blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP1861359

EP1861359 - N-(N-SULFONYLAMINOMETHYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF PAIN [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  20.09.2013
Database last updated on 02.11.2024
Most recent event   Tooltip01.07.2016Lapse of the patent in a contracting state
New state(s): IS		published on 03.08.2016  [2016/31]
Applicant(s)For all designated states
Pfizer Inc.
235 East 42nd Street
New York, NY 10017 / US
[2012/46]
Former [2007/49]For all designated states
Pfizer, Inc.
235 East 42nd Street
New York, NY 10017 / US
Inventor(s)01 / HANAZAWA, Takeshi
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
02 / HIRANO, Misato
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
03 / INOUE, Tadashi
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
04 / NAGAYAMA, Satoshi
Pfizer Global Res. and Dev., 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
05 / NAKAO, Kazunari
Pfizer Global Res. and Dev.
Ramsgate Road
Sandwich Kent CT13 9NJ / GB
06 / SHISHIDO, Yuji
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
07 / TANAKA, Hirotaka
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
 [2012/46]
Former [2008/16]01 / HANAZAWA, Takeshi
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
02 / HIRANO, Misato
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
03 / INOUE, Tadashi
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
04 / NAGAYAMA, Satoshi
Pfizer Global Res. and Dev., 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
05 / NAKAO, Kazunari
Pfizer Global Res. and Dev. Ramsgate Road
Sandwich Kent CT13 9NJ / GB
06 / SHISHIDO, Yuji
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
07 / TANAKA, Hirotaka
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
Former [2007/49]01 / HANAZAWA, Takeshi
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
02 / HIRANO, Misato
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
03 / INOUE, Tadashi
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
04 / NAGAYAMA, Satoshi
Pfizer Global Res. and Dev., 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
05 / NAKAO, Kazunari
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
06 / SHISHIDO, Yuji
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
07 / TANAKA, Hirotaka
Pfizer Global Res. and Dev. 2, Aza 5-gochi
Taketoyo-cho, Chita-gun, Aichi-ken 470-2393 / JP
Representative(s)Pfizer
European Patent Department
23-25 avenue du Docteur Lannelongue
75668 Paris Cedex 14 / FR
[2012/32]
Former [2012/09]Lane, Graham Mark Hamilton, et al
Pfizer
European Patent Department
23-25, avenue du Docteur Lannelongue
75668 Paris Cedex 14 / FR
Former [2007/49]Hodge, Emma Jane, et al
Pfizer Limited European Patent Department Ramsgate Road
Sandwich, Kent CT13 9NJ / GB
Application number, filing date06710543.707.03.2006
[2007/49]
WO2006IB00557
Priority number, dateUS20050663374P17.03.2005         Original published format: US 663374 P
US20050699800P15.07.2005         Original published format: US 699800 P
US20050733651P04.11.2005         Original published format: US 733651 P
[2007/49]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2006097817
Date:21.09.2006
Language:EN
[2006/38]
Type: A1 Application with search report 
No.:EP1861359
Date:05.12.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 21.09.2006 takes the place of the publication of the European patent application.
