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Extract from the Register of European Patents

EP About this file: EP1802302

EP1802302 - NOVEL USE OF alpha-SYMPATHOMIMETICS HAVING A 2-IMIDAZOLINE STRUCTURE [Right-click to bookmark this link]
Former [2007/27]NOVEL USE OF a-SYMPATHOMIMETICS HAVING A 2-IMIDAZOLINE STRUCTURE
[2016/15]
StatusThe patent has been granted
Status updated on  23.09.2016
Database last updated on 19.07.2024
Most recent event   Tooltip14.04.2024New entry: Despatch of examination report in opposition + time limit 
Applicant(s)For all designated states
The Procter & Gamble Company
One Procter & Gamble Plaza
Cincinnati, OH 45202 / US
[2019/27]
Former [2007/27]For all designated states
Merck Patent GmbH
Frankfurter Strasse 250
64293 Darmstadt / DE
Inventor(s)01 / SACHER, Fritz
Kaiser-Karl-Strasse 27
55435 Gau-Algesheim / DE
02 / TSCHAIKIN, Marion
Pfungstaedter Strasse 11
64297 Darmstadt / DE
03 / KOELSCH, Stephan
Dirolfstrasse 14
67549 Worms / DE
 [2007/27]
Representative(s)Elkington and Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
[N/P]
Application number, filing date05784163.716.09.2005
[2007/27]
WO2005EP10026
Priority number, dateDE2004104900805.10.2004         Original published format: DE102004049008
[2007/27]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report
No.:WO2006037452
Date:13.04.2006
Language:DE
[2006/15]
Type: A1 Application with search report 
No.:EP1802302
Date:04.07.2007
Language:DE
The application published by WIPO in one of the EPO official languages on 13.04.2006 takes the place of the publication of the European patent application.
[2007/27]
Type: B1 Patent specification 
No.:EP1802302
Date:26.10.2016
Language:DE
[2016/43]
Search report(s)International search report - published on:EP13.04.2006
ClassificationIPC:A61K31/4174, A61P31/16
[2016/14]
CPC:
A61K31/4174 (EP,KR,US); A61P31/12 (EP); A61P31/16 (EP)
Former IPC [2007/27]A61K31/4174, A61P31/12
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/43]
Former [2007/27]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:NEUE VERWENDUNG FÜR alpha-SYMPATHOMIMETIKA MIT 2-IMIDAZOLINSTRUKTUR[2016/15]
English:NOVEL USE OF alpha-SYMPATHOMIMETICS HAVING A 2-IMIDAZOLINE STRUCTURE[2016/15]
French:NOUVELLE UTILISATION D'(alpha)-SYMPATHOMIMETIQUES PRESENTANT UNE STRUCTURE 2-IMIDAZOLINE[2016/15]
Former [2007/27]NEUE VERWENDUNG FÜR a-SYMPATHOMIMETIKA MIT 2-IMIDAZOLINSTRUKTUR
Former [2007/27]NOVEL USE OF a-SYMPATHOMIMETICS HAVING A 2-IMIDAZOLINE STRUCTURE
Former [2007/27]NOUVELLE UTILISATION D'(a)-SYMPATHOMIMETIQUES PRESENTANT UNE STRUCTURE 2-IMIDAZOLINE
Entry into regional phase13.02.2007National basic fee paid 
13.02.2007Designation fee(s) paid 
13.02.2007Examination fee paid 
Examination procedure13.02.2007Examination requested  [2007/27]
18.01.2011Despatch of a communication from the examining division (Time limit: M04)
20.05.2011Reply to a communication from the examining division
19.02.2013Despatch of a communication from the examining division (Time limit: M06)
16.07.2013Reply to a communication from the examining division
02.06.2015Despatch of a communication from the examining division (Time limit: M02)
20.07.2015Reply to a communication from the examining division
06.04.2016Communication of intention to grant the patent
13.07.2016Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
13.07.2016Fee for grant paid
13.07.2016Fee for publishing/printing paid
20.09.2016Information about intention to grant a patent
20.09.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.01.2011
