blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP1687427

EP1687427 - METHODS FOR MODULATING NEURONAL RESPONSES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.06.2017
Database last updated on 20.12.2024
Most recent event   Tooltip13.07.2018Lapse of the patent in a contracting state
New state(s): TR		published on 15.08.2018  [2018/33]
Applicant(s)For all designated states
Qingdao Primedicine Pharmaceutical Co., Ltd
Floor 1-2, Building 12
Qingdao International Academician Park
171 Jinshui Road
Licang District
Qingdao, Shandong / CN
[2017/25]
Former [2006/32]For all designated states
THE UNIVERSITY OF BRITISH COLUMBIA
No. 103-6190 Agronomy Road Vancouver
British Columbia, V6T 1Z3 / CA
Inventor(s)01 / WANG, Yu, Tian
2437 West 51st Avenue
Vancouver, British Columbia V6P 1E9 / CA
02 / WANG, Yushan
60 Park Meadows Court, SE
Medicine Hat, Alberta T1B 4C3 / CA
03 / PHILLIPS, Anthony
6272 Balaclava Street
Vancouver, British Columbia V6N 1L6 / CA
04 / LIU, Lidong
8515 Ash Street
Richmond, British Columbia V6Y 2S5 / CA
05 / LIU, Yitao
103-7140 Granville Avenue
Richmond, British Columbia V6Y 1N8 / CA
 [2006/32]
Representative(s)V.O.
P.O. Box 87930
2508 DH Den Haag / NL
[2016/34]
Former [2012/17]Jansen, Cornelis Marinus, et al
Vereenigde
Johan de Wittlaan 7
2517 JR Den Haag / NL
Former [2008/34]van Loon, C.J.J., et al
Vereenigde Johan de Wittlaan 7
2517 JR Den Haag / NL
Former [2006/32]van Loon, C.J.J., et al
c/o VEREENIGDE Johan de Wittlaan 7
2517 JR The Hague / NL
Application number, filing date04789721.008.10.2004
[2006/32]
WO2004CA01813
Priority number, dateUS20030509249P08.10.2003         Original published format: US 509249 P
[2006/32]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005033311
Date:14.04.2005
Language:EN
[2005/15]
Type: A2 Application without search report 
No.:EP1687427
Date:09.08.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 14.04.2005 takes the place of the publication of the European patent application.
[2006/32]
Type: B1 Patent specification 
No.:EP1687427
Date:24.08.2016
Language:EN
[2016/34]
Search report(s)International search report - published on:CA27.10.2005
(Supplementary) European search report - dispatched on:EP20.06.2007
ClassificationIPC:C12N15/12, C07K7/06, C07K14/705, C07K16/28, A61K38/17, A61K38/08, A61K39/395, A61K31/7088, G01N33/566
[2006/32]
CPC:
A61K31/7088 (EP,US); A61P25/00 (EP); A61P25/04 (EP);
A61P25/08 (EP); A61P25/14 (EP); A61P25/16 (EP);
A61P25/18 (EP); A61P25/20 (EP); A61P25/22 (EP);
A61P25/24 (EP); A61P25/28 (EP); A61P25/30 (EP);
A61P25/34 (EP); A61P25/36 (EP); A61P3/00 (EP);
A61P3/04 (EP); A61P3/10 (EP); A61P9/00 (EP);
A61P9/02 (EP); A61P9/04 (EP); A61P9/10 (EP);
A61P9/12 (EP); C07K14/705 (EP,US); C07K7/06 (EP,US);
C12N9/1205 (EP,US); A61K38/00 (EP,US); G01N2333/705 (EP,US);
G01N2500/02 (EP,US); G01N2500/04 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/34]
Former [2006/32]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IT,  LI,  LU,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:VERFAHREN ZUR MODULATION NEURONALER REAKTIONEN[2006/32]
English:METHODS FOR MODULATING NEURONAL RESPONSES[2006/32]
French:METHODES DE MODULATION DES REPONSES NEURONALES[2006/32]
Entry into regional phase08.05.2006National basic fee paid 
08.05.2006Search fee paid 
08.05.2006Designation fee(s) paid 
08.05.2006Examination fee paid 
Examination procedure08.05.2006Examination requested  [2006/32]
21.07.2006Amendment by applicant (claims and/or description)
23.06.2009Despatch of a communication from the examining division (Time limit: M06)
05.02.2010Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
12.04.2010Reply to a communication from the examining division
