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Extract from the Register of European Patents

EP About this file: EP1833988

EP1833988 - NOVEL GENES AND MARKERS ASSOCIATED TO TYPE 2 DIABETES MELLITUS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  20.06.2014
Database last updated on 05.10.2024
Most recent event   Tooltip24.07.2015Lapse of the patent in a contracting state
New state(s): BG, HU		published on 26.08.2015  [2015/35]
Applicant(s)For all designated states
DSM IP Assets B.V.
Het Overloon 1
6411 TE Heerlen / NL
[2013/33]
Former [2009/35]For all designated states
DSM IP Assets B.V.
Het Overloon 1
6411 TE Heerlen / NL
Former [2007/38]For all designated states
Oy Jurilab Ltd
Microkatu 1
FI-70210 Kuopio / FI
Inventor(s)01 / SALONEN, Jukka T.
Honkasaarentie 14
FI-70100 Kuopio / FI
02 / AALTO, Juha-matti
Jännepolku 5
FI-71800 Siilinjärvi / FI
03 / FUENTES, Ricardo
Kasarmikatu 11 B 36
FI-70110 Kuopio / FI
04 / KONTKANEN, Outi
Hiidenkatu 17
FI-70840 Kuopio / FI
05 / PIRSKANEN, Mia
Minna Canthinkatu 2 A 18
FI-70100 Kuopio / FI
06 / UIMARI, Pekka
Kalevalankatu 18 A 3
FI-70500 Kuopio / FI
 [2013/12]
Former [2007/38]01 / AALTO, Juha-Matti
Honkasaarentie 14
FI-70100 Kuopio / FI
02 / FUENTES, Ricardo
Kasarmikatu 11B 36
FI-70110 Kuopio / FI
03 / KONTKANEN, Outi
Hiidenkatu 17
FI-70840 Kupio / FI
04 / PIRSKANEN, Mia
Minna Canthinkatu 2 A 18
FI-70100 Kuopio / FI
05 / UIMARI, Pekka
Vuorikatu 34 A 22
FI-70100 Kuopio / FI
06 / SALONEN, Jukka T.
Kalevalankatu 18 A 3
FI-70500 Kuopio / FI
Representative(s)Schwander, Kuno, et al
DSM Nutritional Products Ltd
Patent Department
Wurmisweg 576
4303 Kaiseraugst / CH
[2012/29]
Former [2011/01]Schwander, Kuno, et al
DSM Nutritional Products Ltd., Wurmisweg 576
4303 Kaiseraugst / CH
Former [2009/35]Biermann, Jan, et al
DSM Intellectual Property Delft Office (600-0240) P.O. Box 1
NL-2600 MA Delft / NL
Former [2007/38]Karvinen, Leena Maria, et al
Oy Jalo Ant-Wuorinen Ab Iso Roobertinkatu 4-6 A
00120 Helsinki / FI
Application number, filing date05820627.723.12.2005
[2007/38]
WO2005FI50486
Priority number, dateFI2005000001105.01.2005         Original published format: FI 20050011
[2007/38]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2006072654
Date:13.07.2006
Language:EN
[2006/28]
Type: A1 Application with search report 
No.:EP1833988
Date:19.09.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 13.07.2006 takes the place of the publication of the European patent application.
[2007/38]
Type: B1 Patent specification 
No.:EP1833988
Date:14.08.2013
Language:EN
[2013/33]
Search report(s)International search report - published on:FI13.07.2006
(Supplementary) European search report - dispatched on:EP08.10.2009
ClassificationIPC:C12Q1/68
[2007/38]
CPC:
G01N33/6893 (EP,FI,US); C12Q1/6813 (FI); A61P3/08 (EP);
A61P3/10 (EP); A61P43/00 (EP); A61P5/50 (EP);
C12Q1/6883 (EP,FI,US); G01N33/50 (FI); C12Q2600/136 (EP,US);
C12Q2600/156 (EP,US); C12Q2600/158 (EP,US); C12Q2600/172 (EP,US);
G01N2500/00 (EP,US); G01N2800/042 (EP,US); G01N2800/52 (EP,US);
Y02A90/10 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/38]
TitleGerman:NEUE, MIT DIABETES MELLITUS TYP 2 ASSOZIIERTE GENE UND MARKER[2007/38]
English:NOVEL GENES AND MARKERS ASSOCIATED TO TYPE 2 DIABETES MELLITUS[2007/38]
French:NOUVEAUX GENES ET MARQUEURS ASSOCIES AU DIABETE SUCRE DE TYPE 2[2007/38]
Entry into regional phase26.06.2007National basic fee paid 
26.06.2007Search fee paid 
26.06.2007Designation fee(s) paid 
26.06.2007Examination fee paid 
Examination procedure26.06.2007Examination requested  [2007/38]
29.08.2007Amendment by applicant (claims and/or description)
25.11.2009Despatch of a communication from the examining division (Time limit: M06)
12.05.2010Reply to a communication from the examining division
07.03.2011Despatch of a communication from the examining division (Time limit: M04)
28.06.2011Reply to a communication from the examining division
26.10.2012Despatch of a communication from the examining division (Time limit: M02)
11.12.2012Reply to a communication from the examining division
19.02.2013Communication of intention to grant the patent
15.03.2013Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
02.04.2013Communication of intention to grant the patent
04.07.2013Fee for grant paid
04.07.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  25.11.2009
Opposition(s)15.05.2014No opposition filed within time limit [2014/30]
Fees paidRenewal fee
24.12.2007Renewal fee patent year 03
18.12.2008Renewal fee patent year 04
