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Extract from the Register of European Patents

EP About this file: EP1888749

EP1888749 - OLIGONUCLEOTIDES FOR RNA INTERFERENCE AND BIOLOGICAL APPLICATIONS THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  21.08.2015
Database last updated on 02.11.2024
Most recent event   Tooltip13.10.2017Lapse of the patent in a contracting state
New state(s): BG, HU, TR		published on 15.11.2017  [2017/46]
Applicant(s)For all designated states
POLYPLUS TRANSFECTION
Bioparc, BP 90018
Boulevard Sébastien Brandt
67401 Illkirch / FR
[2013/31]
Former [2008/08]For all designated states
Polyplus-Transfection SA
Boulevard Sébastien Brandt Bioparc BP 90018
67401 Illkirch / FR
Inventor(s)01 / BEHR, Jean-Paul
7, Rue Eugénie
F-67100 Strasbourg / FR
02 / BOLCATO BELLEMIN, Anne-Laure
39, Rue Du Markstein
F-67100 Strasbourg / FR
03 / ERBACHER, Patrick
6, Rue Pont Neuf
F-67230 Benfeld / FR
 [2008/08]
Representative(s)Paris, Fabienne
Ernest Gutmann - Yves Plasseraud S.A.S.
3, rue Auber
75009 Paris / FR
[2014/42]
Former [2013/04]Paris, Fabienne
Ernest Gutmann - Yves Plasseraud S.A.S. 3, rue Auber
75009 Paris / FR
Former [2012/32]Desaix, Anne
Ernest Gutmann - Yves Plasseraud S.A.S. 3, rue Auber
75009 Paris / FR
Former [2008/08]Peaucelle, Chantal
Cabinet Armengaud Aîné 3, Avenue Bugeaud
75116 Paris / FR
Application number, filing date06754634.101.06.2006
[2008/08]
WO2006EP06340
Priority number, dateUS20050686010P01.06.2005         Original published format: US 686010 P
[2008/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2006128739
Date:07.12.2006
Language:EN
[2006/49]
Type: A1 Application with search report 
No.:EP1888749
Date:20.02.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 07.12.2006 takes the place of the publication of the European patent application.
[2008/08]
Type: B1 Patent specification 
No.:EP1888749
Date:15.10.2014
Language:EN
[2014/42]
Search report(s)International search report - published on:EP07.12.2006
ClassificationIPC:C12N15/113, A61K31/713
[2014/19]
CPC:
C12N15/113 (EP,US); A61K31/713 (EP,US); A61K47/34 (US);
A61P31/12 (EP); A61P35/00 (EP); C12N15/111 (EP,US);
C12N2310/14 (EP,US); C12N2310/51 (EP,US); C12N2320/30 (US);
C12N2320/51 (EP,US); C12N2320/52 (EP,US) (-)
Former IPC [2008/08]C12N15/11, A61K31/713
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2008/08]
TitleGerman:OLIGONUKLEOTIDE FÜR RNA-INTERFERENZ UND BIOLOGISCHE ANWENDUNGEN DAVON[2008/08]
English:OLIGONUCLEOTIDES FOR RNA INTERFERENCE AND BIOLOGICAL APPLICATIONS THEREOF[2008/08]
French:OLIGONUCLÉOTIDES POUR INTERFÉRENCE ARN ET APPLICATIONS BIOLOGIQUES ASSOCIÉES[2008/08]
Entry into regional phase27.11.2007National basic fee paid 
27.11.2007Designation fee(s) paid 
27.11.2007Examination fee paid 
Examination procedure27.11.2007Examination requested  [2008/08]
04.11.2008Despatch of a communication from the examining division (Time limit: M06)
11.05.2009Reply to a communication from the examining division
14.01.2010Despatch of a communication from the examining division (Time limit: M06)
23.07.2010Reply to a communication from the examining division
29.12.2011Despatch of a communication from the examining division (Time limit: M04)
16.03.2012Reply to a communication from the examining division
