blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP1735434

EP1735434 - METHOD FOR MODIFICATION OF NMDA RECEPTORS THROUGH INHIBITION OF SRC [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  05.06.2015
Database last updated on 19.10.2024
Most recent event   Tooltip13.10.2017Lapse of the patent in a contracting state
New state(s): HU, TR		published on 15.11.2017  [2017/46]
Applicant(s)For all designated states
The Hospital for Sick Children
555 University Avenue
Elm Street Wing, 10th Floor, Rm 10126
Toronto, ON M5G 1X8 / CA
[2014/31]
Former [2006/52]For all designated states
The Hospital for Sick Children Research Institute
10th Fl, Rm 10126, Elm Street Wing 555 University Avenue
Toronto, ON M5G 1X8 / CA
Inventor(s)01 / SALTER, Michael, W.
88 Strath Avenue
Toronto, Ontario M8X 1R5 / CA
02 / GINGRICH, Jeffrey, R.
112 Banmoor Boulevard
Scarborough, Ontario M1J 2Z6 / CA
 [2007/16]
Former [2006/52]01 / SALTER, Michael, W.
88 Strath Avenue
Toronto, Ontario M8X 1R5 / CA
02 / GINGRICH, Jeffrey, R.
707-95 Thorncliffe Park Drive
Toronto, Ontario M4H 1L7 / CA
Representative(s)Taylor, Kate Laura, et al
HGF Limited
Saviour House
9 St Saviourgate
York YO1 8NQ / GB
[2014/31]
Former [2007/33]Taylor, Kate Laura, et al
Harrison Goddard Foote 106 Micklegate York
YO1 6JX / GB
Former [2006/52]Harrison Goddard Foote
Fountain Precinct, Balm Green
Sheffield S1 2JA / GB
Application number, filing date05729989.330.03.2005
[2006/52]
WO2005CA00477
Priority number, dateUS2004081410930.03.2004         Original published format: US 814109
[2006/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2005095593
Date:13.10.2005
Language:EN
[2005/41]
Type: A1 Application with search report 
No.:EP1735434
Date:27.12.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 13.10.2005 takes the place of the publication of the European patent application.
[2006/52]
Type: B1 Patent specification 
No.:EP1735434
Date:30.07.2014
Language:EN
[2014/31]
Search report(s)International search report - published on:CA13.10.2005
(Supplementary) European search report - dispatched on:EP21.10.2008
ClassificationIPC:C12N9/02, A61K38/08, A61K38/17
[2006/52]
CPC:
C07K7/08 (EP,US); C07K14/005 (EP,US); A61K38/00 (EP,US);
C12N2740/16122 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/52]
TitleGerman:VERFAHREN ZUR MODIFIKATION VON NMDA-REZEPTOREN DURCH HEMMUNG VON SRC[2006/52]
English:METHOD FOR MODIFICATION OF NMDA RECEPTORS THROUGH INHIBITION OF SRC[2006/52]
French:PROCEDE DE MODIFICATION DES RECEPTEURS NMDA PAR INHIBITION DE LA SRC[2006/52]
Entry into regional phase30.10.2006National basic fee paid 
30.10.2006Search fee paid 
30.10.2006Designation fee(s) paid 
30.10.2006Examination fee paid 
Examination procedure30.10.2006Amendment by applicant (claims and/or description)
30.10.2006Examination requested  [2006/52]
20.02.2009Despatch of a communication from the examining division (Time limit: M06)
29.08.2009Reply to a communication from the examining division
20.04.2011Despatch of a communication from the examining division (Time limit: M02)
20.06.2011Reply to a communication from the examining division
08.01.2014Communication of intention to grant the patent
06.05.2014Fee for grant paid
06.05.2014Fee for publishing/printing paid
