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Extract from the Register of European Patents

EP About this file: EP1885919

EP1885919 - GENE METHYLATION AND EXPRESSION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  20.12.2013
Database last updated on 11.09.2024
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU, LU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
Dana-Farber Cancer Institute, Inc.
450 Brookline Avenue
Boston, MA 02215 / US
[2011/46]
Former [2008/07]For all designated states
DANA-FARBER CANCER INSTITUTE, INC.
44 Binney Street
Boston, MA 02115 / US
Inventor(s)01 / POLYAK, Kornelia
1856 Beacon Street, 6f
Brookline, MA 02445-1946 / US
02 / HU, Min
10 Soden Street, Apt. 28
Cambridge, MA 02139 / US
03 / QIMRON, Noga
47 Englewood Ave. Apt. 4
Brighton, MA 02135 / US
04 / YAO, Jun
34 Gerry Road
Chestnut Hill, MA 02467 / US
 [2008/27]
Former [2008/07]01 / POLYAK, Kornelia
1856 Beacon Street, 6f
Brookline, MA 02445-1946 / US
02 / HU, Min
11A Parker Hill Avenue, 6A
Boston, MA 02120 / US
03 / QIMRON, Noga
47 Englewood Ave. Apt. 4
Brighton, MA 02135 / US
04 / YAO, Jun
34 Gerry Road
Chestnut Hill, MA 02467 / US
Representative(s)White, Martin Paul
Whites IP Ltd
24A Carnatic Road
Liverpool L18 8BZ / GB
[N/P]
Former [2013/07]White, Martin Paul
Whites IP Ltd
7 Berwick Road
Bournemouth
BH3 7BB / GB
Former [2008/07]White, Martin Paul
Patents Designs & Brands Ltd. Suite 46, Oriel Chambers 14 Water Street
Liverpool L2 8TD / GB
Application number, filing date06771539.130.05.2006
[2008/07]
WO2006US20843
Priority number, dateUS20050685104P27.05.2005         Original published format: US 685104 P
[2008/07]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2006128140
Date:30.11.2006
Language:EN
[2006/48]
Type: A2 Application without search report 
No.:EP1885919
Date:13.02.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 30.11.2006 takes the place of the publication of the European patent application.
[2008/07]
Type: B1 Patent specification 
No.:EP1885919
Date:13.02.2013
Language:EN
[2013/07]
Search report(s)International search report - published on:US27.03.2008
(Supplementary) European search report - dispatched on:EP23.09.2009
ClassificationIPC:C07H21/02, C07H21/04, C12N9/99, C12Q1/68
[2008/20]
CPC:
C12N15/1093 (EP,US); C12Q1/6855 (EP,US); C12Q1/6881 (EP,US);
C12Q2600/154 (EP,US); C12Q2600/158 (EP,US)
C-Set:
C12Q1/6855, C12Q2521/331 (EP,US)
Former IPC [2008/07]C40B30/06, C40B40/08
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2008/07]
TitleGerman:METHYLIERUNG UND EXPRESSION VON GENEN[2008/07]
English:GENE METHYLATION AND EXPRESSION[2008/07]
French:METHYLATION ET EXPRESSION DE GENES[2008/07]
Entry into regional phase20.11.2007National basic fee paid 
20.11.2007Search fee paid 
20.11.2007Designation fee(s) paid 
20.11.2007Examination fee paid 
Examination procedure20.11.2007Amendment by applicant (claims and/or description)
20.11.2007Examination requested  [2008/07]
10.11.2009Despatch of a communication from the examining division (Time limit: M06)
14.05.2010Reply to a communication from the examining division
03.11.2010Despatch of a communication from the examining division (Time limit: M06)
04.05.2011Reply to a communication from the examining division
20.09.2012Despatch of a communication from the examining division (Time limit: M02)
21.09.2012Reply to a communication from the examining division
24.09.2012Despatch of a communication from the examining division (Time limit: M02)
15.10.2012Reply to a communication from the examining division
09.11.2012Communication of intention to grant the patent
18.12.2012Fee for grant paid
18.12.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  10.11.2009
Opposition(s)14.11.2013No opposition filed within time limit [2014/04]
Fees paidRenewal fee
28.05.2008Renewal fee patent year 03
27.05.2009Renewal fee patent year 04
25.05.2010Renewal fee patent year 05
25.05.2011Renewal fee patent year 06
25.05.2012Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.05.2006
