EP1852441 - Agents that modulate EPH receptor activity [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 01.02.2013 Database last updated on 24.01.2025 | Most recent event Tooltip | 18.07.2014 | Lapse of the patent in a contracting state New state(s): HU | published on 20.08.2014 [2014/34] | Applicant(s) | For all designated states The Burnham Institute 10901 North Torrey Pines Road La Jolla, CA 92037 / US | [2007/45] | Inventor(s) | 01 /
Pasquale, Elena B. 6105 Dirac Street San Diego, CA 92122 / US | 02 /
Murai, Keith K. 36 De Lacroix Candiac Quebec J5R 6J4 / CA | 03 /
Koolpe, Mitchell 5262 Camino Playa Malaga San Diego, CA 92124 / US | [2007/45] | Representative(s) | Chapman, Paul Gilmour, et al Marks & Clerk LLP The Beacon 176 St Vincent Street Glasgow G2 5SG / GB | [N/P] |
Former [2012/13] | Chapman, Paul Gilmour, et al Marks & Clerk LLP Aurora 120 Bothwell Street Glasgow G2 7JS / GB | ||
Former [2008/33] | Chapman, Paul Gilmour, et al Marks & Clerk 19 Royal Exchange Square Glasgow G1 3AE / GB | ||
Former [2007/45] | Chapman, Paul Gilmour, et al Marks & Clerk 19 Royal Exchange Square Glasgow G1 3AE / GB | Application number, filing date | 07007396.0 | 29.08.2003 | [2007/45] | Priority number, date | US20020413342P | 24.09.2002 Original published format: US 413342 P | [2007/45] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP1852441 | Date: | 07.11.2007 | Language: | EN | [2007/45] | Type: | A3 Search report | No.: | EP1852441 | Date: | 13.02.2008 | [2008/07] | Type: | B1 Patent specification | No.: | EP1852441 | Date: | 28.03.2012 | Language: | EN | [2012/13] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 11.01.2008 | Classification | IPC: | C07K14/52, A61K38/19 | [2007/45] | CPC: |
C07K14/52 (EP)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PT, RO, SE, SI, SK, TR [2007/45] | Title | German: | Mittel zur Modulierung der EPH-Rezeptor-Aktivität | [2007/45] | English: | Agents that modulate EPH receptor activity | [2007/45] | French: | Agents qui modulent l'activité du récepteur EPH | [2007/45] | Examination procedure | 20.04.2007 | Examination requested [2007/45] | 27.08.2008 | Despatch of a communication from the examining division (Time limit: M06) | 05.03.2009 | Reply to a communication from the examining division | 28.12.2009 | Despatch of a communication from the examining division (Time limit: M02) | 08.03.2010 | Reply to a communication from the examining division | 05.01.2011 | Cancellation of oral proceeding that was planned for 04.02.2011 | 14.01.2011 | Despatch of a communication from the examining division (Time limit: M02) | 04.02.2011 | Date of oral proceedings (cancelled) | 24.03.2011 | Reply to a communication from the examining division | 01.07.2011 | Despatch of communication that the application is refused, reason: formalities examination {1} | 18.10.2011 | Communication of intention to grant the patent | 14.02.2012 | Fee for grant paid | 14.02.2012 | Fee for publishing/printing paid | Appeal following examination | 14.07.2011 | Appeal received | 14.07.2011 | Statement of grounds filed | 06.09.2011 | Interlocutory revision of appeal | Parent application(s) Tooltip | EP03749303.8 / EP1553963 