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Extract from the Register of European Patents

EP About this file: EP1846024

EP1846024 - MYCOBACTERIAL MUTANTS AFFECTING HOST APOPTOSIS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.01.2017
Database last updated on 15.07.2024
Most recent event   Tooltip06.03.2020Lapse of the patent in a contracting state
New state(s): TR		published on 08.04.2020  [2020/15]
Applicant(s)For all designated states
Albert Einstein College of Medicine, Inc.
1300 Morris Park Avenue
Bronx, NY 10461 / US
[2016/01]
Former [2007/43]For all designated states
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, a division of YESHIVA UNIVERSITY
1300 Morris Park Avenue Bronx
New York 10461 / US
Inventor(s)01 / JACOBS, William, R., Jr.
47 Iden Avenue
Pelham, New York 10803 / US
02 / PORCELLI, Steven, A.
86 Reynold Street
Bronx, New York 10461 / US
03 / BRIKEN, Volker
4312 Regalwood Terrace
Burtonsville, Maryland 20866 / US
04 / BRAUNSTEIN, Miriam
105 Marin Place
Chapel Hill, North Carolina 27516 / US
 [2007/43]
Representative(s)Paemen, Liesbet R.J., et al
De Clercq & Partners cvba Edgard Gevaertdreef 10 a
9830 Sint-Martens-Latem / BE
[2016/12]
Former [2008/46]Paemen, Liesbet R.J., et al
De Clercq, Brants & Partners E. Gevaertdreef 10 A
9830 Sint-Martens-Latem / BE
Former [2007/43]De Clercq, Ann G. Y., et al
De Clercq, Brants & Partners c.v. Edgard Gevaertdreef 10a
9830 Sint-Martens-Latem / BE
Application number, filing date06733693.312.01.2006
[2007/43]
WO2006US01132
Priority number, dateUS20050643614P12.01.2005         Original published format: US 643614 P
[2007/43]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2006076519
Date:20.07.2006
Language:EN
[2006/29]
Type: A2 Application without search report 
No.:EP1846024
Date:24.10.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 20.07.2006 takes the place of the publication of the European patent application.
[2007/43]
Type: B1 Patent specification 
No.:EP1846024
Date:23.03.2016
Language:EN
[2016/12]
Search report(s)International search report - published on:US11.12.2008
(Supplementary) European search report - dispatched on:EP01.07.2009
ClassificationIPC:A61K39/04, A61K39/02, A61K39/00, A61K49/00, C12P21/04, C07H21/04
[2009/08]
CPC:
C07K14/35 (EP,US); A61P37/04 (EP); A61K2039/522 (EP,US);
A61K48/00 (EP,US)
Former IPC [2007/43]A61K39/04, A61K48/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/12]
Former [2007/43]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:AUF EINE WIRTS-APOPTOSE EINWIRKENDE MYKOBAKTERIELLE MUTANTEN[2007/43]
English:MYCOBACTERIAL MUTANTS AFFECTING HOST APOPTOSIS[2007/43]
French:MUTANTS MYCOBACTERIENS AFECTANT L'APOPTOSE CHEZ L'HÔTE[2007/43]
Entry into regional phase10.08.2007National basic fee paid 
10.08.2007Search fee paid 
10.08.2007Designation fee(s) paid 
10.08.2007Examination fee paid 
Examination procedure10.08.2007Examination requested  [2007/43]
31.08.2009Despatch of a communication from the examining division (Time limit: M06)
25.02.2010Reply to a communication from the examining division
14.11.2011Despatch of a communication from the examining division (Time limit: M06)
16.05.2012Reply to a communication from the examining division
02.10.2013Despatch of a communication from the examining division (Time limit: M04)
29.01.2014Reply to a communication from the examining division
19.05.2014Despatch of a communication from the examining division (Time limit: M04)
19.09.2014Reply to a communication from the examining division
27.08.2015Cancellation of oral proceeding that was planned for 23.09.2015
23.09.2015Date of oral proceedings (cancelled)
24.09.2015Communication of intention to grant the patent
13.01.2016Fee for grant paid
13.01.2016Fee for publishing/printing paid
13.01.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  31.08.2009
Opposition(s)02.01.2017No opposition filed within time limit [2017/09]
