EP1827468 - Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease [Right-click to bookmark this link] | |||
Former [2007/36] | LEUPROLIDE ACETATE AND ACETYLCHOLINESTERASE INHIBITORS OR NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ||
[2012/14] | Status | No opposition filed within time limit Status updated on 28.06.2013 Database last updated on 24.08.2024 | Most recent event Tooltip | 17.07.2015 | Lapse of the patent in a contracting state New state(s): HU | published on 19.08.2015 [2015/34] | Applicant(s) | For all designated states Curaxis Pharmaceutical Corporation 1004 Chagford Way Raleigh, NC 27614 / US | [2012/24] |
Former [2010/08] | For all designated states Voyager Pharmaceutical Corporation 12600 Deerfield Parkway Suite 100 Alpharetta, GA 30004 / US | ||
Former [2007/36] | For all designated states Voyager Pharmaceutical Corporation 8540 Colonnade Center Drive, Suite 409 Raleigh, NC 27615 / US | Inventor(s) | 01 /
GREGORY, Christopher, W. 102 Avella Court Cary, NC 27519 / US | 02 /
SMITH, Patrick, S. 4800 Wynneford Way Raleigh, NC 27614 / US | [2007/36] | Representative(s) | Harris, Jennifer Lucy, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | [N/P] |
Former [2011/37] | Harris, Jennifer Lucy, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | ||
Former [2007/36] | Lee, Nicholas John, et al Kilburn & Strode 20 Red Lion Street London WC1R 4PJ / GB | Application number, filing date | 05771273.9 | 13.07.2005 | [2007/36] | WO2005US24656 | Priority number, date | US20040638123P | 23.12.2004 Original published format: US 638123 P | [2007/36] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2006071274 | Date: | 06.07.2006 | Language: | EN | [2006/27] | Type: | A2 Application without search report | No.: | EP1827468 | Date: | 05.09.2007 | Language: | EN | The application published by WIPO in one of the EPO official languages on 06.07.2006 takes the place of the publication of the European patent application. | [2007/36] | Type: | B1 Patent specification | No.: | EP1827468 | Date: | 22.08.2012 | Language: | EN | [2012/34] | Search report(s) | International search report - published on: | US | 11.01.2007 | (Supplementary) European search report - dispatched on: | EP | 06.07.2009 | Classification | IPC: | A61P25/28, A61K31/445, A61K31/55 | [2012/14] | CPC: |
A61K31/55 (EP,US);
A61K31/445 (EP,US);
A61K38/09 (EP,US);
A61K45/06 (EP,US);
A61P25/28 (EP);
A61P39/00 (EP);
| C-Set: |
A61K31/445, A61K2300/00 (US,EP);
A61K31/55, A61K2300/00 (US,EP);
A61K38/09, A61K2300/00 (EP,US)
|
Former IPC [2007/36] | A61K38/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2007/36] | Title | German: | Acetylcholinesterasehemmer und Leuprolidacetat zur Behandlung von Alzheimer-Krankheit | [2012/14] | English: | Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease | [2012/14] | French: | Inhibiteurs de l'acetylcholinesterase et acétate de leuprolide pour le traitement de la maladie d'Alzheimer | [2012/16] |
