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Extract from the Register of European Patents

EP About this file: EP1661578

EP1661578 - SKIN ULCER PREVENTIVE CURATIVE AGENT CONTAINING HUMAN RECOMBINANT HGF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.01.2019
Database last updated on 25.09.2024
FormerThe patent has been granted
Status updated on  09.02.2018
FormerGrant of patent is intended
Status updated on  20.09.2017
FormerExamination is in progress
Status updated on  22.08.2017
FormerGrant of patent is intended
Status updated on  23.03.2017
Most recent event   Tooltip19.06.2020Lapse of the patent in a contracting state
New state(s): IE		published on 22.07.2020  [2020/30]
Applicant(s)For all designated states
Nakamura, Toshikazu
1-4, Hoshojicho, Okazaki, Sakyo-ku, Kyoto-shi
Kyoto 606-8333 / JP
For all designated states
Kringle Pharma Inc.
2F Saito Biotechnology Incubator 7-7-15
Saitoasagi
Ibaraki-shi
Osaka 567-0085 / JP
[2018/11]
Former [2006/22]For all designated states
Nakamura, Toshikazu
1-4, Hoshojicho, Okazaki, Sakyo-ku, Kyoto-shi
Kyoto 606-8333 / JP
For all designated states
Kringle Pharma Inc.
8F Senri Asahi Hankyu Bldg. 5-3, Shinsenrihigashimachi 1-chome
Toyonaka-shi, Osaka 560-0082 / JP
Inventor(s)01 / NAKAMURA, Toshikazu
1-4, Hoshojicho, Okazaki
Sakyo-ku
Kyoto-shi, Kyoto 606-8333 / JP
02 / YOSHIDA, Saho
5-29, Sakurai 1-chome, Mino-shi
Osaka 562-0043 / JP
03 / MATSUMOTO, Kunio
c/o Kanazawa University
Kakuma-machi, Kanazawa-shi
Ishikawa 920-1192 / JP
04 / ITAMI, Satoshi
37-7, Keyakizaka 3-chome
Kawanishi-shi, Hyogo 666-0145 / JP
05 / YOSHIKAWA, Kunihiko
3-14, Higashitokiwadai 9-chome
Toyono-cho
Toyono-gun, Osaka 563-0103 / JP
 [2018/10]
Former [2006/22]01 / NAKAMURA, Toshikazu
1-4, Hoshojicho, Okazaki, Sakyo-ku
Kyoto-shi, Kyoto 606-8333 / JP
02 / YOSHIDA, Saho
5-29, Sakurai 1-chome, Mino-shi
Osaka 562-0043 / JP
03 / MATSUMOTO, Kunio
25-2-204, Onoharahigashi 6-chome
Mino-shi, Osaka 562-0031 / JP
04 / ITAMI, Satoshi
37-7, Keyakizaka 3-chome
Kawanishi-shi, Hyogo 666-0145 / JP
05 / YOSHIKAWA, Kunihiko
3-14, Higashitokiwadai 9-chome, Toyono-cho
Toyono-gun, Osaka 563-0103 / JP
Representative(s)Witte, Weller & Partner Patentanwälte mbB
Postfach 10 54 62
70047 Stuttgart / DE
[2018/11]
Former [2006/22]Findeisen, Marco, et al
Witte, Weller & Partner Patentanwälte Postfach 105462
70047 Stuttgart / DE
Application number, filing date04772317.627.08.2004
[2006/22]
WO2004JP12361
Priority number, dateJP2003031193603.09.2003         Original published format: JP 2003311936
[2006/22]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2005023287
Date:17.03.2005
Language:EN
[2005/11]
Type: A1 Application with search report 
No.:EP1661578
Date:31.05.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 17.03.2005 takes the place of the publication of the European patent application.
