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EP1851339
European procedure
Extract from the Register of European Patents
EP Citations: EP1851339
| Cited in | Search | Type: | Non-patent literature | Publication information: | [Y] - BLENCKE STEPHANIE ET AL, "Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 25 APR 2003, (20030425), vol. 278, no. 17, ISSN 0021-9258, pages 15435 - 15440, XP009114694 [Y] 1,2,7-26 * the whole document * | DOI: | http://dx.doi.org/10.1074/jbc.M211158200 | Type: | Non-patent literature | Publication information: | [Y] - BLENCKE STEPHANIE ET AL, "Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors.", CHEMISTRY & BIOLOGY MAY 2004, (200405), vol. 11, no. 5, ISSN 1074-5521, pages 691 - 701, XP009114660 [Y] 1,2,7-26 * the whole document * | DOI: | http://dx.doi.org/10.1016/j.chembiol.2004.02.029 | Type: | Non-patent literature | Publication information: | [Y] - MARCHETTI A ET AL, "EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, (20050201), vol. 23, no. 4, ISSN 0732-183X, pages 857 - 865, XP002369910 [Y] 1,2,7-26 * page 856, column L * | DOI: | http://dx.doi.org/10.1200/JCO.2005.08.043 | Type: | Non-patent literature | Publication information: | [Y] - RUSSOM A ET AL, "Single nucleotide polymorphism analysis by allele-specific primer extension with real-time bioluminescence detection in a microfluidic device", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, (20031003), vol. 1014, no. 1-2, ISSN 0021-9673, pages 37 - 45, XP004456338 [Y] 3-6 * the whole document * | DOI: | http://dx.doi.org/10.1016/S0021-9673(03)01033-1 | Type: | Non-patent literature | Publication information: | [Y] - PASTINEN T ET AL, "A SYSTEM FOR SPECIFIC, HIGH-THROUGPUT GENOTYPING BY ALLELE-SPECIFIC PRIMER EXTENSION ON MICROARRAYS", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, WOODBURY, NY, US, (20000701), vol. 10, no. 7, ISSN 1088-9051, pages 1031 - 1042, XP008013561 [Y] 3-6 * the whole document * | DOI: | http://dx.doi.org/10.1101/gr.10.7.1031 | Type: | Non-patent literature | Publication information: | [Y] - UGOZZOLI L ET AL, "Detection of specific alleles by using allele-specific primer extension followed by capture on solid support", GENETIC ANALYSIS: BIOMOLECULAR ENGINEERING, ELSEVIER SCIENCE PUBLISHING, US, vol. 9, no. 4, ISSN 1050-3862, (19920801), pages 107 - 112, (19920801), XP023939232 [Y] 3-6 * the whole document * | DOI: | http://dx.doi.org/10.1016/1050-3862(92)90049-B | Type: | Non-patent literature | Publication information: | [Y] - PAEZ J G ET AL, "EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, WASHINGTON, DC, (20040604), vol. 304, no. 5676, ISSN 0036-8075, pages 1497 - 1500, XP002359959 [Y] 1,2,7-26 * the whole document * | DOI: | http://dx.doi.org/10.1126/science.1099314 | Type: | Non-patent literature | Publication information: | [Y] - LYNCH T J ET AL, "Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US, (20040520), vol. 350, no. 21, ISSN 0028-4793, pages 2129 - 2139, XP002447439 [Y] 1,2,7-26 * the whole document * | DOI: | http://dx.doi.org/10.1056/NEJMoa040938 | Cited in | International search | Type: | Patent literature | Publication No.: | US4683195
[Y] (MULLIS KARY B [US], et al); | Type: | Non-patent literature | Publication information: | [X] - ONO ET AL., "Epidermal Growth Factor Receptor", GENBANK, (19930508), Database accession no. (S50852), XP008114694 | Type: | Non-patent literature | Publication information: | [ ] - LOCUS, (19930508), page 1 | Type: | Non-patent literature | Publication information: | [A] - FREDERICK ET AL., "Diversity of Epidermal Growth Factor Receptor Mutations in Human Glioblastomas", CANCER RESEARCH, (20000301), vol. 60, pages 1383 - 1387, XP002533730 | Type: | Non-patent literature | Publication information: | [A] - SYVANEN ET AL., "From Gels to Chips: "Minisequencing" Primer Extension for Analysis of Point Mutations and Single Nucleotide Polymorphisms", HUMAN MUTATION, (1999), vol. 13, pages 1 - 10, XP009114919 | DOI: | http://dx.doi.org/10.1002/(SICI)1098-1004(1999)13:1<1::AID-HUMU1>3.0.CO;2-I | Cited in | Examination | Type: | Non-patent literature | Publication information: | - WU D Y ET AL, "ALLELE-SPECIFIC ENZYMATIC AMPLIFICATION OF BETA-GLOBIN GENOMIC DNA FOR DIAGNOSIS OF SICKLE CELL ANEMIA", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.86.8.2757, (19890401), vol. 86, ISSN 0027-8424, pages 2757 - 2760, XP002944058 | DOI: | http://dx.doi.org/10.1073/pnas.86.8.2757 | Type: | Non-patent literature | Publication information: | - RIEGER THEOPHIL ET AL, "Detection of small amounts of mutated mitochondrial DNA by allele-specific PCR (AS-PCR)", METHODS IN MOLECULAR AND CELLULAR BIOLOGY, NEW YORK, NY, US, (19930101), vol. 4, no. 3, ISSN 0898-7750, pages 121 - 127, XP009132502 | Type: | Non-patent literature | Publication information: | - BEAULIEU M ET AL, "A novel method for molecular haplotyping combining an improved AS-PCR technique with base specific cleavage of nucleic acid analyzed by mass spectrometry", POSTERS: GENOMICS, (20031101), vol. 73, no. 5, page 441, XP002338051 | Type: | Non-patent literature | Publication information: | - MERCEDES E GORRE ET AL, "Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, (20010803), vol. 293, doi:10.1126/SCIENCE.1062538, ISSN 0036-8075, pages 876 - 880, XP002508646 | DOI: | http://dx.doi.org/10.1126/science.1062538 | Type: | Non-patent literature | Publication information: | - GORRE M E ET AL, "CLINICAL RESISTANCE TO STI-571 CANCER THERAPY CAUSED BY BCR-ABL GENE MUTATION OR AMPLIFICATION", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, (20010803), vol. 293, no. 5531, doi:10.1126/SCIENCE.1062538, ISSN 0036-8075, pages 876 - 880, XP001122032 | DOI: | http://dx.doi.org/10.1126/science.1062538 | Type: | Non-patent literature | Publication information: | - ANONYMOUS, "Lung Cancer (Non-Small Cell)", AMERICAN CANCER SOCIETY, (20150304), page 82PP, URL: http://www.cancer.org/acs/groups/cid/documents/webcontent/003115-pdf.pdf, (20150709), XP055201189 | Cited in | Opposition | Type: | Patent literature | Publication No.: | US4683195
| Type: | Patent literature | Publication No.: | WO2005118876
| Type: | Patent literature | Publication No.: | WO2006091899
| Type: | Patent literature | Publication No.: | WO02102976
| Type: | Patent literature | Publication No.: | WO2005094357
| Type: | Patent literature | Publication No.: | WO2006084058
| Type: | Non-patent literature | Publication information: | - KOBAYASHI et al., "EGFR Mutation and Resistance of Non-Small- Cell Lung Cancer to Gefitinib", N Engl J Med, (20050224), vol. 352, no. 8, pages 786 - 792, XP002395764 | Type: | Non-patent literature | Publication information: | - PAO et al., "Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib is Associated with a Second Mutation in the EGFR Kinase Domain. artE73", PLOS Medicine, (20050222), vol. 2, no. Issue 3, pages 225 - 235, XP002573275 | DOI: | http://dx.doi.org/10.1371/journal.pmed.0020073 | Type: | Non-patent literature | Publication information: | - KWAK et al., "Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib", PNAS, (20050524), vol. 102, no. 21, pages 7665 - 7670, XP002499170 | DOI: | http://dx.doi.org/10.1073/pnas.0502860102 | Type: | Non-patent literature | Publication information: | - CARTER et al., "Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases", PNAS, (20050802), vol. 102, no. 31, pages 11011 - 11016, XP002440841 | DOI: | http://dx.doi.org/10.1073/pnas.0504952102 | Type: | Non-patent literature | Publication information: | - PAO et al., "EGF receptor gene mutations are common in lung cancers from ''never smokers'' and are associated with sensitivity of tumors to gefitnib and erlotinib;", PNAS, (20040000), vol. 101, no. 36, pages 13306 - 13311, XP002334314 | DOI: | http://dx.doi.org/10.1073/pnas.0405220101 | Type: | Non-patent literature | Publication information: | - LYNCH et al., "Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small- cell lung cancer to gefitinib", N Engl J Med, (20040429), vol. 350, pages 2129 - 2139, XP002447439 | DOI: | http://dx.doi.org/10.1056/NEJMoa040938 | Type: | Non-patent literature | Publication information: | - GORRE et al., "Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification;", Science, (20010803), vol. 293, no. 5531, pages 876 - 880, XP001122032 | DOI: | http://dx.doi.org/10.1126/science.1062538 | Type: | Non-patent literature | Publication information: | - BLENCKE et al., "Mutation of Threonine 766 in the Epidermal Growth Factor Receptor Reveals a Hotspot for Resistance Formation against Selective Tyrosine Kinase Inhibitors;", J. Biol. Chem., (20030425), vol. 278, no. 1, pages 15435 - 15440, XP009114694 | DOI: | http://dx.doi.org/10.1074/jbc.M211158200 | Type: | Non-patent literature | Publication information: | - BLENCKE et al., "Characterization of a Conserved Structural Determinant Controlling Protein Kinase Sensitivity to Selective Inhibitors;", Chemistry & Biology, (20040521), vol. 11, no. 5, pages 691 - 701, XP009114660 | DOI: | http://dx.doi.org/10.1016/j.chembiol.2004.02.029 | Type: | Non-patent literature | Publication information: | - VOGELSTEIN et al., "The Nature and Mechanisms of Human Gene Mutation", The Genetic Basis of Cancer, New York, pages 65 - 71, XP055355123 | Type: | Non-patent literature | Publication information: | - "Chapter 28. Nucleic Acid Structures and Manipulation", Voet & Voet, Biochemistry, (19950101), pages 887 - 888, 904-905, XP055355136 | Type: | Non-patent literature | Publication information: | - VAN DER HEIDEN et al., "Sequencing: Not Always the ''Gold Standard''", Clinical Chemistry, (20040100), vol. 50, no. 1, pages 248 - 249, XP055355145 | DOI: | http://dx.doi.org/10.1373/clinchem.2003.024604 | Type: | Non-patent literature | Publication information: | - ZHANG et al., "SNP Cutter: a comprehensive tool for SNP PCR-RFLP assay design;", Nucleic Acids Res., (20050701), vol. 33, pages W489 - W492, XP002541711 | DOI: | http://dx.doi.org/10.1093/nar/gki358 | Type: | Non-patent literature | Publication information: | - PAEZ et al., "EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy", Science, (20040604), vol. 304, no. 5676, pages 1497 - 1500, XP002359959 | DOI: | http://dx.doi.org/10.1126/science.1099314 | Type: | Non-patent literature | Publication information: | - MARCHETTI et al., "EGFR Mutations in Non-Small- Cell Lung Cancer: Analysis of a Large Series of Cases and Development of a Rapid and Sensitive Method for Diagnostic Screening With Potential Implications on Pharmacologic Treatment", Journal of Clinical Oncology, (20050201), vol. 23, no. 4, pages 857 - 865, XP002369910 | DOI: | http://dx.doi.org/10.1200/JCO.2005.08.043 | Type: | Non-patent literature | Publication information: | - Chien-Hung Gow, Jin-Yuan Shih, Yih-Leong Chang, Chong-Jen Yu, "Aquired Gefitinib-Resistantt Mutation of EGFR in a Chemonaive Lung Adenocarcinoma Harboring Gefitinib-Sensitive Mutation L858R", PLoS Medicine, (20050900), vol. 2, no. Issue 9, pages 0924 - 0925, XP055360358 | DOI: | http://dx.doi.org/http://dx.doi.org/10.1371/journal.pmed.0020269 | Type: | Non-patent literature | Publication information: | - PAO W et al., "EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib", PNAS, (20040000), vol. 101, no. 36, pages 13306 - 13311, XP002334314 | DOI: | http://dx.doi.org/10.1073/pnas.0405220101 | Type: | Non-patent literature | Publication information: | - GORRE M E et al., "CLINICAL RESISTANCE TO STI-571 CANCER THERAPY CAUSED BY BCR-ABL GENE MUTATION OR AMPLIFICATION", Science, (20010803), vol. 293, no. 5531, pages 876 - 880, XP001122032 | DOI: | http://dx.doi.org/10.1126/science.1062538 | Type: | Non-patent literature | Publication information: | - BLENCKE S et al., "Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors", Chemistry & Biology, (20040000), vol. 11, no. 5, pages 691 - 701, XP009114660 | DOI: | http://dx.doi.org/10.1016/j.chembiol.2004.02.029 | Type: | Non-patent literature | Publication information: | - BLENCKE S et al., "Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors", J. Biol. Chem., (20030425), vol. 278, pages 15435 - 15440, XP009114694 | DOI: | http://dx.doi.org/10.1074/jbc.M211158200 | Type: | Non-patent literature | Publication information: | - KOSAKA TAKAYUKI; ET AL, "Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications", Cancer Research, (20040000), vol. 64, pages 8919 - 8923, XP002369912 | DOI: | http://dx.doi.org/10.1158/0008-5472.CAN-04-2818 | Type: | Non-patent literature | Publication information: | - LYNCH T J et al., "Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib", N Engl J Med, (20040000), vol. 350, no. 21, pages 2129 - 2139, XP002359960 | DOI: | http://dx.doi.org/10.1056/NEJMoa040938 | Type: | Non-patent literature | Publication information: | - PAO W et al., "KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib", PLoS Medicine, (20050100), vol. 2, no. Issue 1, pages 0057 - 0061, XP002400935 | DOI: | http://dx.doi.org/10.1371/journal.pmed.0020017 | Type: | Non-patent literature | Publication information: | - PAO W et al., "Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain", PLoS Medicine, (20050300), vol. 2, no. Issue 3, pages 0225 - 0235, XP002359961 | DOI: | http://dx.doi.org/10.1371/journal.pmed.0020073 | Type: | Non-patent literature | Publication information: | - PAO et al., "Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib is Associated with a Second Mutation in the EGFR Kinase Domain.", PloS Mede, (20050222), vol. 2, no. 3, pages 225 - 235, XP002573275 | DOI: | http://dx.doi.org/10.1371/journal.pmed.0020073 | Type: | Non-patent literature | Publication information: | - CARTER et al., "Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases", Proc Natl Acad Sci USA, (20050802), vol. 102, no. 31, pages 11011 - 11016, XP002440841 | DOI: | http://dx.doi.org/10.1073/pnas.0504952102 | Type: | Non-patent literature | Publication information: | - PAO et al., "EGF receptor gene mutations are common in lung cancers from ''never smokers'' and are associated with sensitivity of tumors to gefitnib and erlotinib", PNAS, (20040000), vol. 101, no. 36, pages 13306 - 13311, XP002334314 | DOI: | http://dx.doi.org/10.1073/pnas.0405220101 | Type: | Non-patent literature | Publication information: | - LYNCH et al., "Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small- cell lung cancer to gefitinib", N Engl J Med, (20040000), vol. 350, no. 21, pages 2129 - 2139, XP002447439 | DOI: | http://dx.doi.org/10.1056/NEJMoa040938 | Type: | Non-patent literature | Publication information: | - GORRE et al., "Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification", SCI Reports, (20010000), vol. 293, no. 5531, pages 876 - 880, XP001122032 | DOI: | http://dx.doi.org/10.1126/science.1062538 | Type: | Non-patent literature | Publication information: | - BLENCKE et al., "Mutation of Threonine 766 in the Epidermal Growth Factor Receptor Reveals a Hotspot for Resistance Formation against Selective Tyrosine Kinase Inhibitors", J Biol Chem, (20030425), vol. 278, no. 17, pages 