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EP About this file: EP1962896

EP1962896 - NOVEL SYNTHETIC AGONISTS OF TOLL-LIKE RECEPTORS CONTAINING CG DINUCLEOTIDE MODIFICATIONS [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 15.11.2013 Database last updated on 12.11.2024
Most recent event Tooltip	15.11.2013	Application deemed to be withdrawn	published on 18.12.2013 [2013/51]
Applicant(s)	For all designated states Idera Pharmaceuticals, Inc. 345 Vassar Street Cambridge, MA 02139 / US
	[2008/36]
Inventor(s)	01 / KANDIMALLA, Ekambar, R. 6 Candlewood Lane Southboro, MA 01772 / US
	02 / REDDY PUTTA, Mallikarjuna 824 Arboretum Way Burlington, MA 01803 / US
	03 / LI, Yukui 669 Prospect Street Newton, MA 02465 / US
	04 / BHAGAT, Lakshmi 1550 Worcester Street Unit 605 Framingham, MA 01702 / US
	05 / ZHU, Fugang 16 Woodland Road Bedford, MA 01730 / US
	06 / AGRAWAL, Sudhir 61 Lamplighter Drive Shewsbury, MA 01545 / US
	[2008/36]
Representative(s)	Schnappauf, Georg, et al ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
	[N/P]
Former [2008/36]	Schnappauf, Georg, et al Dr. Volker Vossius Patent- und Rechtsanwaltskanzlei Geibelstrasse 6 81679 München / DE
Application number, filing date	06849308.9	19.12.2006
	[2008/36]
	WO2006US48362
Priority number, date	US20050752335P	20.12.2005 Original published format: US 752335 P
	US20060821458P	04.08.2006 Original published format: US 821458 P
	[2008/36]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2007084237
	Date:	26.07.2007
	Language:	EN
	[2007/30]
	Type:	A2 Application without search report
	No.:	EP1962896
	Date:	03.09.2008
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 26.07.2007 takes the place of the publication of the European patent application.
	[2008/36]
Search report(s)	International search report - published on:	US	02.05.2008
	(Supplementary) European search report - dispatched on:	EP	08.07.2009
Classification	IPC:	A61K39/00, C12N15/11	[2009/31]
	CPC:	C12N15/117 (EP,US); A61K39/39 (EP,US); A61P11/06 (EP); A61P17/00 (EP); A61P29/00 (EP); A61P31/00 (EP); (+) A61P35/00 (EP); A61P37/02 (EP); A61P37/04 (EP); A61P37/08 (EP); C07H21/02 (EP,US); A61K2039/55561 (EP,US); C12N2310/17 (EP,US); C12N2310/3183 (EP,US); C12N2310/334 (EP,US); C12N2310/336 (EP,US) (-)
	Former IPC [2008/36]	A61K39/00
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2008/36]
Title	German:	NEUARTIGE SYNTHETISCHE AGONISTEN VON TOLL-LIKE-REZEPTOREN MIT CG-DINUKLEOTIDMODIFIZIERUNGEN	[2008/36]
	English:	NOVEL SYNTHETIC AGONISTS OF TOLL-LIKE RECEPTORS CONTAINING CG DINUCLEOTIDE MODIFICATIONS	[2008/36]
	French:	NOUVEAUX AGONISTES SYNTHETIQUES DE RECEPTEURS "TOLL-LIKE" CONTENANT DES MODIFICATIONS CG DE DINUCLEOTIDE	[2008/36]
Entry into regional phase	28.03.2008	National basic fee paid
	28.03.2008	Search fee paid
	16.05.2008	Designation fee(s) paid
	16.05.2008	Examination fee paid
Examination procedure	16.05.2008	Examination requested [2008/36]
	22.08.2008	Amendment by applicant (claims and/or description)
	08.12.2009	Despatch of a communication from the examining division (Time limit: M04)
	15.04.2010	Reply to a communication from the examining division
	15.03.2013	Despatch of a communication from the examining division (Time limit: M04)
	02.07.2013	Application deemed to be withdrawn, date of legal effect [2013/51]
	08.08.2013	Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time [2013/51]
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 08.12.2009
