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EP About this file: EP1768704

EP1768704 - IMAGING INFECTION WITH COMPOUNDS THAT BIND TO THYMIDINE KINASE [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 08.03.2013 Database last updated on 02.11.2024
Most recent event Tooltip	18.07.2014	Lapse of the patent in a contracting state New state(s): HU	published on 20.08.2014 [2014/34]
Applicant(s)	For all designated states The Johns Hopkins University 3400 North Charles Street Baltimore, MD 21218 / US
	[2012/03]
Former [2011/51]	For all designated states The John Hopkins University 3400 N. Charles Street Baltimore, MD 21218 / US
Former [2007/14]	For all designated states THE JOHNS HOPKINS UNIVERSITY 3400 North Charles Street Baltimore, MD 21218 / US
Inventor(s)	01 / POMPER, Martin, G. 101 Churchwarden's Road Baltimore, MD 21212 / US
	02 / BETTEGOWDA, Chetan 10916 Robinson Rock Court Charlotte, NC 28227 / US
	03 / FOSS, Catherine 5929-C Western Run Drive Baltimore, MD 21209 / US
	04 / ZHOU, Shibin room 589 Cancer Research Bldg 1650 Orleans Street Baltimore, MD 21231 / US
	05 / KINZLER, Kenneth room 589 Cancer Research Bldg 1650 Orleans Street Baltimore, MD 21231 / US
	06 / VOGELSTEIN, Bert room 589 Cancer Research Bldg 1650 Orleans Street Baltimore, MD 21231 / US
	[2012/18]
Former [2007/14]	01 / POMPER, Martin, G. 101 Churchwarden's Road Baltimore, MD 21212 / US
	02 / BETTEGOWDA, Chetan 10916 Robinson Rock Court Charlotte, NC 28227 / US
	03 / FOSS, Catherine 5929-C Western Run Drive Baltimore, MD 21209 / US
	04 / ZHOU, Shibin room 589 Cancer Research Bldg 1650 Orleans Street Baltimore, MD 21231 / US
	05 / KINZLER, Kenneth room 589 Cancer Research Bldg 1650 Orleans Street Baltimore, MD 21231 / US
	06 / VOGELSTEIN, Bert room 589 Cancer Research Bldg 1650 Orleans Street Baltimore, MD 21231 / US
Representative(s)	Hiebl, Inge Elisabeth, et al Kraus & Weisert Patentanwälte PartGmbB Thomas-Wimmer-Ring 15 80539 München / DE
	[N/P]
Former [2011/51]	Hiebl, Inge Elisabeth, et al Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15 80539 München / DE
Former [2007/14]	Adam, Holger Kraus & Weisert, Patent- und Rechtsanwälte, Thomas-Wimmer-Ring 15 80539 München / DE
Application number, filing date	05788432.2	20.06.2005
	[2007/14]
	WO2005US21888
Priority number, date	US20040581222P	18.06.2004 Original published format: US 581222 P
	[2007/14]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2006002142
	Date:	05.01.2006
	Language:	EN
	[2006/01]
	Type:	A2 Application without search report
	No.:	EP1768704
	Date:	04.04.2007
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 05.01.2006 takes the place of the publication of the European patent application.
