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Extract from the Register of European Patents

EP About this file: EP1657252

EP1657252 - PGC-1, a novel brown fat PPAR gamma coactivator [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.04.2014
Database last updated on 14.03.2026
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): LU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
Dana-Farber Cancer Institute, Inc.
450 Brookline Avenue
Boston, MA 02215 / US
[2011/46]
Former [2006/20]For all designated states
DANA-FARBER CANCER INSTITUTE, INC.
44 Binney Street
Boston, MA 02115 / US
Inventor(s)01 / Spiegelman, Bruce
271 Waban Avenue
Waban, MA 02168 / US
02 / Puigserver, Pere
111 Wolcott Road
Brookline, MA 02467 / US
03 / Wu, Zhidan
Apartment 407, 1575 Tremont Street
Boston, MA 02120 / US
04 / Adelmant, Guillaume
118 Inman Street, Apt nr. 3
Cambridge, MA 02139 / US
 [2007/35]
Former [2006/20]01 / Spiegelman, Bruce
271 Waban Avenue
Waban, MA 02168 / US
02 / Puigserver, Pere
74 St. Paul Street
Brookline, MA 02145 / US
03 / Wu, Zhidan
Apartment 407, 1575 Tremont Street
Boston, MA 02120 / US
04 / Adelmant, Guillaume
Apartment No. 2, 126 Pembroke Street
Boston, MA 02118 / US
Representative(s)Lock, Graham James, et al
Fry Heath & Spence LLP
Unit A, Faraday Court
Faraday Road
Crawley, West Sussex RH10 9PU / GB
[N/P]
Former [2013/23]Lock, Graham James, et al
Fry Heath & Spence LLP The Gables Massetts Road Horley
Surrey RH6 7DQ / GB
Former [2006/20]Lock, Graham James, et al
Fry Heath & Spence LLP The Gables Massetts Road Horley
Surrey RH6 7DQ / GB
Application number, filing date05024378.130.11.1999
[2006/20]
Priority number, dateUS1998020345301.12.1998         Original published format: US 203453
[2006/20]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP1657252
Date:17.05.2006
Language:EN
[2006/20]
Type: A3 Search report 
No.:EP1657252
Date:21.06.2006
[2006/25]
Type: B1 Patent specification 
No.:EP1657252
Date:05.06.2013
Language:EN
[2013/23]
Search report(s)(Supplementary) European search report - dispatched on:EP23.05.2006
ClassificationIPC:C07K14/575, C07K14/47
[2013/03]
CPC:
C07K14/5759 (EP,US); A61P1/14 (EP); A61P3/04 (EP);
A61P3/10 (EP); A61P7/00 (EP); C07K14/4702 (EP,US);
A01K2217/05 (EP,US); A01K2217/075 (EP,US); A61K38/00 (EP,US);
C12N2799/026 (EP,US); G01N2500/00 (EP,US); Y10S435/81 (EP,US) (-)
Former IPC [2006/25]A61K38/00, C07H21/02, C07H21/04, C07K1/00, G01N33/53, G01N33/567, C07K14/47
Former IPC [2006/20]C07K14/47
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2006/20]
TitleGerman:PCG-1, ein neuer Koaktivator für den PPAR Gamma Rezeptor im braunen Fettgewebe[2006/20]
English:PGC-1, a novel brown fat PPAR gamma coactivator[2006/20]
French:PGC-1, un nouveau coactivateur du récépteur PPAR gamma des tissus adipeux bruns[2006/25]
Former [2006/20]PGC-1, un nouveau coactivateur du récepteur PPAR gamma des tissus adipeux bruns
Examination procedure16.11.2005Examination requested  [2006/20]
22.12.2006Despatch of a communication from the examining division (Time limit: M06)
21.06.2007Reply to a communication from the examining division
07.07.2009Despatch of a communication from the examining division (Time limit: M06)
19.02.2010Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
12.03.2010Reply to a communication from the examining division
14.02.2012Despatch of a communication from the examining division (Time limit: M04)
25.06.2012Reply to a communication from the examining division
16.01.2013Communication of intention to grant the patent
23.04.2013Fee for grant paid
23.04.2013Fee for publishing/printing paid
Parent application(s)   TooltipEP99960630.4  / EP1135149
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP19990960630) is  10.05.2005
Opposition(s)06.03.2014No opposition filed within time limit [2014/20]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
12.03.2010Request for further processing filed
12.03.2010Full payment received (date of receipt of payment)
Fees paidRenewal fee
16.11.2005Renewal fee patent year 03
16.11.2005Renewal fee patent year 04
16.11.2005Renewal fee patent year 05
16.11.2005Renewal fee patent year 06
16.11.2005Renewal fee patent year 07
27.11.2006Renewal fee patent year 08
27.11.2007Renewal fee patent year 09
25.11.2008Renewal fee patent year 10
25.11.2009Renewal fee patent year 11
24.11.2010Renewal fee patent year 12
23.11.2011Renewal fee patent year 13
26.11.2012Renewal fee patent year 14
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT05.06.2013
BE05.06.2013
CY05.06.2013
DK05.06.2013
FI05.06.2013
IT05.06.2013
MC05.06.2013
NL05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
PT07.10.2013
CH30.11.2013
IE30.11.2013
LI30.11.2013
LU30.11.2013
[2015/34]
Former [2015/30]AT05.06.2013
BE05.06.2013
CY05.06.2013
DK05.06.2013
FI05.06.2013
IT05.06.2013
MC05.06.2013
NL05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
PT07.10.2013
CH30.11.2013
IE30.11.2013
LI30.11.2013
Former [2014/48]AT05.06.2013
BE05.06.2013
DK05.06.2013
FI05.06.2013
IT05.06.2013
MC05.06.2013
NL05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
PT07.10.2013
CH30.11.2013
IE30.11.2013
LI30.11.2013
Former [2014/34]AT05.06.2013
BE05.06.2013
DK05.06.2013
FI05.06.2013
IT05.06.2013
MC05.06.2013
NL05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
PT07.10.2013
CH30.11.2013
LI30.11.2013
Former [2014/33]AT05.06.2013
BE05.06.2013
DK05.06.2013
FI05.06.2013
IT05.06.2013
MC05.06.2013
NL05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
PT07.10.2013
Former [2014/24]AT05.06.2013
BE05.06.2013
DK05.06.2013
FI05.06.2013
IT05.06.2013
NL05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
PT07.10.2013
Former [2014/21]AT05.06.2013
BE05.06.2013
DK05.06.2013
FI05.06.2013
NL05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
PT07.10.2013
Former [2014/14]AT05.06.2013
BE05.06.2013
FI05.06.2013
NL05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
PT07.10.2013
Former [2014/08]AT05.06.2013
BE05.06.2013
FI05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
PT07.10.2013
Former [2013/49]AT05.06.2013
FI05.06.2013
SE05.06.2013
GR06.09.2013
ES16.09.2013
Former [2013/48]AT05.06.2013
ES16.09.2013
Documents cited:Search[EL] US6166192  (SPIEGELMAN BRUCE M et al.)
 [PX] WO9854220  (DANA FARBER CANCER INST INC et al.)
 [A] WO9853091  (BURNHAM INST et al.)
 [A] WO9612018  (SALK INST FOR BIOLOGICAL STUDI et al.)
 [A] US5672473  (GLIMCHER LAURIE H et al.)
 [X]   PUIGSERVER P ET AL: "COLD-INDUCIBLE COACTIVATOR OF NUCLEAR RECEPTORS LINKED TO ADAPTIVE THERMOGENESIS", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 92, 20 March 1998 (1998-03-20), pages 829 - 839, XP000919368, ISSN: 0092-8674

