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Extract from the Register of European Patents

EP About this file: EP1718289

EP1718289 - THERAPEUTIC METHODS EMPLOYING NITRIC OXIDE PRECURSORS [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  08.12.2017
Database last updated on 15.07.2024
Most recent event   Tooltip08.12.2017Withdrawal of applicationpublished on 10.01.2018  [2018/02]
Applicant(s)For all designated states
VANDERBILT UNIVERSITY
Office of Technology Transfer
Suite 105
1207 17th Avenue South
Nashville, TN 37212 / US
[N/P]
Former [2006/45]For all designated states
VANDERBILT UNIVERSITY
Office of Technology Transfer, Suite 105, 1207 17th Avenue South
Nashville, TN 37212 / US
Inventor(s)01 / SUMMAR, Marshall, L.
513 Bel Air Place
Brentwood, TN 37207 / US
02 / CHRISTMAN, Brian
1713 Temple Avenue
Nashville, TN 37215 / US
03 / BARR, Frederick, E.
2507 Natchez Trace
Nashville, TN 37212 / US
 [2006/45]
Representative(s)Isarpatent
Patent- und Rechtsanwälte Barth
Charles Hassa Peckmann & Partner mbB
Postfach 44 01 51
80750 München / DE
[N/P]
Former [2012/18]Isarpatent
Patent- und Rechtsanwälte
Postfach 44 01 51
80750 München / DE
Former [2006/45]Behnisch, Werner, et al
Reinhard-Skuhra-Weise & Partner GbR, Friedrichstrasse 31
80801 München / DE
Application number, filing date05723789.324.02.2005
[2006/45]
WO2005US06081
Priority number, dateUS2004078537424.02.2004         Original published format: US 785374
[2006/45]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005082042
Date:09.09.2005
Language:EN
[2005/36]
Type: A2 Application without search report 
No.:EP1718289
Date:08.11.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 09.09.2005 takes the place of the publication of the European patent application.
[2006/45]
Search report(s)International search report - published on:US04.05.2006
(Supplementary) European search report - dispatched on:EP13.03.2007
ClassificationIPC:A61K31/198
[2007/14]
CPC:
A61K31/198 (EP,US); A61K31/195 (EP,US); A61P1/04 (EP);
A61P1/16 (EP); A61P11/00 (EP); A61P11/06 (EP);
A61P15/10 (EP); A61P29/00 (EP); A61P31/04 (EP);
A61P37/00 (EP); A61P37/06 (EP); A61P43/00 (EP);
A61P9/00 (EP); A61P9/12 (EP); C12N9/93 (EP,US);
A01K2217/05 (EP,US); A61K38/00 (EP,US) (-)
Former IPC [2006/45]A61K31/195, C07H21/04, C12Q1/68, C12N9/12
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/45]
Extension statesAL24.08.2006
BA24.08.2006
HR24.08.2006
LV24.08.2006
MK24.08.2006
YU24.08.2006
TitleGerman:THERAPEUTISCHE VERFAHREN UNTER VERWENDUNG VON STICKOXID-VORLÄUFERN[2006/45]
English:THERAPEUTIC METHODS EMPLOYING NITRIC OXIDE PRECURSORS[2006/45]
French:METHODES THERAPEUTIQUES FAISANT APPEL A DES PRECURSEURS D'OXYDE NITRIQUE[2006/45]
Entry into regional phase24.08.2006National basic fee paid 
24.08.2006Search fee paid 
24.08.2006Designation fee(s) paid 
24.08.2006Examination fee paid 
Examination procedure24.08.2006Amendment by applicant (claims and/or description)
24.08.2006Examination requested  [2006/45]
14.09.2007Despatch of a communication from the examining division (Time limit: M06)
14.03.2008Reply to a communication from the examining division
04.08.2008Despatch of a communication from the examining division (Time limit: M06)
13.02.2009Reply to a communication from the examining division
31.03.2011Despatch of a communication from the examining division (Time limit: M06)
16.11.2011Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
26.01.2012Reply to a communication from the examining division
26.11.2014Despatch of a communication from the examining division (Time limit: M06)
08.06.2015Reply to a communication from the examining division
04.12.2017Application withdrawn by applicant  [2018/02]
04.12.2017Cancellation of oral proceeding that was planned for 08.12.2017
08.12.2017Date of oral proceedings (cancelled)
Divisional application(s)EP10184493.4  / EP2319507
EP18158829.4  / EP3351241
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  14.09.2007
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
26.01.2012Request for further processing filed
26.01.2012Full payment received (date of receipt of payment)
Request granted
08.02.2012Decision despatched
Fees paidRenewal fee
28.02.2007Renewal fee patent year 03
28.02.2008Renewal fee patent year 04
26.02.2009Renewal fee patent year 05
26.02.2010Renewal fee patent year 06
28.02.2011Renewal fee patent year 07
29.02.2012Renewal fee patent year 08
27.02.2013Renewal fee patent year 09
27.02.2014Renewal fee patent year 10
26.02.2015Renewal fee patent year 11
26.02.2016Renewal fee patent year 12
27.02.2017Renewal fee patent year 13
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]AU3460571  (RICHARDSON MERRELL SPA) [X] 1-28 * page 2, line 1 - line 3 * * page 3, paragraph 2 - page 4, paragraph 1 *;
 [X]WO9416740  (BRIGHAM & WOMENS HOSPITAL [US], et al) [X] 1-28 * page 1, line 3 - line 5 * * page 5, line 10 - line 20 *;
 [X]WO0006151  (KUHRTS ERIC [US]) [X] 1-28 * page 1, paragraph 1 * * page 16, paragraph L - page 17, paragraph 1 *;
 [X]WO0073322  (UNIV VANDERBILT [US], et al) [X] 1-28 * page 6, line 14 - line 18 * * page 46, line 10 - line 25 *;
 [X]US2001056068  (CHWALISZ KRISTOF [DE], et al) [X] 1-28 * paragraph [0033] - paragraph [0034] * * paragraph [0052] *;
 [X]  - BARR F E ET AL, "Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery", THE JOURNAL OF PEDIADRICS, (2003), vol. 142, no. 1, pages 26 - 30, XP002422409 [X] 1-28 * abstract * * page 29, column R *
 [X]  - SUSCHEK C V ET AL, "Critical role of L-arginine in endothelial cell survival during oxidative stress", EMBASE, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20030527), Database accession no. EMB-2003218186, XP002422418 [X] 1-28 * abstract *
 [X]  - DAGENAIS CAROLINE ET AL, "Acute L-arginine supplement and cardiac surgery", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (1996), Database accession no. PREV199699075415, XP002422419 [X] 1-28 * abstract *
 [X]  - HOJO F ET AL, "Inhibition of spontaneous pulmonary metastases by L-arginine associated with induction of cytotoxic macrophages", EMBASE, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (1990), Database accession no. EMB-1990075119, XP002422420 [X] 1-28 * abstract *
 [X]  - GARDINER K R ET AL, "Reduced intestinal absorption of arginine during sepsis.", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (199507), Database accession no. NLM7600831, XP002422421 [X] 1-28 * abstract *
 [X]  - PERNOW JOHN ET AL, "L-Arginine protects from ischemia-reperfusion-induced endothelial dysfunction in humans in vivo.", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (200312), Database accession no. PREV200400055833, XP002422422 [X] 1-28 * abstract *
 [X]  - AKISU METE ET AL, "Protective effect of dietary supplementation with L-arginine and L-carnitine on hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (200205), Database accession no. PREV200200378590, XP002422423 [X] 1-28 * abstract *
 [X]  - SAIJYO TETSUYA ET AL, "Autonomic nervous system activity during infusion of L-arginine in patients with liver cirrhosis", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (199802), Database accession no. PREV199800177848, XP002422424 [X] 1-28 * abstract *
 [X]  - MITANI YOSHIHIDE ET AL, "Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (1997), Database accession no. PREV199799686392, XP002422425 [X] 1-28 * abstract *
    [ ] - CIRCULATION 27 MAY 2003 UNITED STATES, (20030527), vol. 107, no. 20, ISSN 0009-7322, pages 2607 - 2614
    [ ] - CANADIAN JOURNAL OF ANAESTHESIA, ANNUAL MEETING OF THE CANADIAN ANAESTHETISTS' SOCIETY; MONTREAL, QUEBEC, CANADA; JUNE 14-18, 1996, (1996), vol. 43, no. 5 PART 2, ISSN 0832-610X, page A16
    [ ] - CANCER JOURNAL 1990 FRANCE, (1990), vol. 3, no. 1, ISSN 0765-7846, pages 14 - 19
    [ ] - CRITICAL CARE MEDICINE JUL 1995, (199507), vol. 23, no. 7, ISSN 0090-3493, pages 1227 - 1232
    [ ] - JOURNAL OF APPLIED PHYSIOLOGY, (200312), vol. 95, no. 6, ISSN 8750-7587, pages 2218 - 2222
    [ ] - BIOLOGY OF THE NEONATE, (200205), vol. 81, no. 4, ISSN 0006-3126, pages 260 - 265
    [ ] - LIVER, (199802), vol. 18, no. 1, ISSN 0106-9543, pages 27 - 31
    [ ] - CIRCULATION, (1997), vol. 96, no. 2, ISSN 0009-7322, pages 689 - 697
International search[X]  - AMIN H.J. ET AL, "Arginine supplementation prevents necrotizing enterocolitis in the premature infant", JOURNAL OF PEDIATRICS, (200204), vol. 140, no. 4, pages 425 - 431, XP002993971