[2007/49]
Type: B1 Patent specification 
No.:EP1861359
Date:14.11.2012
Language:EN
[2012/46]
Search report(s)International search report - published on:EP21.09.2006
ClassificationIPC:C07C311/08, C07C317/44, C07C323/62, C07D213/56, C07D213/74, C07D213/76, A61P29/00, A61K31/145, A61K31/44
[2007/49]
CPC:
C07C61/28 (EP,US); C07C311/08 (EP,KR,US); A61P1/00 (EP);
A61P1/02 (EP); A61P1/04 (EP); A61P1/08 (EP);
A61P11/00 (EP); A61P11/06 (EP); A61P11/08 (EP);
A61P11/14 (EP); A61P13/10 (EP); A61P19/00 (EP);
A61P19/02 (EP); A61P25/00 (EP); A61P25/02 (EP);
A61P25/06 (EP); A61P25/08 (EP); A61P25/16 (EP);
A61P27/16 (EP); A61P29/00 (EP); A61P3/02 (EP);
A61P3/04 (EP); A61P37/08 (EP); A61P43/00 (EP);
A61P5/14 (EP); A61P9/10 (EP); C07C317/44 (EP,KR,US);
C07C323/62 (EP,KR,US); C07C61/40 (EP,US); C07D213/26 (EP,US);
C07D213/56 (EP,KR,US); C07D213/74 (EP,US); C07D213/76 (EP,US);
C07C2601/02 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/49]
Extension statesAL17.10.2007
BA17.10.2007
HR17.10.2007
MK17.10.2007
YU17.10.2007
TitleGerman:FÜR DIE BEHANDLUNG VON SCHMERZEN GEEIGNETE N-(N-SULFONYLAMINOMETHYL)CYCLOPROPANCARBONSÄURE-AMIDDERIVATE[2007/49]
English:N-(N-SULFONYLAMINOMETHYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF PAIN[2007/49]
French:DERIVES DE N-(N-SULFONYLAMINOMETHYL)CYCLOPROPANECARBOXAMIDE UTILISES POUR TRAITER UNE DOULEUR[2007/49]
Entry into regional phase17.10.2007National basic fee paid 
17.10.2007Designation fee(s) paid 
17.10.2007Examination fee paid 
Examination procedure13.04.2006Request for preliminary examination filed
International Preliminary Examining Authority: EP
03.10.2007Amendment by applicant (claims and/or description)
17.10.2007Examination requested  [2007/49]
03.03.2010Despatch of a communication from the examining division (Time limit: M04)
24.06.2010Reply to a communication from the examining division
22.09.2010Despatch of a communication from the examining division (Time limit: M02)
17.11.2010Reply to a communication from the examining division
18.06.2012Communication of intention to grant the patent
04.10.2012Fee for grant paid
04.10.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  03.03.2010
Opposition(s)15.08.2013No opposition filed within time limit [2013/43]
Fees paidRenewal fee
10.03.2008Renewal fee patent year 03
06.03.2009Renewal fee patent year 04
31.03.2010Renewal fee patent year 05
31.03.2011Renewal fee patent year 06
31.03.2012Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.03.2006
AT14.11.2012
BE14.11.2012
CY14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
IS14.11.2012
IT14.11.2012
LT14.11.2012
LV14.11.2012
NL14.11.2012
PL14.11.2012
RO14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
TR14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
GB07.03.2013
IE07.03.2013
LU07.03.2013
PT14.03.2013
CH31.03.2013
LI31.03.2013
MC31.03.2013
FR02.04.2013
[2016/31]
Former [2015/34]HU07.03.2006
AT14.11.2012
BE14.11.2012
CY14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
IT14.11.2012
LT14.11.2012
LV14.11.2012
NL14.11.2012
PL14.11.2012
RO14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
TR14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
GB07.03.2013
IE07.03.2013
LU07.03.2013
PT14.03.2013
CH31.03.2013