Opposition(s)Opponent(s)01  26.07.2017  01.08.2017  ADMISSIBLE
Maria Clementine Martin Klosterfrau Vertriebsgesellschaft mbH
50670 Köln / DE
Opponent's representative
Von Rohr Patentanwälte Partnerschaft mbB
Rüttenscheider Straße 62
45130 Essen / DE
 [N/P]
Former [2017/36]
Opponent(s)01  26.07.2017  01.08.2017  ADMISSIBLE
Maria Clementine Martin Klosterfrau Vertriebsgesellschaft mbH
50670 Köln / DE
Opponent's representative
Von Rohr Patentanwälte Partnerschaft mbB
Rüttenscheider Straße 62
45130 Essen / DE
01.09.2017Invitation to proprietor to file observations on the notice of opposition
08.03.2018Reply of patent proprietor to notice(s) of opposition
10.01.2019Date of oral proceedings
27.02.2019Despatch of interlocutory decision in opposition
27.02.2019Despatch of minutes of oral proceedings
15.04.2024Despatch of a communication from the opposition division (Time limit: M04)
Appeal following opposition16.04.2019Appeal received No.  T0687/19
08.07.2019Statement of grounds filed
11.12.2023Result of appeal procedure: maintenance in amended form
31.01.2024Despatch of the decision of the Board of Appeal
05.03.2019Appeal received No.  T0687/19
03.07.2019Statement of grounds filed
11.12.2023Result of appeal procedure: maintenance in amended form
31.01.2024Despatch of the decision of the Board of Appeal
11.12.2023Date of oral proceedings
Fees paidRenewal fee
12.09.2007Renewal fee patent year 03
31.03.2008Renewal fee patent year 04
11.09.2009Renewal fee patent year 05
14.09.2010Renewal fee patent year 06
29.09.2011Renewal fee patent year 07
12.09.2012Renewal fee patent year 08
12.09.2013Renewal fee patent year 09
12.09.2014Renewal fee patent year 10
11.09.2015Renewal fee patent year 11
13.09.2016Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipMC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
IE16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SK16.09.2019
TR16.09.2019
SE17.09.2019
SI17.09.2019
DK30.09.2019
EE30.09.2019
IS01.10.2019
NL01.10.2019
GR16.04.2020
PT22.04.2020
CZ16.09.2020
IT16.09.2020
ES17.09.2020
HU17.09.2020
[2022/30]
Former [2022/23]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
IE16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SK16.09.2019
SE17.09.2019
SI17.09.2019
DK30.09.2019
EE30.09.2019
IS01.10.2019
NL01.10.2019
GR16.04.2020
PT22.04.2020
CZ16.09.2020
IT16.09.2020
ES17.09.2020
HU17.09.2020
Former [2021/48]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
IE16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SK16.09.2019
SE17.09.2019
SI17.09.2019
DK30.09.2019
EE30.09.2019
IS01.10.2019
NL01.10.2019
GR16.04.2020
PT22.04.2020
CZ16.09.2020
IT16.09.2020
HU17.09.2020
Former [2021/38]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
IE16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SK16.09.2019
SE17.09.2019
SI17.09.2019
DK30.09.2019
EE30.09.2019
IS01.10.2019
NL01.10.2019
GR16.04.2020
PT22.04.2020
CZ16.09.2020
HU17.09.2020
Former [2021/31]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
IE16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SK16.09.2019
SE17.09.2019
SI17.09.2019
DK30.09.2019
EE30.09.2019
IS01.10.2019
NL01.10.2019
GR16.04.2020
PT22.04.2020
CZ16.09.2020
Former [2021/22]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
IE16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SK16.09.2019
SE17.09.2019
SI17.09.2019
DK30.09.2019
EE30.09.2019
NL01.10.2019
GR16.04.2020
PT22.04.2020
CZ16.09.2020
Former [2020/47]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
IE16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SK16.09.2019
