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Extract from the Register of European Patents

EP About this file: EP1866633

EP1866633 - METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  05.04.2013
Database last updated on 08.10.2024
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
Quest Diagnostics Investments Incorporated
300 Delaware Avenue
Wilmington, DE 19899 / US
[2007/51]
Inventor(s)01 / CLARKE, Nigel
862 Masters Drive
Oceanside, CA 92057 / US
02 / HOLMQUIST, Brett
21858 Bahamas
Mission Viejo, CA 92692 / US
03 / LEE, Kwang-ja
10 Apple Valley
Irvine, CA 92602 / US
04 / REITZ, Richard, E.
3710 Calle Fino Clarete
San Clemente, CA 92673 / US
 [2007/51]
Representative(s)Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte
Hamborner Straße 53
40472 Düsseldorf / DE
[N/P]
Former [2012/09]Viering, Jentschura & Partner
Kennedydamm 55/Roßstr.
40476 Düsseldorf / DE
Former [2009/36]Viering, Jentschura & Partner
Postfach 22 14 43
80504 München / DE
Former [2007/51]Viering, Jentschura & Partner
Grillparzerstrasse 14
81675 München / DE
Application number, filing date06749272.805.04.2006
[2007/51]
WO2006US12539
Priority number, dateUS2005010116606.04.2005         Original published format: US 101166
US2006038621521.03.2006         Original published format: US 386215
[2007/51]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2006107992
Date:12.10.2006
Language:EN
[2006/41]
Type: A2 Application without search report 
No.:EP1866633
Date:19.12.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 12.10.2006 takes the place of the publication of the European patent application.
[2007/51]
Type: B1 Patent specification 
No.:EP1866633
Date:30.05.2012
Language:EN
[2012/22]
Search report(s)International search report - published on:US01.03.2007
(Supplementary) European search report - dispatched on:EP02.02.2009
ClassificationIPC:G01N33/82, G01N33/68
[2009/09]
CPC:
G01N33/82 (EP,US); G01N2030/8813 (EP,US); G01N2030/8822 (EP,US);
G01N30/72 (EP,US); H01J49/004 (EP,US); Y10T436/203332 (EP,US);
Y10T436/24 (EP,US) (-)
Former IPC [2007/51]G01N24/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/51]
TitleGerman:VERFAHREN ZUM NACHWEIS VON VITAMIN-D-METABOLITEN DURCH MASSENSPEKTROMETRIE[2007/51]
English:METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY[2007/51]
French:PROCEDES POUR DETECTER DES METABOLITES DE LA VITAMINE D PAR SPECTROMETRIE DE MASSE[2007/51]
Entry into regional phase22.10.2007National basic fee paid 
22.10.2007Search fee paid 
22.10.2007Designation fee(s) paid 
22.10.2007Examination fee paid 
Examination procedure22.10.2007Examination requested  [2007/51]
20.04.2009Amendment by applicant (claims and/or description)
29.09.2009Despatch of a communication from the examining division (Time limit: M04)
23.01.2010Reply to a communication from the examining division
25.11.2011Cancellation of oral proceeding that was planned for 29.11.2011
29.11.2011Date of oral proceedings (cancelled)
14.12.2011Communication of intention to grant the patent
28.03.2012Fee for grant paid
28.03.2012Fee for publishing/printing paid
Divisional application(s)EP11184151.6  / EP2405273
EP16154623.9  / EP3032262
EP18194579.1  / EP3432001
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  29.09.2009
Opposition(s)01.03.2013No opposition filed within time limit [2013/19]
Fees paidRenewal fee
22.10.2007Renewal fee patent year 03
07.04.2009Renewal fee patent year 04
26.03.2010Renewal fee patent year 05
21.04.2011Renewal fee patent year 06
28.03.2012Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU05.04.2006
AT30.05.2012
