EP1731152 - Sustained analgesia achieved with transdermal delivery of buprenorphine [Right-click to bookmark this link] | Status | Patent revoked Status updated on 17.02.2020 Database last updated on 03.09.2024 | Most recent event Tooltip | 21.02.2020 | Revocation of patent | published on 25.03.2020 [2020/13] | Applicant(s) | For:AT
BE
CH
ES
FR
GR
IT
LI
LU
MC
PT
EURO-CELTIQUE S.A. 1, rue Jean Piret 2350 Luxembourg / LU | For:DE
Mundipharma Laboratories GmbH St. Alban-Rheinweg 74 4020 Basel / CH | For:GB
Napp Pharmaceutical Holdings Limited Cambridge Science Park Milton Road Cambridge CB4 0AB / GB | For:NL
Mundipharma Pharmaceuticals B.V. De Wel 20 3871 Hoevelaken / NL | For:SE
Mundipharma AB Mölndalsvägen 26 412 63 Göteborg / SE | For:IE
Mundipharma Pharmaceuticals Limited Millbank House Arkle Road Sandyford Dublin 18 / IE | For:DK
Norpharma A/S Frydenlundsvej 30 2950 Vedbaek / DK | For:FI
Mundipharma OY Rajatorpantie 41 C 01640 Vantaa / FI | [2016/24] |
Former [2016/11] | For:AT
BE
CH
ES
FR
GR
IT
LI
LU
MC
PT
EURO-CELTIQUE S.A. 2, avenue Charles de Gaulle 1653 Luxembourg / LU | ||
For:DE
Mundipharma Laboratories GmbH St. Alban-Rheinweg 74 4020 Basel / CH | |||
For:GB
Napp Pharmaceutical Holdings Limited Cambridge Science Park Milton Road Cambridge CB4 0AB / GB | |||
For:NL
Mundipharma Pharmaceuticals B.V. De Wel 20 3871 Hoevelaken / NL | |||
For:SE
Mundipharma AB Mölndalsvägen 26 412 63 Göteborg / SE | |||
For:IE
Mundipharma Pharmaceuticals Limited Millbank House Arkle Road Sandyford Dublin 18 / IE | |||
For:DK
Norpharma A/S Frydenlundsvej 30 2950 Vedbaek / DK | |||
For:FI
Mundipharma OY Rajatorpantie 41 C 01640 Vantaa / FI | |||
Former [2008/23] | For all designated states EURO-CELTIQUE S.A. 2, avenue Charles de Gaulle 1653 Luxembourg / LU | ||
Former [2006/50] | For all designated states EURO-CELTIQUE S.A. 122 Boulevard de la Petrusse 2330 Luxembourg / LU | Inventor(s) | 01 /
Reder, Robert, F. 1111 Legacy Lane West Chester, PA 19382 / US | 02 /
Goldenheim, Paul, D. 4 Bald Hill Place Wilton, CT 06897 / US | 03 /
Kaiko, Robert, F. 10 Norfield Woods Road Weston, CT 06883 / US | [2013/18] |
Former [2007/02] | 01 /
Reder, Robert, F. 1111 Legacy Lane West Chester, PA 19382 / US | ||
02 /
Goldenheim, Paul, D. 4 Bald Hill Place Wilton, CT 06897 / US | |||
03 /
Kaiko, Robert, F. 10 Norfield Woods Road Weston, CT 06883 / US | |||
Former [2006/50] | 01 /
REDER, Robert, F. 2 Mercia Lane Greenwich, CT 06830 / US | ||
02 /
GOLDENHEIM, Paul, D. 4 Bald Hill Place Wilton, CT 06897 / US | |||
03 /
KAIKO, Robert, F. 10 Norfield Woods Road Weston, CT 06883 / US | Representative(s) | Hansen, Norbert Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE | [N/P] |
Former [2013/18] | Hansen, Norbert Maiwald Patentanwalts GmbH Elisenhof Elisenstraße 3 80335 München / DE | ||
Former [2006/50] | Hansen, Norbert Maiwald Patentanwalts GmbH Elisenhof Elisenstraße 3 D-80335 München / DE | Application number, filing date | 06118876.9 | 24.02.1998 | [2006/50] | Priority number, date | US19970038919P | 24.02.1997 Original published format: US 38919 P | US19970939068 | 29.09.1997 Original published format: US 939068 | [2006/50] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP1731152 | Date: | 13.12.2006 | Language: | EN | [2006/50] | Type: | A3 Search report | No.: | EP1731152 | Date: | 14.11.2007 | [2007/46] | Type: | B1 Patent specification | No.: | EP1731152 | Date: | 01.05.2013 | Language: | EN | [2013/18] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 12.10.2007 | Classification | IPC: | A61F13/00, A61K31/485, A61K9/70, A61P25/04 | [2007/41] | CPC: |