DOI:   http://dx.doi.org/10.1067/mpd.2002.123289
 [X]  - MIZUTANI N. ET AL, "Oral administration of arginine and citrulline in the treatment of lysinuric protein intolerance", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, (1984), vol. 142, pages 15 - 24, XP008059480
 [Y]  - DAVIES S.M. ET AL, "Idiopathic hyperammonemia: a frequently lethal complication of bone marrow transplantation", BONE MARROW TRANSPLANTATION, (199606), vol. 17, pages 1119 - 1125, XP008059479
 [Y]  - VASSAL G. ET AL, "Busulfan disposition and hepatic veno-occlusive disease in children undergoing bone marrow transplantation", CANCER, CHEMOTHERAPY AND PHARMACOLOGY, (1996), vol. 37, pages 247 - 253, XP008059483

DOI:   http://dx.doi.org/10.1007/BF00688324
Examination   - EREZ AYELET ET AL, "Requirement of argininosuccinate lyase for systemic nitric oxide production.", NATURE MEDICINE DEC 2011, (201112), vol. 17, no. 12, ISSN 1546-170X, pages 1619 - 1626
    - DHANAKOTI S N ET AL, "RENAL ARGININE SYNTHESIS STUDIES IN-VITRO AND IN-VIVO", AMERICAN JOURNAL OF PHYSIOLOGY, (1990), vol. 259, no. 3 PART 1, ISSN 0002-9513, pages E437 - E442, XP008183898

DOI:   http://dx.doi.org/10.1152/ajpendo.1990.259.3.E437
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.