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Extract from the Register of European Patents

EP About this file: EP1763371

EP1763371 - NOVEL IMAGING AGENTS COMPRISING CASPASE-3 INHIBITORS [Right-click to bookmark this link]
StatusThe application has been refused
Status updated on  07.02.2014
Database last updated on 05.10.2024
Most recent event   Tooltip07.02.2014Refusal of applicationpublished on 12.03.2014  [2014/11]
Applicant(s)For all designated states
GE Healthcare Limited
Amersham Place
Little Chalfont, Buckinghamshire HP7 9NA / GB
[N/P]
Former [2007/12]For all designated states
GE Healthcare Limited
Amersham Place Little Chalfont
Buckinghamshire HP7 9NA / GB
Inventor(s)01 / HISCOCK, Duncan
GE Healthcare Bio-Sciences, White Lion Road
Amersham Buckinghamshire HP7 9LL / GB
02 / NEWTON, Ben
GE Healthcare Bio-Sciences, White Lion Road
Amersham Buckinghamshire HP7 9LL / GB
03 / GUILBERT, Benedicte
GE Healthcare Bio-Sciences, White Lion Road
Amersham Buckinghamshire HP7 9LL / GB
 [2007/12]
Representative(s)Canning, Lewis R.
GE Healthcare Limited
Amersham Place
Little Chalfont
Buckinghamshire HP7 9NA / GB
[N/P]
Former [2007/12]Canning, Lewis R.
GE Healthcare Limited Amersham Place Little Chalfont
Bucks. HP7 9NA / GB
Application number, filing date04805892.926.11.2004
[2007/12]
WO2004GB05003
Priority number, dateGB2003002749426.11.2003         Original published format: GB 0327494
[2007/12]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005053752
Date:16.06.2005
Language:EN
[2005/24]
Type: A2 Application without search report 
No.:EP1763371
Date:21.03.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 16.06.2005 takes the place of the publication of the European patent application.
[2007/12]
Search report(s)International search report - published on:EP06.10.2005
ClassificationIPC:A61K51/00, A61K49/00, A61K49/06, A61K49/08, A61K49/10, A61K49/12, A61K49/14, A61K51/02, A61K51/04, A61K51/06, A61K51/08
[2007/12]
CPC:
A61K51/0455 (EP,US); A61K51/04 (KR); A61K51/0431 (EP,US);
A61K51/0446 (EP,US); A61K51/0459 (EP,US); A61K51/08 (KR);
A61K51/088 (EP,US); A61P1/16 (EP); A61P13/08 (EP);
A61P13/10 (EP); A61P19/02 (EP); A61P21/00 (EP);
A61P25/00 (EP); A61P25/14 (EP); A61P25/16 (EP);
A61P25/28 (EP); A61P3/10 (EP); A61P31/04 (EP);
A61P31/18 (EP); A61P35/00 (EP); A61P35/02 (EP);
A61P37/04 (EP); A61P37/06 (EP); A61P43/00 (EP);
A61P9/10 (EP); Y02P20/582 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/12]
TitleGerman:NEUE BILDDARSTELLUNGSMITTEL MIT CASPASE-3-HEMMERN[2007/12]
English:NOVEL IMAGING AGENTS COMPRISING CASPASE-3 INHIBITORS[2007/12]
French:NOUVEAUX AGENTS D'IMAGERIE COMPRENANT DES INHIBITEURS DE LA CASPASE-3[2007/12]
Entry into regional phase12.05.2006National basic fee paid 
12.05.2006Designation fee(s) paid 
12.05.2006Examination fee paid 
Examination procedure09.06.2005Request for preliminary examination filed
International Preliminary Examining Authority: EP
12.05.2006Amendment by applicant (claims and/or description)
12.05.2006Examination requested  [2007/12]
20.07.2007Despatch of a communication from the examining division (Time limit: M04)
19.11.2007Reply to a communication from the examining division
18.12.2007Despatch of a communication from the examining division (Time limit: M02)
16.01.2008Reply to a communication from the examining division
26.03.2008Despatch of a communication from the examining division (Time limit: M04)
04.08.2008Reply to a communication from the examining division
23.04.2009Date of oral proceedings
26.05.2009Despatch of communication that the application is refused, reason: substantive examination [2014/11]
26.05.2009Minutes of oral proceedings despatched
11.12.2013Application refused, date of legal effect [2014/11]
Appeal following examination23.07.2009Appeal received No.  T2017/09
25.09.2009Statement of grounds filed
11.12.2013Result of appeal procedure: appeal of the applicant was rejected
11.12.2013Date of oral proceedings
02.01.2014Minutes of oral proceedings despatched
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  20.07.2007
Fees paidRenewal fee
27.11.2006Renewal fee patent year 03
27.11.2007Renewal fee patent year 04
25.11.2008Renewal fee patent year 05
25.11.2009Renewal fee patent year 06
24.11.2010Renewal fee patent year 07
23.11.2011Renewal fee patent year 08
26.11.2012Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
30.11.201310   M06   Not yet paid
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Cited inInternational search[DY]WO0189584  (NYCOMED IMAGING AS [NO], et al) [DY] 1-31 * examples 16-18,21 *;
 [Y]US6589503  (PIWNICA-WORMS DAVID [US]) [Y] 1-31 * figure 2 * * column 34 - column 37; examples 8-10 *;
 [PX]WO2004069773  (MERCK FROSST CANADA INC [CA], et al) [PX] 1-4,14,16-18,26,28,29,31 * figure 1 ** page 3, paragraph 3; claim 12 *;
 [DXY]  - HABERKORN UWE; KINSCHERF RALF; KRAMMER PETER H; MIER WALTER; EISENHUT MICHAEL, "Investigation of a potential scintigraphic marker of apoptosis: Radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone", NUCLEAR MEDICINE AND BIOLOGY, (200110), vol. 28, no. 7, pages 793 - 798, XP002333221 [DX] 1,3,4,7,10,11,16-18,26-31 * figure 1 * [Y] 1-31
 [T]  - DECKWERTH ET AL, "Long-term protection of brain tissue from cerebral ischemia by peripherally administered peptidomimetic caspase inhibitors", DRUG DEVELOPMENT RESEARCH, (200104), vol. 52, no. 4, pages 579 - 586, XP002333222 [T] 1,3,4,7,10,11,16-18,26-31 * page 582; table 1 *

DOI:   http://dx.doi.org/10.1002/ddr.1161
 [Y]  - BHARATHI ET AL, "Noninvasive real-time imaging of apoptosis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATE OF AMERICA, (20021224), vol. 99, no. 26, pages 16551 - 16555, XP002333223 [Y] 1-31 * page 16551, column L, paragraph 2 - column R, paragraph 1 * * figures 1,5 * * page 16554, column R, paragraph 3 *

DOI:   http://dx.doi.org/10.1073/pnas.252644499
Examination   - CHENG ET AL, "RELATIONSHIP BETWEEN THE INHIBITION CONSTANT (KI) AND THE CONCENTRATION OF INHIBITOR WHICH CAUSES 50 PER CENT INHIBITION (I50) OF AN ENZYMATIC REACTION", BIOCHEMICAL PHARMACOLOGY, (1973), vol. 22, no. 19, pages 3099 - 3108, XP001106687

DOI:   http://dx.doi.org/10.1016/0006-2952(73)90196-2
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