SE17.09.2019
SI17.09.2019
DK30.09.2019
EE30.09.2019
NL01.10.2019
GR16.04.2020
PT22.04.2020
Former [2020/37]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
IE16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SK16.09.2019
SE17.09.2019
SI17.09.2019
EE30.09.2019
NL01.10.2019
GR16.04.2020
PT22.04.2020
Former [2020/36]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
IE16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SE17.09.2019
EE30.09.2019
NL01.10.2019
GR16.04.2020
PT22.04.2020
Former [2020/35]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
LT16.09.2019
LU16.09.2019
LV16.09.2019
RO16.09.2019
SE17.09.2019
NL01.10.2019
Former [2020/33]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
LV16.09.2019
RO16.09.2019
SE17.09.2019
NL01.10.2019
Former [2020/24]MC26.10.2016
BG26.01.2017
CY16.09.2019
FI16.09.2019
LV16.09.2019
RO16.09.2019
SE17.09.2019
Former [2020/23]MC26.10.2016
BG26.01.2017
FI16.09.2019
LV16.09.2019
RO16.09.2019
SE17.09.2019
Former [2018/30]MC26.10.2016
BG26.01.2017
Former [2017/46]BG26.01.2017
Cited inInternational search[X]JPH06211659  ;
 [X]WO9625163  (GEBHARDT BRYAN M [US]) [X] 1-10 * page 7, lines 4-24; claims 1,4,14 *;
 [X]WO9915203  (ASTA MEDICA AG [DE]) [X] 1-10 * Seite 1, "Technical field" *;
 [X]US6423724  (CUPPS THOMAS LEE [US], et al) [X] 1-10 * column 1, lines 10-15 * * column 2, lines 15-31 *;
 [X]WO03024433  (NYCOMED DANMARK AS [DK], et al) [X] 1-10 * page 1, lines 32-34 * * page 4, lines 25-27 *;
 [X]  - DATABASE WPI, 0, Derwent World Patents Index, vol. 1994, no. 35, Database accession no. 1994-283256, XP002354491 & JPH06211659 A 19940802 (KOWA CO LTD) [X] 1-10 * abstract *
 [PX]  - SACHER F ET AL, "The mechanism of the antiviral action of oxymetazoline", DEUTSCHE APOTHEKER ZEITUNG 03 FEB 2005 GERMANY, (20050203), vol. 145, no. 5, ISSN 0011-9857, pages 111 - 112, XP001207744 [PX] 1-10 * the whole document *
Examination   - INGRID U SCOTT, "Viral Conjunctivitis", (20130128), pages 1 - 1, XP055052046
OppositionWO9309764
 JPH06211659
 DE4438589
 WO9625163
 DE19541919
 JPH09507219
 WO9915203
 JP2001517639
 US2002037297
 US6423724
 WO03024433
 JP2004509920
 WO2004039350
 US2004248924
 US2008108685
    - DATABASE WPI, 1, Derwent World Patents Index, vol. 1994, no. 35, Database accession no. 1994-283256, XP055413441
    - SACHER F et al., "The mechanism of the antiviral action of oxymetazoline", DEUTSCHE APOTHEKER ZEITUNG, GERMANY, (20050203), vol. 145, no. 5, ISSN 0011-9857, pages 111 - 112, XP001207744
    - INGRID U SCOTT, "Viral Conjunctivitis", Medscape, (20130128), pages 1 - 2, XP055052046
    - Anonymous, "Rhinitis", Wikipedia, the free encyclopedia, URL: https://de.wikipedia.org/wiki/Rhinitis, XP055413451
    - "Influenza", Wikipedia, URL: https://de.wikipedia.org/wiki/Influenza, XP055413457
    - "Parainfluenza", Wikipedia, URL: https://de.wikipedia.org/wiki/Parainfluenza, XP055413459
    - "Akute Mittelohrentzündung", Wikipedia, URL: https://de.wikipedia.org/wiki/Akute_Mittelohrentzündung
    - "Otitis media acuta", DocCheck Flexikon, URL: http://flexikon.doccheck.com/de/Otitis_media_acuta, XP055413469
    - "Xylometazolin", Wikipedia, URL: https://de.wikipedia.org/wiki/Xylometazolin, XP055413473
    - "Oxymetazolin", Wikipedia, URL: https://de.wikipedia.org/wiki/Xylometazolin, XP055413473
    - Helmut Hilderbrandt et al, Pschyrembel Medizinisches Wörterbuch, Hamburg, (19930000), pages 1331 - 1333, ISBN 978-3-933203-04-5, XP055413476
    - Dr. Norbert Boss Et Al, Roche Lexikon Medizin, München, Wien, Baltimore, (19930000), pages 1430 - 1431, ISBN 3541112131, XP055413478
