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EP2021467
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EP About this file: EP2021467
| EP2021467 - CHIMERIC PCSK9 PROTEINS, CELLS COMPRISING SAME, AND ASSAYS USING SAME [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 26.08.2011 Database last updated on 15.07.2024 | Most recent event Tooltip | 26.08.2011 | Application deemed to be withdrawn | published on 28.09.2011 [2011/39] | Applicant(s) | For all designated states Adaerata, Limited Partnership 3535, Chemin Queen-Mary, Bureau 220 Montréal, QC H3V 1H8 / CA | [N/P] |
| Former [2009/07] | For all designated states Adaerata, Limited Partnership 5160 Decarie Boulevard, Suite 770 Montréal, QC H3X 2H9 / CA | Inventor(s) | 01 /
SEIDAH, Nabil 100 ave. Des Sommets 1101 Ile des Soeurs Arrondissement de Verdun, Québec H3E 1Z8 / CA | 02 /
DAVIGNON, Jean 768 Hartland Montreal, Québec H2V 2X6 / CA | 03 /
DUBUC, Geneviève 2434 Cartier Longueuil, Québec J4K 4G3 / CA | 04 /
BERNIER, Lise 1551, rue Rachel Est Montreal, Québec H2J 2K4 / CA | 05 /
TREMBLAY, Michel 2580, Place Voltaire Mascouche, Québec J7K 3Z9 / CA | [2009/07] | Representative(s) | Desaix, Anne, et al Ernest Gutmann - Yves Plasseraud S.A.S. 66, rue de la Chaussée d'Antin 75009 Paris / FR | [N/P] |
| Former [2009/07] | Desaix, Anne, et al Ernest Gutmann - Yves Plasseraud S.A.S. 3, rue Auber 75009 Paris / FR | Application number, filing date | 07719719.2 | 08.05.2007 | [2009/07] | WO2007CA00794 | Priority number, date | US20060746692P | 08.05.2006 Original published format: US 746692 P | [2009/07] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2007128121 | Date: | 15.11.2007 | Language: | EN | [2007/46] | Type: | A1 Application with search report | No.: | EP2021467 | Date: | 11.02.2009 | Language: | EN | The application published by WIPO in one of the EPO official languages on 15.11.2007 takes the place of the publication of the European patent application. | [2009/07] | Search report(s) | International search report - published on: | CA | 15.11.2007 | (Supplementary) European search report - dispatched on: | EP | 22.12.2009 | Classification | IPC: | C12N9/64, A61K38/17, A61K38/48, A61P3/06, C07K14/05, C07K16/40, C07K19/00, C12N1/21, C12N5/10, C12Q1/02, C12Q1/37, G01N33/567, G01N33/573, G01N33/68 | [2009/07] | CPC: |
G01N33/5008 (EP,US);
A61P3/06 (EP);
C07K16/40 (EP,US);
C12N9/6424 (EP,US);
A61K38/00 (EP,US);
C07K2319/01 (EP,US);
C07K2319/03 (EP,US)
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| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR [2009/07] | Extension states | AL | Not yet paid | BA | Not yet paid | HR | Not yet paid | MK | Not yet paid | RS | Not yet paid | Title | German: | CHIMÄRE PCSK9-PROTEINE, DIESE ENTHALTENDE ZELLEN UND TESTVERFAHREN DAMIT | [2009/07] | English: | CHIMERIC PCSK9 PROTEINS, CELLS COMPRISING SAME, AND ASSAYS USING SAME | [2009/07] | French: | PROTÉINES PCSK9 CHIMÉRIQUES, CELLULES LES COMPRENANT ET DOSAGES LES UTILISANT | [2009/07] | Entry into regional phase | 02.12.2008 | National basic fee paid | 02.12.2008 | Search fee paid | 02.12.2008 | Designation fee(s) paid | 02.12.2008 | Examination fee paid | Examination procedure | 02.12.2008 | Amendment by applicant (claims and/or description) | 02.12.2008 | Examination requested [2009/07] | 09.04.2010 | Despatch of a communication from the examining division (Time limit: M04) | 26.07.2010 | Reply to a communication from the examining division | 21.09.2010 | Despatch of a communication from the examining division (Time limit: M06) | 02.04.2011 | Application deemed to be withdrawn, date of legal effect [2011/39] | 12.05.2011 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2011/39] | Divisional application(s) | EP11159089.9 / EP2348106 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 09.04.2010 | Fees paid | Renewal fee | 25.05.2009 | Renewal fee patent year 03 | 28.05.2010 | Renewal fee patent year 04 | 30.05.2011 | Renewal fee patent year 05 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [Y] - NOUR N ET AL, "The Cysteine-rich Domain of the Secreted Proprotein Convertases PC5A and PACE4 Functions as a Cell Surface Anchor and Interacts with Tissue Inhibitors of Metalloproteinases", MOLECULAR BIOLOGY OF THE CELL, BETHESDA, MD, US, (20051101), vol. 16, ISSN 1059-1524, pages 5215 - 5226, XP003011118 [Y] 1-11,15 * page 5216, column R, paragraph 2 * DOI: http://dx.doi.org/10.1091/mbc.E05-06-0504 | [Y] - CONESA MAGALI ET AL, "Down-regulation of alphav/beta3 integrin via misrouting to lysosomes by overexpression of a beta3Lamp1 fusion protein.", BIOCHEMICAL JOURNAL, (20030301), vol. 370, no. 2, ISSN 0264-6021, pages 703 - 711, XP002559423 [Y] 1-11,15 * page 703, column L * DOI: http://dx.doi.org/10.1042/BJ20021301 | [A] - DONOGHUE MARY ET AL, "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, (20000901), vol. 87, no. 5, ISSN 0009-7330, pages e1 - e9, XP002207553 [A] 6 * the whole document * | [A] - LAMBERT G ET AL, "PCSK9: a promising therapeutic target for dyslipidemias?", TRENDS IN ENDOCRINOLOGY AND METABOLISM, ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, US, vol. 17, no. 3, ISSN 1043-2760, (20060401), pages 79 - 81, (20060401), XP024907557 [A] 1-11,15 * the whole document * DOI: http://dx.doi.org/10.1016/j.tem.2006.02.001 | [T] - POIRIER STEVE ET AL, "The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2", JOURNAL OF BIOLOGICAL CHEMISTRY, (200801), vol. 283, no. 4, ISSN 0021-9258, pages 2363 - 2372, XP002559424 [T] 1-11,15 * page 2367, column R, paragraph L - page 2368, column L * DOI: http://dx.doi.org/10.1074/jbc.M708098200 | International search | [A]EP1471152 (INST NAT SANTE RECH MED [FR]); | [XP] - BENJANNET S. ET AL., "The Proprotein Convertase (PC) PCSK9 is Inactivated by Furin and/or PC5/6A: Functional Consequences of Natural Mutations and Post-translational Modifications", J. BIOL. CHEM., (20061013), vol. 281, no. 41, pages 30561 - 30572, XP002508324 DOI: http://dx.doi.org/10.1074/JBC.M606495200 | [Y] - BENJANNET S. ET AL., "NARC-1/PCSK9 and its Natural Mutants: Zymogen Cleavage and Effect on the Low Density Lipoprotein (LDL) Receptor and LDL Cholesterol", J. BIOL. CHEM., (20041119), vol. 279, no. 47, pages 48865 - 48875, XP002495460 DOI: http://dx.doi.org/10.1074/jbc.M409699200 | [A] - COHEN J. ET AL., "Low LDL Cholesterol in Individuals of African Descent Resulting from Frequent Nonsense Mutations in PCSK9", NATURE GENETICS, (200502), vol. 37, no. 2, pages 161 - 165, XP008102949 DOI: http://dx.doi.org/10.1038/ng1509 | [A] - ATTIE A.D. AND SEIDAH N.G., "Dual Regulation of the LDL Receptor-Some Clarity and New Questions", CELL METAB., (200505), vol. 1, no. 5, pages 290 - 292, XP008100535 DOI: http://dx.doi.org/10.1016/j.cmet.2005.04.006 | [A] - KOTOWSKI I.K. ET AL., "A Spectrum of PCSK9 Alleles Contributes to Plasma Levels of Low-Density Lipoprotein Cholesterol", AM. J. HUM. GENET., (200603), vol. 78, no. 3, pages 410 - 422, XP008100000 |