes the place of the publication of the European patent application.
[2006/20]
Search report(s)International search report - published on:EP12.05.2005
ClassificationIPC:A61K31/40, C07D207/34, A61P3/06, A61K31/4025, C07D401/04, C07D401/12, C07D207/32, C07D405/06, C07D319/06, C07C311/11
[2006/20]
CPC:
C04B35/632 (EP,US); A61P13/08 (EP); A61P19/10 (EP);
A61P25/28 (EP); A61P3/06 (EP); A61P43/00 (EP);
A61P9/10 (EP); C07C303/40 (EP,US); C07C311/13 (EP,US);
C07D207/33 (EP,US); C07D207/34 (EP,US); C07D207/36 (EP,US);
C07D319/06 (EP,US); C07D401/04 (EP,US); C07D401/12 (EP,US);
C07D403/12 (EP,US); C07D405/06 (EP,US); C07D405/12 (EP,US);
C07D405/14 (EP,US); C07D413/12 (EP,US); C07D413/14 (EP,US) (-)
C-Set:
C07C303/40, C07C311/13 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/20]
Extension statesALNot yet paid
HRNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:NEUE HMG-COA-REDUCTASE-HEMMER AUF PYRROLBASIS[2006/20]
English:NOVEL PYRROLE-BASED HMG-COA REDUCTASE INHIBITORS[2006/20]
French:INHIBITEURS NOUVEAUX DE L'HMG-COA REDUCTASE A BASE DE PYRROLE[2006/20]
Entry into regional phase13.03.2006National basic fee paid 
13.03.2006Designation fee(s) paid 
13.03.2006Examination fee paid 
Examination procedure17.09.2004Request for preliminary examination filed
International Preliminary Examining Authority: EP
13.03.2006Examination requested  [2006/20]
01.12.2008Despatch of a communication from the examining division (Time limit: M04)
02.02.2009Application deemed to be withdrawn, date of legal effect  [2009/31]
10.03.2009Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2009/31]
Fees paidRenewal fee
31.07.2006Renewal fee patent year 03
31.07.2007Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
31.07.200805   M06   Not yet paid
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Cited inInternational search[A]   GRAUL A ET AL: "Atorvastatin Calcium", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 22, no. 9, 1997, pages 956 - 968, XP000904817, ISSN: 0377-8282 [A] 1-5,8-11,14,15 * the whole document *
 [YA]   JAHNG Y: "Design of a new class of HMG-CoA reductase inhibitors", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 20, no. 4, 1995, pages 387 - 404, XP001055605, ISSN: 0377-8282 [Y] 1,4,8,10,14 * the whole document * [A] 2,3,5,9,11,15
 [YA]   ROTH B D ET AL: "Inhibitors of Cholesterol Biosynthesis. 3. Tetrahydro-4-hydroxy-6-(2- (1H-pyrrol-1-yl)ethyl)-2H-pyran-2-one Inhibitors of HMG-CoA Reductase. 2. Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 34, no. 1, January 1991 (1991-01-01), pages 357 - 366, XP002922115, ISSN: 0022-2623 [Y] 1,4,8,10,14 * the whole document * [A] 2,3,5,9,11,15

DOI:   http://dx.doi.org/10.1021/jm00105a056
 [YA]   PROCOPIOU P A ET AL.: "Inhibitors of Cholesterol Biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a Novel Series of HMG-CoA Reductase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY., vol. 36, no. 23, 1993, USAMERICAN CHEMICAL SOCIETY. WASHINGTON., pages 3658 - 3662, XP002303229 [Y] 1,4,8,10,14 * the whole document *[A] 2,3,5,9,11,15

DOI:   http://dx.doi.org/10.1021/jm00075a021
 [X]   HLASTA D J ET AL: "Steric Effects on the Regioselectivity of an Azide-Alkyne Dipolar Cycloaddition Reaction: The Synthesis of Human Leukocyte Elastase Inhibitors", JOURNAL OF ORGANIC CHEMISTRY., vol. 59, no. 21, 1994, USAMERICAN CHEMICAL SOCIETY. EASTON., pages 6184 - 6189, XP002313042 [X] 9 * table 3 *

DOI:   http://dx.doi.org/10.1021/jo00100a019
 [X]   BAUDIN J B ET AL: "Unsaturated sulfinamides. X. A simple and efficient preparation of N,N-disubstituted (1-alkyne)- or (E)-(1-alkene)sulfinamides and their conversion into the corresponding sulfinates or sulfonamides", SYNLETT., no. 11, 1992, DETHIEME VERLAG, STUTTGART., pages 911 - 913, XP001204490 [X] 9 * scheme 2 *

DOI:   http://dx.doi.org/10.1055/s-1992-21539
 [X]   BABIN P ET AL: "Electrophilic properties of sulfamoyl chloride. Application to the synthesis of .alpha.,.beta.-acetylenic sulfonamides", JOURNAL OF CHEMICAL RESEARCH. SYNOPSES, no. 1, 1982, GBLONDON, pages 16 - 17, XP009042402 [X] 9 * table 2 *
 [X]   ELLING H A, MAK H J: "Acetylenic sulfinamides: a novel class of compounds", SYNTHETIC COMMUNICATIONS., vol. 6, no. 2, 1976, USMARCEL DEKKER, NEW YORK, NY., pages 129 - 134, XP009042401 [X] 9 * compound 10 *

DOI:   http://dx.doi.org/10.1080/00397917608072622
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