07.05.2010Despatch of a communication from the examining division (Time limit: M06)
17.11.2010Reply to a communication from the examining division
28.09.2011Despatch of a communication from the examining division (Time limit: M06)
04.04.2012Reply to a communication from the examining division
23.10.2012Despatch of a communication from the examining division (Time limit: M06)
01.05.2013Reply to a communication from the examining division
10.04.2014Despatch of a communication from the examining division (Time limit: M06)
22.09.2014Reply to a communication from the examining division
08.01.2015Despatch of a communication from the examining division (Time limit: M04)
13.05.2015Reply to a communication from the examining division
14.03.2016Communication of intention to grant the patent
13.07.2016Fee for grant paid
13.07.2016Fee for publishing/printing paid
13.07.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.06.2009
Opposition(s)26.05.2017No opposition filed within time limit [2017/31]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
12.04.2010Request for further processing filed
12.04.2010Full payment received (date of receipt of payment)
Fees paidRenewal fee
04.07.2006Renewal fee patent year 03
15.10.2007Renewal fee patent year 04
29.04.2009Renewal fee patent year 05
31.03.2010Renewal fee patent year 06
18.10.2010Renewal fee patent year 07
18.10.2011Renewal fee patent year 08
15.10.2012Renewal fee patent year 09
14.10.2013Renewal fee patent year 10
14.10.2014Renewal fee patent year 11
12.10.2015Renewal fee patent year 12
Penalty fee
Additional fee for renewal fee
31.10.200805   M06   Fee paid on   29.04.2009
31.10.200906   M06   Fee paid on   31.03.2010
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU08.10.2004
AT24.08.2016
BE24.08.2016
CY24.08.2016
CZ24.08.2016
DK24.08.2016
EE24.08.2016
FI24.08.2016
MC24.08.2016
NL24.08.2016
PL24.08.2016
RO24.08.2016
SE24.08.2016
SI24.08.2016
SK24.08.2016
TR24.08.2016
IE08.10.2016
LU08.10.2016
CH31.10.2016
LI31.10.2016
BG24.11.2016
GR25.11.2016
PT26.12.2016
[2018/29]
Former [2018/28]HU08.10.2004
AT24.08.2016
BE24.08.2016
CY24.08.2016
CZ24.08.2016
DK24.08.2016
EE24.08.2016
FI24.08.2016
MC24.08.2016
NL24.08.2016
PL24.08.2016
RO24.08.2016
SE24.08.2016
SI24.08.2016
SK24.08.2016
IE08.10.2016
LU08.10.2016
CH31.10.2016
LI31.10.2016
BG24.11.2016
GR25.11.2016
PT26.12.2016
Former [2017/51]AT24.08.2016
BE24.08.2016
CZ24.08.2016
DK24.08.2016
EE24.08.2016
FI24.08.2016
NL24.08.2016
PL24.08.2016
RO24.08.2016
SE24.08.2016
SI24.08.2016
SK24.08.2016
IE08.10.2016
LU08.10.2016
CH31.10.2016
LI31.10.2016
BG24.11.2016
GR25.11.2016
PT26.12.2016
Former [2017/43]AT24.08.2016
BE24.08.2016
CZ24.08.2016
DK24.08.2016
EE24.08.2016
FI24.08.2016
NL24.08.2016
PL24.08.2016
RO24.08.2016
SE24.08.2016
SI24.08.2016
SK24.08.2016
LU08.10.2016
CH31.10.2016
LI31.10.2016
BG24.11.2016
GR25.11.2016
PT26.12.2016
Former [2017/37]AT24.08.2016
BE24.08.2016
CZ24.08.2016
DK24.08.2016
EE24.08.2016
FI24.08.2016
NL24.08.2016
PL24.08.2016
RO24.08.2016
SE24.08.2016
SI24.08.2016
SK24.08.2016
CH31.10.2016
LI31.10.2016
BG24.11.2016
GR25.11.2016
PT26.12.2016
Former [2017/35]AT24.08.2016
BE24.08.2016
CZ24.08.2016
DK24.08.2016
EE24.08.2016
FI24.08.2016
NL24.08.2016
PL24.08.2016
RO24.08.2016
SE24.08.2016
SK24.08.2016
CH31.10.2016
LI31.10.2016
BG24.11.2016
GR25.11.2016
PT26.12.2016
Former [2017/23]AT24.08.2016
BE24.08.2016
CZ24.08.2016
DK24.08.2016
EE24.08.2016
FI24.08.2016
NL24.08.2016
PL24.08.2016
RO24.08.2016
SE24.08.2016
SK24.08.2016
BG24.11.2016
GR25.11.2016
PT26.12.2016
Former [2017/23]AT24.08.2016
BE24.08.2016
CZ24.08.2016
EE24.08.2016
FI24.08.2016
NL24.08.2016
PL24.08.2016
RO24.08.2016
SE24.08.2016
SK24.08.2016
BG24.11.2016
GR25.11.2016
PT26.12.2016