21.11.2012Despatch of a communication from the examining division (Time limit: M06)
27.05.2013Reply to a communication from the examining division
20.09.2013Despatch of a communication from the examining division (Time limit: M06)
20.03.2014Reply to a communication from the examining division
26.05.2014Communication of intention to grant the patent
08.09.2014Fee for grant paid
08.09.2014Fee for publishing/printing paid
08.09.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.11.2008
Opposition(s)16.07.2015No opposition filed within time limit [2015/39]
Fees paidRenewal fee
10.03.2008Renewal fee patent year 03
23.04.2009Renewal fee patent year 04
03.05.2010Renewal fee patent year 05
12.04.2011Renewal fee patent year 06
16.04.2012Renewal fee patent year 07
23.05.2013Renewal fee patent year 08
20.05.2014Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.06.2006
AT15.10.2014
BG15.10.2014
CY15.10.2014
CZ15.10.2014
EE15.10.2014
ES15.10.2014
FI15.10.2014
IT15.10.2014
LT15.10.2014
LV15.10.2014
MC15.10.2014
PL15.10.2014
RO15.10.2014
SI15.10.2014
SK15.10.2014
TR15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
IE01.06.2015
LU01.06.2015
[2017/39]
Former [2016/20]AT15.10.2014
CY15.10.2014
CZ15.10.2014
EE15.10.2014
ES15.10.2014
FI15.10.2014
IT15.10.2014
LT15.10.2014
LV15.10.2014
MC15.10.2014
PL15.10.2014
RO15.10.2014
SI15.10.2014
SK15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
IE01.06.2015
LU01.06.2015
Former [2016/11]AT15.10.2014
CY15.10.2014
CZ15.10.2014
EE15.10.2014
ES15.10.2014
FI15.10.2014
IT15.10.2014
LT15.10.2014
LV15.10.2014
MC15.10.2014
PL15.10.2014
RO15.10.2014
SI15.10.2014
SK15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
LU01.06.2015
Former [2016/09]AT15.10.2014
CY15.10.2014
CZ15.10.2014
EE15.10.2014
ES15.10.2014
FI15.10.2014
IT15.10.2014
LT15.10.2014
LV15.10.2014
MC15.10.2014
PL15.10.2014
RO15.10.2014
SK15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
Former [2015/37]AT15.10.2014
CY15.10.2014
CZ15.10.2014
EE15.10.2014
ES15.10.2014
FI15.10.2014
IT15.10.2014
LT15.10.2014
LV15.10.2014
PL15.10.2014
RO15.10.2014
SK15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
Former [2015/36]AT15.10.2014
CY15.10.2014
CZ15.10.2014
EE15.10.2014
ES15.10.2014
FI15.10.2014
LT15.10.2014
LV15.10.2014
PL15.10.2014
RO15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
Former [2015/35]AT15.10.2014
CY15.10.2014
EE15.10.2014
ES15.10.2014
FI15.10.2014
LT15.10.2014
LV15.10.2014
PL15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
Former [2015/26]AT15.10.2014
CY15.10.2014
ES15.10.2014
FI15.10.2014
LT15.10.2014
LV15.10.2014
PL15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
Former [2015/25]AT15.10.2014
ES15.10.2014
FI15.10.2014
LT15.10.2014
LV15.10.2014
PL15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
Former [2015/24]ES15.10.2014
FI15.10.2014
LT15.10.2014
LV15.10.2014
PL15.10.2014
GR16.01.2015
IS15.02.2015
PT16.02.2015
Former [2015/23]ES15.10.2014
FI15.10.2014
LT15.10.2014
IS15.02.2015
PT16.02.2015
Former [2015/22]LT15.10.2014
PT16.02.2015
Former [2015/20]LT15.10.2014
Cited inInternational search[A]  - ELBASHIR S.M. ET AL., "RNA interference is mediated by 21- and 22-nucleotide RNAs", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY, US, (20010115), vol. 15, no. 2, ISSN 0890-9369, pages 188 - 200, XP002204651 [A] * the whole document *

