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Extract from the Register of European Patents

EP About this file: EP1891082

EP1891082 - NOVEL INHIBITORS OF PYRUVATE KINASE AS THERAPEUTIC AGENTS FOR CANCER [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  27.03.2009
Database last updated on 20.09.2024
Most recent event   Tooltip27.03.2009Withdrawal of applicationpublished on 29.04.2009  [2009/18]
Applicant(s)For all designated states
Leyland-Jones, Brian
1455 Sherbrooke Street West, Apt. 411
Montréal, Québec H3B 1L2 / CA
[2008/09]
Inventor(s)01 / SMITH, Brian R.
Apartment 7 1175 Baxter Street
Lasalle, Québec H8N 2S4 / CA
02 / CHAN, Tak-Hang
Suite 302 1140 Pierce Street
Montréal, Québec H3H 2K2 / CA
03 / LEYLAND-JONES, Brian
1455 Sherbrooke Street West, Apt. 411
Montréal, Québec H3B 1L2 / CA
 [2008/09]
Representative(s)Fleuchaus, Michael A., et al
Fleuchaus & Gallo Partnerschaft mbB
Patent- und Rechsanwälte
Steinerstraße 15/Haus A
81369 München / DE
[N/P]
Former [2008/38]Fleuchaus, Michael A., et al
Fleuchaus & Gallo Partnerschaft Patent- und Rechtsanwälte Sollner Strasse 36
81479 München / DE
Former [2008/09]Fleuchaus, Michael A., et al
Fleuchaus & Gallo Melchiorstrasse 42
D-81479 München / DE
Application number, filing date06741580.229.05.2006
[2008/09]
WO2006CA00871
Priority number, dateUS20050684979P27.05.2005         Original published format: US 684979 P
[2008/09]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2006125323
Date:30.11.2006
Language:EN
[2006/48]
Type: A1 Application with search report 
No.:EP1891082
Date:27.02.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 30.11.2006 takes the place of the publication of the European patent application.
[2008/09]
Search report(s)International search report - published on:CA30.11.2006
(Supplementary) European search report - dispatched on:EP21.01.2009
ClassificationIPC:C07F15/00, A61K31/661, A61K31/282, A61K31/6615, A61K31/662, A61K31/695, A61K45/06, A61P35/00, C07C305/04, C07F7/02, C07F7/08, C07F7/18, C07F9/08, C07F9/09, C07F9/141, C07F9/28, C07F9/40
[2008/09]
CPC:
C07C305/14 (EP,US); A61K31/282 (EP,US); A61K31/661 (EP,US);
A61K31/6615 (EP,US); A61K31/662 (EP,US); A61K31/695 (EP,US);
A61K45/06 (EP,US); A61P35/00 (EP); A61P35/04 (EP);
C07F9/113 (EP,US); C07F9/3891 (EP,US); C07F9/4065 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2008/09]
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
MKNot yet paid
YUNot yet paid
TitleGerman:NEUE INHIBITOREN VON PYRUVATKINASE ALS THERAPEUTISCHE MITTEL GEGEN KREBS[2008/09]
English:NOVEL INHIBITORS OF PYRUVATE KINASE AS THERAPEUTIC AGENTS FOR CANCER[2008/09]
French:NOUVEAUX INHIBITEURS DE LA PYRUVATE KINASE COMME AGENTS THERAPEUTIQUES ANTICANCEREUX[2008/09]
Entry into regional phase27.12.2007National basic fee paid 
27.12.2007Search fee paid 
27.12.2007Designation fee(s) paid 
27.12.2007Examination fee paid 
Examination procedure20.12.2006Request for preliminary examination filed
International Preliminary Examining Authority: CA
27.12.2007Examination requested  [2008/09]
29.02.2008Amendment by applicant (claims and/or description)
24.03.2009Application withdrawn by applicant  [2009/18]
Fees paidRenewal fee
30.05.2008Renewal fee patent year 03
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Documents cited:Search[A]WO9948490  (ALLOS THERAPEUTICS INC [US], et al) [A] 1 * page 3, line 14 - line 18 * * page 4, line 7 - line 8 * * table 1 * * abstract *
 [X]  - LI, YAW KUEN ET AL, "Alkylation of glyceraldehyde-3-phosphate dehydrogenase with haloacetylphosphonates. An unusual pH-dependence", BIOCHEMICAL JOURNAL , 275(3), 767-72 CODEN: BIJOAK; ISSN: 0306-3275, (1991), XP002496790 [X] 1,2,12-19 * abstract * * Introduction *
International search[X]US2956919  (BAKER JOSEPH W, et al);
 [X]US2719167  (PAUL SCHMIDT);
 [Y]US2004009981  (BEBBINGTON DAVID [GB], et al);
 [Y]US2004198750  (GREEN JEREMY [US], et al)
 [X]  - GUREVICH I.E. ET AL, "Dimethyl-3-chloroprop-1-en-2-ylphosphonate. Part 3. Alkylation of anionic O and C nucleophiles and preparation of 1-alkenyl-2-phosphonates", PHOSPHORUS, SULFUR AND SILICON AND RELATED ELEMENTS, (1999), vol. 148, pages 61 - 78, XP008075139
 [X]  - CSUK R. ET AL, "Allylphosphonates by heteroanalogous zinc-silver/graphite mediated Dreiding-Schmidt reactions", JOURNAL OF CARBOHYDRATE CHEMISTRY, (1999), vol. 18, no. 3, pages 285 - 295, XP008075142
 [X]  - KRAWCZYK H., "A convenient route to monodealkylation of diethyl phosphonates", SYNTHETIC COMMUNICATIONS, (1997), vol. 27, no. 18, pages 3151 - 3161, XP008075143

DOI:   http://dx.doi.org/10.1080/00397919708004173
 [X]  - KNOCHEL P. ET AL., "Synthese de dienes-1,4-fonctionnalises par addition de zinciques allyliques fonctionnalises sur des alcynes vrais et leur cyclisation en heterocycles ou carbocycles", J. ORGANOMETALLIC CHEMISTRY, (1986), vol. 309, no. 1-2, pages 1 - 23, XP003005332

DOI:   http://dx.doi.org/10.1016/S0022-328X(00)99569-X
 [X]  - BRITTELLI D.R., "A study of the reaction of 2-haloacyl halides with trialkyl phosphites. Synthesis of (2-substituted acyl) phosphonates", J. ORGANIC CHEMISTRY, (1985), vol. 50, no. 11, pages 1845 - 1847, XP003005333

DOI:   http://dx.doi.org/10.1021/jo00211a011
 [X]  - KNOCHEL P. ET AL., "Addition of functionalized allylic bromides to terminal alkynes", TETRAHEDRON LETTERS, (1984), vol. 25, no. 14, pages 1475 - 1478, XP003005334

DOI:   http://dx.doi.org/10.1016/S0040-4039(01)80190-8
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.