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Extract from the Register of European Patents

EP About this file: EP2010182

EP2010182 - USE OF C-SRC INHIBITORS DASATUNIB OR BOSUTINIB IN COMBINATION WITH NILOTINIB FOR THE TREATMENT OF LEUKEMIA [Right-click to bookmark this link]
Former [2009/02]USE OF C-SRC INHIBITORS IN COMBINATION WITH A PYRIMIDYLAMINOBENZAMIDE COMPOUND FOR THE TREATMENT OF LEUKEMIA
[2014/16]
StatusThe application is deemed to be withdrawn
Status updated on  09.01.2015
Database last updated on 14.09.2024
Most recent event   Tooltip09.01.2015Application deemed to be withdrawnpublished on 11.02.2015  [2015/07]
Applicant(s)For all designated states
Novartis AG
Lichtstrasse 35
4056 Basel / CH
[N/P]
Former [2009/02]For all designated states
NOVARTIS AG
Lichtstrasse 35
4056 Basel / CH
Inventor(s)01 / MANLEY, Paul, W.
Bruggweg 12
CH-4144 Arlesheim / CH
 [2009/02]
Representative(s)Krauss, Jan, et al
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Pettenkoferstrasse 22
80336 München / DE
[N/P]
Former [2009/19]Krauss, Jan, et al
Forrester & Boehmert Pettenkoferstrasse 20-22
80336 München / DE
Former [2009/02]Roth, Peter Richard, et al
Novartis Pharma AG Patent Department
4002 Basel / CH
Application number, filing date07727867.905.04.2007
[2009/02]
WO2007EP53399
Priority number, dateUS20060790437P07.04.2006         Original published format: US 790437 P
[2009/02]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2007116025
Date:18.10.2007
Language:EN
[2007/42]
Type: A2 Application without search report 
No.:EP2010182
Date:07.01.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 18.10.2007 takes the place of the publication of the European patent application.
[2009/02]
Search report(s)International search report - published on:EP13.12.2007
ClassificationIPC:A61K31/506, A61K31/4709, A61K31/519, A61P35/02
[2009/02]
CPC:
A61K31/4709 (EP,US); A61K31/519 (EP,KR,US); A61K31/00 (EP,US);
A61K31/506 (EP,KR,US); A61P35/00 (EP); A61P35/02 (EP);
A61P43/00 (EP); C07D487/04 (EP,US) (-)
C-Set:
A61K31/00, A61K2300/00 (EP,US);
A61K31/506, A61K2300/00 (US,EP);
A61K31/519, A61K2300/00 (US,EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/02]
TitleGerman:VERWENDUNG VON C-SRC-HEMMERN DASATUNIB ODER BOSUTINIB IN KOMBINATION MIT NILOTINIB ZUR BEHANDLUNG VON LEUKÄMIE[2014/17]
English:USE OF C-SRC INHIBITORS DASATUNIB OR BOSUTINIB IN COMBINATION WITH NILOTINIB FOR THE TREATMENT OF LEUKEMIA[2014/17]
French:UTILISATION DES INHIBITEURS DE C-SRC DASATUNIB OU BOSUTINIB EN COMBINAISON AVEC LE NILOTINIB POUR TRAITER LA LEUCÉMIE[2014/17]
Former [2009/02]VERWENDUNG VON C-SRC-HEMMERN IN KOMBINATION MIT EINER PYRIMIDYLAMINOBENZAMID-VERBINDUNG ZUR BEHANDLUNG VON LEUKÄMIE
Former [2009/02]USE OF C-SRC INHIBITORS IN COMBINATION WITH A PYRIMIDYLAMINOBENZAMIDE COMPOUND FOR THE TREATMENT OF LEUKEMIA
Former [2009/02]UTILISATION D'INHIBITEURS DE C-SRC EN COMBINAISON AVEC UN COMPOSÉ PYRIMIDYLAMINOBENZAMIDE POUR TRAITER LA LEUCÉMIE
Entry into regional phase07.11.2008National basic fee paid 
07.11.2008Designation fee(s) paid 
07.11.2008Examination fee paid 
Examination procedure07.11.2008Examination requested  [2009/02]
11.02.2009Despatch of a communication from the examining division (Time limit: M06)
20.08.2009Reply to a communication from the examining division
21.09.2009Despatch of a communication from the examining division (Time limit: M06)
29.04.2010Reply to a communication from the examining division
16.10.2012Despatch of a communication from the examining division (Time limit: M06)
01.03.2013Reply to a communication from the examining division
26.03.2014Communication of intention to grant the patent
05.08.2014Fee for grant paid
05.08.2014Fee for publishing/printing paid
06.08.2014Application deemed to be withdrawn, date of legal effect  [2015/07]
15.09.2014Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2015/07]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  11.02.2009
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
29.04.2010Request for further processing filed
29.04.2010Full payment received (date of receipt of payment)
Request granted
12.05.2010Decision despatched
Fees paidRenewal fee
16.04.2009Renewal fee patent year 03
25.03.2010Renewal fee patent year 04
12.04.2011Renewal fee patent year 05
30.03.2012Renewal fee patent year 06
12.04.2013Renewal fee patent year 07
25.03.2014Renewal fee patent year 08
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Cited inInternational search[DY]WO9728161  (CIBA GEIGY AG [CH], et al) [DY] 1-13 * page 7, paragraphs 1-3 * * page 8, paragraph 2 * * claims 9,11 *;
 [Y]WO03013540  (NOVARTIS AG [CH], et al) [Y] 1-13 * page 1, paragraph 2 - page 2, paragraph 3 * * page 3, line 1 - page 5 * * claims 1-19 *;
 [Y]EP1473043  (BOEHRINGER INGELHEIM PHARMA [DE]) [Y] 1,3-6,8-12 * page 3, paragraphs 14,20 * * claims 1,3,8 *;
 [X]  - O'HARE T ET AL, "In vitro Activity of Bcr-Abl Inhibitors AMN107 and BMS-354825 against Clinically Relevant Imatinib -Resistant Abl Kinase Domain Mutants", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, (20050601), vol. 65, no. 11, ISSN 0008-5472, pages 4500 - 4505, XP002414413 [X] 1,3-6,8-13 * page 4505, paragraph 5 - page 4505, paragraph 1 *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-05-0259
 [Y]  - SHEILA A. DOGGRELL, "Is AMN-107 a step forward from Imatinib in the treatment of chronic myeloid leukaemia?", EXPERT OPINION ON INVESTIGATIONAL DRUGS, (2005), vol. 7, pages 1063 - 1066, XP002452410 [Y] 1,3-6,8-13 * page 1065, column 2, paragraphs 2,3 *
 [Y]  - MANLEY ET AL, "Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS & PROTEOMICS, ELSEVIER, (20051230), vol. 1754, no. 1-2, ISSN 1570-9639, pages 3 - 13, XP005214189 [Y] 1,3-6,8-13 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.bbapap.2005.07.040
 [PX]  - BRADEEN HEATHER A ET AL, "COMPARISON OF IMATINIB, MESYLATE, DASATINIB (BMS-354825), AND NILOTINIB (AMN107) IN AN N-ETHYL-N-NITROSOUREA (ENU)-BASED MUTAGENESIS SCREEN: HIGH EFFICACY OF DRUG COMBINATIONS", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, (20061001), vol. 108, no. 7, ISSN 0006-4971, pages 2332 - 2338, XP009082064 [PX] 1,3-6,8-13 * the whole document *

DOI:   http://dx.doi.org/10.1182/blood-2006-02-004580
ExaminationWO2005047259
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