DOI:   http://dx.doi.org/10.1016/S0092-8674(00)81410-5
 [X]   DATABASE EMBL [online] 16 April 1998 (1998-04-16), PUIGSERVER ET AL.: "Mus musculus PPAR gamma coactivator (PGC-1) mRNA, complete cds", XP002219673, retrieved from EMBL Database accession no. AF049330
 [X]   LOWELL B. B.: "Adaptive thermogenesis: Turning on the heat", CURRENT BIOLOGY, vol. 8, no. 15, 16 July 1998 (1998-07-16), pages R517 - R520, XP001098892

DOI:   http://dx.doi.org/10.1016/S0960-9822(07)00336-3
 [PX]   ESTERBAUER H ET AL: "HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 (PPARGC1) GENE: CDNA SEQUENCE, GENOMIC ORGANIZATION, CHROMOSOMAL LOCALIZATION, AND TISSUE EXPRESSION", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 62, no. 1, 1999, pages 98 - 102, XP002945451, ISSN: 0888-7543

DOI:   http://dx.doi.org/10.1006/geno.1999.5977
 [PX]   BUTOW RONALD A ET AL: "Adaptive thermogenesis: Orchestrating mitochondrial biogenesis.", CURRENT BIOLOGY, vol. 9, no. 20, 21 October 1999 (1999-10-21), pages R767 - R769, XP002220995, ISSN: 0960-9822

DOI:   http://dx.doi.org/10.1016/S0960-9822(00)80008-1
 [PX]   WU ZHIDAN ET AL: "Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 98, no. 1, 9 July 1999 (1999-07-09), pages 115 - 124, XP002169686, ISSN: 0092-8674

DOI:   http://dx.doi.org/10.1016/S0092-8674(00)80611-X
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.