LI31.03.2013
MC31.03.2013
FR02.04.2013
Former [2015/32]AT14.11.2012
BE14.11.2012
CY14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
IT14.11.2012
LT14.11.2012
LV14.11.2012
NL14.11.2012
PL14.11.2012
RO14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
TR14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
GB07.03.2013
IE07.03.2013
PT14.03.2013
CH31.03.2013
LI31.03.2013
MC31.03.2013
FR02.04.2013
Former [2014/09]AT14.11.2012
BE14.11.2012
CY14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
IT14.11.2012
LT14.11.2012
LV14.11.2012
NL14.11.2012
PL14.11.2012
RO14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
GB07.03.2013
IE07.03.2013
PT14.03.2013
CH31.03.2013
LI31.03.2013
MC31.03.2013
FR02.04.2013
Former [2014/08]AT14.11.2012
BE14.11.2012
CY14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
IT14.11.2012
LT14.11.2012
LV14.11.2012
NL14.11.2012
PL14.11.2012
RO14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
IE07.03.2013
PT14.03.2013
CH31.03.2013
LI31.03.2013
MC31.03.2013
FR02.04.2013
Former [2014/07]AT14.11.2012
BE14.11.2012
CY14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
IT14.11.2012
LT14.11.2012
LV14.11.2012
NL14.11.2012
PL14.11.2012
RO14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
IE07.03.2013
PT14.03.2013
MC31.03.2013
FR02.04.2013
Former [2013/52]AT14.11.2012
BE14.11.2012
CY14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
IT14.11.2012
LT14.11.2012
LV14.11.2012
NL14.11.2012
PL14.11.2012
RO14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
PT14.03.2013
MC31.03.2013
Former [2013/47]AT14.11.2012
BE14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
IT14.11.2012
LT14.11.2012
LV14.11.2012
NL14.11.2012
PL14.11.2012
RO14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
PT14.03.2013
MC31.03.2013
Former [2013/37]AT14.11.2012
BE14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
IT14.11.2012
LT14.11.2012
LV14.11.2012
NL14.11.2012
PL14.11.2012
RO14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
PT14.03.2013
Former [2013/35]AT14.11.2012
BE14.11.2012
CZ14.11.2012
DK14.11.2012
EE14.11.2012
FI14.11.2012
LT14.11.2012
LV14.11.2012
PL14.11.2012
SE14.11.2012
SI14.11.2012
SK14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
PT14.03.2013
Former [2013/34]AT14.11.2012
BE14.11.2012
DK14.11.2012
FI14.11.2012
LT14.11.2012
LV14.11.2012
PL14.11.2012
SE14.11.2012
SI14.11.2012
BG14.02.2013
GR15.02.2013
ES25.02.2013
PT14.03.2013
Former [2013/31]AT14.11.2012
BE14.11.2012
FI14.11.2012
LT14.11.2012
LV14.11.2012
PL14.11.2012
SE14.11.2012
SI14.11.2012
GR15.02.2013
ES25.02.2013
PT14.03.2013
Former [2013/28]BE14.11.2012
FI14.11.2012
LT14.11.2012
LV14.11.2012
PL14.11.2012
SE14.11.2012
SI14.11.2012
GR15.02.2013
ES25.02.2013
PT14.03.2013
Former [2013/27]BE14.11.2012
FI14.11.2012
LT14.11.2012
LV14.11.2012
PL14.11.2012
SE14.11.2012
SI14.11.2012
GR15.02.2013
ES25.02.2013
Former [2013/26]FI14.11.2012
LT14.11.2012
LV14.11.2012
PL14.11.2012
SE14.11.2012
SI14.11.2012
GR15.02.2013
ES25.02.2013
Former [2013/24]FI14.11.2012
LT14.11.2012
LV14.11.2012
PL14.11.2012
SE14.11.2012
GR15.02.2013
ES25.02.2013
Former [2013/23]FI14.11.2012
LT14.11.2012
LV14.11.2012
PL14.11.2012
SE14.11.2012
ES25.02.2013
Former [2013/22]FI14.11.2012
LT14.11.2012
SE14.11.2012
