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Extract from the Register of European Patents

EP About this file: EP1812475

EP1812475 - IMMUNOGLOBULIN FRACTIONS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  29.08.2014
Database last updated on 09.04.2026
Most recent event   Tooltip10.06.2016Change - lapse in a contracting state
Updated state(s): GR		published on 13.07.2016  [2016/28]
Applicant(s)For all designated states
CSL Behring AG
Wankdorfstrasse 10
3014 Bern / CH
[2008/32]
Former [2007/31]For all designated states
ZLB Behring AG
Wankdorfstrasse 10
3000 Bern / CH
Inventor(s)01 / MIESCHER, Sylvia
Hintere Engelhalden Strasse 78
CH-3004 Bern / CH
02 / BOLLI, Reinhard, Franz
Niesenstrasse 7
CH-3076 Worb / CH
 [2007/31]
Representative(s)Lauppe, Hans Friedrich, et al
CSL Behring GmbH
Patente und Lizenzen
Postfach 12 30
35002 Marburg / DE
[N/P]
Former [2009/52]Lauppe, Hans Friedrich, et al
CSL Behring GmbH Patente und Lizenzen Postfach 12 30
35002 Marburg / DE
Former [2007/31]Lauppe, Hans Friedrich, et al
CSL Behring GmbH Postfach 1230
35002 Marburg / DE
Application number, filing date05807416.227.10.2005
[2007/31]
WO2005EP11494
Priority number, dateEP2004002593602.11.2004         Original published format: EP 04025936
[2007/31]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2006048174
Date:11.05.2006
Language:EN
[2006/19]
Type: A2 Application without search report 
No.:EP1812475
Date:01.08.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 11.05.2006 takes the place of the publication of the European patent application.
[2007/31]
Type: B1 Patent specification 
No.:EP1812475
Date:23.10.2013
Language:EN
[2013/43]
Search report(s)International search report - published on:EP20.09.2007
ClassificationIPC:C07K16/06, C07K16/00, A61K39/00, A61K39/395
[2007/31]
CPC:
C07K16/065 (EP,US); A61K39/395 (KR); A61P31/00 (EP);
A61P31/04 (EP); A61P31/10 (EP); A61P31/12 (EP);
A61P33/00 (EP); A61P33/02 (EP); A61P37/02 (EP);
A61P43/00 (EP); C07K16/00 (KR); C07K2317/21 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/31]
TitleGerman:IMMUNGLOBULINFRAKTIONEN[2007/31]
English:IMMUNOGLOBULIN FRACTIONS[2007/31]
French:FRACTIONS D'IMMUNOGLOBULINE[2007/31]
Entry into regional phase04.06.2007National basic fee paid 
08.08.2007Designation fee(s) paid 
08.08.2007Examination fee paid 
Examination procedure08.08.2007Examination requested  [2007/39]
15.02.2008Despatch of a communication from the examining division (Time limit: M04)
14.05.2008Reply to a communication from the examining division
30.05.2008Despatch of a communication from the examining division (Time limit: M04)
29.09.2008Reply to a communication from the examining division
17.10.2008Despatch of a communication from the examining division (Time limit: M04)
30.10.2008Reply to a communication from the examining division
13.11.2008Despatch of a communication from the examining division (Time limit: M04)
06.03.2009Reply to a communication from the examining division
20.03.2009Despatch of a communication from the examining division (Time limit: M04)
03.07.2009Reply to a communication from the examining division
14.07.2009Despatch of a communication from the examining division (Time limit: M04)
26.10.2009Reply to a communication from the examining division
11.11.2009Despatch of a communication from the examining division (Time limit: M06)
19.05.2010Reply to a communication from the examining division
04.06.2010Despatch of a communication from the examining division (Time limit: M04)
12.10.2010Reply to a communication from the examining division
10.11.2010Despatch of a communication from the examining division (Time limit: M04)
21.03.2011Reply to a communication from the examining division
17.05.2011Despatch of a communication from the examining division (Time limit: M06)
23.11.2011Reply to a communication from the examining division
27.12.2011Despatch of a communication from the examining division (Time limit: M06)
