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Extract from the Register of European Patents

EP About this file: EP1681302

EP1681302 - ANGIOGENESIS INHIBITOR, PRODUCTION PROCESS AND USE THEREOF [Right-click to bookmark this link]
Former [2006/29]NOVEL PROTEIN AND PRODUCTION PROCESS AND USE THEREOF
[2010/47]
StatusNo opposition filed within time limit
Status updated on  05.10.2012
Database last updated on 31.08.2024
Most recent event   Tooltip18.07.2014Lapse of the patent in a contracting state
New state(s): HU		published on 20.08.2014  [2014/34]
Applicant(s)For all designated states
Teijin Pharma Limited
1-1, Uchisaiwaicho 2-chome, Chiyoda-ku
Tokyo 100-0011 / JP
[2006/29]
Inventor(s)01 / YAMANA, Kei, c/o Teijin Pharma Limited
Tokyo Research Center
3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
02 / NAKAYAMA, Yasunori, c/o Teijin Pharma Limited
Tokyo Research Center
3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
03 / TAKAHASHI, Yoshimasa, c/o Teijin Pharma Limited
Tokyo Research Center
3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
04 / OCHIAI, Eiji, c/o Teijin Pharma Limited
Tokyo Research Center
3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
05 / WADA, Hitoshi, c/o Teijin Pharma Limited
1-1 Uchisaiwaicho 2-chome
Chiyoda-ku
Tokyo 100-0011 / JP
06 / AZUMA, Yoshiaki, c/o Teijin Pharma Limited
Tokyo Research Center
3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
 [2011/48]
Former [2006/29]01 / YAMANA, Kei, c/o Teijin Pharma Limited
Tokyo Research Center, 3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
02 / NAKAYAMA, Yasunori, c/o Teijin Pharma Limited
Tokyo Research Center, 3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
03 / TAKAHASHI, Yoshimasa, c/o Teijin Pharma Limited
Tokyo Research Center, 3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
04 / OCHIAI, Eiji, c/o Teijin Pharma Limited
Tokyo Research Center, 3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
05 / WADA, Hitoshi, c/o Teijin Pharma Limited
1-1 Uchisaiwaicho 2-chome, Chiyoda-ku
Tokyo 100-0011 / JP
06 / AZUMA, Yoshiaki, c/o Teijin Pharma Limited
Tokyo Research Center, 3-2 Asahigaoka 4-chome
Hino-shi, Tokyo 191-0065 / JP
Representative(s)Hallybone, Huw George
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2011/48]Hallybone, Huw George
Carpmaels & Ransford One Southampton Row London
WC1B 5HA / GB
Former [2009/51]Hallybone, Huw George
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Former [2006/29]Hallybone, Huw George
Carpmaels and Ransford, 43-45 Bloomsbury Square
London WC1A 2RA / GB
Application number, filing date04792769.421.10.2004
[2006/29]
WO2004JP15620
Priority number, dateJP2003036061721.10.2003         Original published format: JP 2003360617
JP2004014342113.05.2004         Original published format: JP 2004143421
[2006/29]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2005037864
Date:28.04.2005
Language:EN
[2005/17]
Type: A1 Application with search report 
No.:EP1681302
Date:19.07.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 28.04.2005 takes the place of the publication of the European patent application.
[2006/29]
Type: B1 Patent specification 
No.:EP1681302
Date:30.11.2011
Language:EN
[2011/48]
Search report(s)International search report - published on:JP28.04.2005
(Supplementary) European search report - dispatched on:EP11.05.2007
ClassificationIPC:C07K14/47
[2007/07]
CPC:
C12P21/02 (EP,US); C07K14/47 (KR); A61P17/02 (EP);
A61P17/06 (EP); A61P19/00 (EP); A61P19/02 (EP);
A61P21/00 (EP); A61P27/02 (EP); A61P27/06 (EP);
A61P29/00 (EP); A61P35/00 (EP); A61P43/00 (EP);
A61P9/00 (EP); A61P9/10 (EP); C07K14/4703 (EP,US);
C12N1/20 (KR); C12N15/11 (KR); A01K2217/05 (EP,US);
A01K2267/0306 (EP,US); A61K38/00 (EP,US) (-)
Former IPC [2006/29]C07K14/47, C07K19/00, C12N15/12, C12N1/21, C12N5/10, C12P21/02, G01N33/53, A01K67/027, A61K38/17, A61K48/00, A61P9/10, A61P17/02, A61P17/06, A61P19/02, A61P21/00, A61P27/02, A61P27/06, A61P29/00, A61P35/00, A61P43/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/29]
TitleGerman:ANGIOGENESE-INHIBITOR, HERSTELLUNGSVERFAHREN UND VERWENDUNG DAVON[2010/47]