Former [2017/12]AT24.08.2016
FI24.08.2016
NL24.08.2016
SE24.08.2016
BE31.10.2016
GR25.11.2016
PT26.12.2016
Former [2017/10]FI24.08.2016
NL24.08.2016
SE24.08.2016
BE31.10.2016
Former [2017/09]FI24.08.2016
NL24.08.2016
Documents cited:Search[X]US6383764  (CIVELLI OLIVIER [US], et al) [X] 38,39,43 * sequence 27 *;
 [PX]  - AHMADIAN GHOLAMREZA ET AL, "Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, (20040310), vol. 23, no. 5, ISSN 0261-4189, pages 1040 - 1050, XP002430623 [PX] 1-50 * the whole document *

DOI:   http://dx.doi.org/10.1038/sj.emboj.7600126
    [ ] - REGISTRY, Database accession no. 405140-74-1, URL: STN, XP002430624 [ ] * column A *
International search[XP]  - WANG Y. ET AL, "alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor (AMPAR) endocytosis is essential for N-methyl-D-aspartate-induced neural apoptosis", J. BIOL. CHEM., (200410), vol. 279, no. 40, pages 41267 - 41270, XP003009247

DOI:   http://dx.doi.org/10.1074/jbc.C400199200
 [X]  - NAKANISHI N. ET AL, "A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties", NEURON, (199011), vol. 5, no. 5, pages 569 - 581, XP003009248

DOI:   http://dx.doi.org/10.1016/0896-6273(90)90212-X
 [X]  - IWAKURA Y. ET AL, "N-methyl-D-aspartate-induced alpha-Amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor down-regulation involves interaction of the carboxyl terminus of GluR2/3 with Pick1", J. BIOL. CHEM., (200110), vol. 276, no. 43, pages 40025 - 40032, XP003009249

DOI:   http://dx.doi.org/10.1074/jbc.M103125200
 [Y]  - WANG Y.S. ET AL, "Requirement for clathrin-mediated endocytosis in NMDA-induced neural apoptosis", SOCIETY FOR NEUROSCIENCE, (2002), no. 303.11, XP008077746
 [Y]  - CHAN S.L. ET AL, "Evidence for caspase-mediated cleavage of AMPA receptor subunits in neural apoptosis and Alzheimer's disease", J. NEUROSCI. RES., (199908), vol. 57, no. 3, pages 315 - 323, XP003009250

DOI:   http://dx.doi.org/10.1002/(SICI)1097-4547(19990801)57:3<315::AID-JNR3>3.0.CO;2-#
 [Y]  - XIAO M-Y. ET AL, "Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors", NEUROPHARMACOLOGY, (200111), vol. 41, no. 6, pages 664 - 671, XP003009251

DOI:   http://dx.doi.org/10.1016/S0028-3908(01)00134-4
 [Y]  - COLLEDGE M. ET AL, "Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression", NEURON, (200310), vol. 40, no. 3, pages 595 - 607, XP003009252

DOI:   http://dx.doi.org/10.1016/S0896-6273(03)00687-1
 [Y]  - BEATTIE E.C. ET AL, "Regulation of AMPA receptor endocytosis by a signalling mechanism shared with LTD", NATURE NEUROSCIENCE, (200012), vol. 3, no. 12, pages 1291 - 1300, XP003009253

DOI:   http://dx.doi.org/10.1038/81823
 [A]  - IWASAKI K. ET AL, "Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats", BRAIN RES., (200401), vol. 995, no. 1, pages 131 - 139, XP003009254

DOI:   http://dx.doi.org/10.1016/j.brainres.2003.09.064
Examination   - MORRIS M C ET AL, "A peptide carrier for the delivery of biologically active proteins into mammalian cells", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20011201), vol. 19, doi:10.1038/NBT1201-1173, ISSN 1087-0156, pages 1173 - 1176, XP002969667

DOI:   http://dx.doi.org/10.1038/nbt1201-1173
by applicant   - MATTSON M. P., NAT.REV.MOL. CELL BIOL., (2000), vol. 1, pages 120 - 129
    - GRAHAM S. H.; J. CHEN, J.CEREB.BLOOD FLOW METAB, (2001), vol. 21, pages 99 - 109
    - YU S. P.; L. M. CANZONIERO; D. W. CHOI, CURR. OPIN. CELL BIOL., vol. 13, pages 405 - 411
    - NICOTERA P.; S. A. LIPTON, J.CEREB.BLOOD FLOW METAB, (1999), vol. 19, pages 583 - 5 1
    - H. Y. MAN; W. JU; G. AHMADIAN; Y. T. WANG, CELL MOL.LIFE SCI., (2000), vol. 57, pages 1526 - 1534
    - R. MALINOW; R. C. MALENKA, ANNU.REV.NEUROSCI., (2002), vol. 25, pages 103 - 126
