EP1831365 - USE OF RNA TRANS-SPLICING FOR ANTIBODY GENE TRANSFER AND ANTIBODY POLYPEPTIDE PRODUCTION [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 13.06.2014 Database last updated on 24.08.2024 | Most recent event Tooltip | 24.07.2015 | Lapse of the patent in a contracting state New state(s): BG, HU, LU | published on 26.08.2015 [2015/35] | Applicant(s) | For all designated states VIRxSYS Corporation 200 Perry Parkway Suite 1A Gaithersburg, MD 20877 / US | [2013/32] |
Former [2008/03] | For all designated states VIRxSYS Corporation 200 Perry Parkway, Suite 1A Gaithersburg Maryland 20877 / US | ||
Former [2007/37] | For all designated states Intronn, Inc. 9700 Great Seneca Highway Rockville, MD 20850 / US | Inventor(s) | 01 /
MCGARRITY, Gerard, J. 105 Leekes Lot Way Gaithersburg, MD 20878 / US | 02 /
PUTTARAJU, Madaiah 12115 Stardrift Drive Germantown, MD 20876 / US | 03 /
GARCIA-BLANCO, Mariano, A. 12 Saderling Court Durham, NC 27713 / US | [2007/37] | Representative(s) | Lord, Hilton David, et al Marks & Clerk LLP 90 Long Acre London WC2E 9RA / GB | [N/P] |
Former [2013/32] | Lord, Hilton David, et al Marks & Clerk LLP 90 Long Acre London WC2E 9RA / GB | ||
Former [2011/43] | Lord, Hilton David, et al Marks & Clerk LLP 90 Long Acre London WC2E 9RA / GB | ||
Former [2009/31] | Irvine, Jonquil Claire, et al Marks & Clerk LLP 4220 Nash Court Oxford Business Park South Oxford OX4 2RU / GB | ||
Former [2007/37] | Lucas, Phillip Brian Lucas & Co. 135 Westhall Road Warlingham, Surrey CR6 9HJ / GB | Application number, filing date | 05815099.6 | 07.10.2005 | [2007/37] | WO2005US36215 | Priority number, date | US20040617012P | 08.10.2004 Original published format: US 617012 P | US20040629821P | 19.11.2004 Original published format: US 629821 P | [2007/37] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2006083331 | Date: | 10.08.2006 | Language: | EN | [2006/32] | Type: | A2 Application without search report | No.: | EP1831365 | Date: | 12.09.2007 | Language: | EN | The application published by WIPO in one of the EPO official languages on 10.08.2006 takes the place of the publication of the European patent application. | [2007/37] | Type: | B1 Patent specification | No.: | EP1831365 | Date: | 07.08.2013 | Language: | EN | [2013/32] | Search report(s) | International search report - published on: | EP | 26.07.2007 | Classification | IPC: | C12N15/10 | [2007/37] | CPC: |
C07K16/084 (EP,US);
A61P19/02 (EP);
A61P29/00 (EP);
A61P31/04 (EP);
A61P35/00 (EP);
A61P37/06 (EP);
C07K16/00 (EP,US);
C12N15/1027 (EP,US);
A61K2039/505 (EP,US);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2007/37] | Title | German: | VERWENDUNG VON RNS TRANS-SPLICING ZUM ANTIKÖRPER GEN TRANSFER UND ZUR ANTIKÖRPERHERSTELLUNG | [2007/37] | English: | USE OF RNA TRANS-SPLICING FOR ANTIBODY GENE TRANSFER AND ANTIBODY POLYPEPTIDE PRODUCTION | [2007/37] | French: | UTILISATION D'UN TRANS-EPISSAGE D'ARN POUR LE TRANSFERT GENIQUE D'ANTICORPS ET LA PRODUCTION POLYPEPTIDIQUE D'ANTICORPS | [2007/37] | Entry into regional phase | 27.03.2007 | National basic fee paid | 27.03.2007 | Designation fee(s) paid | 27.03.2007 | Examination fee paid | Examination procedure | 27.03.2007 | Examination requested [2007/37] | 21.01.2008 | Despatch of a communication from the examining division (Time limit: M08) | 01.08.2008 | Reply to a communication from the examining division | 09.08.2011 | Despatch of a communication from the examining division (Time limit: M06) | 27.12.2011 | Reply to a communication from the examining division | 16.01.2012 | Despatch of a communication from the examining division (Time limit: M06) | 10.07.2012 | Reply to a communication from the examining division | 15.02.2013 | Communication of intention to grant the patent | 24.06.2013 | Fee for grant paid | 24.06.2013 | Fee for publishing/printing paid | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 21.01.2008 | Opposition(s) | 08.05.2014 | No opposition filed within time limit [2014/29] | Fees paid | Renewal fee | 23.10.2007 | Renewal fee patent year 03 | 31.03.2008 | Renewal