Former [2007/36] | LEUPROLIDACETAT UND ACETYLCHOLINESTERASE-HEMMER ODER NMDA-REZEPTORANTAGONISTEN ZUR BEHANDLUNG VON ALZHEIMER-KRANKHEIT | ||
Former [2007/36] | LEUPROLIDE ACETATE AND ACETYLCHOLINESTERASE INHIBITORS OR NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ||
Former [2007/36] | ACETATE DE LEUPROLIDE ET INHIBITEURS DE L'ACETYLCHOLINESTERASE OU ANTAGONISTES DES RECEPTEURS NMDA POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER | Entry into regional phase | 04.07.2007 | National basic fee paid | 04.07.2007 | Search fee paid | 04.07.2007 | Designation fee(s) paid | 04.07.2007 | Examination fee paid | Examination procedure | 18.07.2006 | Request for preliminary examination filed International Preliminary Examining Authority: US | 28.06.2007 | Amendment by applicant (claims and/or description) | 04.07.2007 | Examination requested [2007/36] | 03.09.2009 | Despatch of a communication from the examining division (Time limit: M06) | 15.03.2010 | Reply to a communication from the examining division | 02.08.2011 | Despatch of a communication from the examining division (Time limit: M04) | 01.11.2011 | Reply to a communication from the examining division | 20.01.2012 | Despatch of a communication from the examining division (Time limit: M02) | 31.01.2012 | Reply to a communication from the examining division | 28.03.2012 | Communication of intention to grant the patent | 26.06.2012 | Fee for grant paid | 26.06.2012 | Fee for publishing/printing paid | Divisional application(s) | EP11181112.1 / EP2425845 | EP11181114.7 / EP2425846 | EP11181115.4 Application deemed to be withdrawn : 14.09.2011 | EP11181117.0 Application deemed to be withdrawn : 14.10.2011 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 03.09.2009 | Opposition(s) | 23.05.2013 | No opposition filed within time limit [2013/31] | Fees paid | Renewal fee | 04.07.2007 | Renewal fee patent year 03 | 21.01.2009 | Renewal fee patent year 04 | 13.01.2010 | Renewal fee patent year 05 | 14.07.2010 | Renewal fee patent year 06 | 26.07.2011 | Renewal fee patent year 07 | 13.07.2012 | Renewal fee patent year 08 | Penalty fee | Additional fee for renewal fee | 31.07.2008 | 04   M06   Fee paid on   21.01.2009 | 31.07.2009 | 05   M06   Fee paid on   13.01.2010 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 13.07.2005 | AT | 22.08.2012 | BE | 22.08.2012 | CY | 22.08.2012 | CZ | 22.08.2012 | DK | 22.08.2012 | EE | 22.08.2012 | FI | 22.08.2012 | IT | 22.08.2012 | LT | 22.08.2012 | LV | 22.08.2012 | MC | 22.08.2012 | NL | 22.08.2012 | PL | 22.08.2012 | RO | 22.08.2012 | SE | 22.08.2012 | SI | 22.08.2012 | SK | 22.08.2012 | TR | 22.08.2012 | BG | 22.11.2012 | GR | 23.11.2012 | ES | 03.12.2012 | IS | 22.12.2012 | PT | 24.12.2012 | [2015/34] |
Former [2015/32] | AT | 22.08.2012 | |
BE | 22.08.2012 | ||
CY | 22.08.2012 | ||
CZ | 22.08.2012 | ||
DK | 22.08.2012 | ||
EE | 22.08.2012 | ||
FI | 22.08.2012 | ||
IT | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
MC | 22.08.2012 | ||
NL | 22.08.2012 | ||
PL | 22.08.2012 | ||
RO | 22.08.2012 | ||
SE | 22.08.2012 | ||
SI | 22.08.2012 | ||