28.12.2009Renewal fee patent year 05
27.12.2010Renewal fee patent year 06
27.12.2011Renewal fee patent year 07
11.12.2012Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU23.12.2005
AT14.08.2013
BE14.08.2013
BG14.08.2013
CY14.08.2013
CZ14.08.2013
DK14.08.2013
EE14.08.2013
ES14.08.2013
FI14.08.2013
IT14.08.2013
LT14.08.2013
LV14.08.2013
MC14.08.2013
NL14.08.2013
PL14.08.2013
RO14.08.2013
SE14.08.2013
SI14.08.2013
SK14.08.2013
TR14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
IE23.12.2013
LU23.12.2013
CH31.12.2013
LI31.12.2013
[2015/34]
Former [2015/32]AT14.08.2013
BE14.08.2013
CY14.08.2013
CZ14.08.2013
DK14.08.2013
EE14.08.2013
ES14.08.2013
FI14.08.2013
IT14.08.2013
LT14.08.2013
LV14.08.2013
MC14.08.2013
NL14.08.2013
PL14.08.2013
RO14.08.2013
SE14.08.2013
SI14.08.2013
SK14.08.2013
TR14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
IE23.12.2013
LU23.12.2013
CH31.12.2013
LI31.12.2013
Former [2014/48]AT14.08.2013
BE14.08.2013
CY14.08.2013
CZ14.08.2013
DK14.08.2013
EE14.08.2013
ES14.08.2013
FI14.08.2013
IT14.08.2013
LT14.08.2013
LV14.08.2013
MC14.08.2013
NL14.08.2013
PL14.08.2013
RO14.08.2013
SE14.08.2013
SI14.08.2013
SK14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
IE23.12.2013
LU23.12.2013
CH31.12.2013
LI31.12.2013
Former [2014/46]AT14.08.2013
BE14.08.2013
CY14.08.2013
CZ14.08.2013
DK14.08.2013
EE14.08.2013
ES14.08.2013
FI14.08.2013
IT14.08.2013
LT14.08.2013
LV14.08.2013
MC14.08.2013
NL14.08.2013
PL14.08.2013
RO14.08.2013
SE14.08.2013
SI14.08.2013
SK14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
LU23.12.2013
CH31.12.2013
LI31.12.2013
Former [2014/38]AT14.08.2013
BE14.08.2013
CY14.08.2013
CZ14.08.2013
DK14.08.2013
EE14.08.2013
ES14.08.2013
FI14.08.2013
IT14.08.2013
LT14.08.2013
LV14.08.2013
MC14.08.2013
NL14.08.2013
PL14.08.2013
RO14.08.2013
SE14.08.2013
SI14.08.2013
SK14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
LU23.12.2013
Former [2014/24]AT14.08.2013
BE14.08.2013
CY14.08.2013
CZ14.08.2013
DK14.08.2013
EE14.08.2013
ES14.08.2013
FI14.08.2013
IT14.08.2013
LT14.08.2013
LV14.08.2013
NL14.08.2013
PL14.08.2013
RO14.08.2013
SE14.08.2013
SI14.08.2013
SK14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
Former [2014/23]AT14.08.2013
BE14.08.2013
CY14.08.2013
CZ14.08.2013
DK14.08.2013
EE14.08.2013
FI14.08.2013
LT14.08.2013
LV14.08.2013
NL14.08.2013
PL14.08.2013
RO14.08.2013
SE14.08.2013
SI14.08.2013
SK14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
Former [2014/22]AT14.08.2013
BE14.08.2013
CY14.08.2013
DK14.08.2013
FI14.08.2013
LT14.08.2013
LV14.08.2013
NL14.08.2013
PL14.08.2013
RO14.08.2013
SE14.08.2013
SI14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
Former [2014/21]AT14.08.2013
BE14.08.2013
CY14.08.2013
DK14.08.2013
FI14.08.2013
LT14.08.2013
LV14.08.2013
PL14.08.2013
SE14.08.2013
SI14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
Former [2014/18]AT14.08.2013
BE14.08.2013
CY14.08.2013
FI14.08.2013
LT14.08.2013
LV14.08.2013
PL14.08.2013
SE14.08.2013
SI14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
Former [2014/14]CY24.07.2013
AT14.08.2013
BE14.08.2013
FI14.08.2013
LT14.08.2013
LV14.08.2013
PL14.08.2013
SE14.08.2013
SI14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
Former [2014/12]CY24.07.2013
AT14.08.2013
FI14.08.2013
LT14.08.2013
LV14.08.2013
PL14.08.2013
SE14.08.2013
SI14.08.2013
GR15.11.2013
IS14.12.2013
PT16.12.2013
Former [2014/11]CY24.07.2013
AT14.08.2013
FI14.08.2013
LT14.08.2013
PL14.08.2013
SE14.08.2013
IS14.12.2013
PT16.12.2013
Former [2014/10]CY24.07.2013
AT14.08.2013
LT14.08.2013
SE14.08.2013
IS14.12.2013
PT16.12.2013
Former [2014/09]AT14.08.2013
LT14.08.2013
SE14.08.2013
PT16.12.2013
Former [2014/08]LT14.08.2013
PT16.12.2013
Documents cited:Search[XI]WO0157190  (HYSEQ INC [US], et al) [X] 37,41-57,76-81 * page 1, line 28 - line 32 * * claims 1-5,10-16,27,28 * * sequences 790,1774 * [I] 38-40,58-60;
 [I]WO2004053158  (JURILAB LTD OY [FI], et al) [I] 1-81 * the whole document *;
 [I]WO2004067771  (HVIDOVRE HOSPITAL [DK], et al) [I] 1-81 * the whole document *;
 [I]WO2004074514  (CENTRE NAT RECH SCIENT [FR], et al) [I] 1-81 * the whole document *;
 [I]  - DAS SWAPAN KUMAR; CHU WINSTON; ZHANG ZHENGXIAN; HASSTEDT SANDRA J; ELBEIN STEVEN C, "Calsquestrin 1 (CASQ1) gene polymorphisms under chromosome 1q21 linkage peak are associated with type 2 diabetes in Northern European Caucasians.", DIABETES DEC 2004, (200412), vol. 53, no. 12, ISSN 0012-1797, pages 3300 - 3306, XP002369382 [I] 1-81 * the whole document *

