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Extract from the Register of European Patents

EP About this file: EP1721908

EP1721908 - NOVEL METHOD OF SYNTHESIZING NUCLEIC ACID WITHOUT PROTECTING NUCLEOTIDE BASES [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  03.01.2014
Database last updated on 26.04.2025
Most recent event   Tooltip03.01.2014Application deemed to be withdrawnpublished on 05.02.2014  [2014/06]
Applicant(s)For all designated states
Japan Science and Technology Agency
4-1-8-, Honcho Kawaguchi-shi
Saitama 332-0012 / JP
[2006/46]
Inventor(s)01 / SEKINE, Mitsuo
1-26-46, Azamino,Aoba-ku, Yokohama-shi
Kanagawa 225-0011 / JP
02 / SEIO, Kohji, Daini Parkside Uchida 102
48-5, Shiratoridai Aoba-ku, Yokohama-shi
Kanagawa 227-0054 / JP
03 / OHKUBO, Akihiro
1-10-5-202, Ogawa,Machida-shi
Tokyo 194-0003 / JP
 [2006/46]
Representative(s)Strehl & Partner mbB
Maximilianstrasse 54
80538 München / DE
[N/P]
Former [2006/46]Strehl Schübel-Hopf & Partner
Maximilianstrasse 54
80538 München / DE
Application number, filing date05710654.424.02.2005
[2006/46]
WO2005JP03053
Priority number, dateJP2004005670701.03.2004         Original published format: JP 2004056707
[2006/46]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2005082923
Date:09.09.2005
Language:EN
[2005/36]
Type: A1 Application with search report 
No.:EP1721908
Date:15.11.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 09.09.2005 takes the place of the publication of the European patent application.
[2006/46]
Search report(s)International search report - published on:JP09.09.2005
(Supplementary) European search report - dispatched on:EP13.11.2009
ClassificationIPC:C07H21/04, C12N15/09
[2006/46]
CPC:
C07H21/04 (EP,US)
Designated contracting statesDE,   FR,   GB [2007/23]
Former [2006/46]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
LVNot yet paid
MKNot yet paid
YUNot yet paid
TitleGerman:NEUES VERFAHREN ZUR SYNTHESE VON NUKLEINSÄUREN OHNE SCHÜTZEN DER NUKLEOTIDBASEN[2006/46]
English:NOVEL METHOD OF SYNTHESIZING NUCLEIC ACID WITHOUT PROTECTING NUCLEOTIDE BASES[2006/46]
French:NOUVEAU PROCEDE DE SYNTHESE D' ACIDE NUCLEIQUE SANS PROTEGER LES BASES DES NUCLEOTIDES[2006/46]
Entry into regional phase04.09.2006Translation filed 
22.09.2006National basic fee paid 
22.09.2006Search fee paid 
22.09.2006Designation fee(s) paid 
22.09.2006Examination fee paid 
Examination procedure26.12.2005Request for preliminary examination filed
International Preliminary Examining Authority: JP
04.09.2006Amendment by applicant (claims and/or description)
22.09.2006Examination requested  [2006/46]
30.09.2010Despatch of a communication from the examining division (Time limit: M06)
07.04.2011Reply to a communication from the examining division
03.09.2013Application deemed to be withdrawn, date of legal effect  [2014/06]
25.09.2013Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2014/06]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  30.09.2010
Fees paidRenewal fee
13.02.2007Renewal fee patent year 03
20.02.2008Renewal fee patent year 04
19.02.2009Renewal fee patent year 05
23.02.2010Renewal fee patent year 06
24.02.2011Renewal fee patent year 07
22.02.2012Renewal fee patent year 08
Penalty fee
Additional fee for renewal fee
28.02.201309   M06   Not yet paid
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]  - OHKUBO A ET AL, "A new approach for pyrophosphate bond formation starting from phosphoramidite derivatives by use of 6-trifluoromethyl-1-hydroxybenz otriazole-mediated O-N phosphoryl migration", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, (20040126), vol. 45, no. 5, ISSN 0040-4039, pages 979 - 982, XP004483304 [X] 1,3-5 * page 979 - page 982 *

DOI:   http://dx.doi.org/10.1016/j.tetlet.2003.11.110
 [X]  - SEIO K ET AL, "Enhanced stereoselectivity in internucleosidic bond formation by the use of the chiral ribose moiety of thymidine", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON.; US, (20030101), vol. 68, ISSN 0022-3263, pages 3849 - 3859, XP002328262 [X] 1-8 * page 3850 - page 3855 *

DOI:   http://dx.doi.org/10.1021/jo020533l
 [X]  - M. SEKINE ET AL., "proton-block strategy for the synthesis of oligodeoxynucleotides without base protection", JOURNAL OF ORGANIC CHEMISTRY, usa, (2003), vol. 68, no. 14, pages 5478 - 5492, XP002553901 [X] 1-8 * page 5479 - page 5482; tables sch.2a,3a *

DOI:   http://dx.doi.org/10.1021/jo034204k
 [X]  - A. OHKUBO ET AL., "a new strategy for the synthesis of oligodeoxynucleotides in the phosphoramidite method", NUCLEIC ACID RESEARCH SUPPLEMENT, gb, (2002), vol. 2, pages 29 - 30, XP002553902 [X] 1,3 * page 29 - page 30 *

DOI:   http://dx.doi.org/10.1093/nass/2.1.29
International search[A]JPS6251695  (YUKI GOSEI YAKUHIN KOGYO KK);
 [Y]JPH1180185  (JAPAN RES DEV CORP);
 [Y]JP2003002895  (TOKYO INST TECH);
 [X]JP2003028871  (FUJI PHOTO FILM CO LTD);
 [XP]JP2004099532  (SIGMA GENOSYS JAPAN KK);
 [X]  - OHKUBO A. ET AL., "A new strategy for the synthesis of oligodeoxynucleotides directed towards perfect O selective internucleotidic bond formation without base protection.", TETRAHEDRON LETTERS., (2004), vol. 45, no. 2, pages 363 - 366, XP004478904

DOI:   http://dx.doi.org/10.1016/j.tetlet.2003.10.156
 [X]  - DABKOWSKI W. ET AL., "2,4-dinitrophenol: a novel activating reagent in nucleotide synthesis via the phosphoramidite route.", TETRAHEDRON LETTERS., (2000), vol. 41, no. 39, pages 7535 - 7539, XP004217345

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)01178-3
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.