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Extract from the Register of European Patents

EP About this file: EP1742924

EP1742924 - CALCILYTIC COMPOUNDS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  27.05.2011
Database last updated on 15.11.2024
Most recent event   Tooltip27.05.2011Application deemed to be withdrawnpublished on 29.06.2011  [2011/26]
Applicant(s)For all designated states
GlaxoSmithKline LLC
One Franklin Plaza
200 North 16th Street
Philadelphia, PA 19102 / US
[N/P]
Former [2010/09]For all designated states
GlaxoSmithKline LLC
One Franklin Plaza 200 North 16th Street
Philadelphia, PA 19102 / US
Former [2007/03]For all designated states
SMITHKLINE BEECHAM CORPORATION
One Franklin Plaza P.O. Box 7929
Philadelphia, PA 19101 / US
Inventor(s)01 / LUENGO, Juan, I.
1250 South Collegeville Road
Collegeville, PA 19426 / US
02 / MARQUIS, Robert, W., Jr.
1250 South Collegeville Road
Collegeville, PA 19426 / US
03 / XIE, Ren
1250 South Collegeville Road
Collegeville, PA 19426 / US
04 / YAMASHITA, Dennis, S.
1250 South Collegeville Road
Collegeville, PA 19426 / US
 [2007/03]
Representative(s)Billson, Siân Catherine, et al
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
[N/P]
Former [2007/03]Billson, Siân Catherine, et al
GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road
Brentford, Middlesex TW8 9GS / GB
Application number, filing date05744198.203.05.2005
[2007/03]
WO2005US15224
Priority number, dateUS20040568585P06.05.2004         Original published format: US 568585 P
[2007/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2005108376
Date:17.11.2005
Language:EN
[2005/46]
Type: A1 Application with search report 
No.:EP1742924
Date:17.01.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 17.11.2005 takes the place of the publication of the European patent application.
[2007/03]
Search report(s)International search report - published on:US17.11.2005
(Supplementary) European search report - dispatched on:EP07.09.2010
ClassificationIPC:C07D239/36, C07D239/91, A61K31/513, A61K31/517
[2007/03]
CPC:
C07D239/91 (EP,US); A61P1/02 (EP); A61P19/00 (EP);
A61P19/02 (EP); A61P19/08 (EP); A61P19/10 (EP);
A61P29/00 (EP); A61P3/02 (EP); A61P3/12 (EP);
A61P3/14 (EP); A61P35/00 (EP); A61P43/00 (EP);
A61P5/18 (EP); A61P5/30 (EP) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/03]
Extension statesALNot yet paid
BANot yet paid
HR01.11.2006
LV01.11.2006
MKNot yet paid
YUNot yet paid
TitleGerman:KALZILYTISCHE VERBINDUNGEN[2007/03]
English:CALCILYTIC COMPOUNDS[2007/03]
French:COMPOSES CALCILYTIQUES[2007/03]
Entry into regional phase01.11.2006National basic fee paid 
01.11.2006Search fee paid 
01.11.2006Designation fee(s) paid 
01.11.2006Examination fee paid 
Examination procedure01.11.2006Examination requested  [2007/03]
07.12.2010Application deemed to be withdrawn, date of legal effect  [2011/26]
14.01.2011Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2011/26]
Fees paidRenewal fee
07.05.2007Renewal fee patent year 03
18.03.2008Renewal fee patent year 04
07.05.2009Renewal fee patent year 05
31.03.2010Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]WO03106435  (SANKYO CO [JP], et al) [X] 1,3,4,10,12 * examples 2-23,2-53 - 2-60 * * examples 3-5, 3-6 * * examples 4-1 - 4-3 * * examples 6-1 - 6-3, 6-119 - 6-121 * * examples 7-1 - 7-3 * * Use in therapy of rheumatoid arthritis, osteoarthritis, osteoporosis:; page 1, line 7 - line 15 *;
 [XP]WO2005032527  (SOLVAY PHARM BV [NL]) [XP] 1,3-6,8-12 * compounds 22,23,42-44 * * tables 1,2 * * Use in therapy of osteoporosis and rheumatoid arthritis:;; claim 34 *;
 [I]WO03084938  (ORCHID CHEMICALS & PHARM LTD [IN], et al) [I] 1,3-6,8-12 * Use in therapy of osteoporosis, osteoarthritis, rheumatoid arthritis, bone resorption diseases:; page 3, line 19 - line 28 * * examples 1-8 *;
 [IP]WO2004092120  (NPS PHARMA INC [US], et al) [IP] 1,3-6,8-12 * General teaching of:;; claim 1 * * Use in therapy of osteoarthritis, osteoporosis, rheumatoid arthritis etc.:;; claim 18 * * Use of compounds as calcilytics:; page 3, paragraph 0011 *;
 [IP]WO2004041755  (NPS PHARMA INC [US], et al) [IP] 1,3-6,8-12 * General teaching of:;; claim 1 * * Use in therapy of osteoarthritis, osteoporosis, rheumatoid arthritis etc.:;; claim 15 * * Use as calcilytics:; page 3, line 10 *;
 [X]  - TAKUZO HISANO ET AL, "studies on organosulfur compounds. XII.synthesis and pharmacological activities of 2-heterocyclic subst. 4(3h)-quinazolinones", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, (19750101), vol. 23, no. 9, ISSN 0009-2363, pages 1910 - 1916, XP002398577 [X] 1 * page 1911; compound a * * table 1; compounds 1-3 , 5-9, 12 *
 [X]  - NIGAM R ET AL, "SYNTHESIS AND PHARMACOLOGICAL SCREENING OF SOME NEW 2-(PHENYL/CHLOROMETHYL)- 3 -ÄN, N-DISUBSTITUTED AMINOCARBONYL) PHENYLÜ 8-SUBSTITUTED-4 (3H)-QUINAZOLONES", INDIAN DRUGS, INDIAN DRUG MANUFACTURERS' ASSOCIATION, IN, (19900101), vol. 27, no. 4, ISSN 0019-462X, pages 238 - 243, XP008070162 [X] 1 * table 1; compound 8 *
 [X]  - KIDWAI, MAZAAHIR ET AL, "A novel route to the Niementowski reaction", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (2003), Database accession no. 2004:14624, URL: STN, XP007914586 [X] 1 * abstract * * Compound with CAS Registry number 675200-75-6 *
 [X]  - TIWARI, S. S. ET AL, "Search for new anthelmintics: Part I. Synthesis of piperazine derivatives", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1979), Database accession no. 1980:146718, URL: STN, XP007914585 [X] 1 * abstract * * Compound with CAS Registry number 73265-32-4 *
 [X]  - EL-AHL, A.-A. S., "A novel synthesis of 2-substituted-4H-thieno[2,3-d][1,3]oxazin-4-one and 2,3-disubstituted thieno[2,3-d]pyrimidin-4(3H)-one derivatives", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (2000), Database accession no. 2000:530813, URL: STN, XP007914587 [X] 1 * abstract * * Compounds with CAS Registry number 296238-21-6 and 296238-23-8 *
 [X]  - K. A. GUPTA, A. K. SAXENA, "A convenient Methofor the synthesis of 2,6-disubstituted 3-Aryl-4(3H)-pyrimidones", SYNTHESIS, (1981), pages 905 - 907, XP007914589 [X] 1 * table 1; compounds 3a,3b *
 [X]  - SUJIT N. MAZUMDAR AND MOHINDER P. MAHAJAN, "[4+2] cycloaddition reactions of various 1,3-diaza-1.3-Butadienes with ketenes", TETRAHEDRON, (1991), vol. 47, no. 8, doi:10.1016/S0040-4020(01)86423-1, pages 1473 - 1484, XP007914588 [X] 1 * compounds 3a-3d *

