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Extract from the Register of European Patents

EP About this file: EP1758864

EP1758864 - Substituted tetrahydro-2H-isoquinolin-1-one derivatives, method for their preparation, and their use as medicaments [Right-click to bookmark this link]
Former [2007/10]SUBSTITUTED TETRAHYDRO-2H-ISOQUINOLIN-1-ONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF THE SAME AS MEDICAMENTS
[2012/27]
StatusNo opposition filed within time limit
Status updated on  14.02.2014
Database last updated on 17.07.2024
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU, LU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
Sanofi-Aventis Deutschland GmbH
Brüningstrasse 50
65929 Frankfurt am Main / DE
[2013/15]
Former [2007/10]For all designated states
Sanofi-Aventis Deutschland GmbH
Brüningstrasse 50
65929 Frankfurt am Main / DE
Inventor(s)01 / PEUKERT, Stefan
19 Albermarle Street
Arlington, MA 02476 / US
02 / GUESSREGEN, Stefan
An der Laach 12
65205 Wiesbaden / DE
03 / HOFMEISTER, Armin
Am Doktorweg 6
55278 Dexheim / DE
04 / SCHREUDER, Herman
Jahnstrasse 22
65719 Hofheim-Lorsbach / DE
05 / SCHWAHN, Uwe
Antoniterweg 8
65843 Sulzbach / DE
 [2007/10]
Application number, filing date05754335.701.06.2005
[2007/10]
WO2005EP05871
Priority number, dateDE2004102897316.06.2004         Original published format: DE102004028973
[2007/10]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report
No.:WO2005123687
Date:29.12.2005
Language:DE
[2005/52]
Type: A1 Application with search report 
No.:EP1758864
Date:07.03.2007
Language:DE
The application published by WIPO in one of the EPO official languages on 29.12.2005 takes the place of the publication of the European patent application.
[2007/10]
Type: B1 Patent specification 
No.:EP1758864
Date:10.04.2013
Language:DE
[2013/15]
Search report(s)International search report - published on:EP29.12.2005
ClassificationIPC:C07D217/24, C07D417/14, C07D401/12, C07D405/04, C07D409/04, C07D401/04, C07D401/14, C07D413/14, C07D405/14, A61K31/472, A61K31/4725, A61P9/00
[2007/10]
CPC:
C07D413/14 (EP,US); C07D217/24 (EP,KR,US); A61K31/472 (KR);
A61P17/00 (EP); A61P19/02 (EP); A61P21/00 (EP);
A61P25/00 (EP); A61P25/28 (EP); A61P27/02 (EP);
A61P3/10 (EP); A61P35/00 (EP); A61P37/08 (EP);
A61P43/00 (EP); A61P9/00 (EP); A61P9/02 (EP);
A61P9/04 (EP); A61P9/10 (EP); C07D401/04 (EP,US);
C07D401/12 (EP,US); C07D401/14 (EP,US); C07D405/04 (EP,US);
C07D405/14 (EP,US); C07D409/04 (EP,US); C07D417/14 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/10]
TitleGerman:Substituierte Tetrahydro-2H-isochinolin-1-on-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente[2012/27]
English:Substituted tetrahydro-2H-isoquinolin-1-one derivatives, method for their preparation, and their use as medicaments[2012/27]
French:Dérivés substitués de tetrahydro-2H-isoquinolein-1-one, leur procédé de préparation et leur utilisation en tant que médicaments[2012/27]
Former [2007/10]SUBSTITUIERTE TETRAHYDRO-2H-ISOCHINOLIN-1-ON-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS MEDIKAMENT
Former [2007/10]SUBSTITUTED TETRAHYDRO-2H-ISOQUINOLIN-1-ONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF THE SAME AS MEDICAMENTS
Former [2007/10]DERIVES SUBSTITUES DE TETRAHYDRO-2H-ISOQUINOLEIN-1-ONE, LEUR PROCEDE DE PRODUCTION, ET LEUR UTILISATION EN TANT QUE MEDICAMENTS
Entry into regional phase16.01.2007National basic fee paid 
16.01.2007Designation fee(s) paid 
16.01.2007Examination fee paid 
Examination procedure16.01.2007Examination requested  [2007/10]
30.10.2009Despatch of a communication from the examining division (Time limit: M04)
18.02.2010Reply to a communication from the examining division
06.09.2011Despatch of a communication from the examining division (Time limit: M04)
11.01.2012Reply to a communication from the examining division
18.06.2012Communication of intention to grant the patent
06.09.2012Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
19.10.2012Communication of intention to grant the patent
27.02.2013Fee for grant paid
27.02.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  30.10.2009
