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Extract from the Register of European Patents

EP About this file: EP1931709

EP1931709 - FC VARIANTS WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.10.2017
Database last updated on 24.08.2024
FormerThe patent has been granted
Status updated on  04.11.2016
Most recent event   Tooltip06.03.2020Lapse of the patent in a contracting state
New state(s): TR		published on 08.04.2020  [2020/15]
Applicant(s)For all designated states
Xencor, Inc.
111 W. Lemon Avenue
Monrovia, CA 91016 / US
[2016/49]
Former [2008/25]For all designated states
Xencor, Inc.
111 W. Lemon Avenue
Monrovia, CA 91016 / US
Inventor(s)01 / DESJARLAIS, John, R.
1030 North Michigan Avenue
Pasadena, California 91104 / US
02 / KARKI, Sher, Bahadur
2833 Providence Way
Pomona, CA 91767 / US
03 / LAZAR, Gregory, Alan
750 Arcadia Avenue, No. 6
Arcadia, California 91007 / US
04 / RICHARDS, John, Owen
893 San Marcus Lane
Duarte, CA 91010 / US
05 / MOORE, Gregory, L.
152 Acacia Avenue
Monrovia, California 91016 / US
06 / CARMICHAEL, David, Forrester
423 N, Primrose Avenue
Monrovia, CA 91016 / US
 [2008/33]
Former [2008/25]01 / DESJARLAIS, John, R.
1030 North Michigan Avenue
Pasadena, California 91104 / US
02 / KARKI, Sher, Bahadur
300 North El Molino Avenue
Pasadena, California 91101 / US
03 / LAZAR, Gregory, Alan
750 Arcadia Avenue, No. 6
Arcadia, California 91007 / US
04 / RICHARDS, John, Owen
893 San Marcus Lane
Duarte, CA 91010 / US
05 / MOORE, Gregory, L.
152 Acacia Avenue
Monrovia, California 91016 / US
06 / CARMICHAEL, David, Forrester
423 N, Primrose Avenue
Monrovia, CA 91016 / US
Representative(s)HGF
HGF Limited
Mill House
North Street
York YO1 6JD / GB
[N/P]
Former [2016/49]Taylor, Kate Laura
HGF Limited
Saviour House
9 St Saviourgate
York YO1 8NQ / GB
Former [2008/25]Kiddle, Simon John, et al
Mewburn Ellis LLP York House, 23 Kingsway
London WC2B 6HP / GB
Application number, filing date06816248.603.10.2006
[2008/25]
WO2006US38842
Priority number, dateUS20050723294P03.10.2005         Original published format: US 723294 P
US20050723335P03.10.2005         Original published format: US 723335 P
US20050739696P23.11.2005         Original published format: US 739696 P
US20050741966P02.12.2005         Original published format: US 741966 P
US20050750699P15.12.2005         Original published format: US 750699 P
US20060774358P17.02.2006         Original published format: US 774358 P
US20060779961P06.03.2006         Original published format: US 779961 P
US2006039649531.03.2006         Original published format: US 396495
US20060745078P18.04.2006         Original published format: US 745078 P
[2008/25]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2007041635
Date:12.04.2007
Language:EN
[2007/15]
Type: A2 Application without search report 
No.:EP1931709
Date:18.06.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 12.04.2007 takes the place of the publication of the European patent application.
[2008/25]
Type: B1 Patent specification 
No.:EP1931709
Date:07.12.2016
Language:EN
[2016/49]
Search report(s)International search report - published on:EP13.11.2008
ClassificationIPC:C07K16/00
[2008/25]
CPC:
C07K16/00 (EP,US); C07K16/2863 (EP,US); C07K16/2887 (EP,US);
C07K16/30 (EP,US); C07K2317/41 (EP,US); C07K2317/52 (EP,US);
C07K2317/72 (EP,US); C07K2317/732 (EP,US); C07K2317/77 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/49]
Former [2008/25]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
MKNot yet paid
RSNot yet paid
TitleGerman:FC-VARIANTEN MIT OPTIMIERTEN REZEPTORBINDUNGSEIGENSCHAFTEN[2008/25]
English:FC VARIANTS WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES[2008/25]
French:VARIANTS DE FC DOTÉS DE PROPRIÉTÉS DE LIAISON AUX RÉCEPTEURS FC OPTIMISÉES[2008/25]
Entry into regional phase27.03.2008National basic fee paid 
27.03.2008Designation fee(s) paid 
27.03.2008Examination fee paid 
Examination procedure27.03.2008Examination requested  [2008/25]
04.03.2011Despatch of a communication from the examining division (Time limit: M06)
21.10.2011Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