DOI:   http://dx.doi.org/10.1016/S0040-4020(01)86423-1
 [X]  - BENJAMIN STASKUN AND HENRY STEPHEN, "A new synthesis of 2 : 3 : 5 : 6-substituted 4-pyrimidones", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LETCHWORTH; GB LNKD- DOI:10.1039/JR9560004708, (19560101), ISSN 0368-1769, pages 4708 - 4710, XP008126084 [X] 1 * Compounds 1-5, 9-11 of Table 1 on:; page 1956 *

DOI:   http://dx.doi.org/10.1039/jr9560004708
 [IP]  - SHCHERBAKOVA I ET AL, "Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/J.BMCL.2005.03.054, vol. 15, no. 10, ISSN 0960-894X, (20050412), pages 2537 - 2540, (20050516), XP025314324 [IP] 1,3,10,12 * compounds 2d-2o * * Cycilytic activity disclosed in:;; table 1 *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2005.03.054
 [IP]  - SHCHERBAKOVA I ET AL, "3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/J.BMCL.2005.01.078, vol. 15, no. 6, ISSN 0960-894X, (20050315), pages 1557 - 1560, (20050315), XP025313563 [IP] 1,3,10,12 * Cacilytic activity disclosed in first paragraph page 1557:;; tables 1,2; compounds 5k-5t *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2005.01.078
International search[Y]US6146715  (KIM CHANG NAM [KR], et al);
 [Y]US4756765  (WOODROFFE JAIME A [US]);
 [Y]US2003143326  (BUBB DANIEL [US], et al);
 [A]US5688551  (LITTMAN JON ERIC [US], et al);
 [A]US5208437  (MIYAUCHI TATEOKI [JP], et al);
 [AP]US2004161695  (BOROSON MICHAEL L [US], et al);
 [A]US4684437  (DONELON JOHN J [US], et al);
 [A]US6522066  (SHEU CHAI-YUAN [TW], et al)
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.