    - A. V. VIEIRA; C. LAMAZE; S. L. SCHMID, SCIENCE, (1996), vol. 274, pages 2086 - 2089
    - A. KISELEV ET AL., NEURON, (2000), vol. 28, pages 139 - 152
    - P. G. ALLOWAY; L. HOWARD; P. J. DOLPH, NEURON, (2000), vol. 28, pages 129 - 138
    - K. L. PIERCE; R. J. LEFKOWITZ, NAT.REV.NEUROSCI., (2001), vol. 2, pages 727 - 733
    - S. L. BUDD; L. TENNETI; T. LISHNAK; S. A. LIPTON, PROC.NATL.ACAD.SCI. U.S.A, (2000), vol. 97, pages 6161 - 6166
    - S. H. HANSEN; K. SANDVIG; B. VAN DEURS, J. CELL BIOL., (1993), vol. 121, pages 61 - 72
    - H. Y. MAN ET AL., NEURON, (2000), vol. 25, pages 649 - 662
    - B. MARKS; H. T. MCMAHON, CURR.BIOL., (1998), vol. 8, pages 740 - 749
    - S. S. OKAMOTO ET AL., PROC.NATL.ACAD.SCI. U.S.A, (2002), vol. 99, pages 3974 - 3979
    - H. DUDEK ET AL., SCIENCE, (1997), vol. 275, pages 661 - 665
    - E. CHALECKA-FRANASZEK; D. M. CHUANG, PROC.NATL.ACAD.SCI.U.S.A, (1999), vol. 96, pages 8745 - 8750
    - P. J. COFFER; J. JIN; J. R. WOODGETT, BIOCHEM.J, (1998), vol. 335, pages 1 - 13
    - J. W. LIN ET AL., NAT.NEUROSCI., (2000), vol. 3, pages 1282 - 1290
    - M. D. EHLERS, NEURON, (2000), vol. 28, pages 511 - 525
    - E. C. BEATTIE ET AL., NAT.NEUROSCI., (2000), vol. 3, pages 1291 - 1300
    - M. C. MORRIS; J. DEPOLLIER; J. MERY; F. HEITZ; G. DIVITA, NAT.BIOTECHNOL., (2001), vol. 19, pages 1173 - 1176
    - C. LUSCHER ET AL., NEURON, (1999), vol. 24, pages 649 - 658
    - Y. T. WANG; D. J. LINDEN, NEURON, (2000), vol. 25, pages 635 - 647
    - Y. T. WANG; M. W. SALTER, NATURE, (1994), vol. 369, pages 233 - 235
    - BENKE,T.A; LUTHI,A.; ISAAC,J.T.; COLLINGRIDGE,G.L., "Modulation of AMPA receptor unitary conductance by synaptic activity", NATURE, (1998), vol. 393, pages 793 - 797
    - BONIFACINO,J.S.; DELL'ANGELICA,E.C., "Molecular bases for the recognition of tyrosine-based sorting signals", J. CELL BIOL., (1999), vol. 145, pages 923 - 926
    - BOXALL,A.R.; LANCASTER,B.; GARTHWAITE,J., "Tyrosine kinase is required for long-term depression in the cerebellum", NEURON, (1996), vol. 16, pages 805 - 813
    - CARROLL,R.C.; BEATTIE,E.C.; XIA,H.; SCHER,C.; ALTSCHULER,Y.; NICOLL,R.A.; MALENKA,R.C.; VON ZASTROW,M, "Dynamin-dependent endocytosis of ionotropic glutamate receptors", PROC.NATL.ACAD.SCI. U.S.A, (1999), vol. 96, pages 14112 - 14117
    - CHUNG,H.J.; XIA,J.; SCANNEVIN,R.H.; ZHANG,X.; HUGANIR,R.L., "Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins", J.NEUROSCI., (2000), vol. 20, pages 7258 - 7267
    - DAW,M.I.; CHITTAJALLU,R.; BORTOLOTTO,Z.A.; DEV,K.K.; DUPRAT,F.; HENLEY,J.M.; COLLINGRIDGE,G.L.; ISAAC,J.T., "PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.", NEURON, (2000), vol. 28, pages 873 - 886
    - DERKACH,V.; BARRIA,A.; SODERLING,T.R., "Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors", PROC.NATL.ACAD.SCI. U.S.A, (1999), vol. 96, pages 3269 - 3274
    - GREENGARD,P.; JEN,J.; NAIRN,A.C.; STEVENS,C.F., "Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons", SCIENCE, (1991), vol. 253, pages 1135 - 1138
    - HAYASHI,Y.; SHI,S.H.; ESTEBAN,J.A.; PICCINI,A.; PONCER,J.C.; MALINOW,R., "Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR and PDZ domain interaction", SCIENCE, (2000), vol. 287, pages 2262 - 2267
    - HOLLMANN,M; HEINEMANN,S., "Cloned glutamate receptors", ANNU.REV.NEUROSCI., (1994), vol. 17, pages 31 - 108
    - KAROOR,V.; WANG,L.; WANG,H.Y.; MALBON,C.C, "Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 via tyrosine 350", J.BIOL.CHEM., (1998), vol. 273, pages 33035 - 33041
    - KIM,C.H.; CHUNG,H.J.; LEE,H.K.; HUGANIR,R.L, "Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression", PROC.NATL.ACAD.SCI. U.S.A, (2001), vol. 98, pages 11725 - 11730