06.05.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  20.02.2009
Opposition(s)04.05.2015No opposition filed within time limit [2015/28]
Fees paidRenewal fee
07.03.2007Renewal fee patent year 03
26.03.2008Renewal fee patent year 04
13.03.2009Renewal fee patent year 05
08.03.2010Renewal fee patent year 06
15.03.2011Renewal fee patent year 07
14.03.2012Renewal fee patent year 08
11.03.2013Renewal fee patent year 09
12.03.2014Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.03.2005
AT30.07.2014
BE30.07.2014
CY30.07.2014
CZ30.07.2014
DK30.07.2014
EE30.07.2014
ES30.07.2014
FI30.07.2014
IT30.07.2014
LT30.07.2014
MC30.07.2014
PL30.07.2014
RO30.07.2014
SE30.07.2014
SI30.07.2014
SK30.07.2014
TR30.07.2014
BG30.10.2014
GR31.10.2014
IS30.11.2014
PT02.12.2014
LU30.03.2015
[2017/39]
Former [2016/32]AT30.07.2014
BE30.07.2014
CY30.07.2014
CZ30.07.2014
DK30.07.2014
EE30.07.2014
ES30.07.2014
FI30.07.2014
IT30.07.2014
LT30.07.2014
MC30.07.2014
PL30.07.2014
RO30.07.2014
SE30.07.2014
SI30.07.2014
SK30.07.2014
BG30.10.2014
GR31.10.2014
IS30.11.2014
PT02.12.2014
LU30.03.2015
Former [2015/50]AT30.07.2014
CY30.07.2014
CZ30.07.2014
DK30.07.2014
EE30.07.2014
ES30.07.2014
FI30.07.2014
IT30.07.2014
LT30.07.2014
MC30.07.2014
PL30.07.2014
RO30.07.2014
SE30.07.2014
SI30.07.2014
SK30.07.2014
BG30.10.2014
GR31.10.2014
IS30.11.2014
PT02.12.2014
LU30.03.2015
Former [2015/47]AT30.07.2014
CY30.07.2014
CZ30.07.2014
DK30.07.2014
EE30.07.2014
ES30.07.2014
FI30.07.2014
IT30.07.2014
LT30.07.2014
MC30.07.2014
PL30.07.2014
RO30.07.2014
SE30.07.2014
SK30.07.2014
BG30.10.2014
GR31.10.2014
IS30.11.2014
PT02.12.2014
LU30.03.2015
Former [2015/46]AT30.07.2014
CY30.07.2014
CZ30.07.2014
DK30.07.2014
EE30.07.2014
ES30.07.2014
FI30.07.2014
IT30.07.2014
LT30.07.2014
MC30.07.2014
PL30.07.2014
RO30.07.2014
SE30.07.2014
SK30.07.2014
BG30.10.2014
GR31.10.2014
IS30.11.2014
PT02.12.2014
Former [2015/23]AT30.07.2014
CY30.07.2014
CZ30.07.2014
DK30.07.2014
EE30.07.2014
ES30.07.2014
FI30.07.2014
IT30.07.2014
LT30.07.2014
PL30.07.2014
RO30.07.2014
SE30.07.2014
SK30.07.2014
BG30.10.2014
GR31.10.2014
IS30.11.2014
PT02.12.2014
Former [2015/22]AT30.07.2014
CY30.07.2014
DK30.07.2014
ES30.07.2014
FI30.07.2014
IT30.07.2014
LT30.07.2014
PL30.07.2014
RO30.07.2014
SE30.07.2014
BG30.10.2014
GR31.10.2014
IS30.11.2014
PT02.12.2014
Former [2015/12]AT30.07.2014
CY30.07.2014
ES30.07.2014
FI30.07.2014
LT30.07.2014
PL30.07.2014
SE30.07.2014
BG30.10.2014
GR31.10.2014
IS30.11.2014
PT02.12.2014
Former [2015/11]CY30.07.2014
ES30.07.2014
FI30.07.2014
LT30.07.2014
PL30.07.2014
SE30.07.2014
BG30.10.2014
GR31.10.2014
PT02.12.2014
Former [2015/10]ES30.07.2014
FI30.07.2014
LT30.07.2014
SE30.07.2014
BG30.10.2014
Former [2015/09]FI30.07.2014
LT30.07.2014
SE30.07.2014
Former [2015/08]LT30.07.2014
Documents cited:Search[X]WO9746877  (UNIV EDINBURGH [GB], et al) [X] 1,2,4-6,8,17,18,20-22,24,26,27 * abstract *;
 [Y]US2003224993  (LAND HARTMUT [US], et al) [Y] 3,7,19,23* claims 41-58 *;
 [XY]  - XIAN-MIN YU ET AL, "NMDA CHANNEL REGULATION BY CHANNEL-ASSOCIATED PROTEIN TYROSINE KINASE SRC", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, WASHINGTON, DC, (19970131), vol. 275, no. 5300, ISSN 0036-8075, pages 674 - 678, XP008074764 [X] 1,2,4-6,8,17,18,20-22,24,26,27 * abstract * * page 677, column R, paragraph 1 * [Y] 3,7,19,23