    - Thomas Lenarz et al, Hals-Nasen-Ohrenheilkunde für Medizinstudenten, Boenninghaus, (19930000), pages 210-213, 220 - 221, ISBN 978-3-540-56122-4, XP055413494
    - "Chapter 11", Friedrich-Carl Sitzmann, Pädiatrie, pages 341 - 342, XP055413498
    - "Leitsymptome und Krankheitsbilder", PATRICK NAGEL et al., Hals-Nasen-Ohren-Heilkunde, München, (20090000), page 38 ff., ISBN 9783437421778, XP055413500
    - "Virusinfektionen", PROF. DR. K. WIEMANN, MSD-Manual der Diagnostik und Therapie, München, Wien, Baltimore, (19930000), pages 1497 - 1498, ISBN 3541018550, XP055413504
    - S. KOELSCH et al., "Anti-Rhinovirus-specific Activity of the Alpha- sympathomimetic Oxymetazoline", Arzneimittelforschung (drug research, (20070000), vol. 57, no. 7, pages 475 - 482, XP001537348
    - Swiss Pharmaceutical Society, Index Nominum, International Drug Directory, Stuttgart, (19950000), page 912, 1316, ISBN 978-3-88763-035-5, XP055413515
    - J.B. ENGLE, "Topical Nasal Decongestants", American Pharmacy, (19920500), vol. 32, no. 5, pages 33 - 37, XP055413572

DOI:   http://dx.doi.org/10.1016/S0160-3450(15)31120-X
    - DR. RER. NAT. DR. MED. ERNST MUTSCHLER, Arzneimittelwirkungen - Lehrbuch der Pharmakologie und Toxikologie, Stuttgart, (19860000), pages 262 - 265, XP055413575
    - "2.B.1.3. Sympatho- mimetika", Bundesverband der Pharmazeutischen Industrie e.V., Rote Liste, (19860000), XP055413581
    - "71 033 Balkis® '' sowie ''71 037 Nasivin®", Bundesverband Der Pharmazeutischen Industrie E.V., Rote Liste, (19950000), pages 71 033 - 71 090, XP055413589
    - "71 045 Otriven®", Rote Liste, (19870000), pages 71044 - 71049, XP055413597
    - "71 086 Wick® Schnupfenspray", Rote Liste, (19830000), pages 71075 - 71094, XP055413600
    - GUSTAV ERHART et al., Arzneimittel: Entwicklung, Wirkung, Darstellung, Weinheim, (19720000), vol. 2, pages 150 - 151, XP055413610
    - R. WISEMAN, "Is it really a cold?", The Journal of Modern Pharmacy, (20030600), vol. 10, no. 6, pages 12 - 16, XP055413625
    - C.A. MARANTA et al., "Abschwellende Nasensprays-Ergebnisse einer rhinomanometrisch objektivierten, doppeltblind durchgeführten Studie", Schweiz Med Wochenschr, (19960000), vol. 126, no. 44, pages 1875 - 1881, XP055413628
    - A. YUTA et al., "Rhinovirus infection induces mucus hypersecretion", Rhinovirus and Mucus, (19980000), pages L1017 - L1023, XP055413632

DOI:   http://dx.doi.org/10.1152/ajplung.1998.274.6.L1017
    - K.-E. ANDERSSON et al., "Adrenoceptors in the control of human nasal mucosal blood flow", Ann. Otol. Rhinol. Laryngol., (19840000), vol. 93, pages 179 - 182, XP055413634
    - "Decongestant, Cough, and Cold Preparations", American Medical Association, AMA Drug Evaluations, (19830000), pages 549 - 576, ISBN 9780899701608, XP055413639
    - H. BREUNINGER, "Diagnose, Differentialdiagnose und Therapie der Nasenschleimhautentzündung", tägl. prax., (19760000), vol. 17, pages 305 - 310, XP002096520
    - Hans Heinz Naumann et al, "Nase, Nasennebenhöhlen, Gesicht, Mundhöhle und Pharynx, Kopfspeicheldrüsen", Oto-Rhino-Laryngologie in Klinik und Praxis, Stuttgart, (19920000), vol. 2, pages 411 - 413, XP055413646
    - "Experimentelle Untersuchungen zum Effekt einiger schleimhautabschwellender Nasentropfen", J. KNOTHE et al., Hals-Nasen-Ohren-Erkrankungen, (19690000), pages 2384 - 2388, XP055413655
    - Anonym, "Monographie zu Oxymetazolin Bundesanzeiger Nr.139", (19940726), pages VIm509 - VIm513, XP055418927
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.