05.07.2012Reply to a communication from the examining division
23.11.2012Despatch of a communication from the examining division (Time limit: M03)
26.02.2013Reply to a communication from the examining division
16.05.2013Communication of intention to grant the patent
09.09.2013Fee for grant paid
09.09.2013Fee for publishing/printing paid
Divisional application(s)EP09002383.9  / EP2062915
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.02.2008
Opposition(s)24.07.2014No opposition filed within time limit [2014/40]
Fees paidRenewal fee
31.10.2007Renewal fee patent year 03
31.10.2008Renewal fee patent year 04
02.11.2009Renewal fee patent year 05
02.11.2010Renewal fee patent year 06
31.10.2011Renewal fee patent year 07
31.10.2012Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU27.10.2005
AT23.10.2013
BE23.10.2013
BG23.10.2013
CY23.10.2013
CZ23.10.2013
EE23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
MC23.10.2013
PL23.10.2013
RO23.10.2013
SI23.10.2013
SK23.10.2013
TR23.10.2013
IE27.10.2013
LU27.10.2013
GR24.01.2014
IS23.02.2014
PT24.02.2014
[2016/28]
Former [2015/38]HU27.10.2005
AT23.10.2013
BE23.10.2013
BG23.10.2013
CY23.10.2013
CZ23.10.2013
EE23.10.2013
FI23.10.2013
GR23.10.2013
LT23.10.2013
LV23.10.2013
MC23.10.2013
PL23.10.2013
RO23.10.2013
SI23.10.2013
SK23.10.2013
TR23.10.2013
IE27.10.2013
LU27.10.2013
IS23.02.2014
PT24.02.2014
Former [2015/34]HU27.10.2005
AT23.10.2013
BE23.10.2013
BG23.10.2013
CY23.10.2013
CZ23.10.2013
EE23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
MC23.10.2013
PL23.10.2013
RO23.10.2013
SI23.10.2013
SK23.10.2013
TR23.10.2013
IE27.10.2013
LU27.10.2013
IS23.02.2014
PT24.02.2014
Former [2015/32]AT23.10.2013
BE23.10.2013
CY23.10.2013
CZ23.10.2013
EE23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
MC23.10.2013
PL23.10.2013
RO23.10.2013
SI23.10.2013
SK23.10.2013
TR23.10.2013
IE27.10.2013
IS23.02.2014
PT24.02.2014
Former [2015/14]AT23.10.2013
BE23.10.2013
CY23.10.2013
CZ23.10.2013
EE23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
MC23.10.2013
PL23.10.2013
RO23.10.2013
SI23.10.2013
SK23.10.2013
IE27.10.2013
IS23.02.2014
PT24.02.2014
Former [2014/48]AT23.10.2013
BE23.10.2013
CY23.10.2013
CZ23.10.2013
EE23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
MC23.10.2013
PL23.10.2013
RO23.10.2013
SK23.10.2013
IE27.10.2013
IS23.02.2014
PT24.02.2014
Former [2014/37]AT23.10.2013
BE23.10.2013
CY23.10.2013
CZ23.10.2013
EE23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
MC23.10.2013
PL23.10.2013
RO23.10.2013
SK23.10.2013
IS23.02.2014
PT24.02.2014
Former [2014/36]AT23.10.2013
BE23.10.2013
CY23.10.2013
EE23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
MC23.10.2013
IS23.02.2014
PT24.02.2014
Former [2014/33]AT23.10.2013
BE23.10.2013
CY23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
MC23.10.2013
IS23.02.2014
PT24.02.2014
Former [2014/28]AT23.10.2013
BE23.10.2013
CY23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
IS23.02.2014
PT24.02.2014
Former [2014/26]AT23.10.2013
BE23.10.2013
CY23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
IS23.02.2014
Former [2014/25]AT23.10.2013
BE23.10.2013
FI23.10.2013
LT23.10.2013
LV23.10.2013
IS23.02.2014
Former [2014/24]AT23.10.2013
BE23.10.2013
FI23.10.2013
LT23.10.2013
IS23.02.2014
Former [2014/23]BE23.10.2013
FI23.10.2013
LT23.10.2013
IS23.02.2014
Former [2014/22]FI23.10.2013
LT23.10.2013
Former [2014/20]LT23.10.2013
Documents cited:Search[X]   VAN MIRRE EDWIN ET AL: "Monomeric IgG in intravenous Ig preparations is a functional antagonist of FcgammaRII and FcgammaRIIIb", JOURNAL OF IMMUNOLOGY, vol. 173, no. 1, 1 July 2004 (2004-07-01), pages 332 - 339, XP002464547, ISSN: 0022-1767
 [X]   BAYRY JAGADEESH ET AL: "Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin.", BLOOD, vol. 101, no. 2, 15 January 2003 (2003-01-15), pages 758 - 765, XP002464548, ISSN: 0006-4971 [X] 14-19,25-27 * see the whole document *