DOI:   http://dx.doi.org/10.1126/science.275.5300.674
 [X]  - THORNTON CLAIRE ET AL, "H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 27 JUN 2003, (20030627), vol. 278, no. 26, ISSN 0021-9258, pages 23823 - 23829, XP002498793 [X] 1,2,4-6,8,17,18,20-22,24,26,27 * abstract *

DOI:   http://dx.doi.org/10.1074/jbc.M302389200
 [X]  - VIVIANI B ET AL, "Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases.", THE JOURNAL OF NEUROSCIENCE : THE OFFICIAL JOURNAL OF THE SOCIETY FOR NEUROSCIENCE 24 SEP 2003, (20030924), vol. 23, no. 25, ISSN 1529-2401, pages 8692 - 8700, XP002498794 [X] 1,2,4-6,8,17,18,20-22,24,26,27 * abstract *
 [X]  - WISE,C.A ET AL., "Homo sapiens NADH dehydrogenase subunit 2 (ND2) gene", GENBANK, (19990506), Database accession no. AF014899, URL: STN, XP002498795 [X] 14-16 * the whole document *
 [X]  - INGMAN,M. ET AL., "Homo sapiens mitochondrion, complete genome.", GENBANK, (20030722), XP002498796 [X] 14-16 * the whole document *
International search[A]US5523323  (MACCECCHINI MARIA-LUISA [US]);
 [A]EP1244638  (UNIV NEBRASKA [US]);
 [X]  - YU X.M. ET AL, "NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src.", SCIENCE., (19970131), vol. 275, pages 674 - 678, XP008074764

DOI:   http://dx.doi.org/10.1126/science.275.5300.674
 [X]  - INGMAN M. ET AL, "NADH Dehydrogenase Subunit 2(Homo sapiens).", GENBANK, (20030822), Database accession no. (AAK17620), XP008111114
 [A]  - DINGLEDINE R. ET AL, "The Glutamate Receptor ion Channels.", PHARMACOL REV., (199903), vol. 51, no. 1, pages 7 - 61, XP000999879
 [A]  - LEI S. ET AL, "Platelet-derived Growth FActor Receptor-induced Feed-forward Inhibition of Excitatory Transmission between Hippocmpal Pyramidal Neurons.", J BIOL CHEM., (19991022), vol. 274, no. 43, pages 30617 - 30623, XP008074763

DOI:   http://dx.doi.org/10.1074/jbc.274.43.30617
 [A]  - CHEN M. ET AL, "Tyrosine Kinase and Tyrosine Phosphatase Participate in Regualtory of Interactions of NMDA Receptor subunit 2A with Scr and Fyn Mediated by PSD-95 After Transient Brain Ischemia.", NEUROSCI LETT., (20030313), vol. 339, pages 29 - 32, XP008074761

DOI:   http://dx.doi.org/10.1016/S0304-3940(02)01439-8
Examination   - LIU XUE JUN ET AL, "Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex.", NATURE MEDICINE DEC 2008, (200812), vol. 14, no. 12, ISSN 1546-170X, pages 1325 - 1332
by applicantWO9746877
 US2003050243
 US2003224993
    - AARTS ET AL., SCIENCE, (2002), vol. 298, pages 846 - 850
    - YU ET AL., SCIENCE, (1997), vol. 275, pages 674 - 678
    - LU ET AL., SCIENCE, (1998), vol. 279, pages 1363 - 1368
    - ALI ET AL., CURRENT OPINION IN NEUROBIOLOGY
    - XIAN-MIN ET AL., SCIENCE, (1997), vol. 275, pages 674 - 678
    - THORNTON-CLAIRE ET AL., J. BIOL. CHEM., (2003), vol. 278, pages 23823 - 23829
    - VIVANI ET AL., NEUROSCIENCE, (2003), vol. 23, pages 2692 - 8700
    - MALENKA ET AL., SCIENCE, (1999), vol. 285, pages 1870 - 1874
    - SANNA ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE, (2000), vol. 97, pages 8653 - 8657
    - GUO ET AL., JOURNAL OF NEUROSCIENCE, (2002), vol. 22, pages 6208 - 6217
    - PEI ET AL., JOURNAL OF CEREBRAL BLOOD FLOW METABOLISM, (2001), vol. 21, pages 955 - 963
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.