ES25.02.2013
Former [2013/21]LT14.11.2012
SE14.11.2012
Former [2013/20]LT14.11.2012
Cited inInternational search[X]JPS565435  ;
 [XD]WO0216318  (PACIFIC CORP [KR], et al) [XD] 18 * page 34; compound 21.6 * * pages 21,38,39; compound 3.4 * * page 24; compound 8.3 * * page 44; compound 36.6 *;
 [X]US2003153596  (SUH YOUNG GER [KR], et al) [X] 18 * pages 6,16; compound 3.4 * * page 8; compound 8.3 * * page 8; compounds 9D,9E; sequence 9 * * page 19; compound 36.3 *;
 [ADX]WO2004047738  (BRISTOL MYERS SQUIBB CO [US]) [AD] 1,11,13,15-18 * page 22; sequence 3 * * page 27; sequence 6 * [X] 19;
 [ADX]WO2005003084  (DIGITALBIOTECH CO LTD [KR], et al) [AD] 1,11,13,15-17,19 * page 25; compounds 13.11,13.12 * * page 26; compounds 14.3,14.4 * * page 28; compounds 17.2,17.5 * * page 30; compounds 20.8,20.9 * * page 31; compounds 21.4-21.6 * [X] 18;
 [X]WO2005007614  (US GOV HEALTH & HUMAN SERV [US], et al) [X] 19 * page 32 - page 33; example 15; compounds CIS-MN8 *;
 [X]  - YOUNG-GER SUH ET ALL., "Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2003), vol. 13, pages 4389 - 4396, XP002385177 [X] 18 * page 4391; compound 4; sequence 1 *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2003.09.024
 [X]  - HEE-DOO KIM ET ALL, "Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2004), vol. 14, pages 1751 - 1755, XP002385178 [X] 18 * page 1753; compound 25; sequence 3 *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2003.10.042
 [X]  - JEEWOO LEE ET ALL, "N-(3-Acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea Analogues: Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid Receptor", J. MED. CHEM., (2003), vol. 46, pages 3116 - 3126, XP002385179 [X] 18 * page 3118; compounds 13-16,34,35; sequences 1,4 *

DOI:   http://dx.doi.org/10.1021/jm030089u
 [X]  - JEEWOO LEE ET ALL, "Analysis of structure-activity relationships with the N-(3-acyloxy-2- benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism", BIOORGANIC & MEDICINAL CHEMISTRY, (2004), vol. 12, page 3420, XP002385180 [X] 18 * page 3413; compound 5; sequence 1 *
 [X]  - RODRIQUES ET AL, "A Novel route to Cyclo}ropyl Ketones, Aldehydes, and Carboxylic acids", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, (1991), vol. 32, no. 10, ISSN 0040-4039, pages 1275 - 1278, XP002987399 [X] 19 * page 1277; table 2 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)79644-4
 [X]  - PATENT ABSTRACTS OF JAPAN, (19810415), vol. 005, no. 054, Database accession no. (C - 050), & JP56005435 A 19810120 (NISSAN CHEM IND LTD) [X] 19 * page 235; compounds 1-15 *
 [X]  - KENNETH A. JACOBSON ET ALL, "Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands", BIOORGANIC & MEDICINAL CHEMISTRY, (2004), vol. 12, pages 2021 - 2034, XP002385181 [X] 19 * page 2030; compound 40; sequence 1 *

DOI:   http://dx.doi.org/10.1016/j.bmc.2004.02.037
by applicantUS3526634
 JPS56535
 EP0188887
 WO9111172
 JPH05262698
 WO9402518
 WO9855148
 WO0035298
 US6106864
 WO0216318
 US2003153596
 WO2004047738
 WO2004074270
 WO2005003084
 WO2005007614
    - EUROPEAN JOURNAL OF PHYSIOLOGY, (2005), vol. 451, pages 151 - 159
    - CLINICAL THERAPEUTICS., (1991), vol. 13, no. 3, pages 338 - 395
    - JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, (2005), vol. 314, pages 410 - 421