AT13.02.2013
BE13.02.2013
CY13.02.2013
CZ13.02.2013
DK13.02.2013
EE13.02.2013
FI13.02.2013
LT13.02.2013
LV13.02.2013
MC13.02.2013
NL13.02.2013
PL13.02.2013
RO13.02.2013
SE13.02.2013
SI13.02.2013
SK13.02.2013
TR13.02.2013
BG13.05.2013
GR14.05.2013
IE30.05.2013
LU30.05.2013
IS13.06.2013
PT13.06.2013
[2015/34]
Former [2015/32]AT13.02.2013
BE13.02.2013
CY13.02.2013
CZ13.02.2013
DK13.02.2013
EE13.02.2013
FI13.02.2013
LT13.02.2013
LV13.02.2013
MC13.02.2013
NL13.02.2013
PL13.02.2013
RO13.02.2013
SE13.02.2013
SI13.02.2013
SK13.02.2013
TR13.02.2013
BG13.05.2013
GR14.05.2013
IE30.05.2013
IS13.06.2013
PT13.06.2013
Former [2015/30]AT13.02.2013
BE13.02.2013
CY13.02.2013
CZ13.02.2013
DK13.02.2013
EE13.02.2013
FI13.02.2013
LT13.02.2013
LV13.02.2013
MC13.02.2013
NL13.02.2013
PL13.02.2013
RO13.02.2013
SE13.02.2013
SI13.02.2013
SK13.02.2013
BG13.05.2013
GR14.05.2013
IE30.05.2013
IS13.06.2013
PT13.06.2013
Former [2014/20]AT13.02.2013
BE13.02.2013
CZ13.02.2013
DK13.02.2013
EE13.02.2013
FI13.02.2013
LT13.02.2013
LV13.02.2013
MC13.02.2013
NL13.02.2013
PL13.02.2013
RO13.02.2013
SE13.02.2013
SI13.02.2013
SK13.02.2013
BG13.05.2013
GR14.05.2013
IE30.05.2013
IS13.06.2013
PT13.06.2013
Former [2014/03]AT13.02.2013
BE13.02.2013
CZ13.02.2013
DK13.02.2013
EE13.02.2013
FI13.02.2013
LT13.02.2013
LV13.02.2013
MC13.02.2013
NL13.02.2013
PL13.02.2013
RO13.02.2013
SE13.02.2013
SI13.02.2013
SK13.02.2013
BG13.05.2013
GR14.05.2013
IS13.06.2013
PT13.06.2013
Former [2013/49]AT13.02.2013
BE13.02.2013
CZ13.02.2013
DK13.02.2013
EE13.02.2013
FI13.02.2013
LT13.02.2013
LV13.02.2013
NL13.02.2013
PL13.02.2013
RO13.02.2013
SE13.02.2013
SI13.02.2013
SK13.02.2013
BG13.05.2013
GR14.05.2013
IS13.06.2013
PT13.06.2013
Former [2013/48]AT13.02.2013
BE13.02.2013
DK13.02.2013
EE13.02.2013
FI13.02.2013
LT13.02.2013
LV13.02.2013
NL13.02.2013
PL13.02.2013
SE13.02.2013
SI13.02.2013
BG13.05.2013
GR14.05.2013
IS13.06.2013
PT13.06.2013
Former [2013/40]AT13.02.2013
BE13.02.2013
FI13.02.2013
LT13.02.2013
LV13.02.2013
PL13.02.2013
SE13.02.2013
SI13.02.2013
BG13.05.2013
GR14.05.2013
IS13.06.2013
PT13.06.2013
Former [2013/38]AT13.02.2013
BE13.02.2013
FI13.02.2013
LT13.02.2013
LV13.02.2013
PL13.02.2013
SE13.02.2013
SI13.02.2013
BG13.05.2013
GR14.05.2013
IS13.06.2013
Former [2013/37]AT13.02.2013
FI13.02.2013
LT13.02.2013
PL13.02.2013
SE13.02.2013
SI13.02.2013
BG13.05.2013
GR14.05.2013
IS13.06.2013
Former [2013/36]AT13.02.2013
LT13.02.2013
PL13.02.2013
SE13.02.2013
BG13.05.2013
IS13.06.2013
Former [2013/34]LT13.02.2013
SE13.02.2013
BG13.05.2013
IS13.06.2013
Former [2013/33]LT13.02.2013
Documents cited:Search[X]US2004096892  (WANG TIAN-LI [US], et al) [X] 1-10 * the whole document *;
 [A]WO2004085621  (DANA FARBER CANCER INST INC [US], et al) [A] 1-10 * claims 1-77 *;
 [X]  - WANG TIAN-LI ET AL, "Digital karyotyping.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 10 DEC 2002, (20021210), vol. 99, no. 25, ISSN 0027-8424, pages 16156 - 16161, XP002545371 [X] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1073/PNAS.202610899
 [X]  - DUNN JOHN J ET AL, "Genomic signature tags (GSTs): A system for profiling genomic DNA", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, WOODBURY, NY, US, (20021101), vol. 12, no. 11, ISSN 1088-9051, pages 1756 - 1765, XP002304617 [X] 1-10 * page 1762, column 1, paragraph 1; figure 1 *
 [A]  - SIDRANSKY D, "EMERGING MOLECULAR MARKERS OF CANCER", NATURE REVIEWS. CANCER, NATUR PUBLISHING GROUP, LONDON, GB, (20020301), vol. 2, no. 3, ISSN 1474-175X, pages 210 - 219, XP008042781 [A] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1038/nrc755
 [A]  - SAHA S ET AL, "USING THE TRANSCRIPTOME TO ANNOTATE THE GENOME", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20020501), vol. 20, no. 5, ISSN 1087-0156, pages 508 - 512, XP001157218 [A] 1-10 * page 511, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1038/nbt0502-508
International search[Y]  - WANG ET AL., "Digital Karyotyping", PNAS, (2002), vol. 99, no. 25, pages 16156 - 16161, XP002545371