A61K31/485 (EP,NO,US);
A61K9/70 (KR,NO);
A61K31/4748 (US);
A61K9/0014 (US);
A61K9/0019 (EP,US);
A61K9/7023 (US);
A61K9/7053 (EP,US);
A61K9/7061 (EP,US);
A61P25/00 (EP);
|
Former IPC [2006/50] | A61K31/485, A61K9/70, A61P25/04 | Designated contracting states | AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2006/50] | Title | German: | Verzögerte Analgesie erreicht mit transdermaler Verabreichung von Buprenorphin | [2006/50] | English: | Sustained analgesia achieved with transdermal delivery of buprenorphine | [2006/50] | French: | Analgésie à effet prolongé grâce à l'administration transdermale de la buprénorphine | [2006/50] | Examination procedure | 14.08.2006 | Examination requested [2006/50] | 08.02.2008 | Despatch of a communication from the examining division (Time limit: M04) | 06.06.2008 | Reply to a communication from the examining division | 25.09.2009 | Despatch of a communication from the examining division (Time limit: M04) | 21.01.2010 | Reply to a communication from the examining division | 28.05.2010 | Despatch of a communication from the examining division (Time limit: M06) | 12.01.2011 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 08.03.2011 | Reply to a communication from the examining division | 02.04.2012 | Despatch of a communication from the examining division (Time limit: M01) | 19.04.2012 | Reply to a communication from the examining division | 03.05.2012 | Despatch of a communication from the examining division (Time limit: M04) | 09.05.2012 | Reply to a communication from the examining division | 19.07.2012 | Communication of intention to grant the patent | 17.09.2012 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 29.10.2012 | Communication of intention to grant the patent | 04.03.2013 | Fee for grant paid | 04.03.2013 | Fee for publishing/printing paid | Parent application(s) Tooltip | EP98906678.2 / EP0964677 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP19980906678) is 28.02.2003 | Opposition(s) | Opponent(s) | 01
23.01.2014
31.01.2014
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Ter Meer Steinmeister & Partner, et al, et al Patentanwälte mbB Nymphenburger Straße 4 80335 München / DE | 02
24.01.2014
31.01.2014
ADMISSIBLE Gallafent, Alison Alison Gallafent Ltd 21 Bridge St Llandeilo SA19 6BN / GB Opponent's representative Bird & Bird LLP, et al, et al Maximiliansplatz 22 80333 München / DE | 03
20.12.2017
03.01.2018
INTERVENTION tesa Labtec GmbH Raiffeisenstrasse 4 40764 Langenfeld / DE Opponent's representative Bird & Bird LLP Maximiliansplatz 22 80333 München / DE | [2018/06] |
Former [2018/04] | |||
Opponent(s) | 01
23.01.2014
31.01.2014
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Ter Meer Steinmeister & Partner, et al, et al Patentanwälte mbB Nymphenburger Straße 4 80335 München / DE | ||
02
24.01.2014
31.01.2014