[2006/22]
Type: B1 Patent specification 
No.:EP1661578
Date:14.03.2018
Language:EN
[2018/11]
Search report(s)International search report - published on:JP17.03.2005
(Supplementary) European search report - dispatched on:EP13.11.2009
ClassificationIPC:A61K38/18, A61K9/70, A61P17/02, A61P9/00, A61P43/00
[2006/22]
CPC:
A61L26/0047 (EP,US); A61K38/1833 (EP,US); A61P17/02 (EP);
A61P43/00 (EP); A61P7/00 (EP); A61P9/00 (EP);
A61P9/14 (EP) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/11]
Former [2006/22]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IT,  LI,  LU,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:MITTEL ZUR PRÄVENTION UND HEILUNG VON HAUTGESCHWÜREN MIT HUMANEM REKOMBINANTEM HGF[2006/22]
English:SKIN ULCER PREVENTIVE CURATIVE AGENT CONTAINING HUMAN RECOMBINANT HGF[2006/22]
French:AGENT CURATIF ET PREVENTIF DE L'ULCERE DE LA PEAU CONTENANT UN HGF DE RECOMBINAISON HUMAIN[2006/22]
Entry into regional phase01.03.2006Translation filed 
01.03.2006National basic fee paid 
01.03.2006Search fee paid 
01.03.2006Designation fee(s) paid 
01.03.2006Examination fee paid 
Examination procedure01.03.2006Amendment by applicant (claims and/or description)
01.03.2006Examination requested  [2006/22]
08.03.2011Despatch of a communication from the examining division (Time limit: M06)
19.09.2011Reply to a communication from the examining division
12.08.2013Despatch of a communication from the examining division (Time limit: M04)
06.12.2013Reply to a communication from the examining division
02.07.2015Despatch of a communication from the examining division (Time limit: M04)
06.11.2015Reply to a communication from the examining division
24.03.2017Communication of intention to grant the patent
03.08.2017Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
21.09.2017Communication of intention to grant the patent
01.02.2018Fee for grant paid
01.02.2018Fee for publishing/printing paid
01.02.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.03.2011
Opposition(s)17.12.2018No opposition filed within time limit [2019/08]
Fees paidRenewal fee
01.03.2006Renewal fee patent year 03
23.08.2007Renewal fee patent year 04
13.03.2008Renewal fee patent year 05
25.08.2009Renewal fee patent year 06
20.08.2010Renewal fee patent year 07
19.08.2011Renewal fee patent year 08
21.08.2012Renewal fee patent year 09
22.08.2013Renewal fee patent year 10
20.08.2014Renewal fee patent year 11
19.08.2015Renewal fee patent year 12
23.08.2016Renewal fee patent year 13
23.08.2017Renewal fee patent year 14
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU27.08.2004
AT14.03.2018
CY14.03.2018
CZ14.03.2018
DK14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
MC14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SI14.03.2018
SK14.03.2018
TR14.03.2018
BG14.06.2018
GR15.06.2018
PT16.07.2018
IE27.08.2018
LU27.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
[2020/30]
Former [2020/28]HU27.08.2004
AT14.03.2018
CY14.03.2018
CZ14.03.2018
DK14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
MC14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SI14.03.2018
SK14.03.2018
TR14.03.2018
BG14.06.2018
GR15.06.2018
PT16.07.2018
LU27.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
Former [2020/16]AT14.03.2018
CY14.03.2018
CZ14.03.2018
DK14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
MC14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SI14.03.2018
SK14.03.2018
TR14.03.2018
BG14.06.2018
GR15.06.2018
PT16.07.2018
LU27.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
Former [2019/38]AT14.03.2018
CY14.03.2018
CZ14.03.2018
DK14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
MC14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SI14.03.2018
SK14.03.2018
BG14.06.2018
GR15.06.2018
