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Extract from the Register of European Patents

EP About this file: EP1850852

EP1850852 - USE OF SILDENAFIL, VARDENAFIL AND OTHER 5-PHOSPHODIESTERASE INHIBITORS TO ENHANCE PERMEABILITY OF THE ABNORMAL BLOOD-BRAIN BARRIER [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  14.12.2012
Database last updated on 06.07.2024
Most recent event   Tooltip14.12.2012Application deemed to be withdrawnpublished on 16.01.2013  [2013/03]
Applicant(s)For all designated states
Cedars-Sinai Medical Center
8700 Beverly Boulevard
Los Angeles, CA 90048 / US
[N/P]
Former [2007/45]For all designated states
Cedars-Sinai Medical Center
8700 Beverly Boulevard Los Angeles
California 90048 / US
Inventor(s)01 / BLACK, Keith
1233 Roberto Lane
Los Angeles, California 90077 / US
 [2007/45]
Representative(s)Wells, Andrew, et al
HGF Limited
4th Floor, Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
[N/P]
Former [2010/29]Wells, Andrew, et al
Harrison Goddard Foote 4th Floor, Merchant Exchange 17-19 Whitworth Street West
Manchester M1 5WG / GB
Former [2007/45]Banford, Paul Clifford, et al
Marks & Clerk, Sussex House, 83-85 Mosley Street
Manchester M2 3LG / GB
Application number, filing date06735574.322.02.2006
[2007/45]
WO2006US05980
Priority number, dateUS20050655075P22.02.2005         Original published format: US 655075 P
[2007/45]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2006091542
Date:31.08.2006
Language:EN
[2006/35]
Type: A2 Application without search report 
No.:EP1850852
Date:07.11.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 31.08.2006 takes the place of the publication of the European patent application.
[2007/45]
Search report(s)International search report - published on:US16.04.2009
(Supplementary) European search report - dispatched on:EP21.10.2009
ClassificationIPC:A61K31/22, A61P25/28, A61K31/44, A61K31/415
[2009/47]
CPC:
A61K31/415 (EP,US); A61K31/22 (EP,US); A61K31/519 (EP,US);
A61P25/28 (EP); A61P7/00 (EP)
Former IPC [2009/23]A01N43/42, A01N43/50, A61K31/44, A61K31/415
Former IPC [2007/45]A61K31/519
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/45]
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
MKNot yet paid
YUNot yet paid
TitleGerman:VERWENDUNG VON SILDENAFIL, VARDENAFIL UND ANDEREN 5-PHOSPHODIESTERASE-HEMMERN ZUR ERHÖHUNG DER DURCHLÄSSIGKEIT DER ABNORMALEN BLUT-HIRN-SCHRANKE[2007/45]
English:USE OF SILDENAFIL, VARDENAFIL AND OTHER 5-PHOSPHODIESTERASE INHIBITORS TO ENHANCE PERMEABILITY OF THE ABNORMAL BLOOD-BRAIN BARRIER[2007/45]
French:UTILISATION DU SILDENAFIL, DU VARDENAFIL ET D'AUTRES INHIBITEURS DE LA 5-PHOSPHODIESTERASE POUR AUGMENTER LA PERMEABILITE D'UNE BARRIERE SANG /CERVEAU ANORMALE[2007/45]
Entry into regional phase28.06.2007National basic fee paid 
28.06.2007Search fee paid 
28.06.2007Designation fee(s) paid 
28.06.2007Examination fee paid 
Examination procedure25.06.2007Amendment by applicant (claims and/or description)
28.06.2007Examination requested  [2007/45]
18.02.2010Despatch of a communication from the examining division (Time limit: M06)
05.08.2010Reply to a communication from the examining division
28.02.2012Despatch of a communication from the examining division (Time limit: M04)
11.07.2012Application deemed to be withdrawn, date of legal effect  [2013/03]
20.08.2012Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2013/03]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.02.2010
Fees paidRenewal fee
25.02.2008Renewal fee patent year 03
26.02.2009Renewal fee patent year 04
24.02.2010Renewal fee patent year 05
23.02.2011Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
29.02.201207   M06   Not yet paid
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Documents cited:Search[X]WO9924053  (UNIV CALIFORNIA [US]) [X] 1-28 * the whole document *;
 [X]  - SUGITA MASAO ET AL, "Cyclic GMP-specific phosphodiesterase inhibition and intracarotid bradykinin infusion enhances permeability into brain tumors", CANCER RESEARCH, (19980301), vol. 58, no. 5, ISSN 0008-5472, pages 914 - 920, XP002548317 [X] 1-28 * the whole document *
 [PX]  - BLACK K L ET AL, "PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1230, ISSN 0006-8993, (20080916), pages 290 - 302, (20080714), XP024521420 [PX] 1-28 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.brainres.2008.06.122
International search[Y]US2002094326  (DONAHUE J KEVIN [US], et al);
 [Y]  - PHILLIPS, B.G. ET AL., CIRCULATION, (2000), vol. 102, pages 3068 - 3073, XP008122152
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.