ADMISSIBLE Gallafent, Alison Alison Gallafent Ltd 21 Bridge St Llandeilo SA19 6BN / GB Opponent's representative Bird & Bird LLP, et al, et al Maximiliansplatz 22 80333 München / DE | |||
03
20.12.2017
INTERVENTION tesa Labtec GmbH Raiffeisenstrasse 4 40764 Langenfeld / DE Opponent's representative Bird & Bird LLP Maximiliansplatz 22 80333 München / DE | |||
Former [2017/16] | |||
Opponent(s) | 01
23.01.2014
31.01.2014
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Ter Meer Steinmeister & Partner, et al, et al Patentanwälte mbB Nymphenburger Straße 4 80335 München / DE | ||
02
24.01.2014
31.01.2014
ADMISSIBLE Gallafent, Alison Alison Gallafent Ltd 21 Bridge St Llandeilo SA19 6BN / GB Opponent's representative Bird & Bird LLP, et al, et al Maximiliansplatz 22 80333 München / DE | |||
Former [2016/24] | |||
Opponent(s) | 01
23.01.2014
31.01.2014
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Ter Meer Steinmeister & Partner, et al, et al Patentanwälte mbB Nymphenburger Straße 4 80335 München / DE | ||
02
24.01.2014
31.01.2014
ADMISSIBLE Gallafent, Alison Alison Gallafent Ltd 21 Bridge St Llandeilo SA19 6BN / GB Opponent's representative Gallafent, Alison, et al, et al Alison Gallafent 21 Bridge St Llandeilo SA19 6BN / GB | |||
Former [2015/41] | |||
Opponent(s) | 01
23.01.2014
31.01.2014
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Ter Meer Steinmeister & Partner, et al, et al Patentanwälte mbB Nymphenburger Straße 4 80335 München / DE | ||
02
24.01.2014
31.01.2014
ADMISSIBLE Gallafent, Alison Alison Gallafent Ltd 21 Bridge St Llandeilo SA19 6BN / GB Opponent's representative Gallafent, Alison, et al, et al Alison Gallafent Ltd 21 Bridge St Llandeilo SA19 6BN / GB | |||
Former [2014/10] | |||
Opponent(s) | 01
23.01.2014
Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Ter Meer Steinmeister & Partner, et al, et al Patentanwälte Mauerkircherstrasse 45 81679 München / DE | ||
02
24.01.2014
Gallafent, Alison 4 George Street Llandeilo Dyfed SA19 6AS / GB Opponent's representative Gallafent, Alison, et al, et al Alison Gallafent Ltd 4 George Street Llandeilo Dyfed SA19 6AS / GB | |||
Former [2014/09] | |||
Opponent(s) | 01
23.01.2014
Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Ter Meer Steinmeister & Partner, et al, et al Patentanwälte Mauerkircherstrasse 45 81679 München / DE | 21.03.2014 | Invitation to proprietor to file observations on the notice of opposition | 29.09.2014 | Reply of patent proprietor to notice(s) of opposition | 09.11.2015 | Date of oral proceedings | 03.03.2016 | Despatch of interlocutory decision in opposition | 03.03.2016 | Despatch of minutes of oral proceedings | 30.01.2020 | Despatch of communication that the patent will be revoked | 09.02.2020 | Legal effect of revocation of patent [2020/13] | Appeal following opposition | 02.05.2016 | Appeal received No. T0548/16 | 13.07.2016 | Statement of grounds filed | 17.01.2020 | Result of appeal procedure: revocation of the patent | 10.03.2016 | Appeal received No. T0548/16 | 13.07.2016 | Statement of grounds filed | 17.01.2020 | Result of appeal procedure: revocation of the patent | 07.03.2016 | Appeal received No. T0548/16 | 28.06.2016 | Statement of grounds filed | 17.01.2020 | Result of appeal procedure: revocation of the patent | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 08.03.2011 | Request for further processing filed | 08.03.2011 | Full payment received (date of receipt of payment) Request granted | 21.03.2011 | Decision despatched | Fees paid | Renewal fee | 14.08.2006 | Renewal fee patent year 03 | 14.08.2006 | Renewal fee patent year 04 | 14.08.2006 | Renewal fee patent year 05 | 14.08.2006 | Renewal fee patent year 06 | 14.08.2006 | Renewal fee patent year 07 | 14.08.2006 | Renewal fee patent year 08 | 14.08.2006 | Renewal fee patent year 09 | 22.12.2006 | Renewal fee patent year 10 | 08.02.2008 | Renewal fee patent year 11 | 09.02.2009 | Renewal fee patent year 12 | 08.02.2010 | Renewal fee patent year 13 | 19.08.2011 | Renewal fee patent year 14 | 07.02.2012 | Renewal fee patent year 15 | 07.02.2013 | Renewal fee patent year 16 | Penalty fee | Additional fee for renewal fee | 28.02.2011 | 14   M06   Fee paid on   19.08.2011 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | GB | 23.02.2018 | IE | 24.02.2018 | PT | 06.03.2018 | [2018/27] |
Former [2018/23] | GB | 23.02.2018 | |
IE | 24.02.2018 | ||
Former [2018/21] | GB | 23.02.2018 | Documents cited: | Search | [Y]US4588580 (GALE ROBERT M [US], et al) [Y] 1-11* column 3, paragraph 1 *; | [X]US4956171 (CHANG YUNIK [US]) [X] 1-11 * examples 1,3 * * column 4, lines 29,45,53 *; | [Y]US5026556 (DRUST EUGENE G [US], et al) [Y] 1-11 * examples I-IV *; | [X]US5240711 (HILLE THOMAS [DE], et al) [X] 1-11 * column 2, line 46 - line 56 *; | [Y]US5486362 (KITCHELL JUDITH P [US], et al) [Y] 1-11 * example 7 *; | [DY]WO9619975 (LOHMANN THERAPIE SYST LTS [DE], et al) [DY] 1-11 * claims 1-5 *; | [Y] - FRIEND D ET AL, "SIMPLE ALKYL ESTERS AS SKIN PERMEATION ENHANCERS", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, (19890601), vol. 9, no. 1, ISSN 0168-3659, pages 33 - 41, XP000007883 [Y] 1-11 * figures 11,12 * DOI: http://dx.doi.org/10.1016/0168-3659(89)90031-X | [Y] - FRIEND D ET AL, "TRANSDERMAL DELIVERY OF LEVONORGESTREL I: ALKANOLS AS PERMEATION ENHANCERS IN VITRO", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, (19880901), vol. 7, no. 3, ISSN 0168-3659, pages 243 - 250, XP000566313 [Y] 1-11 * figures 2,3 * DOI: http://dx.doi.org/10.1016/0168-3659(88)90057-0 | [Y] - ROY S D ET AL, "CONTROLLED TRANSDERMAL DELIVERY OF FENTANYL: CHARACTERIZATIONS OF PRESSURE-SENSITIVE ADHESIVES FOR MATRIX PATCH DESIGN", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, (19960501), vol. 85, no. 5, ISSN 0022-3549, pages 491 - 495, XP000583527 [Y] 1-11 * figure 5 * * page 495, second paragraph * DOI: http://dx.doi.org/10.1021/js950415w | Examination | US4806341 | US5069909 | US5225199 | - ROY S.D. ET AL., "Transdermal delivery of buprenorphine through cadaver skin", JOURNAL OF PHARMACEUTICAL SCIENCES, (199402), vol. 83, no. 2, pages 126 - 130 | Opposition | US4588580 | US4938759 | US4956171 | US5026556 | US5069909 | US5171576 | US5225199 | DE4237453 | US5240711 | WO9619975 | WO9836728 | WO2012065740 | - K. HEILMANN, Therapeutische Systeme, Stuttgart, Ferdinand Enke Verlag, (19840000), pages 26 - 27 , 48-53 | - K. HEILMANN, Therapeutische Systeme, Stuttgart, Ferdinand Enke Verlag, (19840000), pages 67 - 77 , 83-86, XP055449911 | - K. HEILMANN, Therapeutische Systeme, Stuttgart, Ferdinand