    - NEUROSCIENCE LETTER, (2005), vol. 388, pages 75 - 80
    - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2003), vol. 13, pages 4389 - 4393
    - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2004), vol. 14, pages 1751 - 1755
    - J. MED. CHEM., (2003), vol. 46, pages 3116 - 3126
    - BIOORGANIC & MEDICINAL CHEMISTRY, (2004), vol. 12, pages 3411 - 3420
    - TETRAHEDRON LETTERS, (1991), vol. 32, no. 10, pages 1275 - 1278
    - BIOORGANIC & MEDICINAL CHEMISTRY, (2004), vol. 12, pages 2021 - 2034
    - JOURNAL OF THE CHEMICAL SOCIETY.PERKIN TRANSACTIONS2: PHYSICAL ORGANIC CHEMISTRY, (1982), vol. 1, pages 25 - 29
    - CHEMISCHE BERICHTE, (1983), vol. 116, no. 1, pages 220 - 229
    - MILLAN, PROG. NEUROBIOL., (1999), vol. 57, pages 1 - 164
    - WOOLF; SALTER, SCIENCE, (2000), vol. 288, pages 1765 - 1768
    - MEYER ET AL., TEXTBOOK OF PAIN, (1994), pages 13 - 44
    - WOOLF; MANNION, LANCET, (1999), vol. 353, pages 1959 - 1964
    - WOOLF; DECOSTERD, PAIN SUPP., (1999), vol. 6, pages S141 - S147
    - LEVINE; TAIWO, TEXTBOOK OF PAIN, (1994), pages 45 - 56
    - GRENNAN; JAYSON, TEXTBOOK OF PAIN, (1994), pages 397 - 407
    - HOUGE; MERSFELDER, ANN PHARMACOTHER., (2002), vol. 36, pages 679 - 686
    - MCCARTHY ET AL., TEXTBOOK OF PAIN, (1994), pages 387 - 395
    - BUCHWALD, S.L., JOURNAL OF AMERICAN CHEMICAL SOCIETY, (2002), vol. 124, pages 6043 - 6048
    - D. COGAN, JOURNAL OF AMERICAN CHEMICAL SOCIETY, (1999), vol. 121, pages 268 - 269
    - KOSTSOVA, A. G.; TKACHENKO, N. N.; EVESEEVA, I.I., ZHURNAL OBSHCHEI KHIMII, (1961), vol. 31, pages 2241 - 6
    - THE JOURNAL ARTICLE; NATURE, (1997), vol. 389, pages 816 - 824
    - BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (2002), vol. 291, pages 124 - 129
    - NAT. BIOTECHNOL., (2001), vol. 19, pages 440 - 445
    - BENNETT, G.J.; XIE, Y.K., PAIN, (1988), vol. 33, pages 87 - 107
    - SHIYIN YEE, PHARMACEUTICAL RESEARCH, (1997), vol. 763
    - Z.ZHOU ET AL., BIOPHYSICAL JOURNAL, (1998), vol. 74, pages 230 - 241
    - LIANG; CHEN, EXPERT OPINION IN THERAPEUTIC PATENTS, (2001), vol. 11, no. 6, pages 981 - 986
    - VERMA ET AL., PHARMACEUTICAL TECHNOLOGY ON-LINE, (2001), vol. 25, no. 2, pages 1 - 14
    - FINNIN; MORGAN, J PHARM SCI, (199910), vol. 88, no. 10, pages 955 - 958
    - JOURNAL OF MEDICINAL CHEMISTRY, (2005), vol. 48, pages 71 - 90
    - ORG. LETT., (2002), vol. 4, no. 1, pages 107 - 109
    - "Journal of Chemical Research", SYNOPSES, (1978), vol. 7, page 246
    - ORG. LETT., (2002), vol. 4, page 107
    - TETRAHEDRON, (2003), vol. 59, no. 17, pages 2999 - 3002
    - JOURNAL OF ORGANIC CHEMISTRY, (1997), vol. 62, no. 26, pages 9114 - 9122
    - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2004), vol. 14, no. 7, pages 1751 - 1755
    - J. MED. CHEM., (2005), vol. 48, pages 71 - 90
    - TETRAHEDRON, (1965), vol. 21, pages 2453 - 2467
    - CAN.J.CHEM., (2000), vol. 78, pages 1081 - 1088
    - J. MED. CHEM., (2005), vol. 48, page 71
    - JORNAL OF MEDICINAL CHEMISTRY, (2005), vol. 48, pages 71 - 90
    - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (2001), vol. 48, pages 2447 - 2462
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.