15435 - 15440, XP009114694 | DOI: | http://dx.doi.org/10.1074/jbc.M211158200 | Type: | Non-patent literature | Publication information: | - BLENCKE et al., "Characterization of a Conserved Structural Determinant Controlling Protein Kinase Sensitivity to Selective Inhibitors", Chem Biol, (20040521), vol. 11, no. 5, pages 691 - 701, XP009114660 | DOI: | http://dx.doi.org/10.1016/j.chembiol.2004.02.029 | Type: | Non-patent literature | Publication information: | - David N Cooper; Krawzak Michael; Antonarakis Stylianos E, "Chapter 3. The Nature and Mechanisms of Human Gene Mutation", David N Cooper; Krawzak Michael; Antonarakis Stylianos E, VOGELSTEIN et al., The Genetic Basis of Human Cancer, (19980000), pages 65 - 71, XP055355123 | Type: | Non-patent literature | Publication information: | - "Chapter 28. Nucleic Acid Structures and Manipulation", Donald Voet; Judith G Voet, Biochemistry, second edition, John Wiley & Sons, Inc., (19950000), pages 887-888, 904 - 905, XP055355136 | Type: | Non-patent literature | Publication information: | - VAN DER HEIDEN et al., "Sequencing: Not Always the ''Gold Standard''", Clin Chem, (20040101), vol. 50, no. 1, pages 248 - 249, XP055355145 | DOI: | http://dx.doi.org/10.1373/clinchem.2003.024604 | Type: | Non-patent literature | Publication information: | - ZHANG et al., "SNP Cutter: a comprehensive tool for SNP PCR-RFLP assay design", Nucleic Acids Res, (20050701), vol. 33, pages W489 - W492, XP002541711 | DOI: | http://dx.doi.org/10.1093/nar/gki358 | Type: | Non-patent literature | Publication information: | - PAEZ et al., "EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy", Sci, (20040604), vol. 304, no. 5676, pages 1497 - 1500, XP002359959 | DOI: | http://dx.doi.org/10.1126/science.1099314 | Type: | Non-patent literature | Publication information: | - MARCHETTI et al., "EGFR Mutations in Non-Small- Cell Lung Cancer: Analysis of a Large Series of Cases and Development of a Rapid and Sensitive Method for Diagnostic Screening With Potential Implications on Pharmacologic Treatment", J Clin Oncol, (20050201), vol. 23, no. 4, pages 857 - 865, XP002369910 | DOI: | http://dx.doi.org/10.1200/JCO.2005.08.043 | Type: | Non-patent literature | Publication information: | - DAUB et al., "Strategies to overcome resistance to targeted protein kinase inhibitors", Nature Rev, (20041200), vol. 3, pages 1001 - 1010, XP002552405 | DOI: | http://dx.doi.org/10.1038/nrd1579 | Type: | Non-patent literature | Publication information: | - BISHOP, "A Hot Spot for Protein Kinase Inhibitor Sensitivity", Chemistry & Biology, (20040500), vol. 11, no. 5, pages 587 - 591, XP025916609 | DOI: | http://dx.doi.org/10.1016/j.chembiol.2004.05.002 | Type: | Non-patent literature | Publication information: | - Bert M. 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NASHED et al.,, "Clinical Applications of BCR-ABL Molecular Testing in Acute Leukemia", Journal of Molecular Diagnostics, (20030500), vol. 5, no. 2, pages 63 - 72, XP055363038 | Type: | Non-patent literature | Publication information: | - SHAH et al., "MULTIPLE BCR-ABL KINASE DOMAIN MUTATIONS CONFER POLYCLONAL RESISTANCE TO THE TYROSINE KINASE INHIBITOR IMATINIB (STI571) IN CHRONIC PHASE AND BLAST CRISIS CHRONIC MYELOID LEUKEMIA", Cancer Cell, (20020800), vol. 2, pages 117 - 125, XP009005144 | DOI: | http://dx.doi.org/10.1016/S1535-6108(02)00096-X | Type: | Non-patent literature | Publication information: | - SORDELLA RAFFAELLA; ET AL, "Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways", Science, (20040000), vol. 305, no. 5687, pages 1163 - 1167, XP002447438 | DOI: | http://dx.doi.org/10.1126/science.1101637 | Type: | Non-patent literature | Publication information: | - R.K. 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