	[2007/14]
	Type:	B1 Patent specification
	No.:	EP1768704
	Date:	02.05.2012
	Language:	EN
	[2012/18]
	Type:	B9 Corrected patent specification
	No.:	EP1768704
	Date:	02.01.2013
	[2013/01]
Search report(s)	International search report - published on:	EP	04.05.2006
Classification	IPC:	A61K49/00	[2007/14]
	CPC:	A61K51/1241 (EP,US); A61K51/0491 (EP,US); A61K51/1231 (EP,US)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR [2007/14]
Title	German:	BILDGEBUNG VON INFEKTIONEN MIT AN THYMIDINKINASE BINDENDEN VERBINDUNGEN	[2007/14]
	English:	IMAGING INFECTION WITH COMPOUNDS THAT BIND TO THYMIDINE KINASE	[2007/14]
	French:	VISUALISATION D'UNE INFECTION AVEC DES COMPOSES SE LIANT A LA THYMIDINE KINASE	[2007/14]
Entry into regional phase	05.01.2007	National basic fee paid
	05.01.2007	Designation fee(s) paid
	05.01.2007	Examination fee paid
Examination procedure	05.01.2007	Examination requested [2007/14]
	26.02.2007	Amendment by applicant (claims and/or description)
	03.09.2007	Despatch of a communication from the examining division (Time limit: M06)
	12.03.2008	Reply to a communication from the examining division
	10.03.2011	Despatch of a communication from the examining division (Time limit: M02)
	10.05.2011	Reply to a communication from the examining division
	19.10.2011	Cancellation of oral proceeding that was planned for 19.10.2011
	19.10.2011	Date of oral proceedings (cancelled)
	25.11.2011	Communication of intention to grant the patent
	20.03.2012	Fee for grant paid
	20.03.2012	Fee for publishing/printing paid
Divisional application(s)	EP10012858.6 / EP2283871
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 03.09.2007
Opposition(s)	05.02.2013	No opposition filed within time limit [2013/15]
Fees paid	Renewal fee
	27.06.2007	Renewal fee patent year 03
	25.06.2008	Renewal fee patent year 04
	26.06.2009	Renewal fee patent year 05
	25.06.2010	Renewal fee patent year 06
	25.08.2011	Renewal fee patent year 07
	Penalty fee
	Additional fee for renewal fee
	30.06.2011	07 M06 Fee paid on 25.08.2011
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	20.06.2005
	AT	02.05.2012
	BE	02.05.2012
	CY	02.05.2012
	CZ	02.05.2012
	EE	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	RO	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	SK	02.05.2012
	IE	20.06.2012
	LU	20.06.2012
	CH	30.06.2012
	LI	30.06.2012
	MC	30.06.2012
	BG	02.08.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
	[2014/34]
Former [2014/27]	AT	02.05.2012
	BE	02.05.2012
	CY	02.05.2012
	CZ	02.05.2012
	EE	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	RO	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	SK	02.05.2012
	IE	20.06.2012
	LU	20.06.2012
	CH	30.06.2012
	LI	30.06.2012
	MC	30.06.2012
	BG	02.08.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
Former [2013/34]	AT	02.05.2012
	BE	02.05.2012
	CY	02.05.2012
	CZ	02.05.2012
	EE	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	RO	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	SK	02.05.2012
	IE	20.06.2012
	CH	30.06.2012
	LI	30.06.2012
	MC	30.06.2012
	BG	02.08.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
Former [2013/20]	AT	02.05.2012
	BE	02.05.2012
	CY	02.05.2012
	CZ	02.05.2012
	EE	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	RO	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	SK	02.05.2012
	IE	20.06.2012
	CH	30.06.2012
	LI	30.06.2012
	MC	30.06.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
Former [2013/10]	AT	02.05.2012
	BE	02.05.2012
	CY	02.05.2012
	CZ	02.05.2012
	EE	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	RO	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	SK	02.05.2012
	MC	30.06.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
Former [2013/09]	AT	02.05.2012
	BE	02.05.2012
	CY	02.05.2012
	EE	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	MC	30.06.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
Former [2013/08]	AT	02.05.2012
	BE	02.05.2012
	CY	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	MC	30.06.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
Former [2013/07]	AT	02.05.2012