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20030749303) is 05.12.2006 | Opposition(s) | 03.01.2013 | No opposition filed within time limit [2013/10] | Fees paid | Renewal fee | 20.04.2007 | Renewal fee patent year 03 | 20.04.2007 | Renewal fee patent year 04 | 14.08.2007 | Renewal fee patent year 05 | 14.08.2008 | Renewal fee patent year 06 | 25.08.2009 | Renewal fee patent year 07 | 25.08.2010 | Renewal fee patent year 08 | 25.08.2011 | Renewal fee patent year 09 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 29.08.2003 | AT | 28.03.2012 | BE | 28.03.2012 | CY | 28.03.2012 | CZ | 28.03.2012 | DK | 28.03.2012 | EE | 28.03.2012 | FI | 28.03.2012 | IT | 28.03.2012 | NL | 28.03.2012 | RO | 28.03.2012 | SE | 28.03.2012 | SI | 28.03.2012 | SK | 28.03.2012 | TR | 28.03.2012 | BG | 28.06.2012 | GR | 29.06.2012 | ES | 09.07.2012 | PT | 30.07.2012 | GB | 29.08.2012 | IE | 29.08.2012 | LU | 29.08.2012 | CH | 31.08.2012 | FR | 31.08.2012 | LI | 31.08.2012 | MC | 31.08.2012 | [2014/34] |
Former [2014/27] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
IT | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
TR | 28.03.2012 | ||
BG | 28.06.2012 | ||
GR | 29.06.2012 | ||
ES | 09.07.2012 | ||
PT | 30.07.2012 | ||
GB | 29.08.2012 | ||
IE | 29.08.2012 | ||
LU | 29.08.2012 | ||
CH | 31.08.2012 | ||
FR | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
Former [2014/21] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
IT | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
TR | 28.03.2012 | ||
BG | 28.06.2012 | ||
GR | 29.06.2012 | ||
ES | 09.07.2012 | ||
PT | 30.07.2012 | ||
GB | 29.08.2012 | ||
IE | 29.08.2012 | ||
CH | 31.08.2012 | ||
FR | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
Former [2013/40] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
IT | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
BG | 28.06.2012 | ||
GR | 29.06.2012 | ||
ES | 09.07.2012 | ||
PT | 30.07.2012 | ||
GB | 29.08.2012 | ||
IE | 29.08.2012 | ||
CH | 31.08.2012 | ||
FR | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
Former [2013/34] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
IT | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
BG | 28.06.2012 | ||
GR | 29.06.2012 | ||
ES | 09.07.2012 | ||
PT | 30.07.2012 | ||
GB | 29.08.2012 | ||
IE | 29.08.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
Former [2013/33] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
IT | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
BG | 28.06.2012 | ||
GR | 29.06.2012 | ||
ES | 09.07.2012 | ||
PT | 30.07.2012 | ||
IE | 29.08.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
Former [2013/22] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
IT | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
GR | 29.06.2012 | ||
ES | 09.07.2012 | ||
PT | 30.07.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
Former [2013/20] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
IT | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
GR | 29.06.2012 | ||
PT | 30.07.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
Former [2013/16] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
IT | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