English:ANGIOGENESIS INHIBITOR, PRODUCTION PROCESS AND USE THEREOF[2010/47]
French:INHIBITEUR D'ANGIOGENESE, SON PROCEDE DE PRODUCTION ET SON UTILISATION[2010/47]
Former [2006/29]NEUES PROTEIN UND HERSTELLUNGSVERFAHREN UND VERWENDUNG DAVON
Former [2006/29]NOVEL PROTEIN AND PRODUCTION PROCESS AND USE THEREOF
Former [2006/29]NOUVELLE PROTEINE, SON PROCEDE DE PRODUCTION ET SON UTILISATION
Entry into regional phase04.05.2006Translation filed 
04.05.2006National basic fee paid 
04.05.2006Search fee paid 
04.05.2006Designation fee(s) paid 
04.05.2006Examination fee paid 
Examination procedure04.05.2006Amendment by applicant (claims and/or description)
04.05.2006Examination requested  [2006/29]
16.01.2008Despatch of a communication from the examining division (Time limit: M06)
28.07.2008Reply to a communication from the examining division
18.03.2011Communication of intention to grant the patent
19.07.2011Fee for grant paid
19.07.2011Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  16.01.2008
Opposition(s)31.08.2012No opposition filed within time limit [2012/45]
Fees paidRenewal fee
04.05.2006Renewal fee patent year 03
24.10.2007Renewal fee patent year 04
31.03.2008Renewal fee patent year 05
13.10.2009Renewal fee patent year 06
12.10.2010Renewal fee patent year 07
11.10.2011Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU21.10.2004
AT30.11.2011
BE30.11.2011
CY30.11.2011
CZ30.11.2011
DK30.11.2011
EE30.11.2011
FI30.11.2011
IT30.11.2011
NL30.11.2011
PL30.11.2011
RO30.11.2011
SE30.11.2011
SI30.11.2011
SK30.11.2011
TR30.11.2011
BG29.02.2012
GR01.03.2012
ES11.03.2012
PT30.03.2012
[2014/34]
Former [2014/21]AT30.11.2011
BE30.11.2011
CY30.11.2011
CZ30.11.2011
DK30.11.2011
EE30.11.2011
FI30.11.2011
IT30.11.2011
NL30.11.2011
PL30.11.2011
RO30.11.2011
SE30.11.2011
SI30.11.2011
SK30.11.2011
TR30.11.2011
BG29.02.2012
GR01.03.2012
ES11.03.2012
PT30.03.2012
Former [2013/29]AT30.11.2011
BE30.11.2011
CY30.11.2011
CZ30.11.2011
DK30.11.2011
EE30.11.2011
FI30.11.2011
IT30.11.2011
NL30.11.2011
PL30.11.2011
RO30.11.2011
SE30.11.2011
SI30.11.2011
SK30.11.2011
BG29.02.2012
GR01.03.2012
ES11.03.2012
PT30.03.2012
Former [2013/22]AT30.11.2011
BE30.11.2011
CY30.11.2011
CZ30.11.2011
DK30.11.2011
EE30.11.2011
IT30.11.2011
NL30.11.2011
PL30.11.2011
RO30.11.2011
SE30.11.2011
SI30.11.2011
SK30.11.2011
BG29.02.2012
GR01.03.2012
ES11.03.2012
PT30.03.2012
Former [2013/07]AT30.11.2011
BE30.11.2011
CY30.11.2011
CZ30.11.2011
DK30.11.2011
EE30.11.2011
IT30.11.2011
NL30.11.2011
PL30.11.2011
RO30.11.2011
SE30.11.2011
SI30.11.2011
SK30.11.2011
BG29.02.2012
GR01.03.2012
PT30.03.2012
Former [2012/37]BE30.11.2011
CY30.11.2011
CZ30.11.2011
DK30.11.2011
EE30.11.2011
IT30.11.2011
NL30.11.2011
PL30.11.2011
RO30.11.2011
SE30.11.2011
SI30.11.2011
SK30.11.2011
BG29.02.2012
GR01.03.2012
PT30.03.2012
Former [2012/36]BE30.11.2011
CY30.11.2011
CZ30.11.2011
DK30.11.2011
EE30.11.2011
NL30.11.2011
RO30.11.2011
SE30.11.2011
SI30.11.2011
SK30.11.2011
BG29.02.2012
GR01.03.2012
PT30.03.2012
Former [2012/35]BE30.11.2011
CY30.11.2011
CZ30.11.2011
DK30.11.2011
EE30.11.2011
NL30.11.2011
SE30.11.2011
SI30.11.2011
BG29.02.2012
GR01.03.2012
PT30.03.2012
Former [2012/34]BE30.11.2011
CY30.11.2011
CZ30.11.2011
NL30.11.2011
SE30.11.2011
SI30.11.2011
GR01.03.2012
PT30.03.2012
Former [2012/28]BE30.11.2011
CY30.11.2011
NL30.11.2011
SE30.11.2011
SI30.11.2011
GR01.03.2012
PT30.03.2012
Former [2012/25]BE30.11.2011
NL30.11.2011
SE30.11.2011
SI30.11.2011
GR01.03.2012
PT30.03.2012
Former [2012/24]NL30.11.2011
SE30.11.2011
SI30.11.2011
GR01.03.2012
PT30.03.2012
Former [2012/23]NL30.11.2011
GR01.03.2012
PT30.03.2012
Documents cited:Search[X]WO0029579  (ZYMOGENETICS INC [US]) [X] 1-17,20-26 *Whole document, in particular claim 2*;
 [X]EP1219710  (TEIJIN LTD [JP]) [X] 1-17,20-26 *Whole document, in particular claim 1*;
 [X]  - HIRAKI YUJI ET AL, "Chondromodulin-I as a novel cartilage-specific growth-modulating factor", PEDIATRIC NEPHROLOGY, (200007), vol. 14, no. 7, ISSN 0931-041X, pages 602 - 605, XP002411352 [X] 1-17,20-26 *Whole document, in particular Abstract and Figure 2*