DOI:   http://dx.doi.org/10.1073/PNAS.202610899
 [Y]  - DAI ET AL., "An Ascl Boundary library for the studies of genetic and epigenetic alterations in CpG Islands", GENOME RESEARCH, (2002), vol. 12, pages 1591 - 1598, XP008124588

DOI:   http://dx.doi.org/10.1101/GR.197402
 [A]  - HU ET AL., "Distinct epigenetic changes in the stromal cells of breast cancers", NATURE GENETICS, (200507), vol. 37, no. 8, pages 899 - 905, XP008124589

DOI:   http://dx.doi.org/10.1038/NG1596
 [Y]  - KOMINSKY ET AL., "Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast", ONCOGENE, (2003), vol. 22, pages 2021 - 2033, XP008124590

DOI:   http://dx.doi.org/10.1038/SJ.ONC.1206199
 [X]  - SHI ET AL., "Expressed CpG Island sequence tag microarray for dual screening of DNA hypermethylation and gene silencing in cancer cells", CANCER RESEARCH, (200206), vol. 62, pages 3214 - 3220, XP002430002
 [Y]  - PAZ ET AL., "Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferase", HUMAN MOLECULAR GENETICS, (2003), vol. 12, no. 17, pages 2209 - 2219, XP002543571

DOI:   http://dx.doi.org/10.1093/hmg/ddg226
 [Y]  - EVRON ET AL., "Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation", CANCER RESEARCH, (2001), vol. 61, pages 2782 - 2787, XP008124596
 [Y]  - CANTILE ET AL., "In vivo expression of the whole HOX gene network in human breast cancer", EUROPEAN JOURNAL OF CANCER, (2003), vol. 39, pages 257 - 264, XP004400273

DOI:   http://dx.doi.org/10.1016/S0959-8049(02)00599-3
 [Y]  - UMBRICHT ET AL., "Hypermethylation of 14-3-3 (stratifin) is an early event in breast cancer", ONCOGENE, (2001), vol. 20, pages 3348 - 3353, XP008124600

DOI:   http://dx.doi.org/10.1038/sj.onc.1204438
 [Y]  - HUANG ET AL., "Methylation profiling of CpG islands in human breast cancer cells", HUMAN MOLECULAR GENETICS, (1999), vol. 8, no. 3, pages 459 - 470, XP002175857

DOI:   http://dx.doi.org/10.1093/hmg/8.3.459
Examination   - Jost J P, Saluz H P, DNA Methylation Molecular Biology and BIological Significance, Basel, Switzerland, Birkhäuser Verlag, (1992), ISBN 3-7643-2778-2
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.