EP1778629 - PROCESS FOR THE SYNTHESIS C-2, C-3 SUBSTITUTED N-ALKYLATED INDOLES USEFUL AS CPLA2 INHIBITORS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 25.05.2012 Database last updated on 12.07.2024 | Most recent event Tooltip | 04.10.2013 | Lapse of the patent in a contracting state New state(s): HU | published on 06.11.2013 [2013/45] | Applicant(s) | For all designated states Wyeth LLC Five Giralda Farms Madison, NJ 07940 / US | [2010/16] |
Former [2007/18] | For all designated states Wyeth Five Giralda Farms Madison, New Jersey 07940 / US | Inventor(s) | 01 /
MICHALAK, Ronald, S. 28 Corners Road Congers, NY 10920 / US | 02 /
LEVENT, Mahmut 27 Donald Street, Apt. D Bloomfield, NJ 07003 / US | 03 /
VYVERBERG, Frederick, J. 101 Knollcrest Lane Chester, NY 10918 / US | 04 /
BOYAJIAN, Ara, R. 308 Alpine Circle River Vale, NJ 07675 / US | 05 /
RAVEENDRANATH, Panolil 2 Whitman Place Monroe, NY 10950 / US | 06 /
CANTIN, Michel 1891 boulevard Alexis-Nihon, Saint-Laurent Québec H4R 3A7 / CA | 07 /
STOCKTON, Alan 50 rue de la Barre, 704 Longueuil Québec J4K 5G2 / CA | 08 /
WINKLEY, Michael, W. 1 Arbor Road Campbell Hall, NY 10916 / US | 09 /
GHOSH, Mousumi 45 Parkview Avenue Elmwood Park, NJ 07407 / US | 10 /
DEHNHARDT, Christoph 423 East 83rd Street, Apt. 4E New York, NY 10028 / US | 11 /
GUINOSSO, Charles One Pamela Drive Chestnut Ridge, NY 10977 / US | [2007/18] | Representative(s) | Motion, Keith Robert, et al Pfizer ATTENTION: ADDRESS INACTIVE - USE ASS-NR - CDR / FR | [N/P] |
Former [2010/16] | Motion, Keith Robert, et al Pfizer Limited European Patent Department Ramsgate Road Sandwich, Kent CT13 9NJ / GB | ||
Former [2007/18] | Wileman, David Francis, et al Wyeth Pharmaceuticals, Huntercombe Lane South, Taplow Maidenhead Berkshire SL6 OPH / GB | Application number, filing date | 05788529.5 | 18.08.2005 | [2007/18] | WO2005US29338 | Priority number, date | US20040603124P | 19.08.2004 Original published format: US 603124 P | [2007/18] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2006023611 | Date: | 02.03.2006 | Language: | EN | [2006/09] | Type: | A1 Application with search report | No.: | EP1778629 | Date: | 02.05.2007 | Language: | EN | The application published by WIPO in one of the EPO official languages on 02.03.2006 takes the place of the publication of the European patent application. | [2007/18] | Type: | B1 Patent specification | No.: | EP1778629 | Date: | 20.07.2011 | Language: | EN | [2011/29] | Search report(s) | International search report - published on: | EP | 02.03.2006 | Classification | IPC: | C07C303/38, C07C303/40, C07C311/12, C07D209/14 | [2007/18] | CPC: |
C07C311/14 (EP,KR,US);
C07D209/14 (EP,KR,US);
A61K31/404 (KR);
C07C303/38 (EP,KR,US);
C07C303/40 (EP,KR,US);
C07C311/13 (EP,KR,US)
| C-Set: |
C07C303/38, C07C311/13 (EP,US);
C07C303/38, C07C311/14 (US,EP);
C07C303/40, C07C311/13 (US,EP);
C07C303/40, C07C311/14 (US,EP) | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2007/18] | Extension states | AL | Not yet paid | BA | Not yet paid | HR | Not yet paid | MK | Not yet paid | YU | Not yet paid | Title | German: | VERFAHREN ZUR SYNTHESE VON C-2, C-3-SUBSTITUIERTEN N-ALKYLIERTEN INDOLEN ALS CPLA2 INHIBITOREN | [2007/18] | English: | PROCESS FOR THE SYNTHESIS C-2, C-3 SUBSTITUTED N-ALKYLATED INDOLES USEFUL AS CPLA2 INHIBITORS | [2007/18] | French: | PROCEDE DE SYNTHESE D'INDOLES N-ALKYLES SUBSTITUES EN C-2, C-3 UTILES COMME INHIBITEURS DE LA CPLA2 | [2007/18] | Entry into regional phase | 09.02.2007 | National basic fee paid | 09.02.2007 | Designation fee(s) paid | 09.02.2007 | Examination fee paid | Examination procedure | 09.02.2007 | Examination requested [2007/18] | 29.06.2007 | Despatch of a communication from the examining division (Time limit: M06) | 20.12.2007 | Reply to a communication from the examining division | 15.07.2009 | Despatch of a communication from the examining division (Time limit: M04) | 07.10.2009 | Reply to a communication from the examining division | 08.02.2011 | Communication of intention to grant the patent | 17.05.2011 | Fee for grant paid | 17.05.2011 | Fee for publishing/printing paid | Divisional application(s) | EP10184057.7 Application deemed to be withdrawn : 03.11.2010 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 29.06.2007 | Opposition(s) | 23.04.2012 | No opposition filed within time limit [2012/26] | Fees paid | Renewal fee | 03.08.2007 | Renewal fee patent year 03 | 27.03.2008 | Renewal fee patent year 04 | 07.08.2009 | Renewal fee patent year 05 | 31.08.2010 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 20.07.2011 | BE | 20.07.2011 | CY | 20.07.2011 | CZ | 20.07.2011 | DK | 20.07.2011 | EE | 20.07.2011 | FI | 20.07.2011 | HU | 20.07.2011 | IT | 20.07.2011 | LT | 20.07.2011 | LV | 20.07.2011 | NL | 20.07.2011 | PL | 20.07.2011 | RO | 20.07.2011 | SE | 20.07.2011 | SI | 20.07.2011 | SK | 20.07.2011 | TR | 20.07.2011 | IE | 18.08.2011 | LU | 18.08.2011 | CH | 31.08.2011 | LI | 31.08.2011 | MC | 31.08.2011 | FR | 20.09.2011 | BG | 20.10.2011 | GB | 20.10.2011 | GR | 21.10.2011 | ES | 31.10.2011 | IS | 20.11.2011 | PT | 21.11.2011 | DE | 01.03.2012 | [2013/45] |
Former [2013/44] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
DK | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
TR | 20.07.2011 | ||
IE | 18.08.2011 | ||
LU | 18.08.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
FR | 20.09.2011 | ||
BG | 20.10.2011 | ||
GB | 20.10.2011 | ||
GR | 21.10.2011 | ||
ES | 31.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
DE | 01.03.2012 | ||
Former [2013/30] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
DK | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
IE | 18.08.2011 | ||
LU | 18.08.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
FR | 20.09.2011 | ||
BG | 20.10.2011 | ||
GB | 20.10.2011 | ||
GR | 21.10.2011 | ||
ES | 31.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
DE | 01.03.2012 | ||
Former [2013/29] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
DK | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
IE | 18.08.2011 | ||
LU | 18.08.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
FR | 20.09.2011 | ||
BG | 20.10.2011 | ||
GB | 20.10.2011 | ||
GR | 21.10.2011 | ||
ES | 31.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2013/25] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
DK | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
IE | 18.08.2011 | ||
LU | 18.08.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
FR | 20.09.2011 | ||
GB | 20.10.2011 | ||
GR | 21.10.2011 | ||
ES | 31.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2013/22] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
DK | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
IE | 18.08.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
FR | 20.09.2011 | ||
GB | 20.10.2011 | ||
GR | 21.10.2011 | ||
ES | 31.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/37] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
DK | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
IE | 18.08.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
FR | 20.09.2011 | ||
GB | 20.10.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/36] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