Fees paid	Renewal fee
	24.12.2008	Renewal fee patent year 03
	28.12.2009	Renewal fee patent year 04
	27.12.2010	Renewal fee patent year 05
	27.12.2011	Renewal fee patent year 06
	Penalty fee
	Additional fee for renewal fee
	31.12.2012	07 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[A] - KANDIMALLA EKAMBAR R ET AL, "Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 10 MAY 2005, (20050510), vol. 102, no. 19, ISSN 0027-8424, pages 6925 - 6930, XP002523069 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1073/pnas.0501729102
		[A] - KANDIMALLA E R ET AL, "Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships.", BIOORGANIC & MEDICINAL CHEMISTRY MAR 2001, (200103), vol. 9, no. 3, ISSN 0968-0896, pages 807 - 813, XP002523070 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1016/S0968-0896(00)00316-3
		[A] - KANDIMALLA EKAMBAR R ET AL, "Chemistry of CpG DNA.", CURRENT PROTOCOLS IN NUCLEIC ACID CHEMISTRY / EDITED BY SERGE L. BEAUCAGE ... [ET AL.] MAY 2003, (200305), vol. Chapter 4, ISSN 1934-9289, page Unit 4.16, XP002523071 [A] 1-15 * the whole document *
		[A] - WANG DAQING ET AL, "Oral administration of second-generation immunomodulatory oligonucleotides induces mucosal Th1 immune responses and adjuvant activity.", VACCINE 8 APR 2005, (20050408), vol. 23, no. 20, ISSN 0264-410X, pages 2614 - 2622, XP002523073 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1016/J.VACCINE.2004.11.028
		[A] - LI YUKUI ET AL, "Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice.", INTERNATIONAL IMMUNOPHARMACOLOGY JUN 2005, (200506), vol. 5, no. 6, ISSN 1567-5769, pages 981 - 991, XP002523074 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1016/j.intimp.2005.01.002
		[A] - CONG YAN-PING ET AL, "Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 31 OCT 2003, (20031031), vol. 310, no. 4, ISSN 0006-291X, pages 1133 - 1139, XP002523075 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1016/j.bbrc.2003.09.134
		[A] - KANDIMALLA EKAMBAR R ET AL, "A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 25 NOV 2003, (20031125), vol. 100, no. 24, ISSN 0027-8424, pages 14303 - 14308, XP002523076 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1073/pnas.2335947100
		[A] - AGRAWAL SUDHIR ET AL, "Modulation of Toll-like Receptor 9 Responses through Synthetic Immunostimulatory Motifs of DNA.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES DEC 2003, (200312), vol. 1002, ISSN 0077-8923, pages 30 - 42, XP002523077 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1196/annals.1281.005
		[PX] - PUTTA MALLIKARJUNA REDDY ET AL, "Novel oligodeoxynucleotide agonists of TLR9 containing N3-Me-dC or N1-Me-dG modifications.", NUCLEIC ACIDS RESEARCH 2006, (2006), vol. 34, no. 11, ISSN 1362-4962, pages 3231 - 3238, XP002523197 [PX] 1-15 * the whole document * DOI: http://dx.doi.org/10.1093/nar/gkl430
	International search	[X]US2004097719 (AGRAWAL SUDHIR [US], et al);
		[A] - KANDIMALLA E.R. ET AL., "Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists", PROC. NATL. ACAD. SCI. USA, (20050510), vol. 102, no. 19, pages 6925 - 6930, XP002523069 DOI: http://dx.doi.org/10.1073/pnas.0501729102
		[XP] - PUTTA M.R. ET AL., "Novel oligodeoxynucleotide agonists of TLR9 containing N3-Me-dC or N1-Me-dG modifications", NUCLEIC ACIDS RES., (20060623), vol. 34, no. 11, pages 3231 - 3238, XP002523197 DOI: http://dx.doi.org/10.1093/nar/gkl430

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