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Extract from the Register of European Patents

EP About this file: EP1940412

EP1940412 - NOVEL OPIOID ANTAGONISTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  29.11.2013
Database last updated on 21.03.2026
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
Adolor Corporation
700 Pennsylvania Drive
Exton, PA 19341 / US
[2008/28]
Inventor(s)01 / DOLLE, Roland, E.
526 Elliott Drive
King Of Prussia, PA 19406 / US
02 / LE BOURDONNEC, Bertrand
317 Ivy Lane
East Fallowfield, PA 19320 / US
03 / GOODMAN, Allan, James
116 West 7th Street
Media, PA 19063 / US
 [2008/28]
Representative(s)Hallybone, Huw George, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2013/04]Hallybone, Huw George, et al
Carpmaels & Ransford One Southampton Row London
WC1B 5HA / GB
Former [2008/28]Hallybone, Huw George, et al
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Application number, filing date06826788.926.10.2006
[2008/28]
WO2006US41861
Priority number, dateUS20050730609P27.10.2005         Original published format: US 730609 P
US2006055282725.10.2006         Original published format: US 552827
[2008/28]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2007050802
Date:03.05.2007
Language:EN
[2007/18]
Type: A2 Application without search report 
No.:EP1940412
Date:09.07.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 03.05.2007 takes the place of the publication of the European patent application.
[2008/28]
Type: B1 Patent specification 
No.:EP1940412
Date:23.01.2013
Language:EN
[2013/04]
Search report(s)International search report - published on:US22.11.2007
(Supplementary) European search report - dispatched on:EP03.03.2010
ClassificationIPC:A61K31/555, C07D471/04, A61P25/04
[2010/13]
CPC:
C07D471/04 (EP,US); A61K31/4985 (US); A61K31/198 (US);
A61P25/04 (EP); A61P3/04 (EP)
Former IPC [2008/28]A61K31/555, C07F15/00, C07D211/22, C07D409/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2008/28]
Extension statesAL31.03.2008
BA31.03.2008
HR31.03.2008
MK31.03.2008
RS31.03.2008
TitleGerman:NEUE OPIOID-ANTAGONISTEN[2008/28]
English:NOVEL OPIOID ANTAGONISTS[2008/28]
French:NOUVEAUX ANTAGONISTES OPIOIDES[2008/28]
Entry into regional phase31.03.2008National basic fee paid 
31.03.2008Search fee paid 
31.03.2008Designation fee(s) paid 
31.03.2008Examination fee paid 
Examination procedure31.03.2008Examination requested  [2008/28]
14.07.2008Amendment by applicant (claims and/or description)
11.06.2010Despatch of a communication from the examining division (Time limit: M07)
21.01.2011Reply to a communication from the examining division
20.10.2011Communication of intention to grant the patent
29.02.2012Fee for grant paid
29.02.2012Fee for publishing/printing paid
22.05.2012Despatch of a communication from the examining division (Time limit: M04)
07.06.2012Reply to a communication from the examining division
05.07.2012Despatch of invitation to pay additional claims fees (Time limit: M02)
23.10.2012Despatch of communication that the application is deemed to be withdrawn, reason: non payment of additional claims fees
09.11.2012Payment of the additional claims fees
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  11.06.2010
Opposition(s)24.10.2013No opposition filed within time limit [2014/01]
Request for further processing for:09.11.2012Request for further processing filed
09.11.2012Full payment received (date of receipt of payment)
Request granted
04.01.2013Decision despatched
Fees paidRenewal fee
31.03.2008Renewal fee patent year 03
13.10.2009Renewal fee patent year 04
12.10.2010Renewal fee patent year 05
11.10.2011Renewal fee patent year 06
25.10.2012Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.10.2006
AT23.01.2013
BE23.01.2013
CY23.01.2013
CZ23.01.2013
DK23.01.2013
EE23.01.2013
FI23.01.2013