DOI:   http://dx.doi.org/10.1007/s004670000339
 [X]  - NAKAMICHI YUKO ET AL, "Chondromodulin I is a bone remodeling factor.", MOLECULAR AND CELLULAR BIOLOGY, (200301), vol. 23, no. 2, ISSN 0270-7306, pages 636 - 644, XP002411353 [X] 1-17,20-26 *Whole document, in particular Abstract*

DOI:   http://dx.doi.org/10.1128/MCB.23.2.636-644.2003
 [PX]  - OSHIMA YUSUKE ET AL, "Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I", JOURNAL OF CELL SCIENCE, (20040601), vol. 117, no. 13, ISSN 0021-9533, pages 2731 - 2744, XP002411354 [PX] 1-17,20-26 *Whole document, in particular Abstract and Discussion*

DOI:   http://dx.doi.org/10.1242/jcs.01112
International search[X]WO0123557  (TEIJIN LTD [JP], et al);
 [X]  - OSHIMA Y. ET AL., "Expression and localization of tenomudulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes", INVEST. OPHTHALMOL. VIS. SCI., (200305), vol. 44, no. 5, pages 1814 - 1823, XP001181222

DOI:   http://dx.doi.org/10.1167/iovs.02-0664
 [X]  - YAMANA K. ET AL, "Molecular cloning and characterization of CHM1L, a novel membrane molecule similar to chondromodulin-I", BIOCHEM BIOPHYS RES COMMUN, (2001), vol. 280, no. 4, pages 1101 - 1106, XP002983755

DOI:   http://dx.doi.org/10.1006/bbrc.2000.4245
 [Y]  - HIRAKI Y. ET AL, "Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells", EUR J BIOCHEM, (1999), vol. 260, pages 869 - 878, XP002279021

DOI:   http://dx.doi.org/10.1046/j.1432-1327.1999.00227.x
 [Y]  - HIRAKI Y. ET AL, "Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage", J BIOL CHEM, (1997), vol. 272, no. 51, pages 32419 - 32426, XP002937899

DOI:   http://dx.doi.org/10.1074/jbc.272.51.32419
 [Y]  - HIRAKI Y. ET AL, "Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I", FEBS LETT., (1997), vol. 415, no. 3, pages 321 - 324, XP004261165

DOI:   http://dx.doi.org/10.1016/S0014-5793(97)01151-4
 [Y]  - HAYAMI T. ET AL, "Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo", FEBS LETT., (1999), vol. 458, no. 3, pages 436 - 440, XP004260306

DOI:   http://dx.doi.org/10.1016/S0014-5793(99)01201-6
 [Y]  - LIU S. ET AL, "Removal of endotoxin from recombinant protein preparations", CLIN BIOCHEM., (1997), vol. 30, no. 6, pages 455 - 463, XP002983756

DOI:   http://dx.doi.org/10.1016/S0009-9120(97)00049-0
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.