GR | 29.06.2012 | ||
PT | 30.07.2012 | ||
MC | 31.08.2012 | ||
Former [2013/11] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
IT | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
GR | 29.06.2012 | ||
PT | 30.07.2012 | ||
Former [2013/08] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
DK | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
NL | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
GR | 29.06.2012 | ||
PT | 30.07.2012 | ||
Former [2013/07] | AT | 28.03.2012 | |
BE | 28.03.2012 | ||
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
GR | 29.06.2012 | ||
PT | 30.07.2012 | ||
Former [2013/01] | BE | 28.03.2012 | |
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
GR | 29.06.2012 | ||
PT | 30.07.2012 | ||
Former [2012/50] | BE | 28.03.2012 | |
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
SK | 28.03.2012 | ||
GR | 29.06.2012 | ||
Former [2012/49] | BE | 28.03.2012 | |
CY | 28.03.2012 | ||
CZ | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
RO | 28.03.2012 | ||
SE | 28.03.2012 | ||
SI | 28.03.2012 | ||
GR | 29.06.2012 | ||
Former [2012/48] | BE | 28.03.2012 | |
CY | 28.03.2012 | ||
EE | 28.03.2012 | ||
FI | 28.03.2012 | ||
SE | 28.03.2012 | ||
GR | 29.06.2012 | ||
Former [2012/46] | BE | 28.03.2012 | |
CY | 28.03.2012 | ||
FI | 28.03.2012 | ||
GR | 29.06.2012 | ||
Former [2012/41] | CY | 28.03.2012 | |
FI | 28.03.2012 | ||
GR | 29.06.2012 | ||
Former [2012/37] | FI | 28.03.2012 | |
GR | 29.06.2012 | ||
Former [2012/36] | GR | 29.06.2012 | Documents cited: | Search | [X]WO0037500 (MOUNT SINAI HOSPITAL CORP [CA], et al) [X] 1-6,8,9 * page 22 - page 23; claims 26,27; sequence 32 *; | [X]WO9945121 (US HEALTH [US], et al) [X] 1-6,8,9 * sequences 5,6 *; | [X]WO9000192 (GENENCOR INC [US]) [X] 1-6,8,9 * table 1 *; | [X]US6001964 (GAYNOR BRUCE D [US], et al) [X] 1-6,8,9 * sequence 3 *; | [X]WO9967285 (INNOGENETICS NV [BE], et al) [X] 1-6,8,9 * table 5 *; | [A]WO9626958 (HARVARD COLLEGE [US]) [A] * page 6, line 31 - page 8, line 10; claims 11-13,50-58 * | [PX] - KOOLPE MITCHELL ET AL, "An ephrin mimetic peptide that selectively targets the EphA2 receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, (20020925), vol. 277, no. 49, ISSN 0021-9258, pages 46974 - 46979, XP002309754 [PX] 1-27 * the entire document, particularly figure 1 and the abstract * DOI: http://dx.doi.org/10.1074/jbc.M208495200 | [A] - LIN ET AL, "The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif", JOURNAL OF BIOLOGICAL CHEMISTRY, (19990205), vol. 274, no. 6, ISSN 0021-9258, pages 3726 - 3733, XP002137902 [A] * the whole document * DOI: http://dx.doi.org/10.1074/jbc.274.6.3726 | by applicant | US4631190 | US4569789 | US4356166 | US4171563 | WO9325221 | WO9417784 | EP0613683 | - FLANAGAN, VANDERHAEGHEN, ANN REV NEUROSCI, (1998), vol. 21, pages 309 - 345 | - MANNING ET AL., TRENDS BIOCHEM SCI, (2002), vol. 27, pages 514 - 520 | - MURAI, K., PASQUALE, E., J. CELL SCI, (2003), vol. 116, pages 2823 - 2832 | - FLANAGAN, J.G., VANDERHAEGHEN, P., ANN REV NEUROSCI, (1998), vol. 21, pages 309 - 345 | - DODELET, V.C., PASQUALE, E.B., ONCOGENE, (2000), vol. 19, pages 5614 - 5619 | - YANCOPOULOS, G.D. ET AL., NATURE, (2000), vol. 407, pages 