IT23.01.2013
LT23.01.2013
LV23.01.2013
MC23.01.2013
NL23.01.2013
PL23.01.2013
RO23.01.2013
SE23.01.2013
SI23.01.2013
SK23.01.2013
TR23.01.2013
BG23.04.2013
GR24.04.2013
ES04.05.2013
IS23.05.2013
PT23.05.2013
[2015/34]
Former [2015/32]AT23.01.2013
BE23.01.2013
CY23.01.2013
CZ23.01.2013
DK23.01.2013
EE23.01.2013
FI23.01.2013
IT23.01.2013
LT23.01.2013
LV23.01.2013
MC23.01.2013
NL23.01.2013
PL23.01.2013
RO23.01.2013
SE23.01.2013
SI23.01.2013
SK23.01.2013
TR23.01.2013
BG23.04.2013
GR24.04.2013
ES04.05.2013
IS23.05.2013
PT23.05.2013
Former [2014/25]AT23.01.2013
BE23.01.2013
CY23.01.2013
CZ23.01.2013
DK23.01.2013
EE23.01.2013
FI23.01.2013
IT23.01.2013
LT23.01.2013
LV23.01.2013
MC23.01.2013
NL23.01.2013
PL23.01.2013
RO23.01.2013
SE23.01.2013
SI23.01.2013
SK23.01.2013
BG23.04.2013
GR24.04.2013
ES04.05.2013
IS23.05.2013
PT23.05.2013
Former [2014/03]AT23.01.2013
BE23.01.2013
CY23.01.2013
CZ23.01.2013
DK23.01.2013
EE23.01.2013
FI23.01.2013
IT23.01.2013
LT23.01.2013
LV23.01.2013
NL23.01.2013
PL23.01.2013
RO23.01.2013
SE23.01.2013
SI23.01.2013
SK23.01.2013
BG23.04.2013
GR24.04.2013
ES04.05.2013
IS23.05.2013
PT23.05.2013
Former [2013/49]AT23.01.2013
BE23.01.2013
CY23.01.2013
CZ23.01.2013
DK23.01.2013
EE23.01.2013
FI23.01.2013
LT23.01.2013
LV23.01.2013
NL23.01.2013
PL23.01.2013
RO23.01.2013
SE23.01.2013
SI23.01.2013
SK23.01.2013
BG23.04.2013
GR24.04.2013
ES04.05.2013
IS23.05.2013
PT23.05.2013
Former [2013/48]AT23.01.2013
BE23.01.2013
CY23.01.2013
DK23.01.2013
EE23.01.2013
FI23.01.2013
LT23.01.2013
LV23.01.2013
NL23.01.2013
PL23.01.2013
SE23.01.2013
SI23.01.2013
BG23.04.2013
GR24.04.2013
ES04.05.2013
IS23.05.2013
PT23.05.2013
Former [2013/40]AT23.01.2013
BE23.01.2013
CY23.01.2013
FI23.01.2013
LT23.01.2013
LV23.01.2013
NL23.01.2013
PL23.01.2013
SE23.01.2013
SI23.01.2013
BG23.04.2013
GR24.04.2013
ES04.05.2013
IS23.05.2013
PT23.05.2013
Former [2013/38]AT23.01.2013
BE23.01.2013
CY23.01.2013
FI23.01.2013
LT23.01.2013
LV23.01.2013
NL23.01.2013
PL23.01.2013
SE23.01.2013
SI23.01.2013
BG23.04.2013
GR24.04.2013
ES04.05.2013
IS23.05.2013
Former [2013/37]AT23.01.2013
BE23.01.2013
CY23.01.2013
FI23.01.2013
LT23.01.2013
NL23.01.2013
PL23.01.2013
SE23.01.2013
SI23.01.2013
BG23.04.2013
GR24.04.2013
ES04.05.2013
IS23.05.2013
Former [2013/36]AT23.01.2013
BE23.01.2013
CY23.01.2013
LT23.01.2013
PL23.01.2013
SE23.01.2013
BG23.04.2013
ES04.05.2013
IS23.05.2013
Former [2013/35]BE23.01.2013
CY23.01.2013
LT23.01.2013
SE23.01.2013
BG23.04.2013
IS23.05.2013
Former [2013/34]LT23.01.2013
SE23.01.2013
BG23.04.2013
IS23.05.2013
Former [2013/33]LT23.01.2013
Documents cited:Search[A]   LE BOURDONNEC B ET AL: "trans-3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines: A novel class of mu-selective opioid antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 13, no. 24, 1 January 2003 (2003-01-01), pages 4459 - 4462, XP002285329, ISSN: 0960-894X [A] 1-49 * table 1; compounds 3-11 *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2003.09.012
 [A]   JONG, L. ET AL.,: "The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, 2004, pages 181 - 185, XP002568805 [A] 1-49 * table 1; compounds SR14135-SR14140 *

DOI:   http://dx.doi.org/10.1016/J.BMCL.2003.09.068
International search[Y] US5422356  (ZIMMERMAN DENNIS M et al.) [Y]
 [Y] US6251893  (MADDAFORD SHAWN et al.) [Y]
 [Y] US2005222204  (MITCH CHARLES H et al.) [Y]
 [Y]   BATES ET AL.: "Are Peripheral Opioid Antagonists the Solution to Opioid Side Effects?", ANESTH. ANALG., vol. 98, 2004, pages 116 - 122, XP008127280 [Y]

DOI:   http://dx.doi.org/10.1213/01.ANE.0000090147.97636.77
 [Y]   ALT ET AL.: "Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells", BRITISH JOURNAL OF PHARMACOLOGY, vol. 135, 2002, pages 217 - 225, XP008127281 [Y]

DOI:   http://dx.doi.org/10.1038/sj.bjp.0704430
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.