    - LAU,L.F.; HUGANIR,R.L., "Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits", JOURNAL OF BIOLOGICAL CHEMISTRY, (1995), vol. 270, pages 20036 - 20041
    - LEE,S.H.; LIU,L.; WANG,Y.T.; SHENG,M., "Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD", NEURON, (2002), vol. 36, pages 661 - 674
    - LIANG,F; HUGANIR,R.L, "Coupling of agonist-induced AMPA receptor internalization with receptor recycling", J.NEUROCHEM., (2001), vol. 77, pages 1626 - 1631
    - LU,W.; MAN,H.; JU,W.; TRIMBLE,W.S.; MACDONALD,J.F.; WANG,Y.T., "Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons", NEURON, (2001), vol. 29, pages 243 - 254
    - LUSCHER,C.; NICOLL,R.A; MALENKA,R.C.; MULLER,D., "Synaptic plasticity and dynamic modulation of the postsynaptic membrane", NAT.NEUROSCI.,, (2000), vol. 3, pages 545 - 550
    - LUTHI,A.; CHITTAJALLU,R.; DUPRAT,F.; PALMER,M.J.; BENKE,T.A.; KIDD,F.L.; HENLEY,J.M.; ISAAC,J.T.; COLLINGRIDGE,G.L., "Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction [see comments", NEURON, (1999), vol. 24, pages 389 - 399
    - MALINOW,R.; MAINEN,Z.F.; HAYASHI,Y, "LTP mechanisms: from silence to four-lane traffic", CURR.OPIN.NEUROBIOL., (2000), vol. 10, pages 352 - 357
    - MATSUDA,S.; LAUNEY,T.; MIKAWA,S.; HIRAI,H., "Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons", EMBO J., (2000), vol. 19, pages 2765 - 2774
    - NISHIMUNE,A.; ISAAC,J.T.; MOLNAR,E.; NOEL,J.; NASH,S.R.; TAGAYA,M.; COLLINGRIDGE,G.L.; NAKANISHI,S.; HENLEY,J.M, "NSF binding to GluR2 regulates synaptic transmission", NEURON, (1998), vol. 21, pages 87 - 97
    - OSTEN,P.; SRIVASTAVA,S.; INMAN,G.J.; VILIM,F.S.; KHATRI,L.; LEE,L.M.; STATES,B.A.; EINHEBER,S.; MILNER,T.A.; HANSON,P.I., "The AMPA receptor GluR2 C terminus can mediate a reversible, ATP- dependent interaction with NSF and alpha- and beta-SNAPs.", NEURON, (1998), vol. 21, pages 99 - 110
    - PASSAFARO,M.; PIECH,V.; SHENG,M., "Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons", NAT.NEUROSCI., (2001), vol. 4, pages 917 - 926
    - PICKARD,L.; NOEL,J.; DUCKWORTH,J.K.; FITZJOHN,S.M.; HENLEY,J.M.; COLLINGRIDGE,G.L.; MOLNAR,E., "Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors at hippocampal neuronal plasma membranes", NEUROPHARMACOLOGY, (2001), vol. 41, pages 700 - 713
    - SONG,I.; KAMBOJ,S.; XIA,J.; DONG,H.; LIAO,D.; HUGANIR,R.L., "Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors.", NEURON, (1998), vol. 21, pages 393 - 400
    - STERN-BACH,Y; RUSSO,S; NEUMAN,M.; ROSENMUND,C, "A point mutation in the glutamate binding site blocks desensitization of AMPA receptors", NEURON, (1998), vol. 21, pages 907 - 918
    - WENTHOLD,R.J.; PETRALIA,R.S.; BLAHOS,J., II; NIEDZIELSKI,A.S, "Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons", JOURNAL OF NEUROSCIENCE,, (1996), vol. 16, pages 1982 - 1989
    - XIA,J.; CHUNG,H.J.; WIHLER,C.; HUGANIR,R.L.; LINDEN,D.J., "Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins", NEURON, (2000), vol. 28, pages 499 - 510
    - "Apoptosis in the APO-1 System", KRAMMER ET AL., Apoptosis: The Molecular Basis of Cell Death, COLD SPRING HARBOR LABORATORY PRESS, (1991), pages 87 - 99
    - EISENBERG ET AL., J. MOL. BIO., vol. 179, pages 125 - 142,184
    - BERKE, J.D.; HYMAN, S.E, "Addiction, dopamine and the molecular mechanisms of memory", NEURON, (2000), vol. 25, pages 515 - 532
    - ROBINSON, T.E.; BERRIDGE, K.L, "The neural basis of drug craving: an incentive-sensitization theory of addiction", BRAIN RES., BRAIN RES. REV., (1993), vol. 18, pages 247 - 291
    - JAROUSSE, N.; KELLY, R.B., "Selective inhibition of adaptor complex-mediated vesiculation", TRAFFIC, (2000), vol. 1, pages 378 - 384
