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Extract from the Register of European Patents

EP About this file: EP1644499

EP1644499 - siRNA EXPRESSION SYSTEM [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  19.02.2010
Database last updated on 03.05.2025
Most recent event   Tooltip07.10.2011Lapse of the patent in a contracting state
New state(s): CY, TR		published on 09.11.2011  [2011/45]
Applicant(s)For all designated states
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA"
Piazzale Aldo Moro 5
00185 Roma / IT
[2006/15]
Inventor(s)01 / BOZZONI, Irene, c/o Università degli Studi di Roma
La Sapienza, Piazzale A. Moro, 5
I-00185 Roma / IT
02 / DENTI, Michela A., c/o Univ. degli Studi di Roma
Dip. di Genetica La Sapienza, Piazzale A. Moro, 5
I-00185 Roma / IT
03 / ROSA, Alessandro, c/o Univ. degli Studi di Roma
Dip. di Genetica La Sapienza Piazzale A.Moro, 5.
I-00185 Roma / IT
 [2006/24]
Former [2006/15]01 / BOZZONI, Irene, c/o Università degli Studi di Roma
La Sapienza, Piazzale A. Moro, 5
I-00185 Roma / IT
02 / DENTI, Michela A., c/o Univ. degli Studi di Roma
La Sapienza, Piazzale A. Moro, 5
I-00185 Roma / IT
03 / ROSA, Alessandro, c/o Univ. degli Studi di Roma
La Sapienza, Piazzale A. Moro, 5
I-00185 Roma / IT
Representative(s)Capasso, Olga, et al
De Simone & Partners S.r.l.
Via Vincenzo Bellini, 20
00198 Roma / IT
[N/P]
Former [2006/15]Capasso, Olga, et al
de Simone & Partners SpA Via V.Bellini 20
00198 Roma / IT
Application number, filing date04770721.109.07.2004
[2006/15]
WO2004IT00381
Priority number, dateIT2003RM0033509.07.2003         Original published format: IT RM20030335
[2006/15]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005005634
Date:20.01.2005
Language:EN
[2005/03]
Type: A2 Application without search report 
No.:EP1644499
Date:12.04.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 20.01.2005 takes the place of the publication of the European patent application.
[2006/15]
Type: B1 Patent specification 
No.:EP1644499
Date:15.04.2009
Language:EN
[2009/16]
Search report(s)International search report - published on:EP23.03.2006
ClassificationIPC:C12N15/11, C12N15/85, A61K31/713
[2006/15]
CPC:
C12N15/113 (EP,US); A61P43/00 (EP); C12N2310/111 (EP,US);
C12N2310/14 (EP,US); C12N2330/30 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/15]
Extension statesALNot yet paid
HRNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:EXPRESSIONSSYSTEM FÜR siRNA[2006/15]
English:siRNA EXPRESSION SYSTEM[2006/15]
French:SYSTEME D'EXPRESSION D'ARNsi[2006/15]
Entry into regional phase06.02.2006National basic fee paid 
06.02.2006Designation fee(s) paid 
06.02.2006Examination fee paid 
Examination procedure08.02.2006Examination requested  [2006/15]
18.06.2007Despatch of a communication from the examining division (Time limit: M06)
18.12.2007Reply to a communication from the examining division
25.08.2008Despatch of a communication from the examining division (Time limit: M02)
23.09.2008Reply to a communication from the examining division
24.11.2008Communication of intention to grant the patent
24.02.2009Fee for grant paid
24.02.2009Fee for publishing/printing paid
Opposition(s)18.01.2010No opposition filed within time limit [2010/12]
Fees paidRenewal fee
19.06.2006Renewal fee patent year 03
06.06.2007Renewal fee patent year 04
07.05.2008Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT15.04.2009
BE15.04.2009
CY15.04.2009
CZ15.04.2009
DK15.04.2009
EE15.04.2009
FI15.04.2009
NL15.04.2009
PL15.04.2009
RO15.04.2009
SI15.04.2009
SK15.04.2009
TR15.04.2009
IE09.07.2009
LU09.07.2009
