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Extract from the Register of European Patents

EP About this file: EP1849860

EP1849860 - Process for preparing an immunogenic factor of Corynebacterium diphtheriae using a culture medium with yeast extract as aminoacid source and no protein complexes of animal origin [Right-click to bookmark this link]
Former [2007/44]Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin
[2010/15]
StatusNo opposition filed within time limit
Status updated on  23.09.2011
Database last updated on 23.09.2024
Most recent event   Tooltip17.05.2013Lapse of the patent in a contracting state
New state(s): LU		published on 19.06.2013  [2013/25]
Applicant(s)For all designated states
Novartis AG
Lichtstrasse 35
4056 Basel / CH
[2011/27]
Former [2007/44]For all designated states
Novartis Vaccines and Diagnostics S.r.l.
Via Fiorentina 1
53100 Siena (SI) / IT
Inventor(s)01 / Olivieri, Roberto
Via Dario Neri, 53
53100 Siena / IT
02 / Sabbatini, Fabio
Via della Repubblica, 4
53014 Monteroni d'Arbia / IT
03 / Kontakou, Maria
Via Don Bosco, 16 Casagiove
81100 Caserta / IT
04 / Tagliaferri, Lucia
Via Casato di Sopra, 59
53100 Siena / IT
05 / Giglioli, Antonella
Via Mario Pratesi, 3
53100 Siena / IT
06 / Rappuoli, Rino
c/o Novartis Vaccines and Diagnostics, Inc. 4560 Horton Street
Emeryville CA 94608 / US
 [2010/46]
Former [2008/09]01 / Olivieri, Roberto
Via Dario Neri, 53
53100 Siena / IT
02 / Sabbatini, Fabio
Via della Repubblica, 4
53014 Monteroni d'Arbia / IT
03 / Kontakou, Maria
Via Don Bosco, 16 Casagiove
81100 Caserta / IT
04 / Tagliaferri, Lucia
Via Casato di Sopra, 59
53100 Siena / IT
05 / Giglioli, Antonella
Via Mario Pratesi, 6
53100 Siena / IT
06 / Rappuoli, Rino
c/o Novartis Vaccines and Diagnostics, Inc. 4560 Horton Street
Emeryville CA 94608 / US
Former [2007/44]01 / Olivieri, Roberto
Via Dario Neri, 53
53100 Siena / IT
02 / Sabbatini, Fabio
Via della Repubblica, 4
53014 Monteroni d'Arbia / IT
03 / Kontakou, Maria
Via Don Bosco, 16 Casagiove
81100 Caserta / IT
04 / Tagliaferri, Lucia
Via Casato di Sopra, 59
53100 Siena / IT
05 / Giglioli, Antonella
Via Mario Pratesi, 6
53100 Siena / IT
06 / Rappuoli, Rino
Via Calamandrei, 39 Quercegrossa
53035 Monteriggioni / IT
Representative(s)Hallybone, Huw George, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2009/51]Hallybone, Huw George, et al
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Former [2007/44]Hallybone, Huw George, et al
Carpmaels and Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Application number, filing date07075660.628.05.1998
[2007/44]
Priority number, dateGB1997001098128.05.1997         Original published format: GB 9710981
GB1998000680230.03.1998         Original published format: GB 9806802
[2007/44]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP1849860
Date:31.10.2007
Language:EN
[2007/44]
Type: A3 Search report 
No.:EP1849860
Date:02.04.2008
[2008/14]
Type: B1 Patent specification 
No.:EP1849860
Date:17.11.2010
Language:EN
[2010/46]
Search report(s)(Supplementary) European search report - dispatched on:EP03.03.2008
ClassificationIPC:C12N1/20, A61K39/102, C07K16/12
[2007/44]
CPC:
C12N1/20 (EP,US); A61P31/04 (EP); C12N1/205 (US);
C12R2001/21 (US)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2007/44]