SK | 22.08.2012 | ||
TR | 22.08.2012 | ||
BG | 22.11.2012 | ||
GR | 23.11.2012 | ||
ES | 03.12.2012 | ||
IS | 22.12.2012 | ||
PT | 24.12.2012 | ||
Former [2014/14] | AT | 22.08.2012 | |
BE | 22.08.2012 | ||
CY | 22.08.2012 | ||
CZ | 22.08.2012 | ||
DK | 22.08.2012 | ||
EE | 22.08.2012 | ||
FI | 22.08.2012 | ||
IT | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
MC | 22.08.2012 | ||
NL | 22.08.2012 | ||
PL | 22.08.2012 | ||
RO | 22.08.2012 | ||
SE | 22.08.2012 | ||
SI | 22.08.2012 | ||
SK | 22.08.2012 | ||
BG | 22.11.2012 | ||
GR | 23.11.2012 | ||
ES | 03.12.2012 | ||
IS | 22.12.2012 | ||
PT | 24.12.2012 | ||
Former [2013/34] | AT | 22.08.2012 | |
BE | 22.08.2012 | ||
CY | 22.08.2012 | ||
CZ | 22.08.2012 | ||
DK | 22.08.2012 | ||
EE | 22.08.2012 | ||
FI | 22.08.2012 | ||
IT | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
NL | 22.08.2012 | ||
PL | 22.08.2012 | ||
RO | 22.08.2012 | ||
SE | 22.08.2012 | ||
SI | 22.08.2012 | ||
SK | 22.08.2012 | ||
BG | 22.11.2012 | ||
GR | 23.11.2012 | ||
ES | 03.12.2012 | ||
IS | 22.12.2012 | ||
PT | 24.12.2012 | ||
Former [2013/23] | AT | 22.08.2012 | |
BE | 22.08.2012 | ||
CY | 22.08.2012 | ||
CZ | 22.08.2012 | ||
DK | 22.08.2012 | ||
EE | 22.08.2012 | ||
FI | 22.08.2012 | ||
IT | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
NL | 22.08.2012 | ||
PL | 22.08.2012 | ||
RO | 22.08.2012 | ||
SE | 22.08.2012 | ||
SI | 22.08.2012 | ||
SK | 22.08.2012 | ||
GR | 23.11.2012 | ||
ES | 03.12.2012 | ||
IS | 22.12.2012 | ||
PT | 24.12.2012 | ||
Former [2013/22] | AT | 22.08.2012 | |
BE | 22.08.2012 | ||
CY | 22.08.2012 | ||
CZ | 22.08.2012 | ||
DK | 22.08.2012 | ||
EE | 22.08.2012 | ||
FI | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
NL | 22.08.2012 | ||
SE | 22.08.2012 | ||
SI | 22.08.2012 | ||
GR | 23.11.2012 | ||
ES | 03.12.2012 | ||
IS | 22.12.2012 | ||
PT | 24.12.2012 | ||
Former [2013/21] | AT | 22.08.2012 | |
BE | 22.08.2012 | ||
CY | 22.08.2012 | ||
DK | 22.08.2012 | ||
FI | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
NL | 22.08.2012 | ||
SE | 22.08.2012 | ||
SI | 22.08.2012 | ||
GR | 23.11.2012 | ||
IS | 22.12.2012 | ||
PT | 24.12.2012 | ||
Former [2013/15] | AT | 22.08.2012 | |
BE | 22.08.2012 | ||
CY | 22.08.2012 | ||
FI | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
NL | 22.08.2012 | ||
SE | 22.08.2012 | ||
SI | 22.08.2012 | ||
GR | 23.11.2012 | ||
IS | 22.12.2012 | ||
PT | 24.12.2012 | ||
Former [2013/13] | AT | 22.08.2012 | |
BE | 22.08.2012 | ||
CY | 22.08.2012 | ||
FI | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
SE | 22.08.2012 | ||
SI | 22.08.2012 | ||
GR | 23.11.2012 | ||
IS | 22.12.2012 | ||
PT | 24.12.2012 | ||
Former [2013/12] | AT | 22.08.2012 | |
BE | 22.08.2012 | ||
CY | 22.08.2012 | ||
FI | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
SE | 22.08.2012 | ||
SI | 22.08.2012 | ||
GR | 23.11.2012 | ||
IS | 22.12.2012 | ||
Former [2013/11] | AT | 22.08.2012 | |
CY | 22.08.2012 | ||
FI | 22.08.2012 | ||
LT | 22.08.2012 | ||
LV | 22.08.2012 | ||
SI | 22.08.2012 | ||
GR | 23.11.2012 | ||