242 - 248 | - OGAWA, K. ET AL., ONCOGENE, (2000), vol. 19, pages 6043 - 6052 | - PANDEY, A. ET AL., SCIENCE, (1995), vol. 268, pages 567 - 569 | - CHENG, N. ET AL., MOL CANCER RES, (2002), vol. 1, pages 2 - 11 | - MYERS, C. ET AL., J CELL BIOL, (2000), vol. 148, pages 343 - 351 | - DANIEL, T.O. ET AL., KIDNEY INT, (1996), vol. 57, pages 73 - 81 | - HESS, A.R. ET AL., CANCER RES, (2001), vol. 61, pages 3250 - 3255 | - RUIZ, J.C., ROBERTSON, E.J., MECH DEV, (1994), vol. 46, pages 87 - 100 | - GANJU, P. ET AL., ONCOGENE, (1994), vol. 9, pages 1613 - 1624 | - BERCLAZ, G. ET AL., BIOCHEM BIOPHYS RES COMMUN, (1996), vol. 226, pages 869 - 875 | - KIYUOKAWA, E. ET AL., CANCER RES, (1994), vol. 54, pages 3645 - 3650 | - BENNETT, B.D. ET AL., PNAS USA, (1995), vol. 92, pages 1866 - 1870 | - LIU, W. ET AL., CANCER, (2002), vol. 94, pages 934 - 939 | - STEPHENSON, S. ET AL., BMC MOL BIOL, (2001), vol. 2, pages 15 - 23 | - WANG, H.U. ET AL., CELL, (1998), vol. 93, pages 741 - 753 | - GERETY, S.S. ET AL., MOL CELL, (1999), vol. 4, pages 403 - 414 | - BATTAGLIA, A.A. ET AL., NATURE NEUROSCI, (2003), vol. 6, pages 339 - 340 | - CONOVER, J.C. ET AL., NATURE NEUROSCI, (2000), vol. 3, pages 1091 - 1097 | - MURAI, K.K., PASQUALE, E.B., NEURON, (2002), vol. 33, pages 159 - 162 | - MARTIN ET AL., CANCER RES, (2000), vol. 60, pages 3218 - 3224 | - KREITMAN, PASTAN, BLOOD, (1997), vol. 90, pages 252 - 259 | - ALLAM ET AL., CANCER RES, (1997), vol. 57, pages 2615 - 2618 | - OSBORNE, CORONADO HEINSOHN, CANCER J SCI AM, (1996), vol. 2, page 175 | - MERRIFIELD, J AM CHEM SOC, (1963), vol. 85, page 2149 | - ANDREU ET AL., METH MOL BIO, (1994), vol. 35, no. 7, pages 91 - 169 | - BARKER ET AL., J MED CHEM, (1992), vol. 35, pages 2040 - 2048 | - OR ET AL., J ORG CHEM, (1991), vol. 56, pages 3146 - 3149 | - ARAP, W. ET AL., SCIENCE, (1998), vol. 279, pages 377 - 380 | - OLSON, T.A. ET AL., INT J CANCER, (1997), vol. 73, pages 865 - 870 | - ELLERBY, H.M. ET AL., NAT MED, (1999), vol. 5, pages 1032 - 1038 | - ARAP, W. ET AL., PNAS USA, (2002), vol. 99, pages 1527 - 1531 | - GERLAG, D.M. ET AL., ARTHRITIS RESEARCH, (2001), vol. 3, pages 357 - 361 | - ZANTEK, N.D. ET AL., CELL GROWTH DIFFER, (1999), vol. 10, pages 629 - 638 | - CARLES-KINCH, K. ET AL., CANCER RES, (2002), vol. 62, pages 2840 - 2847 | - VAN DER GEER, P. ET AL., ANNU REV CELL BIOL, (1994), vol. 10, pages 251 - 337 | - CELL BIOL, vol. 2, pages 62 - 69 | - ZELINSKI, D.P. ET AL., J CELL BIOCHEM, (2002), vol. 85, pages 714 - 720 | - DOHN, M. ET AL., ONCOGENE, (2001), vol. 20, pages 6503 - 6515 | - BLATTLER ET AL., BIOCHEMISTRY, (1985), vol. 24, pages 1517 - 1525 | - TICE, BIBI, Treatise on Controlled Drug Delivery, MARCEL DEKKER, (1992), pages 315 - 339 | - MIRANDA ET AL., EXP NEUROL, (1999), vol. 156, pages 218 - 222 | - WILLSON ET AL., CELL TRANSPLANTATION, (2002), vol. 11, pages 229 - 239 | - EBERHART ET AL., DEV BIOL, (2002), vol. 247, pages 89 - 101 | - DOTTORI ET AL., PNAS USA, (1998), vol. 95, pages 13248 - 13253 | - KULLANDER ET AL., NAT REV MOL CELL BIOL, (2001), vol. 3, pages 475 - 486 | - YUE ET AL., J NEUROSCI, (1999), vol. 19, pages 2090 - 2101 | - PREVOST ET AL., PNAS USA, (2002), vol. 99, pages 9219 - 9224 |