	BE	02.05.2012
	CY	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
Former [2013/04]	BE	02.05.2012
	CY	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
Former [2013/01]	CY	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	GR	03.08.2012
	IS	02.09.2012
	PT	03.09.2012
Former [2012/51]	CY	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	SE	02.05.2012
	SI	02.05.2012
	GR	03.08.2012
	IS	02.09.2012
Former [2012/50]	CY	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	SE	02.05.2012
	GR	03.08.2012
	IS	02.09.2012
Former [2012/49]	CY	02.05.2012
	FI	02.05.2012
	LT	02.05.2012
	PL	02.05.2012
	SE	02.05.2012
	IS	02.09.2012
Former [2012/48]	FI	02.05.2012
	LT	02.05.2012
	SE	02.05.2012
Former [2012/47]	LT	02.05.2012
Cited in	International search	[DX]US5879661 (CONTI PETER S [US], et al) [DX] 1,2,21,22 * abstract *;
		[A]US5969139 (MARTIN JOSEPH ARMSTRONG [GB], et al) [A] 1-40 * the whole document *;
		[DX]US6331287 (CONTI PETER S [US], et al) [DX] 1,2,21,22 * abstract *;
		[X]US2002128553 (MISHANI EYAL [IL], et al) [X] 1,2,21,22 * abstract *;
		[PX] - BETTEGOWDA C. ET AL., "Imaging bacterial infections with radiolabelled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil", PNAS, (20050125), vol. 102, no. 4, pages 1145 - 1150, XP002356266 [PX] 1-40 * the whole document * * Electronic Publication: 14-01-2005 * DOI: http://dx.doi.org/10.1073/pnas.0408861102
		[A] - DENG, W-P. ET AL., "Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 kthymidine kinase and ganciclovir", EUR. J. NUCL. MED. MOL. IMAGING, (200401), vol. 31, no. 1, pages 99 - 109, XP002356281 [A] 1-40 * the whole document * * Electronic publication: 25-09-2003 * DOI: http://dx.doi.org/10.1007/s00259-003-1269-z
		[A] - GOLANKIEWICZ B ET AL, "FLUORESCENT TRICYCLIC ANALOGUES OF ACYCLOVIR AND GANCICLOVIR. A STRUCTURE-ANTIVIRAL ACTIVITY STUDY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (2001), vol. 44, ISSN 0022-2623, pages 4284 - 4287, XP001119790 [A] 1-40 * the whole document * DOI: http://dx.doi.org/10.1021/jm010922s
		[A] - GOSLINSKI T ET AL., "Synthesis and biological activity of strongly fluoroescent tricyclic analogues of acyclovir and ganciclovir", J. MED. CHEM., (2002), vol. 45, no. 1, pages 5052 - 5057, XP002356282 [A] 1-40 * the whole document * DOI: http://dx.doi.org/10.1021/jm020827z
	Examination	- CHAKRABARTY A.M., Microorganisms and cancer: quest for a therapy., JOURNAL OF BACTERIOLOGY MAY 2003 LNKD- PUBMED:12700245, VOL. 185, NR. 9, PAGE(S) 2683 - 2686, (200305), ISSN 0021-9193
		- JAIN R.K. ET AL, Can engineered bacteria help control cancer?, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 18 DEC 2001 LNKD- PUBMED:11752416, VOL. 98, NR. 26, PAGE(S) 14748 - 14750, (20011218), ISSN 0027-8424
		- SAITO Y. ET AL, Diagnostic imaging of herpes simplex virus encephalitis using a radiolabeled antiviral drug: autoradiographic assessment in an animal model., ANNALS OF NEUROLOGY JUN 1984 LNKD- PUBMED:6742789, VOL. 15, NR. 6, PAGE(S) 548 - 558, (198406), ISSN 0364-5134
	by applicant	US5879661
		US6331287
		US2002128553
		- DENG W.-P. ET AL., "Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 k thymidine kinase and ganciclovir", EUR. J. NUCL. MED. MOL. IMAGING, (200401), vol. 31, no. 1, pages 99 - 109
		- "Fluorescent Tricyclic Analogues of Acyclovir and Ganciclovir. A Structure-Antiviral Activity Study", GOLANKIEWICZ B. ET AL., Journal of Medicinal Chemistry, AMERICAN CHEMICAL SOCIETY, (2001), vol. 44, pages 4284 - 4287
		- GOSLINSKI T. ET AL., "Synthesis and Biological Activity of Strongly Fluorescent Tricyclic Analogues of Acyclovir and Ganciclovir", J. MED. CHEM., (2002), vol. 45, no. 1, pages 5052 - 5057
		- SAITO Y. ET AL., "Diagnostic Imaging of Herpes Simplex Virus Encephalitis Using a Radiolabelled Antiviral Drug: Autoradiographic Assessment in an Animal Model", ANN. NEUROL., (1984), vol. 15, pages 548 - 558
		- BETTEGOWDA ET AL., PNAS, (2005), vol. 102, no. 1, pages 145 - 50
		- Remington's Pharmaceutical Sciences, MACK PUBLISHING COMPANY

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