TitleGerman:Verfahren zur Herstellung eines immunogenen Faktors von Corynebacterium diphtheriae unter Verwendung eines Kulturmediums mit Hefeextrakt als Aminosäurenquelle und ohne Proteinkomplexe tierischer Herkunft[2010/16]
English:Process for preparing an immunogenic factor of Corynebacterium diphtheriae using a culture medium with yeast extract as aminoacid source and no protein complexes of animal origin[2010/15]
French:Procédé de préparation d'un facteur immunogene de Corynebacterium diphtheriae en utilisant un milieu de culture avec extrait de levure en tant que source d'acides aminés et dépourvu de complexes protéiques d'origine animale[2010/15]
Former [2007/44]Kulturmedium mit Hefe- oder Sojabohnenextrakt als Aminosäurenquelle und ohne Proteinkomplexe tierischer Herkunft
Former [2007/44]Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin
Former [2007/44]Milieu de culture avec extrait d'amidon ou de soja en tant que source d'acides aminés et dépourvu de complexes protéiques d'origine animale
Examination procedure12.09.2008Examination requested  [2008/43]
10.10.2008Despatch of a communication from the examining division (Time limit: M06)
29.05.2009Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
10.08.2009Reply to a communication from the examining division
11.03.2010Date of oral proceedings
29.03.2010Minutes of oral proceedings despatched
19.04.2010Communication of intention to grant the patent
27.08.2010Fee for grant paid
27.08.2010Fee for publishing/printing paid
Parent application(s)   TooltipEP98923023.0  / EP0983342
Divisional application(s)EP10002348.0  / EP2199382
EP10176826.5  / EP2267113
Opposition(s)18.08.2011No opposition filed within time limit [2011/43]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
10.08.2009Request for further processing filed
10.08.2009Full payment received (date of receipt of payment)
Fees paidRenewal fee
03.08.2007Renewal fee patent year 03
03.08.2007Renewal fee patent year 04
03.08.2007Renewal fee patent year 05
03.08.2007Renewal fee patent year 06
03.08.2007Renewal fee patent year 07
03.08.2007Renewal fee patent year 08
03.08.2007Renewal fee patent year 09
03.08.2007Renewal fee patent year 10
28.03.2008Renewal fee patent year 11
12.05.2009Renewal fee patent year 12
31.03.2010Renewal fee patent year 13
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipDK17.11.2010
FI17.11.2010
SE17.11.2010
IE28.05.2011
LU28.05.2011
MC31.05.2011
[2013/25]
Former [2012/20]DK17.11.2010
FI17.11.2010
SE17.11.2010
IE28.05.2011
MC31.05.2011
Former [2012/05]DK17.11.2010
FI17.11.2010
SE17.11.2010
MC31.05.2011
Former [2011/40]DK17.11.2010
FI17.11.2010
SE17.11.2010
Former [2011/30]FI17.11.2010
SE17.11.2010
Documents cited:Search[X]US4695624  (MARBURG STEPHEN [US], et al) [X] 1-3 * the whole document *;
 [X]EP0429816  (HOFFMANN LA ROCHE [CH]) [X] 6-8 * the whole document *;
 [Y]EP0540897  (ISTITUTO RICERCHE IMMUNOBIOLOG [IT]) [Y] 1-3 * the whole document * * page 2, column 1, line 1 - line 46 * * page 2, column 2, line 1 - line 29 * * examples 1,2 *;
 [Y]WO9409115  (MERCK & CO INC [US]) [Y] 1-8 * the whole document *;
 [A]US5494808  (FU JEFFREY [US]) [A] * abstract * * column 3, line 46 - column 4, line 9 * * column 5, line 1 - line 56 * * table 1 *;