fee patent year 04 | 13.10.2009 | Renewal fee patent year 05 | 12.10.2010 | Renewal fee patent year 06 | 11.10.2011 | Renewal fee patent year 07 | 25.10.2012 | Renewal fee patent year 08 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 07.10.2005 | AT | 07.08.2013 | BE | 07.08.2013 | BG | 07.08.2013 | CY | 07.08.2013 | CZ | 07.08.2013 | DK | 07.08.2013 | EE | 07.08.2013 | ES | 07.08.2013 | FI | 07.08.2013 | IT | 07.08.2013 | LT | 07.08.2013 | LV | 07.08.2013 | MC | 07.08.2013 | NL | 07.08.2013 | PL | 07.08.2013 | RO | 07.08.2013 | SE | 07.08.2013 | SI | 07.08.2013 | SK | 07.08.2013 | TR | 07.08.2013 | IE | 07.10.2013 | LU | 07.10.2013 | CH | 31.10.2013 | FR | 31.10.2013 | LI | 31.10.2013 | GB | 07.11.2013 | GR | 08.11.2013 | IS | 07.12.2013 | PT | 09.12.2013 | DE | 01.05.2014 | [2015/34] |
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LI | 31.10.2013 | ||
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IS | 07.12.2013 | ||
PT | 09.12.2013 | ||
DE | 01.05.2014 | ||
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PT | 09.12.2013 | ||
DE | 01.05.2014 | ||
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SI | 07.08.2013 | ||
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PT | 09.12.2013 | ||
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IS | 07.12.2013 | ||
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PT | 09.12.2013 | ||
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AT | 07.08.2013 | ||
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PT | 09.12.2013 | ||
Former [2014/08] | LT | 07.08.2013 | |
PT | 09.12.2013 | Cited in | International search | [XY]WO03072739 (INTRONN INC [US], et al) [X] 1,4-6,14,17-19,27,30-32,40,44-46 * pages 8-11; figure 1; example -; claims 1,9-13 * * same passages * [Y] 1-53; | [XY] - SCHLESINGER J ET AL, "In-cell generation of antibody single-chain Fv transcripts by targeted RNA trans-splicing", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, (200311), vol. 282, no. 1-2, ISSN 0022-1759, pages 175 - 186, XP004471812 [X] 1,7-9,14,20-22,27,33-35,40,41,47-49 * page 177, column R, paragraph L - page 182, column R, paragraph 1; figure 1 * * same passages * [Y] 1-53 DOI: http://dx.doi.org/10.1016/j.jim.2003.08.006 | [Y] - MANSFIELD S GARY ET AL, "RNA repair using spliceosome-mediated RNA trans-splicing.", TRENDS IN MOLECULAR MEDICINE. JUN 2004, (200406), vol. 10, no. 6, ISSN 1471-4914, pages 263 - 268, XP002393373 [Y] 1-53 * page 265 - page 266; figures 1-5 * DOI: http://dx.doi.org/10.1016/j.molmed.2004.04.007 | [Y] - PERGOLIZZI R G ET AL, "Genetic medicine at the RNA level: modifications of the genetic repertoire for therapeutic purposes by pre-mRNA trans-splicing", COMPTES RENDUS - BIOLOGIES, ELSEVIER, PARIS, FR, (200408), vol. 327, no. 8, ISSN 1631-0691, pages 695 - 709, XP004561828 [Y] 1-53 * page 700 - page 702; figures 1-4 * DOI: http://dx.doi.org/10.1016/j.crvi.2004.05.008 | [PY] - PUTTARAJU ET AL, "1113. Spliceosome Mediated RNA Trans-Splicing (SMaRT(TM)) Strategy To Increase the Production of Human Apolipoprotein (ApoA1)", MOLECULAR THERAPY, ACADEMIC PRESS, SAN DIEGO, CA,, US, (20050815), vol. 11, ISSN 1525-0016, page 429, XP005016452 [PY] 1-53 * abstract * | by applicant | WO03072739 | - SCHLESINGER ET AL., J IMMUNOL METHODS, (2003), vol. 282, no. 1-2, pages 175 - 86 | - MANSFIELD ET AL., TRENDS MOL MED, (2004), vol. 10, no. 6, pages 263 - 268 | - PERGOLIZZI ET AL., C R BIOL., (2004), vol. 327, no. 8, pages 695 - 709 | - BREKKE; SANDLIE, "Therapeutic antibodies for human diseases at the dawn of the twenty first century", NATURE REVIEWS DRUG DISCOVERY, (2003), vol. 2, pages 52 - 62 | - ANDERSON; ANDERSON, MOLEC. CELL PROTEOMICS, (2002), vol. 1, page 845 | - UHLMANN ET AL., CHEM. REV., (1990), vol. 90, pages 543 - 584 | - SCHNEIDER ET AL., TETRAHEDRON LETT., (1990), vol. 31, page 335 | - STEIN, C. A. ET AL., NUCLEIC ACIDS RES., (1988), vol. 16, pages 3209 - 3221 | - COSSTICK, R. ET AL., TETRAHEDRON LETTERS, (1989), vol. 30, pages 4693 - 4696 | - BRILL, W. K.-D. ET AL., J. AMER. CHEM. SOC., (1989), vol. 111, pages 2321 - 2322 |