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Extract from the Register of European Patents

EP About this file: EP1833800

EP1833800 - PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  01.10.2010
Database last updated on 09.07.2024
Most recent event   Tooltip01.10.2010Application deemed to be withdrawnpublished on 03.11.2010  [2010/44]
Applicant(s)For all designated states
AstraZeneca AB
151 85 Södertälje / SE
[2007/50]
Former [2007/38]For all designated states
AstraZeneca AB
Astrazeneca R&D Sodertalje
151 85 Sodertalje / SE
For all designated states
NPS PHARMACEUTICALS, INC.
383 Colorow Drive
Salt Lake City, UT 84108 / US
Inventor(s)01 / BALESTRA, Michael, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O. Box 15437
Wilmington, Delaware 19850 / US
02 / BUNTING, Heather, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O. Box 15437
Wilmington, Delaware 19850-5437 / US
03 / CHEN, Deborah, c/o GlaxoSmithKline N&GI CEDD
The Hellos 06-03/04 11, Biopolis Way
138667 Singapore / SG
04 / EGLE, Ian
1700 Egliton Avenue E., Ste.318
North York M4A 2X4 / CA
05 / FORST, Janet, AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
06 / FREY, Jennifer
36 Brydon Crescent
Brampton L6X 3H2 / CA
07 / ISAAC, Methvin
17 Reynolds Avenue
Brampton L6P 2c1 / CA
08 / MA, Fupeng
2 Silver Maple Ct., Apt.1403
Brampton L6T 4R1 / CA
09 / NUGIEL, David, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
10 / SLASSI, Abdelmalik
4780 Fulwell Road
Mississauga L5M 7J7 / CA
11 / STEELMAN, Gary, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
12 / SUN, Guang-ri
31 Piera Gardens
Markham L3R 5G8 / CA
13 / SUNDAR, Babu, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
14 / UKKIRAMAPANDIAN, Radhakrishnan
3589 S.Europa Drive
Salt Lake City, Utah 84106 / US
15 / URBANEK, Rebecca A., c/o AstraZeneca Wilmigton
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
16 / WALSH, Sally, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
 [2007/50]
Former [2007/38]01 / BALESTRA, Michael, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O. Box 15437
Wilmington, Delaware 19850 / US
02 / BUNTING, Heather, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O. Box 15437
Wilmington, Delaware 19850-5437 / US
03 / CHEN, Deborah, c/o GlaxoSmithKline N&GI CEDD
The Hellos 06-03/04 11, Biopolis Way
138667 Singapore / SG
04 / EGLE, Ian
1700 Egliton Avenue E., Ste.318
North York M4A 2X4 / CA
05 / FORST, Janet, AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
06 / FREY, Jennifer
36 Brydon Crescent
Brampton L6P 2C1 / CA
07 / ISAAC, Methvin
17 Reynolds Avenue
Brampton L6P 2c1 / CA
08 / MA, Fupeng
2 Silver Maple Ct., Apt.1403
Brampton L6T 4R1 / CA
09 / NUGIEL, David, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
10 / SLASSI, Abdelmalik
4780 Fulwell Road
Mississauga L5M 7J7 / CA
11 / STEELMAN, Gary, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
12 / SUN, Guang-ri
31 Piera Gardens
Markham L3R 5G8 / CA
13 / SUNDAR, Babu, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
14 / UKKIRAMAPANDIAN, Radhakrishnan
3589 S.Europa Drive
Salt Lake City, Utah 84106 / US
15 / URBANEK, Rebecca A., c/o AstraZeneca Wilmigton
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
16 / WALSH, Sally, c/o AstraZeneca Wilmington
1800 Concord Pike, P.O.Box 15437
Wilmington, Delaware 19850-5437 / US
Representative(s)(deleted)
[2008/32]
Former [2007/38]Plougmann & Vingtoft A/S
Sundkrogsgade 9, P.O. Box 831
2100 Copenhagen O̸ / DK
Application number, filing date05855204.322.12.2005
[2007/38]
WO2005US46606
Priority number, dateUS20040638369P27.12.2004         Original published format: US 638369 P
[2007/38]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2006071730
Date:06.07.2006
Language:EN
[2006/27]
Type: A1 Application with search report 
No.:EP1833800
Date:19.09.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 06.07.2006 takes the place of the publication of the European patent application.