    - ALTSCHUL, S.F., "Amino acid substitution matrices from an information theoretic perspective", JOURNAL OF MOLECULAR BIOLOGY, (1991), vol. 219, pages 555 - 665
    - "A model of evolutionary change in proteins", DAYHOFF, M.O.; SCHWARTZ, R.M.; ORCUTT, B.C., Atlas of Protein Sequence and Structure, NATIONAL BIOMEDICAL RESEARCH FOUNDATION, (1978), vol. 5, pages 345 - 352
    - STATES, D.J.; GISH, W.; ALTSCHUL, S.F., "Improved Sensitivity of Nucleic Acid Database Search Using Application-Specific Scoring Matrices", METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, (1991), vol. 3, no. 1, pages 66 - 77
    - STEVEN HENIKOFF; JORJA G. HENIKOFF., "Amino acid substitution matrices from protein blocks", PROC. NATL. ACAD. SCI. USA., (1992), vol. 89, pages 10915 - 10919
    - M.S. JOHNSON; J.P. OVERINGTON, "A Structural Basis of Sequence Comparisons: An evaluation of scoring methodologies", JOURNAL OF MOLECULAR BIOLOGY, (1993), vol. 233, pages 716 - 738
    - STEVEN HENIKOFF; JORJA G. HENIKOFF, "Performance Evaluation of Amino Acid Substitution Matrices", PROTEINS: STRUCTURE, FUNCTION, AND GENETICS, (1993), vol. 17, pages 46 - 61
    - KARLIN, S; ALTSCHUL, S.F., "Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes", PROC. NATL. ACAD. SCI. USA., (1990), vol. 87, pages 2264 - 2268
    - LONGA EZ; WEINSTEIN PR; CARLSON S; CUMMINS R, "Reversible middle cerebral artery occlusion without craniectomy in rats", STROKE, (1989), vol. 20, pages 84 - 91
    - REGLODI D; TAMAS A; LENGVARI I, "Examination of sensorimotor performance following middle cerebral artery occlusion in rats", BRAIN RES BULL, (2003), vol. 59, pages 459 - 466
    - KAN RK; PLEVA CM; BACKOF DR; HAMILTON TA; PETRALI JP, "Free-floating cryostat sections for immunoelectron microscopy: Bridging the gap from light to electron microscopy", MICROSC RES TECH, (2001), vol. 54, pages 246 - 253
    - TAEPAVARAPRUK P; AG PHILLIPS, "Neurochemical correlates of relapse to D amphetamine self-administration by rats induced by stimulation of the ventral subiculum", PSYCHOPHARMACOLOGY, (2003), vol. 168, pages 99 - 108
    - CHAKI S; A NAKAZATO; L KENNIS; M NAKAMURA; C MACKIE; M SUGIURA; P VINKEN; D ASHTON; X LANGLOIS; T STECKLER, "Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450", EUROPEAN JOURNAL OF PHARMACOLOGY, (2004), vol. 485, pages 145 - 158
    - DAVIS SM; LEES KR; ALBERS GW; DIENER HC; MARKABI S; KARLSSON G; NORRIS J, "Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist", STROKE, (2000), vol. 31, pages 347 - 354
    - LEES KR, "Cerestat and other NMDA antagonists in ischemic stroke", NEUROLOGY, (1997), vol. 49, pages 566 - 69
    - SACCO RL; DEROSA JT; HALEY EC, JR.; LEVIN B; ORDRONNEAU P; PHILLIPS SJ; RUNDEK T; SNIPES RG; THOMPSON JL, "Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial", JAMA, (2001), vol. 285, pages 1719 - 1728
    - ALBERS GW; GOLDSTEIN LB; HALL D; LESKO LM, "Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial", JAMA, (2001), vol. 286, pages 2673 - 2682
    - CLARK WM; RAPS EC; TONG DC; KELLY RE, "Cervene (Nalmefene) in acute ischemic stroke : final results of a phase III efficacy study. The Cervene Stroke Study Investigators", STROKE, (2000), vol. 31, pages 1234 - 1239
    - DIENER HC; HACKE W; HENNERICI M; RADBERG J; HANTSON L; DE KEYSER J, "Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole International Study Group", STROKE, (1996), vol. 27, pages 76 - 81
    - CLARK WM; WECHSLER LR; SABOUNJIAN LA; SCHWIDERSKI UE, "A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients.", NEUROLOGY, (2001), vol. 57, pages 1595 - 1602
    - HORN J; LIMBURG M, "Calcium antagonists for ischemic stroke: a systematic review", STROKE, (2001), vol. 32, pages 570 - 576