Opposition(s)13.01.2014No opposition filed within time limit [2014/12]
Fees paidRenewal fee
02.07.2007Renewal fee patent year 03
30.06.2008Renewal fee patent year 04
30.06.2009Renewal fee patent year 05
30.06.2010Renewal fee patent year 06
13.06.2011Renewal fee patent year 07
24.05.2012Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.06.2005
CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
TR10.04.2013
AT01.06.2013
IE01.06.2013
LU01.06.2013
BE30.06.2013
CH30.06.2013
LI30.06.2013
FR01.07.2013
BG10.07.2013
GB10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
DE01.01.2014
[2015/34]
Former [2015/32]CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
TR10.04.2013
AT01.06.2013
IE01.06.2013
BE30.06.2013
CH30.06.2013
LI30.06.2013
FR01.07.2013
BG10.07.2013
GB10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
DE01.01.2014
Former [2014/51]CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
AT01.06.2013
IE01.06.2013
BE30.06.2013
CH30.06.2013
LI30.06.2013
FR01.07.2013
BG10.07.2013
GB10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
DE01.01.2014
Former [2014/24]CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
IE01.06.2013
BE30.06.2013
CH30.06.2013
LI30.06.2013
FR01.07.2013
BG10.07.2013
GB10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
DE01.01.2014
Former [2014/22]CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
IE01.06.2013
BE30.06.2013
CH30.06.2013
LI30.06.2013
BG10.07.2013
GB10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
DE01.01.2014
Former [2014/21]CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
IE01.06.2013
BE30.06.2013
CH30.06.2013
LI30.06.2013
BG10.07.2013
GB10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2014/20]CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
IE01.06.2013
BE30.06.2013
CH30.06.2013
LI30.06.2013
BG10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2014/18]CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
BE30.06.2013
BG10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2014/11]CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2014/10]CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2014/09]CY10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
SE10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2014/08]CY10.04.2013
FI10.04.2013
LT10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
SE10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2013/52]CY10.04.2013
FI10.04.2013
LT10.04.2013
NL10.04.2013
PL10.04.2013
SE10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2013/50]FI10.04.2013
LT10.04.2013
NL10.04.2013
PL10.04.2013
SE10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2013/49]FI10.04.2013
LT10.04.2013
NL10.04.2013
SE10.04.2013
SI10.04.2013
GR11.07.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2013/48]LT10.04.2013
NL10.04.2013
SI10.04.2013
ES21.07.2013
IS10.08.2013
PT12.08.2013
Former [2013/47]LT10.04.2013
SI10.04.2013
PT12.08.2013
Former [2013/37]SI10.04.2013
Cited inInternational search[A]US3594380  (SULKOWSKI THEODORE S) [A] 1,8 * abstract *;
 [AD]EP0355750  (WARNER LAMBERT CO [US]) [AD] 1,8,13 * claims 1,20 *;
 [AD]WO9911624  (GUILFORD PHARM INC [US]) [AD] 1-17 * page 22, line 15 - page 24, line 24; example 1; claim -; table VIII *;
 [AD]WO02090334  (KUDOS PHARM LTD [GB], et al) [AD] 1-17 * page 6, line 10 - line 15 * * page 20, line 25 - page 23, line 5 * * claim - *;
 [AD]  - J. H. RIGBY ET AL, "Nucleophilic Addition of Silyl Enol Ethers to Aromatic Nitro Compounds: A Facile Synthesis of alpha-Nitroaryl Carbonyl Compounds", JOURNAL OF ORGANIC CHEMISTRY, (1984), vol. 49, no. 23, pages 4569 - 4571, XP002349380 [AD] 1 * Seite 4570, Tabelle I, "entry 6", "pyridone" *

DOI:   http://dx.doi.org/10.1021/jo00197a061
 [A]  - J. H. RIGBY ET AL, "Preparation of Highly Substituted 2-Pyridones by Reaction of Vinyl Isocyanates and Enamines", JOURNAL OF ORGANIC CHEMISTRY, (1989), vol. 54, no. 1, pages 224 - 228, XP002349381 [A] 1 * Seite 226, linke Spalte, Verbindung 9; Seite 227, rechte Spalte, Zeilen 26-38 *

DOI:   http://dx.doi.org/10.1021/jo00262a047
ExaminationWO2005097750
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