BE30.05.2012
CY30.05.2012
CZ30.05.2012
DK30.05.2012
EE30.05.2012
FI30.05.2012
IT30.05.2012
LT30.05.2012
LV30.05.2012
MC30.05.2012
NL30.05.2012
PL30.05.2012
RO30.05.2012
SE30.05.2012
SI30.05.2012
SK30.05.2012
TR30.05.2012
BG30.08.2012
GR31.08.2012
ES10.09.2012
IS30.09.2012
PT01.10.2012
[2015/34]
Former [2015/32]AT30.05.2012
BE30.05.2012
CY30.05.2012
CZ30.05.2012
DK30.05.2012
EE30.05.2012
FI30.05.2012
IT30.05.2012
LT30.05.2012
LV30.05.2012
MC30.05.2012
NL30.05.2012
PL30.05.2012
RO30.05.2012
SE30.05.2012
SI30.05.2012
SK30.05.2012
TR30.05.2012
BG30.08.2012
GR31.08.2012
ES10.09.2012
IS30.09.2012
PT01.10.2012
Former [2014/01]AT30.05.2012
BE30.05.2012
CY30.05.2012
CZ30.05.2012
DK30.05.2012
EE30.05.2012
FI30.05.2012
IT30.05.2012
LT30.05.2012
LV30.05.2012
MC30.05.2012
NL30.05.2012
PL30.05.2012
RO30.05.2012
SE30.05.2012
SI30.05.2012
SK30.05.2012
BG30.08.2012
GR31.08.2012
ES10.09.2012
IS30.09.2012
PT01.10.2012
Former [2013/34]AT30.05.2012
BE30.05.2012
CY30.05.2012
CZ30.05.2012
DK30.05.2012
EE30.05.2012
FI30.05.2012
IT30.05.2012
LT30.05.2012
LV30.05.2012
NL30.05.2012
PL30.05.2012
RO30.05.2012
SE30.05.2012
SI30.05.2012
SK30.05.2012
BG30.08.2012
GR31.08.2012
ES10.09.2012
IS30.09.2012
PT01.10.2012
Former [2013/22]AT30.05.2012
BE30.05.2012
CY30.05.2012
CZ30.05.2012
DK30.05.2012
EE30.05.2012
FI30.05.2012
IT30.05.2012
LT30.05.2012
LV30.05.2012
NL30.05.2012
PL30.05.2012
RO30.05.2012
SE30.05.2012
SI30.05.2012
SK30.05.2012
GR31.08.2012
ES10.09.2012
IS30.09.2012
PT01.10.2012
Former [2013/13]AT30.05.2012
BE30.05.2012
CY30.05.2012
CZ30.05.2012
DK30.05.2012
EE30.05.2012
FI30.05.2012
IT30.05.2012
LT30.05.2012
LV30.05.2012
NL30.05.2012
PL30.05.2012
RO30.05.2012
SE30.05.2012
SI30.05.2012
SK30.05.2012
GR31.08.2012
IS30.09.2012
PT01.10.2012
Former [2013/11]AT30.05.2012
BE30.05.2012
CY30.05.2012
CZ30.05.2012
DK30.05.2012
EE30.05.2012
FI30.05.2012
IT30.05.2012
LT30.05.2012
LV30.05.2012
NL30.05.2012
PL30.05.2012
RO30.05.2012
SE30.05.2012
SI30.05.2012
SK30.05.2012
GR31.08.2012
IS30.09.2012
Former [2013/10]AT30.05.2012
BE30.05.2012
CY30.05.2012
CZ30.05.2012
DK30.05.2012
EE30.05.2012
FI30.05.2012
LT30.05.2012
LV30.05.2012
NL30.05.2012
RO30.05.2012
SE30.05.2012
SI30.05.2012
SK30.05.2012
GR31.08.2012
IS30.09.2012
Former [2013/09]AT30.05.2012
BE30.05.2012
CY30.05.2012
DK30.05.2012
EE30.05.2012
FI30.05.2012
LT30.05.2012
LV30.05.2012
NL30.05.2012
SE30.05.2012
SI30.05.2012
GR31.08.2012
IS30.09.2012
Former [2013/08]AT30.05.2012
BE30.05.2012
CY30.05.2012
DK30.05.2012
FI30.05.2012
LT30.05.2012
LV30.05.2012
NL30.05.2012
SE30.05.2012
SI30.05.2012
GR31.08.2012
IS30.09.2012
Former [2013/07]AT30.05.2012
BE30.05.2012
CY30.05.2012
FI30.05.2012
LT30.05.2012
LV30.05.2012
SE30.05.2012
SI30.05.2012
GR31.08.2012
IS30.09.2012
Former [2013/04]BE30.05.2012
CY30.05.2012
FI30.05.2012
LT30.05.2012
LV30.05.2012
SE30.05.2012
SI30.05.2012
GR31.08.2012
IS30.09.2012
Former [2012/51]CY30.05.2012
FI30.05.2012
LT30.05.2012
LV30.05.2012
SE30.05.2012
SI30.05.2012
GR31.08.2012
IS30.09.2012
Former [2012/50]CY30.05.2012
FI30.05.2012
LT30.05.2012
LV30.05.2012
SE30.05.2012
GR31.08.2012
IS30.09.2012
Former [2012/49]CY30.05.2012
FI30.05.2012
LT30.05.2012
SE30.05.2012
IS30.09.2012
Former [2012/48]FI30.05.2012
LT30.05.2012
SE30.05.2012
Former [2012/47]LT30.05.2012
Documents cited:Search[XY]  - TSUGAWA N ET AL, "DETERMINATION OF 25-HYDROXYVITAMIN D IN HUMAN PLASMA USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 77, ISSN 0003-2700, (20050402), pages 3001 - 3007, XP008075265 [X] 1-16,18-28 *abstract, page 3002, right-hand column, line 26 - page 3003, left-hand column, line 45* [Y] 17

