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Extract from the Register of European Patents

EP About this file: EP1904465

EP1904465 - METHOD OF SYNTHESIS OF IMIDAZOLE-AMINO ACID DERIVATIVES AND RELATED COMPOUNDS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  04.02.2011
Database last updated on 25.09.2024
Most recent event   Tooltip15.08.2014Lapse of the patent in a contracting state
New state(s): GR		published on 17.09.2014  [2014/38]
Applicant(s)For all designated states
Janssen Pharmaceutica NV
Turnhoutseweg 30
2340 Beerse / BE
[2008/14]
Inventor(s)01 / HLASTA, Dennis, J.
5008 Davis Drive
Doylestown, PA 18901 / US
02 / ZIFICSAK, Craig, A.
106 Newport Court
Harleysville, PA 19438 / US
 [2008/14]
Representative(s)Warner, James Alexander
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2008/14]Warner, James Alexander
Carpmaels & Ransford 43 -45 Bloomsbury Square
London WC1A 2RA / GB
Application number, filing date05766686.929.06.2005
[2008/14]
WO2005US23048
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2007005000
Date:11.01.2007
Language:EN
[2007/02]
Type: A1 Application with search report 
No.:EP1904465
Date:02.04.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 11.01.2007 takes the place of the publication of the European patent application.
[2008/14]
Type: B1 Patent specification 
No.:EP1904465
Date:31.03.2010
Language:EN
[2010/13]
Search report(s)International search report - published on:EP11.01.2007
ClassificationIPC:C07D263/24, C07D413/06, C07D233/54, C07D405/04
[2008/14]
CPC:
C07D233/64 (EP); C07D233/56 (EP); C07D405/06 (EP);
C07D413/06 (EP); C07D471/04 (EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2008/14]
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
LV21.01.2008
MKNot yet paid
YUNot yet paid
TitleGerman:VERFAHREN ZUR SYNTHESE VON IMIDAZOLAMINOSÄUREDERIVATEN UND VERWANDTEN VERBINDUNGEN[2008/14]
English:METHOD OF SYNTHESIS OF IMIDAZOLE-AMINO ACID DERIVATIVES AND RELATED COMPOUNDS[2008/14]
French:PROCÉDÉ DE SYNTHÈSE D IMIDAZOLE- DÉRIVÉS D ACIDES AMINÉS ET COMPOSÉS ASSOCIÉS[2008/14]
Entry into regional phase21.01.2008National basic fee paid 
21.01.2008Designation fee(s) paid 
21.01.2008Examination fee paid 
Examination procedure21.01.2008Examination requested  [2008/14]
26.08.2008Despatch of a communication from the examining division (Time limit: M06)
15.04.2009Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
24.06.2009Reply to a communication from the examining division
14.08.2009Communication of intention to grant the patent
21.12.2009Fee for grant paid
21.12.2009Fee for publishing/printing paid
Opposition(s)04.01.2011No opposition filed within time limit [2011/10]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
24.06.2009Request for further processing filed
24.06.2009Full payment received (date of receipt of payment)
Fees paidRenewal fee
21.01.2008Renewal fee patent year 03
21.01.2008Renewal fee patent year 04
16.06.2009Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT31.03.2010
BE31.03.2010
CY31.03.2010
CZ31.03.2010
DK31.03.2010
EE31.03.2010
FI31.03.2010
GR31.03.2010
IT31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
RO31.03.2010
SE31.03.2010
SI31.03.2010
SK31.03.2010
TR31.03.2010
BG30.06.2010
MC30.06.2010
ES12.07.2010
IS31.07.2010
PT02.08.2010
HU01.10.2010
[2014/38]
Former [2013/42]AT31.03.2010
BE31.03.2010
CY31.03.2010
CZ31.03.2010
DK31.03.2010
EE31.03.2010
FI31.03.2010
IT31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
RO31.03.2010
SE31.03.2010
SI31.03.2010
SK31.03.2010
TR31.03.2010
BG30.06.2010
MC30.06.2010
ES12.07.2010
IS31.07.2010
PT02.08.2010
HU01.10.2010
Former [2012/47]AT31.03.2010
BE31.03.2010
BG31.03.2010
CY31.03.2010
CZ31.03.2010
DK31.03.2010
EE31.03.2010
FI31.03.2010
IT31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
RO31.03.2010
SE31.03.2010
SI31.03.2010
SK31.03.2010
TR31.03.2010
MC30.06.2010
ES12.07.2010
IS31.07.2010
PT02.08.2010
HU01.10.2010
Former [2012/42]AT31.03.2010
BE31.03.2010
BG31.03.2010
CY31.03.2010
CZ31.03.2010
DK31.03.2010
EE31.03.2010
FI31.03.2010
IT31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
RO31.03.2010
SE31.03.2010
SI31.03.2010
SK31.03.2010
MC30.06.2010
ES12.07.2010
IS31.07.2010
PT02.08.2010
HU01.10.2010
Former [2012/41]AT31.03.2010
BE31.03.2010
BG31.03.2010
CY31.03.2010
CZ31.03.2010
DK31.03.2010
EE31.03.2010
FI31.03.2010
IT31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
RO31.03.2010
SE31.03.2010
SI31.03.2010
SK31.03.2010
MC30.06.2010
ES12.07.2010
IS31.07.2010
PT02.08.2010
Former [2011/16]AT31.03.2010
BE31.03.2010
CY31.03.2010
CZ31.03.2010
DK31.03.2010
EE31.03.2010
FI31.03.2010
IT31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
RO31.03.2010
SE31.03.2010
SI31.03.2010
SK31.03.2010
MC30.06.2010
ES12.07.2010
IS31.07.2010
PT02.08.2010
Former [2011/09]AT31.03.2010
BE31.03.2010
CY31.03.2010
CZ31.03.2010
DK31.03.2010
EE31.03.2010
FI31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
RO31.03.2010
SE31.03.2010
SI31.03.2010
SK31.03.2010
MC30.06.2010
ES12.07.2010
IS31.07.2010
PT02.08.2010
Former [2011/07]AT31.03.2010
BE31.03.2010
CY31.03.2010
CZ31.03.2010
DK31.03.2010
EE31.03.2010
FI31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
RO31.03.2010
SE31.03.2010
SI31.03.2010
SK31.03.2010
MC30.06.2010
ES12.07.2010
IS31.07.2010
Former [2011/01]AT31.03.2010
BE31.03.2010
CY31.03.2010
CZ31.03.2010
EE31.03.2010
FI31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
RO31.03.2010
SE31.03.2010
SI31.03.2010
SK31.03.2010
ES12.07.2010
IS31.07.2010
Former [2010/46]AT31.03.2010
FI31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
SI31.03.2010
ES12.07.2010
Former [2010/45]AT31.03.2010
FI31.03.2010
LT31.03.2010
NL31.03.2010
PL31.03.2010
SI31.03.2010
Former [2010/39]AT31.03.2010
FI31.03.2010
LT31.03.2010
PL31.03.2010
SI31.03.2010
Cited inInternational search[X]US5360811  (TEGELER JOHN J [US], et al) [X] 31 * compound 186 *;
 [XA]  - DONG ET AL, "Total Synthesis of Exochelin MN and Analogues", JOURNAL OF ORGANIC CHEMISTRY, (2002), vol. 67, no. 14, pages 4759 - 4770, XP002371209 [X] 29 * page 4761; compounds 24,25 * * page 4761, scheme 2 * [A] 1-28,30-56