DOI:   http://dx.doi.org/10.2337/diabetes.53.12.3300
 [XI]  - SHIBATA H; HUYNH D P; PULST S M, "A novel protein with RNA-binding motifs interacts with ataxin-2.", HUMAN MOLECULAR GENETICS 22 MAY 2000, (20000522), vol. 9, no. 9, ISSN 0964-6906, pages 1303 - 1313, XP009123262 [X] 37,41-57,76-81 * the whole document * [I] 38-40,58-60

DOI:   http://dx.doi.org/10.1093/hmg/9.9.1303
 [XI]  - SNPDB, NCBI, (20031113), Database accession no. rs10521039, XP007909883 [X] 37-57 * the whole document * [I] 40,58-60
 [XI]  - SNPDB, NCBI, (20031113), Database accession no. rs10500351, XP007909880 [X] 37-39,41-57 * the whole document * [I] 40,58-60
 [XI]  - snpdb, NCBI, (20010929), Database accession no. rs2346606, XP007909887 [X] 37-39,41-57 * the whole document * [I] 40,58-60
 [XI]  - snpdb, ncbi, (20031113), Database accession no. rs10500352, XP007909881 [X] 37-39,41-57 * the whole document * [I] 40,58-60
 [XI]  - snpdb, ncbi, (20010201), Database accession no. rs1922585, XP007909885 [X] 37-39,41-57 * the whole document * [I] 40,58-60
 [XI]  - snpdb, ncbi, (20000630), Database accession no. rs225246, XP007909886 [X] 37-39,41-57 * the whole document * [I] 40,58-60
 [XI]  - snpdb, ncbi, (20031113), Database accession no. rs10521040, XP007909884 [X] 37-39,41-57 * the whole document * [I] 40,58-60
 [A]  - VAN TILBURG J; VAN HAEFTEN T W; PEARSON P; WIJMENGA C, "Defining the genetic contribution of type 2 diabetes mellitus.", JOURNAL OF MEDICAL GENETICS SEP 2001, (200109), vol. 38, no. 9, ISSN 1468-6244, pages 569 - 578, XP007909868 [A] 1-81
International search[X]WO0162798  (UPJOHN CO [US], et al);
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 [X]US2004146890  (MATSUZAKI HAJIME [US], et al);
 [X]US6812339  (VENTER J CRAIG [US], et al);
 [X]WO2004034969  (REGULOME CORP [US], et al);
 [X]WO03062376  (INCYTE GENOMICS INC [US], et al);
 [A]WO2004084797  (HUBIT GENOMIX INC [JP], et al);
 [XP]JP2005198640  (BIOMARKER SCIENCE KK, et al);
 [XP]WO2006010514  (BAYER HEALTHCARE AG [DE], et al);
 [XP]WO2005003552  (TAMA TLO LTD [JP], et al);
 [XP]WO2005003766  (WHITEHEAD BIOMEDICAL INST [US], et al)
 [A]  - NADLER S.T. ET AL., "The expression of adipogenic genes is decreased in obesity and diabetes mellitus", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20001010), vol. 97, no. 21, pages 11371 - 11376, XP002203186