Fees paidRenewal fee
14.01.2008Renewal fee patent year 03
14.01.2009Renewal fee patent year 04
22.01.2010Renewal fee patent year 05
24.01.2011Renewal fee patent year 06
25.01.2012Renewal fee patent year 07
28.01.2013Renewal fee patent year 08
30.01.2014Renewal fee patent year 09
23.01.2015Renewal fee patent year 10
27.01.2016Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU12.01.2006
AT23.03.2016
BE23.03.2016
CY23.03.2016
CZ23.03.2016
DK23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
IT23.03.2016
LT23.03.2016
LV23.03.2016
MC23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SI23.03.2016
SK23.03.2016
TR23.03.2016
BG23.06.2016
GR24.06.2016
IS23.07.2016
PT25.07.2016
[2020/15]
Former [2019/46]HU12.01.2006
AT23.03.2016
BE23.03.2016
CY23.03.2016
CZ23.03.2016
DK23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
IT23.03.2016
LT23.03.2016
LV23.03.2016
MC23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SI23.03.2016
SK23.03.2016
BG23.06.2016
GR24.06.2016
IS23.07.2016
PT25.07.2016
Former [2019/31]HU12.01.2006
AT23.03.2016
BE23.03.2016
CZ23.03.2016
DK23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
IT23.03.2016
LT23.03.2016
LV23.03.2016
MC23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SI23.03.2016
SK23.03.2016
BG23.06.2016
GR24.06.2016
IS23.07.2016
PT25.07.2016
Former [2017/47]AT23.03.2016
BE23.03.2016
CZ23.03.2016
DK23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
IT23.03.2016
LT23.03.2016
LV23.03.2016
MC23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SI23.03.2016
SK23.03.2016
BG23.06.2016
GR24.06.2016
IS23.07.2016
PT25.07.2016
Former [2017/37]AT23.03.2016
BE23.03.2016
CZ23.03.2016
DK23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
IT23.03.2016
LT23.03.2016
LV23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SI23.03.2016
SK23.03.2016
BG23.06.2016
GR24.06.2016
IS23.07.2016
PT25.07.2016
Former [2017/20]AT23.03.2016
BE23.03.2016
CZ23.03.2016
DK23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
IT23.03.2016
LT23.03.2016
LV23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SK23.03.2016
BG23.06.2016
GR24.06.2016
IS23.07.2016
PT25.07.2016
Former [2017/07]AT23.03.2016
BE23.03.2016
CZ23.03.2016
DK23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
IT23.03.2016
LT23.03.2016
LV23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SK23.03.2016
GR24.06.2016
IS23.07.2016
PT25.07.2016
Former [2017/03]AT23.03.2016
BE23.03.2016
CZ23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
IT23.03.2016
LT23.03.2016
LV23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SK23.03.2016
GR24.06.2016
IS23.07.2016
PT25.07.2016
Former [2016/51]AT23.03.2016
CZ23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
LT23.03.2016
LV23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SK23.03.2016
GR24.06.2016
IS23.07.2016
PT25.07.2016
Former [2016/50]AT23.03.2016
CZ23.03.2016
EE23.03.2016
ES23.03.2016
FI23.03.2016
LT23.03.2016
LV23.03.2016
NL23.03.2016
PL23.03.2016
RO23.03.2016
SE23.03.2016
SK23.03.2016
GR24.06.2016
IS23.07.2016
Former [2016/49]EE23.03.2016
FI23.03.2016
LT23.03.2016
LV23.03.2016
NL23.03.2016
PL23.03.2016
SE23.03.2016
GR24.06.2016
IS23.07.2016
Former [2016/48]FI23.03.2016
LT23.03.2016
LV23.03.2016
NL23.03.2016
SE23.03.2016
GR24.06.2016
IS23.07.2016
Former [2016/40]FI23.03.2016
LT23.03.2016
LV23.03.2016
NL23.03.2016
SE23.03.2016
GR24.06.2016
Former [2016/39]FI23.03.2016
LT23.03.2016
LV23.03.2016
SE23.03.2016
GR24.06.2016
Former [2016/36]FI23.03.2016
LT23.03.2016
GR24.06.2016
Former [2016/35]FI23.03.2016
GR24.06.2016
Documents cited:Search[A]WO2004067718  (UNIV EMORY [US], et al) [A] * claims 1,2,5,6 *;
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 [A]  - BRAUNSTEIN MIRIAM ET AL, "SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis.", MOLECULAR MICROBIOLOGY, (200304), vol. 48, no. 2, ISSN 0950-382X, pages 453 - 464, XP002531543 [A] 1-6,13-23,40-52,55-62 * the whole document *