29.12.2011Reply to a communication from the examining division
29.01.2014Despatch of a communication from the examining division (Time limit: M06)
08.08.2014Reply to a communication from the examining division
12.02.2016Cancellation of oral proceeding that was planned for 18.02.2016
18.02.2016Date of oral proceedings (cancelled)
18.04.2016Communication of intention to grant the patent
24.08.2016Fee for grant paid
24.08.2016Fee for publishing/printing paid
24.08.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.03.2011
Opposition(s)08.09.2017No opposition filed within time limit [2017/46]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
29.12.2011Request for further processing filed
29.12.2011Full payment received (date of receipt of payment)
Request granted
17.01.2012Decision despatched
Fees paidRenewal fee
23.10.2008Renewal fee patent year 03
07.10.2009Renewal fee patent year 04
23.09.2010Renewal fee patent year 05
28.09.2011Renewal fee patent year 06
25.10.2012Renewal fee patent year 07
28.10.2013Renewal fee patent year 08
27.10.2014Renewal fee patent year 09
27.10.2015Renewal fee patent year 10
27.10.2016Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.10.2006
AT07.12.2016
BE07.12.2016
CY07.12.2016
CZ07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
PL07.12.2016
RO07.12.2016
SI07.12.2016
SK07.12.2016
TR07.12.2016
BG07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
[2020/15]
Former [2019/46]HU03.10.2006
AT07.12.2016
BE07.12.2016
CY07.12.2016
CZ07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
PL07.12.2016
RO07.12.2016
SI07.12.2016
SK07.12.2016
BG07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
Former [2019/31]HU03.10.2006
AT07.12.2016
BE07.12.2016
CZ07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
PL07.12.2016
RO07.12.2016
SI07.12.2016
SK07.12.2016
BG07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
Former [2018/29]AT07.12.2016
BE07.12.2016
CZ07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
PL07.12.2016
RO07.12.2016
SI07.12.2016
SK07.12.2016
BG07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
Former [2017/52]AT07.12.2016
BE07.12.2016
CZ07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
PL07.12.2016
RO07.12.2016
SI07.12.2016
SK07.12.2016
BG07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
Former [2017/38]AT07.12.2016
BE07.12.2016
CZ07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
PL07.12.2016
RO07.12.2016
SK07.12.2016
BG07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
Former [2017/35]CZ07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
LT07.12.2016
LV07.12.2016
RO07.12.2016
GR08.03.2017
Former [2017/28]ES07.12.2016
FI07.12.2016
LT07.12.2016
LV07.12.2016
GR08.03.2017
Former [2017/12]LV07.12.2016
Cited inInternational search[X]WO2004099249  (XENCOR INC [US], et al) [X] 1-11,18-21 * pages 137-138 * * page 142; table 65 * * example 13 *;
 [X]WO2004029207  (XENCOR INC [US], et al) [X] 1-7,9-11,18-21 * page 136 * * example 7; table 63 *;
 [Y]WO0042072  (GENENTECH INC [US]) [Y] 1-11,18-21 * table 6 *;
 [E]WO2007044616  (XENCOR INC [US], et al) [E] 1-11,18-21 * page 3, paragraph 11; figure 16 * * page 72, paragraph 271 *;
 [EL]WO2007008943  (XENCOR INC [US], et al) [EL] 1-11,18-21 * page 37, paragraph 144 * * examples 4,7 *;
 [EL]WO2006105338  (XENCOR INC [US], et al) [EL] 1-11,18-21 * paragraphs [0046] - [0048] *
 [Y]  - SHIELDS R L ET AL, "High resolution mapping of the binding site on human IgG1 for FcgammaRI, FcgammaRII, FcgammaRIII, and FcRn and design of IgG1 variants with improved binding to the FcgammaR", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, (20010302), vol. 276, no. 9, ISSN 0021-9258, pages 6591 - 6604, XP002271092 [Y] 1-11,18-21 * pages 6591-2, paragraph BRIDGING; table I *

DOI:   http://dx.doi.org/10.1074/jbc.M009483200
 [XP]  - LAZAR G A ET AL, "Engineered antibody Fc variants with enhanced effector function", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, (200603), vol. 103, no. 11, ISSN 0027-8424, pages 4005 - 4010, XP002403708 [XP] 1-11,18-21 * table 1 *

DOI:   http://dx.doi.org/10.1073/pnas.0508123103
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.