IS | 22.12.2012 | ||
Former [2013/10] | AT | 22.08.2012 | |
CY | 22.08.2012 | ||
FI | 22.08.2012 | ||
LT | 22.08.2012 | ||
IS | 22.12.2012 | ||
Former [2013/09] | AT | 22.08.2012 | |
FI | 22.08.2012 | ||
LT | 22.08.2012 | ||
Former [2013/08] | AT | 22.08.2012 | |
LT | 22.08.2012 | ||
Former [2013/07] | AT | 22.08.2012 | Documents cited: | Search | [X]GB2352716 (LILLY CO ELI [US]) [X] 8,9 * page 2, line 25 - page 3, line 5 * * page 20, lines 10-18 * * claims 2,8 *; | [DY]US6242421 (BOWEN RICHARD LLOYD [US]) [DY] 1-3,5-9 * column 4, lines 3-46 * * column 5, lines 5-19 * * column 7, lines 4-35 * * column 8, lines 15-50; claims 1-12 *; | [A]US2002177556 (ENGEL JURGEN [DE], et al) [A] * the whole document *; | [X]US6610706 (BUSH JULIE KAY [US], et al) [X] 8,9 * col 1 last 2 lines to col 2 line 12 col 10 lines 46-54 *; | [Y] - PRASHER V. P., "Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability population", INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, (200406), vol. 19, no. 6, ISSN 0885-6230, pages 509 - 515, XP002532933 [Y] 1-3,5-9 * pages 510-511 * DOI: http://dx.doi.org/10.1002/gps.1077 | [Y] - HOLMES C. ET AL., "The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease", NEUROLOGY, (20040727), vol. 63, no. 2, ISSN 0028-3878, pages 214 - 219, XP002532378 [Y] 1-3,5-9 * the whole document * | [DY] - GIACOBINI E., "Cholinesterase inhibitors stabilize Alzheimer disease.", NEUROCHEMICAL RESEARCH OCT 2000, (200010), vol. 25, no. 9-10, ISSN 0364-3190, pages 1185 - 1190, XP002532379 [DY] 1-3,5-9 * the whole document * DOI: http://dx.doi.org/10.1023/A:1007679709322 | [Y] - TARIOT P.N. ET AL., "Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial.", JAMA (JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION), (20040121), vol. 291, no. 3, ISSN 0098-7484, pages 317 - 324, XP009075923 [Y] 1-3,5-9 * the whole document * DOI: http://dx.doi.org/10.1001/jama.291.3.317 | International search | [Y]US6242421 (BOWEN RICHARD LLOYD [US]); | [Y] - Japan parma stock market week to May 21, Market letter, Marketletter Publications Ltd. 28 May 2002, pg. 1 | [Y] - RACCHI M. ET AL., "Acetylcholinesterase Inhibitors: Novel Activities of Old Molecules", PHARMACOLOGICAL RESEARCH, (20050518), vol. 50, pages 441 - 451, XP002998429 DOI: http://dx.doi.org/10.1016/j.phrs.2003.12.027 | [Y] - STRAETEMANS R., "Design and Analysis of Drug Combination Experiments", BIOMETRICAL JOURNAL, (2005), vol. 47, no. 3, pages 299 - 308, XP008076858 DOI: http://dx.doi.org/10.1002/bimj.200410124 | Examination | - FELDMAN HOWARD H ET AL, "Cognition, function, and caregiving time patterns in patients with mild-to-moderate Alzheimer disease: a 12-month analysis.", ALZHEIMER DISEASE AND ASSOCIATED DISORDERS 2005 JAN-MAR LNKD- PUBMED:15764869, (200501), vol. 19, no. 1, ISSN 0893-0341, pages 29 - 36 | - STERN R G ET AL, "A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration.", THE AMERICAN JOURNAL OF PSYCHIATRY MAR 1994 LNKD- PUBMED:8109647, (199403), vol. 151, no. 3, ISSN 0002-953X, pages 390 - 396 |