DOI:   http://dx.doi.org/10.1046/j.1365-2958.2003.03438.x
 [AD]  - KRAMER KRISTINA ET AL, "Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis.", MOLECULAR BIOLOGY OF THE CELL, (200303), vol. 14, no. 3, ISSN 1059-1524, pages 848 - 857, XP002531544 [AD] 1-6,13-23,40-52,55-62 * the whole document *

DOI:   http://dx.doi.org/10.1091/MBC.E02-07-0390
 [T]  - HINCHEY JOSEPH ET AL, "Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis", JOURNAL OF CLINICAL INVESTIGATION, (200708), vol. 117, no. 8, ISSN 0021-9738, pages 2279 - 2288, XP002531545 [T] 1-6,13-23,40-52,55-62 * the whole document *

DOI:   http://dx.doi.org/10.1172/JCI31947
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DOI:   http://dx.doi.org/10.1038/sj.cdd.4400761
by applicantWO03070164
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    - BALCEWICZ-SABLINSKA, M. K.; KEANE, J.; KORNFELD, H.; REMOLD, H. G., "Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha.", JIMMUNOL, (1998), vol. 161, pages 2636 - 41
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DOI:   http://dx.doi.org/10.1126/science.282.5389.759
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DOI:   http://dx.doi.org/10.1016/j.tim.2004.12.007
    - BRAUNSTEIN, M.; GRIFFIN, T.I.; KRIAKOV, J.I.; FRIEDMAN, S.T.; GRINDLEY, N.D.; JACOBS, W.R., JR, "Identification of genes encoding exported Mycobacterium tuberculosis proteins using a Tn552'phoA in vitro transposition system", JBACTERIOL, (2000), vol. 182, pages 2732 - 2740
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DOI:   http://dx.doi.org/10.1046/j.1365-2958.2003.03438.x
    - CIARAMELLA, A ET AL., "Mycobacterial 19-kDa lipoprotein mediates Mycobacterium tuberculosis-induced apoptosis in monocytes/macrophages at early stages of infection", CELL DEATH DIFFERENTIATION, (2000), vol. 7, doi:doi:10.1038/sj.cdd.4400761, pages 1270 - 1272, XP003024738

DOI:   http://dx.doi.org/10.1038/sj.cdd.4400761
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DOI:   http://dx.doi.org/10.1054/tuld.1998.0200
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DOI:   http://dx.doi.org/10.1128/IAI.72.4.2067-2074.2004
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DOI:   http://dx.doi.org/10.1001/jama.282.7.677
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DOI:   http://dx.doi.org/10.1172/JCI24617
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    - KEANE, J.; BALCEWICZ-SABLINSKA, M.K.; REMOLD, H.G.; CHUPP, G.L.; MEEK, B.B.; FENTON, M.J.; KORNFELD, H., "Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis", INFECT IMMUN, (1997), vol. 65, pages 298 - 304
    - KEANE, J.; REMOLD, H.G.; KORNFELD, H., "Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages", JLMMUNOL, (2000), vol. 164, pages 2016 - 2020
    - KORNFELD, H. ET AL., "The role of macrophage cell death in tuberculosis", CELL DEATH DIFFERENTIATION, (1999), vol. 6, pages 71 - 78
    - KRAMER, K.; HARRINGTON, E.O.; LU, Q.; BELLAS, R.; NEWTON, J.; SHEAHAN, K.L.; ROUNDS, S., "Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis", MOL BIOL CELL, (2003), vol. 14, doi:doi:10.1091/MBC.E02-07-0390, pages 848 - 857, XP002531544

DOI:   http://dx.doi.org/10.1091/MBC.E02-07-0390
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