DOI:   http://dx.doi.org/10.1101/gad.862301
 [A]  - ELBASHIR S.M. ET AL., "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, (20011203), vol. 20, no. 23, ISSN 0261-4189, pages 6877 - 6888, XP002225998 [A] * the whole document *

DOI:   http://dx.doi.org/10.1093/emboj/20.23.6877
 [A]  - VERMEULEN A. ET AL., "The contributions of dsRNA structure to Dicer specificity and efficiency", RNA, (20050405), vol. 11, pages 674 - 682, XP002403258 [A] * the whole document *

DOI:   http://dx.doi.org/10.1261/rna.7272305
Examination   - SARKAR T ET AL, "Condensation of oligonucleotides assembled into nicked and gapped duplexes: potential structures for oligonucleotide delivery", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD, (20050101), vol. 33, no. 1, doi:10.1093/NAR/GKI156, ISSN 0305-1048, pages 143 - 151, XP002471390

DOI:   http://dx.doi.org/10.1093/nar/gki156
by applicantWO0244321
 WO0175164
    - ELBASHIR, SM ET AL., "Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture", NATURE, (2001), vol. 411, pages 494 - 498
    - ELBASHIR, SM ET AL., "RNA interference is mediated by 21 and 22 nt RNAs", GENES & DEV., (2001), vol. 15, pages 188 - 200
    - FIRE, A., "RNA-triggered gene silencing", TRENDS GENET, (1999), vol. 15, pages 358 - 363
    - GE, Q ET AL., "Inhibition of influenza virus production in virus infected mice by RNA interference", PNAS, (2004), vol. 101, pages 8676 - 8681
    - GUAN, H., "A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model", CLIN CANCER RES, (2005), vol. 7, pages 2662 - 2669
    - HAMMOND, SM ET AL., "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells", NATURE, (2000), vol. 404, pages 363 - 366
    - JEPSEN JS; WENGEL J., "LNA-antisense rivals siRNA for gene silencing", CURR OPIN DRUG DISCOV DEVEL, (2004), vol. 7, no. 2, pages 188 - 94
    - KIM, DH ET AL., "Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy", NATURE BIOTECH., (2005), vol. 23, pages 222 - 226
    - KURRECK J., "Antisense technologies. Improvement through novel chemical modifications", EUR J BIOCHEM., (2003), vol. 270, no. 8, pages 1628 - 44
    - MILLER PS., "Oligonucleoside methylphosphonates as antisense reagents", BIOTECHNOLOGY, (1991), vol. 9, no. 4, pages 358 - 62
    - PAL, A. ET AL., "Systemic delivery if RafsiRNA using cationic cardiolipin liposomes silences Raf-I expression and inhibits tumor growth in xenograft model of human prostate cancer", INT J ONCOL, (2005), vol. 26, pages 1087 - 91
    - PARRISH, S. ET AL., "Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strand in RNA interference", MOL CELL, (2000), vol. 6, pages 1077 - 1087
    - SIOLAS, D ET AL., "Synthetic shRNAs as potent RNAi triggers", NATURE BIOTECH., (2005), vol. 23, pages 227 - 231
    - TUSCHL, T., "RNA interference and small interfering RNAs", CHEMBIOCHEM, (2001), vol. 2, pages 239 - 245
    - TUSCHL, T. ET AL., "Targeted mRNA degradation by double-stranded RNA in vitro", GENES & DEV., (1999), vol. 13, pages 3191 - 3197
    - URBAN-KLEIN, B. ET AL., "RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo", GENE THERAPY, (2004), vol. 23, pages 1 - 6
    - VERMA S; ECKSTEIN F., "Modified oligonucleotides: synthesis and strategy for users", ANNU REV BIOCHEM., (1998), vol. 67, pages 99 - 134
    - VESTER B; WENGEL J., "LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA", BIOCHEMISTRY, (2004), vol. 43, no. 42, pages 13233 - 41
    - YANG, D ET AL., "Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos", CURR BIOL., (2000), vol. 10, pages 1191 - 1200
    - ZAMORE, PD ET AL., "RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotides intervals", CELL, (2000), vol. 101, pages 25 - 33
    - ZON G; GEISER TG., "Phosphorothioate oligonucleotides: chemistry, purification, analysis, scale-up and future directions", ANTICANCER DRUG DES., (1991), vol. 6, no. 6, pages 539 - 68
 EP20010985833
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.