DOI:   http://dx.doi.org/10.1021/jo0256078
 [X]  - OTSUKA ET AL, "Synthetic study towards man-designed bleomycins. Synthesis of a DNA cleaving molecule based on bleomycin", TETRAHEDRON LETTERS, (1986), vol. 27, no. 31, pages 3639 - 3642, XP002371210 [X] 29 * page 3640; 2-t-butoxycarbonyl proteceted compound II (intermediate) *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)84869-8
 [X]  - KITTAKA ET AL, "Transition-metal binding site of bleomycin. A remarkably efficient dioxygen-activating molecule based on bleomycin-Fe(II) complex", TETRAHEDRON LETTERS, (1986), vol. 27, no. 31, pages 3631 - 3634, XP002371211 [X] 29 * page 3632; compound 2 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)84867-4
 [X]  - HECHT ET AL, "Synthesis of L-erythro-beta-Hydroxyhistidine from D-Glucosamine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (1979), vol. 101, pages 3982 - 3983, XP002371212 [X] 29 * page 3982; compound 3 *

DOI:   http://dx.doi.org/10.1021/ja00508a055
 [X]  - KITTAKA ET AL, "Synthetic models for the transition metal binding site of bleomycin. Remarkable improvement of dioxygen activating capability", TETRAHEDRON, (1988), vol. 44, no. 10, pages 2811 - 2820, XP002371213 [X] 29 * page 2814; compounds 12,13 *

DOI:   http://dx.doi.org/10.1016/S0040-4020(88)90017-8
 [X]  - DONDONI ET AL, "Chelation- and Non-chelation-Controlled Addition of 2-(Trimethylsilyl)thiazole to .alpha.-Amino Aldehydes: Stereoselective Synthesis of the .beta.-Amino-.alpha.-hydroxy Aldehyde Intermediate for the Preparation of the Human Immunodeficiency Virus Proteinase Inhibitor Ro 31-8959", JOURNAL OF ORGANIC CHEMISTRY, (1995), vol. 60, no. 24, pages 8074 - 8080, XP002371214 [X] 31 * page 8075; compounds 15,18 *

DOI:   http://dx.doi.org/10.1021/jo00129a057
 [X]  - DONDONI ET AL, "Total Synthesis of (+)-Galactostatin. An Illustration of the Utility of the Thiazole-Aldehyde Synthesis", JOURNAL OF ORGANIC CHEMISTRY, (1995), vol. 60, no. 15, pages 4749 - 4754, XP002371215 [X] 31 * page 4752 *

DOI:   http://dx.doi.org/10.1021/jo00120a017
 [X]  - DONDONI ET AL, "2-Thiazolyl ?-Amino Ketones: A New Class of Reactive Intermediates for the Stereocontrolled Synthesis of Unusual Amino Acids", SYNTHESIS, (1993), vol. 11, pages 1162 - 1176, XP002371216 [X] 31 * page 1165; compounds 17A-B, 19A-B *

DOI:   http://dx.doi.org/10.1055/s-1993-26021
by applicantUS5360811
    - DONG, J. ORG. CHEM., (2002), vol. 67, pages 4759 - 4770
    - OTSUKA, TETRAHEDRON LETTERS, vol. 27, no. 31, pages 3639 - 3642
    - KITTAKA, TETRAHEDRON LETTERS, vol. 27, no. 31, pages 3631 - 3634
    - KITTAKA ET AL., TETRAHEDRON, vol. 11, no. 10, pages 2811 - 2820
    - DONDONI, J. ORG. CHEM., (1995), vol. 60, pages 4749 - 4754
    - DONDONI, SYNTHESIS, (1993), vol. 11, pages 1162 - 1176
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.