PT16.07.2018
LU27.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
Former [2019/21]AT14.03.2018
CY14.03.2018
CZ14.03.2018
DK14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
MC14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SI14.03.2018
SK14.03.2018
BG14.06.2018
GR15.06.2018
PT16.07.2018
LU27.08.2018
CH31.08.2018
LI31.08.2018
Former [2019/15]AT14.03.2018
CY14.03.2018
CZ14.03.2018
DK14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
MC14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SI14.03.2018
SK14.03.2018
BG14.06.2018
GR15.06.2018
PT16.07.2018
Former [2019/13]AT14.03.2018
CY14.03.2018
CZ14.03.2018
DK14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SI14.03.2018
SK14.03.2018
BG14.06.2018
GR15.06.2018
PT16.07.2018
Former [2019/08]AT14.03.2018
CY14.03.2018
CZ14.03.2018
DK14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SK14.03.2018
BG14.06.2018
GR15.06.2018
PT16.07.2018
Former [2019/03]AT14.03.2018
CY14.03.2018
CZ14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SK14.03.2018
BG14.06.2018
GR15.06.2018
PT16.07.2018
Former [2018/50]AT14.03.2018
CY14.03.2018
CZ14.03.2018
EE14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
NL14.03.2018
PL14.03.2018
RO14.03.2018
SE14.03.2018
SK14.03.2018
BG14.06.2018
GR15.06.2018
Former [2018/47]CY14.03.2018
ES14.03.2018
FI14.03.2018
IT14.03.2018
NL14.03.2018
SE14.03.2018
BG14.06.2018
GR15.06.2018
Former [2018/45]CY14.03.2018
ES14.03.2018
FI14.03.2018
NL14.03.2018
SE14.03.2018
BG14.06.2018
GR15.06.2018
Former [2018/40]CY14.03.2018
ES14.03.2018
FI14.03.2018
SE14.03.2018
BG14.06.2018
GR15.06.2018
Former [2018/37]CY14.03.2018
ES14.03.2018
FI14.03.2018
GR15.06.2018
Former [2018/36]CY14.03.2018
ES14.03.2018
FI14.03.2018
Documents cited:Search[X]EP0461560  (NAKAMURA TOSHIKAZU [JP], et al) [X] 1-7,11-12 * figure 3; claims 1-3 * * page 6, column 9, line 31 - line 43 *;
 [X]EP0462277  (SNOW BRAND MILK PROD CO LTD [JP]) [X] 1-12 * claims 1-12 * * page 2, line 3 - line 10 * * figures 15-16 *;
 [AD]EP0492614  (NAKAMURA TOSHIKAZU [JP], et al) [AD] 1-15 * abstract *;
 [X]EP0550769  (TORAY INDUSTRIES [JP]) [X] 1-7,11-12 * claim 8 * * figure 2 * * page 1, line 3 - line 12 *;
 [X]WO9414845  (SNOW BRAND MILK PROD CO LTD [JP], et al) [X] 1-7,11-12 * page 29 - page 40 * * claims 1-6 * * page 1, line 1 - line 7 *;
 [A]WO0078259  (RES DEV FOUNDATION [US]) [A] 1-15* claims 1-31 *
International search[A]JPH07179356  (NAKAMURA TOSHIICHI);
 [X]US5821223  (RUBIN JEFFREY S [US], et al);
 [Y]  - TOYODA, M. ET AL, "Overexpression of hepacyte growth factor/scatter factor promotes vascularizatio n and granulation tissue formation in vivo", FEBS LETTER, (2001), vol. 509, pages 95 - 100, XP004329151

DOI:   http://dx.doi.org/10.1016/S0014-5793(01)03126-X
 [A]  - SEKI, T. ET AL, "Isolation and expression of cdna for different forms of hepatocyte growth factorfrom human leukocyte", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (1990), vol. 172, no. 1, pages 321 - 327, XP002084490

DOI:   http://dx.doi.org/10.1016/S0006-291X(05)80212-8
Examination   - FRANKLIN H. EPSTEIN, "Cutaneous wound healing", THE NEW ENGLAND JOURNAL OF MEDICINE, (1999), pages 738 - 746
    - S. YOSHIDA ET AL, "Recombinant Hepatocyte Growth Factor Accelerates Cutaneous Wound Healing in a Diabetic Mouse Model", GROWTH FACTORS, (200406), vol. 22, no. 2, pages 111 - 119
    - N. SHIMA ET AL, "Hepatocyte Growth Factor and its Variant with a Deletion of Five Amino Acids are Distinguishable in their Biological Activity and Tertiary Structure", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (1994), vol. 200, no. 2, pages 808 - 815
    - Y. SHIRIKATA ET AL, SAIBOUZOUSYOKUINSI TO SAISEIIRYOU, (2006), pages 126 - 130
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.