DOI:   http://dx.doi.org/10.1073/pnas.97.21.11371
 [A]  - PATTI M.E. ET AL., "Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (2003), vol. 100, pages 8466 - 8471, XP008122553

DOI:   http://dx.doi.org/10.1073/PNAS.1032913100
by applicant   - ALTSHULER D; HIRSCHHORN JN; KLANNEMARK M; LINDGREN CM; VOHL MC ET AL., "The common PPARgamma Pro 12AIa polymorphism is associated with decreased risk of type 2 diabetes", NAT. GENET., (2000), vol. 26, pages 76 - 80
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DOI:   http://dx.doi.org/10.1073/pnas.88.4.1484
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DOI:   http://dx.doi.org/10.1016/S1043-2760(01)00524-0
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    - CLEMENT K; PUEYO ME; VAXILLAIRE M; RAKOTOAMBININA B; THUILLIER F; PASSA P; FROGUEL P; ROBERTS J; VELHO G., "Assessment of insulin sensitivity in glucokinase-deficient subjects", DIABETOLOGIA, (1996), vol. 39, pages 82 - 90
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DOI:   http://dx.doi.org/10.1016/j.it.2003.10.013
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DOI:   http://dx.doi.org/10.1038/3099
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    - ERIKSSON JG; LINDI V; UUSITUPA M; FORSEN TJ; LAAKSO M; OSMOND C; BARKER DJ, "The effects of the Prol2Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth", DIABETES, (2002), vol. 51, pages 2321 - 4
    - ERONEN L; GEERTS F; TOIVONEN H., "2004. A Markov chain approach to reconstruction of long haplotypes", PAC SYMP BIOCOMPUT., pages 104 - 15
    - FLOREZ JC; HIRSCHHORN J; ALTSHULER D., "The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits", ANNU REV GENOMICS HUM GENET, (2003), vol. 4, pages 257 - 91
    - FROGUEL P; VAXILLAIRE M; SUN F; VELHO G; ZOUALI H; BUTEL MO; LESAGE S; VIONNET N; CLEMENT K; FOUGEROUSSE F ET AL., "Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus", NATURE, (1992), vol. 356, pages 162 - 164
    - GLOYN AL; HASHIM Y; ASHCROFT SJ; ASH-FIELD R; WILTSHIRE S; TURNER RC, "Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53", DIABETES MED., (2001), vol. 18, pages 206 - 12
    - GLOYN AL; WEEDON MN; OWEN KR; TURNER MJ; KNIGHT BA ET AL., "Large-scale association studies of variants in genes encoding the pancreatic {beta}-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJl E23K variant is associated with type 2 diabetes", DIABETES, (2003), vol. 52, doi:doi:10.2337/diabetes.52.2.568, pages 568 - 72, XP002369699

DOI:   http://dx.doi.org/10.2337/diabetes.52.2.568
    - GOUGH SC; SAKER PJ; PRITCHARD LE; MERRIMAN TR; MERRIMAN ME ET AL., "Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect?", HUM. MOL. GENET., (1995), vol. 4, pages 1609 - 12
    - GRIFFITHS AD; MALMQVIST M; MARKS JD; BYE JM; EMBLETON MJ; MCCAFFERTY J; BAIER M; HOLLIGER KP; GORICK BD; HUGHES-JONES NC ET AL., "Human anti-self antibodies with high specificity from phage display libraries", EMBO J., (1993), vol. 12, pages 725 - 34, XP002733039
    - CELL, (2005), vol. 122, pages 337 - 49
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