 [A]  - ATCC: Bacteria nd viruses, 19th Edition, ROCKVILLE, US, ATCC, PIENTA, P., TANG, J., COTE, R., (1996), ISBN 0-930009-59-2, XP002451189 [A] * pages 71,103 * * page 108 - page 109 * * page 177 - page 178 * * page 183 * * page 249 - page 250 * * page 477 - page 479 * * pages 488,507 *
 [A]  - HERRIOTT R M ET AL, "DEFINED MEDIUM FOR GROWTH OF HAEMOPHILUS-INFLUENZAE", JOURNAL OF BACTERIOLOGY, (1970), vol. 101, no. 2, ISSN 0021-9193, pages 513 - 516, XP002451186 [A] 1-3 * the whole document *
 [Y]  - BUTLER L O, "A defined medium for Haemophilus influenzae and Haemophilus parainfluenzae.", JOURNAL OF GENERAL MICROBIOLOGY JAN 1962, (196201), vol. 27, ISSN 0022-1287, pages 51 - 60, XP008083778 [Y] 1-3 * the whole document *
 [A]  - KLEIN R D ET AL, "Simplified media for the growth of Haemophilus influenzae from clinical and normal flora sources", JOURNAL OF GENERAL MICROBIOLOGY 1979 UNITED KINGDOM, (1979), vol. 113, no. 2, ISSN 0022-1287, pages 409 - 411, XP008083779 [A] 1-3 * the whole document *
 [A]  - WOLIN H L, "Defined medium for Haemophilus influenzae type B.", JOURNAL OF BACTERIOLOGY JAN 1963, (196301), vol. 85, ISSN 0021-9193, pages 253 - 254, XP002451187 [A] 1-3 * the whole document *
 [X]  - VELLA P P ET AL, "Immunogenicity of a new Haemophilus influenzae type b conjugate vaccine (meningococcal protein conjugate) (PedvaxHIB).", PEDIATRICS APR 1990, (199004), vol. 85, no. 4 Pt 2, ISSN 0031-4005, pages 668 - 675, XP008083775 [X] 1-3 * the whole document *
 [X]  - CORBEL M J, "CONTROL TESTING OF COMBINED VACCINES: A CONSIDERATION OF POTENTIAL PROBLEMS AND APPROACHES", BIOLOGICALS, ACADEMIC PRESS LTD., LONDON, GB, (19941201), vol. 22, no. 4, ISSN 1045-1056, pages 353 - 360, XP000603003 [X] 1-3 * the whole document *

DOI:   http://dx.doi.org/10.1006/biol.1994.1054
 [Y]  - TAHA F S ET AL, "Soybean extracts as culture media for the growth and toxin production of Corynebacterium diphtheriae", EGYPTIAN PUBLIC HEALTH ASSOCIATION JOURNAL, EGYPTIAN PUBLIC HEALTH ASSOCIATION,, EG, (1985), vol. 60, no. 1-2, ISSN 0013-2446, pages 113 - 126, XP008083774 [Y] 4-8 * the whole document *
 [X]  - SCHNEERSON R ET AL, "A toxoid vaccine for pertussis as well as diphtheria? Lessons to be relearned", LANCET THE, LANCET LIMITED. LONDON, GB, (19961109), vol. 348, no. 9037, ISSN 0140-6736, pages 1289 - 1292, XP004837631 [X] 6-8 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0140-6736(96)05243-9
by applicantDD294502
 WO9409115
    - "Bacterial Vaccines in Advances", A. MIZRAHI, Biotechnology Processes, WILEY-LISS, (1990), vol. 13
    - "European Journal of Gastroenterology and Hepatology of Helicobacterpylori infection", RAPPUOLI, R. ET AL., Proceedings of an interdisciplinary meeting, CS CURRENT SCIENCE, (19930618), pages S76 - S78
    - RAPPUOLI, R., VACCINE, (1994), vol. 12, pages 579 - 581
    - MANETTI, R. ET AL., INFECT. IMMUN., (1995), vol. 63, pages 4476 - 4480
    - "New and improved vaccines against Diphtheria and Tetanus", RAPPUOLI, R., New Generation of Vaccines, MARCEL DEKKER INC., (1990), pages 251 - 268
    - GUPTA, R. K. ET AL., VACCINE, (1995), vol. 13, pages 1263 - 1276
    - BLASER, M.J., J. INFECT. DIS., (1990), vol. 161, pages 629 - 633
    - PARSONNET, J., NEW ENGL. J. MED., (1991), vol. 325, pages 1127 - 1131
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.