    - "Use of anti-ICAM- therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial", NEUROLOGY, (2001), vol. 57, pages 1428 - 1434
    - LYDEN P; SHUAIB A; NG K; LEVIN K; ATKINSON RP; RAJPUT A; WECHSLER L; ASHWOOD T; CLAESSON L; ODERGREN T, "Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results", STROKE, (2002), vol. 33, pages 122 - 128
    - BECKER-HAPAK M; MCALLISTER SS; DOWDY SF, "TAT-mediated protein transduction into mammalian cells", METHODS, (2001), vol. 24, pages 247 - 256
    - LAU E; BUNGARD TJ; TSUYUKI RT, "Stroke prophylaxis in institutionalized elderly patients with atrial fibrillation", JAM GERIATR SOC, (2004), vol. 52, pages 428 - 433
    - FURLAN A; HIGASHIDA R; WECHSLER L; GENT M; ROWLEY H; KASE C; PESSIN M; AHUJA A; CALLAHAN F; CLARK WM, "Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism", JAMA, (1999), vol. 282, pages 2003 - 2011
    - AHMED N; NASMAN P; WAHLGREN NG, "Effect of intravenous nimodipine on blood pressure and outcome after acute stroke", STROKE, (2000), vol. 31, pages 1250 - 1255
    - OSBORNE KA; SHIGENO T; BALARSKY AM; FORD I; MCCULLOCH J; TEASDALE GM; GRAHAM DI, "Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia", J NEUROL NEUROSURG PSYCHIATRY, (1987), vol. 50, pages 402 - 410
    - WILLIAMS LS; ROTICH J; QI R; FINEBERG N; ESPAY A; BRUNO A; FINEBERG SE; TIERNEY WR, "Effects of admission hyperglycemia on mortality and costs in acute ischemic stroke", NEUROLOGY, (2002), vol. 59, pages 67 - 71
    - LIN B; GINSBERG MD; BUSTO R, "Hyperglycemic exacerbation of neuronal damage following forebrain ischemia: microglial, astrocytic and endothelial alterations", ACTA NEUROPATHOL (BERL, (1998), vol. 96, pages 610 - 620
    - TAKANO K; CARANO RA; TATLISUMAK T; MEILER M; SOTAK CH; KLEINERT HD; FISHER M, "Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging", NEUROLOGY, (1998), vol. 50, pages 870 - 875
    - WANG Y; LIM LL; LEVI C; HELLER RF; FISHER J, "Influence of admission body temperature on stroke mortality", STROKE, (2000), vol. 31, pages 404 - 409
    - THORNHILL J; CORBETT D, "Therapeutic implications of hypothermic and hyperthermic temperature conditions in stroke patients", CAN J PHYSIOL PHARMACOL, (2001), vol. 79, pages 254 - 261
    - MIGUEL-HIDALGO JJ; ALVAREZ XA; CACABELOS R; QUACK G, "Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40", BRAIN RES, (2002), vol. 958, pages 210 - 221
    - DORAISWAMY PM, "Alzheimer's disease and the glutamate NMDA receptor", PSYCHOPHARMACOL BULL, (2003), vol. 37, pages 41 - 49
    - CHERAMY A; BARBEITO L; GODEHEU G; GLOWINSKI J, "Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo", NEUROSCI LETT, (1992), vol. 147, pages 209 - 212
    - ZUDDAS A; OBERTO G; VAGLINI F; FASCETTI F; FORNAI F; CORSINI GU, "MK-801 prevents I -methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-induced parkinsonism in primates", JNEUROCHEM, (1992), vol. 59, pages 733 - 739
    - DOBLE A, "The role of excitotoxicity in neurodegenerative disease: implications for therapy", PHARMACOL THER, (1999), vol. 81, pages 163 - 221
    - BENSIMON G; LACOMBLEZ L; MEININGER V, "A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group", N ENGL J MED, (1994), vol. 330, pages 585 - 591
    - BERKE JD; HYMAN SE, "Addiction, dopamine and the molecular mechanisms of memory", NEURON, (2000), vol. 25, pages 515 - 532
    - EVERITT, BJ; DICKINSON A; ROBBINS TW, "The neuropsychological basis of addictive behaviour", BRAIN RES REV, (2001), vol. 36, pages 129 - 138
    - EVERITT BJ; WOLF ME, "Psychomotor stimulant addiction: a neural systems perspective", JNEUROSCI, (2002), vol. 22, no. 9, pages 3312 - 3320
    - HYMAN SE; MALENKA RC, "Addiction and the brain: the neurobiology of compulsion and its persistence", NAT REV NEUROSCI, (2001), vol. 2, pages 695 - 703
