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Extract from the Register of European Patents

EP About this file: EP1621207

EP1621207 - Mixture of defibrotide and G-CSF, and its use for activating haematopoietic progenitors [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.07.2010
Database last updated on 02.09.2024
Most recent event   Tooltip19.10.2012Lapse of the patent in a contracting state
New state(s): TR
published on 21.11.2012  [2012/47]
Applicant(s)For all designated states
Gentium S.p.A.
Piazza XX Settembre 2
22079 Villa Guardia (Como) / IT
[2006/05]
Inventor(s)01 / FERRO, Laura
Piazza Brera 24/6
I-20100, MILANO (MI) / IT
02 / PORTA, Roberto
Via Aquileia 1
I-22012, CERNOBBIO (CO) / IT
03 / IACOBELLI, Massimo
Via Forze Armate 260/3
I-20152, MILANO (MI) / IT
04 / GIANNI, Alessandro Massimo
Via L. Muratori 29
I-20135, MILANO (MI) / IT
05 / STELLA, Carmelo Carlo
Via Eustachi 47
I-20129, MIlano (MI) / IT
 [2006/05]
Representative(s)Pistolesi, Roberto, et al
Dragotti & Associati Srl
Via Nino Bixio, 7
20129 Milano / IT
[N/P]
Former [2006/05]Pistolesi, Roberto, et al
Dragotti & Associati srl Via Turati 32
20121 Milano / IT
Application number, filing date05108424.210.04.2001
[2006/05]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP1621207
Date:01.02.2006
Language:EN
[2006/05]
Type: A3 Search report 
No.:EP1621207
Date:22.11.2006
[2006/47]
Type: B1 Patent specification 
No.:EP1621207
Date:23.09.2009
Language:EN
[2009/39]
Search report(s)(Supplementary) European search report - dispatched on:EP19.10.2006
ClassificationIPC:A61K38/19, A61P7/00, C12N5/06, // A61K31/70
[2006/47]
CPC:
A61K31/70 (EP,US); A61K38/19 (KR); A61K38/193 (EP,US);
A61P35/00 (EP); A61P43/00 (EP); A61P7/00 (EP);
A61P7/06 (EP) (-)
C-Set:
A61K31/70, A61K2300/00 (EP,US);
A61K38/193, A61K2300/00 (US,EP)
Former IPC [2006/05]A61K38/19, A61P7/00, A61K31/70
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2006/05]
Extension statesAL17.04.2007
LT17.04.2007
LV17.04.2007
MK17.04.2007
TitleGerman:Kombination von Defibrotide und G-CSF und ihre Verwendung zur Aktivierung hämatopoietischer Vorläuferzellen[2006/47]
English:Mixture of defibrotide and G-CSF, and its use for activating haematopoietic progenitors[2006/05]
French:Composition de défibrotide et de G-CSF et son utilisation pour l'activation des progéniteurs hématopoiétiques[2006/05]
Former [2006/05]kombination von Defibrotide und G-CSF und ihre Verwendung zur Aktivierung hämatopoietischer Vorläuferzellen
Examination procedure17.04.2007Examination requested  [2007/22]
22.05.2007Despatch of a communication from the examining division (Time limit: M06)
09.01.2008Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
15.02.2008Reply to a communication from the examining division
25.03.2009Cancellation of oral proceeding that was planned for 31.03.2009
25.03.2009Minutes of oral proceedings despatched
31.03.2009Date of oral proceedings
31.03.2009Date of oral proceedings (cancelled)
06.05.2009Communication of intention to grant the patent
17.08.2009Fee for grant paid
17.08.2009Fee for publishing/printing paid
Parent application(s)   TooltipEP01931582.9  / EP1276497
Opposition(s)24.06.2010No opposition filed within time limit [2010/35]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
15.02.2008Request for further processing filed
15.02.2008Full payment received (date of receipt of payment)
Request granted
17.03.2008Decision despatched
Fees paidRenewal fee
04.10.2005Renewal fee patent year 03
04.10.2005Renewal fee patent year 04
04.10.2005Renewal fee patent year 05
26.04.2006Renewal fee patent year 06
26.04.2007Renewal fee patent year 07
26.03.2008Renewal fee patent year 08
24.04.2009Renewal fee patent year 09
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY23.09.2009
FI23.09.2009
TR23.09.2009
IE10.04.2010
MC30.04.2010
[2012/47]
Former [2011/07]CY23.09.2009
FI23.09.2009
IE10.04.2010
MC30.04.2010
Former [2010/52]CY23.09.2009
FI23.09.2009
MC30.04.2010
Former [2010/16]CY23.09.2009
FI23.09.2009
Former [2010/11]FI23.09.2009
Documents cited:Search[A]EP0317766  (CRINOS INDUSTRIA FARMACO [IT]) [A] 1-9 * claims 1-13 *;
 [A]EP0416678  (CRINOS INDUSTRIA FARMACO [IT]) [A] 1-9 * claims 1-6 *;
 [Y]US5199942  (GILLIS STEVEN [US]) [Y] 1-9 * claims 1-17 *;
 [A]WO9926639  (ALLEGHENY UNIVERSITY OF THE HE [US], et al) [A] 1-9 * claims 1-15 *;
 [Y]US5977083  (BURCOGLU ARSINUR [US]) [Y] 1-9 * claims 1-25 *;
 [A]  - GURSOY A, "PREPARATION, CHARACTERIZATION AND ANTI-INFLAMMATORY EFFECT OF DEFIBROTIDE LIPOSOMES", PHARMAZIE,DD,VEB VERLAG VOLK UND GESUNDHEIT. BERLIN, (19930701), vol. 48, no. 7, ISSN 0031-7144, pages 549 - 550, XP000372658 [A] 1-9 * abstract *
 [T]  - CARLO-STELLA, C. (1) ET AL, "Defibrotide significantly enhances peripheral blood progenitor cell mobilization induced by recombinant human granulocyte colony - stimulating factor ( rhG - CSF.", BLOOD, PART 1, PP. 553A. PRINT. MEETING INFO.: 42ND ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY SAN FRANCISCO, CALIFORNIA, USA DECEMBER 01-05, 2000 AMERICAN SOCIETY OF HEMATOLOGY., (20001116), vol. 96, no. 11, XP002176349 [T] 1-9 * abstract *
by applicantUS3770720
 US3829567
 US3899481
 US4694134
 US4693995
 US4985552
 US5223609
    - C.F. CRADDOCK, "Antibodies to VLA4 Integrin Mobilize Long-Term Repopulating Cells and Augment Cytokine-Induced Mobilization in Primates and Mice", BLOOD, (1997), vol. 90, no. 12, pages 4779 - 4788
    - F. PROSPER, "Mobilization and Homing of Peripheral Blood Progenitors is Related to Reversible Downregulation of a4ß1 Integrin Expression and Function", J. CLIN. INVEST., (1998), vol. 101, no. 11, pages 2456 - 2467
    - M. VERMEULEN, "Role of Adhesion Molecules in the Homing and Mobilization of Murine Hematopoietic Stem and Progenitor Cells", BLOOD, (1998), vol. 92, no. 3, pages 894 - 900
    - CAS REGISTRY NUMBER 143011-2-7/MERCK INDEX, (1996), page 4558
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.