DK | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
IE | 18.08.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
GB | 20.10.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/35] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
DK | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
IE | 18.08.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/31] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
DK | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/23] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
EE | 20.07.2011 | ||
FI | 20.07.2011 | ||
IT | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
RO | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
SK | 20.07.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/21] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
CZ | 20.07.2011 | ||
FI | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/20] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
FI | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
CH | 31.08.2011 | ||
LI | 31.08.2011 | ||
MC | 31.08.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/18] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
FI | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
MC | 31.08.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/12] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
CY | 20.07.2011 | ||
FI | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/11] | AT | 20.07.2011 | |
BE | 20.07.2011 | ||
FI | 20.07.2011 | ||
LT | 20.07.2011 | ||
LV | 20.07.2011 | ||
NL | 20.07.2011 | ||
PL | 20.07.2011 | ||
SE | 20.07.2011 | ||
SI | 20.07.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/10] | BE | 20.07.2011 | |
FI | 20.07.2011 | ||
LT | 20.07.2011 | ||
NL | 20.07.2011 | ||
SE | 20.07.2011 | ||
GR | 21.10.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/09] | BE | 20.07.2011 | |
FI | 20.07.2011 | ||
LT | 20.07.2011 | ||
NL | 20.07.2011 | ||
IS | 20.11.2011 | ||
PT | 21.11.2011 | ||
Former [2012/08] | LT | 20.07.2011 | |
NL | 20.07.2011 | ||
IS | 20.11.2011 | Cited in | International search | [A]WO03048122 (WYETH CORP [US]) [A] 1,22,27,36 * the whole document *; | [PX]WO2005012238 (WYETH CORP [US], et al) [PX] 1-39 * page 6 - page 7; figures 1,2 * * page 8, line 11 - page 9, line 2 * * page 10; examples 1,2 * * claims 1-24 *; | [A] - APPLETON J E ET AL, "A mild and selective C-3 reductive alkylation of indoles", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, (19930226), vol. 34, no. 9, ISSN 0040-4039, pages 1529 - 1532, XP002305011 [A] 1,22,27,36 * the whole document * DOI: http://dx.doi.org/10.1016/S0040-4039(00)60337-4 | [A] - FAGNOLA M C ET AL, "Solid-Phase Synthesis of Indoles Using the Palladium-Catalysed Coupling of alkynes with Iodoaniline Derivatives", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, (19970331), vol. 38, no. 13, ISSN 0040-4039, pages 2307 - 2310, XP004056657 [A] 1,22,27,36 * the whole document * DOI: http://dx.doi.org/10.1016/S0040-4039(97)00300-6 | [A] - JOSÉ BARLUENGA, J. ORG. CHEM., (1996), vol. 61, pages 5804 - 5812, XP002353542 [A] 1,22,27,36 * the whole document * DOI: http://dx.doi.org/10.1021/jo952119+ | [A] - SAKAMOTO T ET AL, "CONDENSED HETEROAROMATIC RING SYSTEMS. XIII.1) ONE-STEP SYNTHESIS OF 2-SUBSTITUTED 1-METHYLSULFONYLINDOLES FROM NU-(2-HALOPHENYL)METHANESU LFONAMIDES", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, (1988), vol. 36, no. 4, ISSN 0009-2363, pages 1305 - 1308, XP002041639 [A] 1,22,27,36 * the whole document * | [A] - SHIN K, OGASAWARA K, SYNLETT, (1995), pages 859 - 860, XP002353543 [A] 1,22,27,36 * the whole document * DOI: http://dx.doi.org/10.1055/s-1995-5110 |