    - KOOB GF; LEMOAL M, "Drug abuse: Hedonic homeostatic dysregulation", SCIENCE, (1997), vol. 278, pages 52 - 58
    - KOOB GF; LEMOAL M, "Drug addiction, dysregulation of reward, and allostasis", NEUROPSYCHOPHARMACOLOGY, (2001), vol. 24, pages 97 - 129
    - ELLENBROEK BA, "Animal models in the genomic era: possibilities and limitations with special emphasis on schizophrenia", BEHAV PHARMACOL, (2003), vol. 14, no. 5-6, pages 409 - 17
    - GEYER MA ET AL., "Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review", PSYCHOPHARMACOLOGY (BERL), (2001), vol. 156, no. 2-3, pages 117 - 54
    - GEYER MA; ELLENBROEK B, "Animal behavior models of the mechanisms underlying antipsychotic atypicality", PROG NEUROPSYCHOPHARMACOL BIOL PSYCHIATRY, (2003), vol. 27, no. 7, pages 1071 - 9
    - HONER WG ET AL., "Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness", CEREB CORTEX, (2002), vol. 12, no. 4, pages 349 - 56
    - MIRNICS K ET AL., "Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex", NEURON, (2000), vol. 28, no. 1, pages 53 - 67
    - THOMAS MJ; C BEURRIER; A BONCI; RC MALENKA, "Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine", NAT. NEUROSCI, vol. 4, pages 1217 - 1223
    - METZLER M; LI B; GAN L; GEORGIOU J; GUTEKUNST CA; WANG Y; TORRE E; DEVON RS; OH R; LEGENDRE-GUILLEMIN V, "Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking", EMBO J, (2003), vol. 22, pages 3254 - 3266
    - KABOURIDIS, PS, "Biological Applications of Protein Transduction Technology", TIBS, (2003), vol. 21, page 498503
    - YEN W; WILLIAMSON J; BERTRAM EH; KAPUR J., "A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus", EPILEPSY RES., (200403), vol. 59, no. 1, pages 43 - 50
    - KAUL M; LIPTON SA, "Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond", J NEUROVIROL., (2004), vol. 10, no. 1, pages 97 - 10 1
    - LI J; PELLETIER MR; PEREZ VELAZQUEZ JL; CARLEN PL, "Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency", MOL CELL NEUROSCI., (200202), vol. 19, no. 2, pages 138 - 51
    - JOHNSTON MV; JEON OH; PEVSNER J; BLUE ME; NAIDU S., "Neurobiology of Rett syndrome: a genetic disorder of synapse development.", BRAIN DEV., (200112), vol. 23, no. 1, pages 5206 - 13
    - ARUNDINE M; TYMIANSKI M., "Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity", CELL CALCIUM, (200310), vol. 34, no. 4-5, pages 325 - 37
    - CORONA JC; TAPIA R, "AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo", J NEUROCHEM, (200405), vol. 89, no. 4, pages 988 - 97
    - ROLLING, F, "Recombinant AAV-mediated gene transfer to the retina: gene therapy perspectives", GENE THER., (200410), vol. 11, no. 1, pages 526 - 32
    - GEOFFROY MC; EPSTEIN AL; TOUBLANC E; MOULLIER P; SALVETTI A, "Herpes Simplex Virus Type 1 ICPO Protein Mediates Activation of Adeno-Associated Virus Type 2 rep Gene Expression from a Latent Integrated Form", J VIROL., (200410), vol. 78, no. 20, pages 10977 - 86
    - X. LIN ET AL., "Behavioural stress facilitates the induction of long-term depression in the hippocampus", NATURE, (1997), vol. 387, page 497
    - F.J. DOMINIQUE ET AL., "Stress and glucocorticoids impair retrieval of long-term spatial memory", NATURE, (1998), vol. 394, page 787
    - ORDYAN NE; PIVINA SG, "haracteristics of the behavior and stress-reactivity of the hypophyseal-adrenal system in prenatally stressed rats", NEUROSCI BEHAV PHYSIOL., (200407), vol. 34, no. 6, pages 569 - 74
    - PELLOW S; CHOPIN P; FILE SE; BRILEY M., "Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat", J NEUROSCI METHODS, (198508), vol. 14, no. 3, pages 149 - 67
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.