Enke Verlag, (19840000), pages 104 - 106, XP055449913 | - S.F. GORDON, "Clinical experience with a seven-day estradiol transdermal system for estrogen replacement therapy", Am J Obstet Gynecol, (19950000), vol. 173, no. 3 Part 2, pages 998 - 1004, XP002953772 DOI: http://dx.doi.org/10.1016/0002-9378(95)90250-3 | - S.D. ROY et al., "TRANSDERMAL DELIVERY OF BUPRENORPHINE THROUGH CADAVER SKIN", Journal of Pharmaceutical Sciences, (19940000), vol. 83, no. 2, pages 126 - 130, XP009079712 DOI: http://dx.doi.org/10.1002/jps.2600830204 | - EMC, "BuTrans 5, 10 and 20µg/h Transdermal Patch", Summary of Product Characteristics, (20100311), URL: http://www.medicines.org.uk/EMC, XP003035774 | - "Chapter 10", H.C. ANSEL et al., Pharmaceutical Dosage Forms and Drug delivery Systems, WILLIAMS & WILKINS, (19950000), pages 357 - 372, XP055449922 | - Margetts L. et al, "Transdermal drug delivery: principles and opioid therapy", Continuing Education in Anaesthesia, Critical Care and Pain, (20071001), vol. 7, no. 5, pages 171 - 176, XP055395614 DOI: http://dx.doi.org/10.1093/bjaceaccp/mkm033 | - Guy R. H., "Current Status and Future Prospects of Transdermal Drug Delivery", Pharmaceutical Research, (19961200), vol. 13, no. 12, pages 1765 - 1769, XP009081195 DOI: http://dx.doi.org/10.1023/A:1016060403438 | - S.D. ROY et al., "Transdermal Delivery of Narcotic Analgesics: Comparative Metabolism and Permeability of Human Cadaver Skin and Hairless Mouse Skin", Journal of Pharmaceutical Sciences, (19940318), vol. 83, no. 12, pages 1723 - 1728, XP055449928 DOI: http://dx.doi.org/10.1002/jps.2600831215 | - Falbe J. et al, Römpp Chemie Lexikon, Georg Thieme Verlag, (19910000), page 3095, XP055449956 | - J.J. KUHLMAN et al., "Human Pharmacokinetics of Intravenous, Sublingual, and Buccal Buprenorphine", Journal of Analytical Toxicology, (19961001), vol. 20, no. 6, pages 369 - 378, XP008114619 | - "Chapter 3", Hadgraft J. et al, Transdermal Drug Delivery, Marcel Dekker, (19890000), pages 59 - 81, XP055449896 | - A. GÖPFERICH et al., "An improved diffusion/ compartmental model for transdermal drug delivery from a matrix-type device", International Journal of Pharmaceutics, (19910000), vol. 71, no. 3, pages 237 - 243, XP025580080 DOI: http://dx.doi.org/10.1016/0378-5173(91)90395-5 | - S. KIYOSHI et al., "Species Differences in Percutaneous Absorption of Nicorandil", Journal of Pharmaceutical Sciences, (19910200), vol. 80, no. 2, pages 104 - 107, XP055449853 DOI: http://dx.doi.org/10.1002/jps.2600800203 | - T. KAKUJI et al., "Stratum Corneum Reservoir Capacity Affecting Dynamics of Transdermal Drug Delivery", Drug Development and Industrial Pharmacy, (19880000), vol. 14, no. 4, pages 561 - 572, XP055449849 DOI: http://dx.doi.org/10.3109/03639048809151884 | - K. WALTER et al., "Pharmacokinetics of physostigmine in man following a single application of a transdermal system", Br J clin Pharmac, (19950100), vol. 39, pages 59 - 63, XP055449846 DOI: http://dx.doi.org/10.1111/j.1365-2125.1995.tb04410.x | - WILDING et al., "Pharmacokinetic evaluation of transdermal buprenorphine in man", International Journal of Pharmaceutics, (19960400), vol. 132, no. 1-2, pages 81 - 87, XP055449841 DOI: http://dx.doi.org/10.1016/0378-5173(96)85198-2 |