DOI:   http://dx.doi.org/10.1182/blood-2002-05-1447
 [X]   DE GRANDMONT MARIE JOELLE ET AL: "Intravenous immunoglobulins induce the in vitro differentiation of human B lymphocytes and the secretion of IgG.", BLOOD, vol. 101, no. 8, 15 April 2003 (2003-04-15), pages 3065 - 3073, XP002464549, ISSN: 0006-4971 [X] 14-19 * see the whole document; esp. p. 759, left col. first full para. *

DOI:   http://dx.doi.org/10.1182/blood-2002-06-1684
 [Y]   LAZARUS ALAN H ET AL: "Mechanism of action of IVIG and anti-D in ITP.", TRANSFUSION AND APHERESIS SCIENCE, vol. 28, no. 3, June 2003 (2003-06-01), pages 249 - 255, XP002464550, ISSN: 1473-0502 [Y] 14-27 * see the whole document *

DOI:   http://dx.doi.org/10.1016/S1473-0502(03)00043-0
 [Y]   SAMUELSSON ASTRID ET AL: "Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 291, no. 5503, 2001, pages 484 - 486, XP002215958, ISSN: 0036-8075 [Y] 14-27 * see the whole document *

DOI:   http://dx.doi.org/10.1126/science.291.5503.484
 [Y]   SHOHAM-KESSARY H ET AL: "Immune complex-like moieties in immunoglobulin for intravenous use (IVIg) bind complement and enhance phagocytosis of human erythrocytes", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 113, no. 1, July 1998 (1998-07-01), pages 77 - 84, XP002464551, ISSN: 0009-9104 [Y] 14-27 * see the whole document *

DOI:   http://dx.doi.org/10.1046/j.1365-2249.1998.00624.x
 [A]   KAZATCHKINE M D ET AL: "IMMUNOMODULATION OF AUTOIMMUNE AND INFLAMMATORY DISEASES WITH INTRAVENOUS IMMUNE GLOBULIN", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, vol. 345, no. 10, 6 September 2001 (2001-09-06), pages 747 - 755, XP009044707, ISSN: 1533-4406 [A]

DOI:   http://dx.doi.org/10.1056/NEJMra993360
International search[X]   VASSILEV T L ET AL: "Variable Region-Connected, Dimeric Fraction of Intravenous immunoglobulin Enriched in Natural Autoantibodies", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 8, no. 3, 1995, pages 405 - 413, XP002265834, ISSN: 0896-8411 [X] 1-13,25-27 * see the whole document *

DOI:   http://dx.doi.org/10.1006/jaut.1995.0032
 [X]   TANKERSLEY D L ET AL: "IMMUNOGLOBULIN G DIMER AN IDIOTYPE-ANTI-IDIOTYPE COMPLEX", MOLECULAR IMMUNOLOGY, vol. 25, no. 1, 1988, pages 41 - 48, XP002323181, ISSN: 0161-5890 [X] 1-13,25-27 * see the whole document *

DOI:   http://dx.doi.org/10.1016/0161-5890(88)90088-0
 [X]   ROUX K H ET AL: "A VIEW OF THE HUMAN IDIOTYPIC REPERTOIRE ELECTRON MICROSCOPIC AND IMMUNOLOGIC ANALYSES OF SPONTANEOUS IDIOTYPE-ANTI-IDIOTYPE DIMERS IN POOLED HUMAN IGG", JOURNAL OF IMMUNOLOGY, vol. 144, no. 4, 1990, pages 1387 - 1395, XP002323182, ISSN: 0022-1767 [X] 1-13,25-27 * see the whole document *
 [PX]   MIESCHER SYLVIA M ET AL: "Comparative analysis of antigen specificities in the monomeric and dimeric fractions of intravenous immunoglobulin.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. JUN 2005, vol. 1051, June 2005 (2005-06-01), pages 582 - 590, XP008058349, ISSN: 0077-8923 [PX] 1-13,25-27 * see the whole document *

DOI:   http://dx.doi.org/10.1196/annals.1361.102
 [Y]   TEELING JESSICA L ET AL: "Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: Studies in experimental immune thrombocytopenia", BLOOD, vol. 98, no. 4, 15 August 2001 (2001-08-15), pages 1095 - 1099, XP002362835, ISSN: 0006-4971 [Y] 1-13,25-27 * see the whole document *

DOI:   http://dx.doi.org/10.1182/blood.V98.4.1095
 [Y]   TANKERSLEY D L: "DIMER FORMATION IN IMMUNOGLOBULIN PREPARATIONS AND SPECULATIONS ON THE MECHANISM OF ACTION OF INTRAVENOUS IMMUNE GLOBULIN IN AUTOIMMUNE DISEASES", IMMUNOLOGICAL REVIEWS, MUNKSGAARD, XX, no. 139, June 1994 (1994-06-01), pages 159 - 172, XP008044439, ISSN: 0105-2896 [Y] 1-13,25-27 * see the whole document *

DOI:   http://dx.doi.org/10.1111/j.1600-065X.1994.tb00861.x
Examination  MAHONEY R J ET AL: "INHIBITION OF HLA ANTIBODY CYTOTOXICITY BY INTRAVENOUS IMMUNOGLOBULIN G F(AB')2 DIMERS, MONOMERS, AND MONOVALENT F(AB)", HUMAN IMMUNOLOGY, NEW YORK, NY, US, vol. 60, no. 6, 1 June 1999 (1999-06-01), pages 492 - 499, XP000892666, ISSN: 0198-8859, DOI: 10.1016/S0198-8859(99)00029-4

DOI:   http://dx.doi.org/10.1016/S0198-8859(99)00029-4
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.