[2007/38]
Search report(s)International search report - published on:EP06.07.2006
ClassificationIPC:C07D231/22, C07D231/20, A61P25/28
[2007/38]
CPC:
C07D401/14 (EP,KR,US); C07D401/06 (EP,KR,US); A61P1/08 (EP);
A61P13/02 (EP); A61P21/00 (EP); A61P25/00 (EP);
A61P25/04 (EP); A61P25/06 (EP); A61P25/08 (EP);
A61P25/14 (EP); A61P25/16 (EP); A61P25/18 (EP);
A61P25/20 (EP); A61P25/22 (EP); A61P25/28 (EP);
A61P25/30 (EP); A61P27/02 (EP); A61P27/16 (EP);
A61P9/00 (EP); A61P9/04 (EP); A61P9/10 (EP);
C07D211/62 (EP,US); C07D231/22 (EP,US); C07D401/12 (EP,US);
C07D403/06 (EP,US); C07D413/14 (EP,US); C07D417/12 (EP,US);
C07D471/08 (EP,US); C07D471/10 (EP,KR,US); C07D491/10 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/38]
Extension statesALNot yet paid
BANot yet paid
HR15.06.2007
MKNot yet paid
YUNot yet paid
TitleGerman:PYRAZOLONVERBINDUNGEN ALS METABOTROPE GLUTAMATREZEPTORAGONISTEN ZUR BEHANDLUNG VON NEUROLOGISCHEN UND PSYCHIATRISCHEN STÖRUNGEN[2007/38]
English:PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS[2007/38]
French:COMPOSES DE PYRAZOLONE UTILISES COMME AGONISTES DU RECEPTEUR DE GLUTAMATE METABOTROPIQUE POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES ET PSYCHIATRIQUES[2007/38]
Entry into regional phase15.06.2007National basic fee paid 
15.06.2007Designation fee(s) paid 
15.06.2007Examination fee paid 
Examination procedure15.06.2007Amendment by applicant (claims and/or description)
15.06.2007Examination requested  [2007/38]
25.08.2008Despatch of a communication from the examining division (Time limit: M04)
17.12.2008Reply to a communication from the examining division
30.12.2009Despatch of a communication from the examining division (Time limit: M04)
11.05.2010Application deemed to be withdrawn, date of legal effect  [2010/44]
15.06.2010Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2010/44]
Fees paidRenewal fee
12.12.2007Renewal fee patent year 03
27.03.2008Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
31.12.200905   M06   Not yet paid
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[A]WO0246166  (HOFFMANN LA ROCHE [CH]) [A] 1-35* the whole document *;
 [A]WO03051833  (MERCK & CO INC [US], et al) [A] 1-35 * the whole document *;
 [A]WO2004030637  (MERCK & CO INC [US], et al) [A] 1-35 * the whole document *;
 [X]  - RUECKER, GERHARD ET AL, "Stability studies of (phenylethylamino)pyrazolones", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1983), Database accession no. 1983:16174, URL: STN, XP002377686 [X] 28 * abstract *
    [ ] - REGISTRY, (20010712), Database accession no. 345652-57-5 [ ] * 3H-Pyrazol-3-one, 4-bromo-1,2-dihydro-1-methyl-5-[[methyl(1-methyl-2-phenylethyl)amino]methyl]-2-phenyl-; column A *
    [ ] - CASREACT, (2001) [ ] * column A *
 [X]  - UEDA, TAISEI ET AL, "Synthesis of pyrazolone derivatives. XXVII. Synthesis of 4-(N-phenyl)aminopyrazolones and 3-(N-phenyl)aminomethylpyrazolones", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1976), Database accession no. 1976:523813, URL: STN, XP002377687 [X] 28 * abstract *
 [X]  - ITO, ISOO ET AL, "Synthesis of pyrazolone derivatives. XX. Cyclization of 4-bromo-3-(2-formamidophenyl)thiomethyl-2-methyl-1-phenyl-3- pyrazolin-5-one", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1973), Database accession no. 1973:159574, URL: STN, XP002377688 [X] 28 * abstract *
 [X]  - ITO, ISOO ET AL, "Synthesis of pyrazolone derivatives. XVIII. Synthesis of 1,2,4,5,6,7-hexahydro-3H-pyrazolo[4,3-c]pyridines", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1971), Database accession no. 1971:488529, URL: STN, XP002377689 [X] 28 * abstract *
 [X]  - ITO, ISOO ET AL, "Synthesis of pyrazolone derivatives. XIII. Synthesis of N,N-dialkyl-N'-substituted-N'-[3-(4-substituted-2-methyl-5-oxo-1- phenyl-3-pyrazolin-3-yl)methyl]ethylenediamines", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1969), Database accession no. 1969:115060, URL: STN, XP002377690 [X] 28 * abstract *
    [ ] - REGISTRY, (19841116), Database accession no. 47701-42-8 [ ] * 3H-Pyrazol-3-one, 4-bromo-5-[[[2-(diethylamino)ethyl](4-ethoxyphenyl)amino]methyl]-1,2-dihydro-1-methyl-2-phenyl-; column A *
 [X]  - ITO, ISOO ET AL, "Synthesis of pyrazolone derivatives. XI. Synthesis of 6-substituted 1,2,6,7-tetrahydro-3H-pyrazolo[4,3-c]pyridine", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1966), Database accession no. 1966:93461, URL: STN, XP002377691 [X] 28 * abstract *
 [X]  - ITO, ISOO, "Syntheses of pyrazolone derivatives. VI. Synthesis of 1, 1-bis [(1-phenyl-2-methyl-5-oxo-3-pyrazolin-3-yl)methyl]methylamine", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1962), Database accession no. 1962:483222, URL: STN, XP002377692 [X] 28 * abstract *
 [X]  - ITO, ISOO, "Syntheses of pyrazolone derivatives. V. Improved synthesis of 1-phenyl-2-methyl-3-(2-aminoethyl)-5-pyrazolone", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1959), Database accession no. 1959:122046, URL: STN, XP002377693 [X] 28 * abstract *
 [X]  - ITO, ISOO, "Syntheses of pyrazolone derivatives. III. Syntheses of 3-formyl- and 3,4-diformyl-2-methyl-5-pyrazolone", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1957), Database accession no. 1957:5443, URL: STN, XP002377694 [X] 28 * abstract *
 [X]  - ITO, ISOO, "Syntheses of pyrazolone derivatives. II. Syntheses of 3-amino-1-phenyl-2-methyl-5-pyrazolone and related compounds", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (1957), Database accession no. 1957:5442, URL: STN, XP002377695 [X] 28 * abstract *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.