DOI:   http://dx.doi.org/10.1021/ac048249c
 [XY]  - KISSMEYER A-M ET AL, "Sensitive analysis of 1alpha,25-dihydroxyvitamin D3 in biological fluids by liquid chromatography-tandem mass spectrometry", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, (20011123), vol. 935, no. 1-2, ISSN 0021-9673, pages 93 - 103, XP004322066 [X] 1-9 * abstract, page 95, right-hand column, line 27 - page 96, figure 2* [Y] 17

DOI:   http://dx.doi.org/10.1016/S0021-9673(01)00985-2
 [Y]  - JONES, G., ET AL, "Biological Activity of 1,25-Dihydroxyvitamin D2 in the Chick", BIOCHEMISTRY, (1976), vol. 15, no. 3, pages 713 - 716, XP002507929 [Y] 17 *the whole document, especially figure 2*

DOI:   http://dx.doi.org/10.1021/bi00648a040
 [A]  - WATSON D ET AL, "ANALYSIS OF VITAMIN D AND ITS METABOLITES USING THERMOSPRAY LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY", BIOMEDICAL CHROMATOGRAPHY, (19910101), vol. 5, pages 153 - 160, XP008075295 [A] 1-29 * figure 1 *

DOI:   http://dx.doi.org/10.1002/bmc.1130050404
International search[XP]  - MAUNSELL Z. ET AL., "Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3", CLINICAL CHEMISTRY, (200509), vol. 51, no. 9, pages 1683 - 1690, XP003005459

DOI:   http://dx.doi.org/10.1373/clinchem.2005.052936
 [X]  - KISSMEYER A.-M. ET AL., "Sensitive analysis of 1a,25-dihydroxyvitamin D3 in biological fluids by liquid chromatography-tandem mass spectrometry", J. CHROM. A, (2001), vol. 935, pages 93 - 103, XP004322066

DOI:   http://dx.doi.org/10.1016/S0021-9673(01)00985-2
 [X]  - YEUNG B. ET AL., "Characterization of the metabolism pathway of 1,25-dihydroxy-16-ene vitamin D3 in rat kidney by on-line high performance liquid chromatography-electrospray tandem mass spectrometry", BIOCHEM. PHARMAC., (1995), vol. 49, no. 8, pages 1099 - 1110, XP003008443

DOI:   http://dx.doi.org/10.1016/0006-2952(95)98507-6
 [Y]  - COLDWELL R.D. ET AL., "Mass fragmentographic assay for 25-hydroxyvitamin D in plasma without derivatization: enhanced sensitivity for metabolites of vitamines D2 and D3 after pre-column dehydration", J. MASS SPECTRUM, (1995), vol. 30, pages 348 - 356, XP003008442

DOI:   http://dx.doi.org/10.1002/jms.1190300218
 [Y]  - WATSON D. ET AL., "Analysis of vitamin D and its metabolites using thermospray liquid chromatography/mass spectrometry", BIOMED. CHROMAT., (1991), vol. 5, pages 153 - 160, XP008075295

DOI:   http://dx.doi.org/10.1002/bmc.1130050404
 [Y]  - HIGASHI ET AL., "Simultaneous determination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human plasma by liquid chromatography-tandem mass spectrometry employing derivatization with a Cookson-type reagent", BIOL. PHARM., (2001), vol. 24, no. 7, pages 738 - 743, XP001207196

DOI:   http://dx.doi.org/10.1248/bpb.24.738
 [Y]  - ODRZYWOLSKA M. ET AL., "Convergent synthesis, chiral HPLC, and vitamin D receptor affinity of analogs of 1,25-dihydroxycholecalciferol", CHIRALITY, (1999), vol. 11, pages 249 - 255, XP009014323

DOI:   http://dx.doi.org/10.1002/(SICI)1520-636X(1999)11:3<249::AID-CHIR12>3.0.CO;2-V
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.