BG15.07.2009
SE15.07.2009
GR16.07.2009
ES26.07.2009
MC31.07.2009
PT15.09.2009
HU16.10.2009
[2011/44]
Former [2011/32]AT15.04.2009
BE15.04.2009
CZ15.04.2009
DK15.04.2009
EE15.04.2009
FI15.04.2009
NL15.04.2009
PL15.04.2009
RO15.04.2009
SI15.04.2009
SK15.04.2009
IE09.07.2009
LU09.07.2009
BG15.07.2009
SE15.07.2009
GR16.07.2009
ES26.07.2009
MC31.07.2009
PT15.09.2009
HU16.10.2009
Former [2011/21]AT15.04.2009
BE15.04.2009
CZ15.04.2009
DK15.04.2009
EE15.04.2009
FI15.04.2009
NL15.04.2009
PL15.04.2009
RO15.04.2009
SI15.04.2009
SK15.04.2009
IE09.07.2009
LU09.07.2009
BG15.07.2009
SE15.07.2009
GR16.07.2009
ES26.07.2009
MC31.07.2009
PT15.09.2009
Former [2010/51]AT15.04.2009
BE15.04.2009
CZ15.04.2009
DK15.04.2009
EE15.04.2009
FI15.04.2009
NL15.04.2009
PL15.04.2009
RO15.04.2009
SI15.04.2009
SK15.04.2009
IE09.07.2009
BG15.07.2009
SE15.07.2009
GR16.07.2009
ES26.07.2009
MC31.07.2009
PT15.09.2009
Former [2010/35]AT15.04.2009
BE15.04.2009
CZ15.04.2009
DK15.04.2009
EE15.04.2009
FI15.04.2009
NL15.04.2009
PL15.04.2009
RO15.04.2009
SI15.04.2009
SK15.04.2009
IE09.07.2009
BG15.07.2009
SE15.07.2009
ES26.07.2009
MC31.07.2009
PT15.09.2009
Former [2010/18]AT15.04.2009
BE15.04.2009
CZ15.04.2009
DK15.04.2009
EE15.04.2009
FI15.04.2009
NL15.04.2009
PL15.04.2009
RO15.04.2009
SI15.04.2009
SK15.04.2009
BG15.07.2009
SE15.07.2009
ES26.07.2009
MC31.07.2009
PT15.09.2009
Former [2010/11]AT15.04.2009
BE15.04.2009
CZ15.04.2009
DK15.04.2009
EE15.04.2009
FI15.04.2009
NL15.04.2009
PL15.04.2009
RO15.04.2009
SI15.04.2009
SK15.04.2009
SE15.07.2009
ES26.07.2009
MC31.07.2009
PT15.09.2009
Former [2010/10]AT15.04.2009
BE15.04.2009
CZ15.04.2009
DK15.04.2009
EE15.04.2009
FI15.04.2009
NL15.04.2009
PL15.04.2009
RO15.04.2009
SI15.04.2009
SK15.04.2009
SE15.07.2009
ES26.07.2009
PT15.09.2009
Former [2010/01]AT15.04.2009
FI15.04.2009
NL15.04.2009
PL15.04.2009
SI15.04.2009
SE15.07.2009
ES26.07.2009
PT15.09.2009
Former [2009/51]AT15.04.2009
FI15.04.2009
NL15.04.2009
SI15.04.2009
SE15.07.2009
ES26.07.2009
PT15.09.2009
Former [2009/46]ES26.07.2009
Cited inInternational search[PX]  - DENTI M A ET AL, "A new vector, based on the PolII promoter for the U1 snRNA gene, for the expression of siRNAs in mammalian cells", MOLECULAR THERAPY, ACADEMIC PRESS, SAN DIEGO, CA,, US, (200407), vol. 10, no. 1, ISSN 1525-0016, pages 191 - 199, XP004660550 [PX] 1-8 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.ymthe.2004.04.008
 [DA]  - SUI GUANGCHAO ET AL, "A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 16 APR 2002, (20020416), vol. 99, no. 8, ISSN 0027-8424, pages 5515 - 5520, XP002311179 [DA] 1-8 * abstract *

DOI:   http://dx.doi.org/10.1073/pnas.082117599
 [A]  - YOUNG DE M B ET AL, "FUNCTIONAL CHARACTERIZATION OF RIBOZYMES EXPRESSED USING U1 AND T7 VECTORS FOR THE INTRACELLULAR CLEAVAGE OF ANF MRNA", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, (19941011), vol. 33, no. 40, ISSN 0006-2960, pages 12127 - 12138, XP000647772 [A] 1-8 * page 12136; figure 3 *

DOI:   http://dx.doi.org/10.1021/bi00206a016
 [AD]  - PAUL C P ET AL, "EFFECTIVE EXPRESSION OF SMALL INTERFERING RNA IN HUMAN CELLS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, (200205), vol. 20, no. 5, ISSN 1087-0156, pages 505 - 508, XP001121066 [AD] 1-8 * abstract *

DOI:   http://dx.doi.org/10.1038/nbt0502-505
 [PA]  - XIA HAIBIN ET AL, "RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.", NATURE MEDICINE. AUG 2004, (200408), vol. 10, no. 8, ISSN 1078-8956, pages 816 - 820, XP002311180 [PA] 1-8 * page 817 *

DOI:   http://dx.doi.org/10.1038/nm1076
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.