EP2004668 - AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 17.01.2014 Database last updated on 03.09.2024 | Most recent event Tooltip | 23.03.2018 | Lapse of the patent in a contracting state | published on 25.04.2018 [2018/17] | Applicant(s) | For all designated states SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Viale Shakespeare 47 00144 Roma / IT | [2008/52] | Inventor(s) | 01 /
CERRI, Alberto Via Barnaba Oriani, 55 20156 Milano / IT | 02 /
TORRI, Marco Via MOnte Grappa, 20 20017 Rho / IT | 03 /
ARMAROLI, Silvia Via della Chiesa, 24 44020 Gallo Poggio Renatico / IT | 04 /
BANFI, Leonardo via 1· Maggio 6/8 20026 Novate Milanese (MI) / IT | 05 /
BIANCHI, Giuseppe Iazza Adigrat, 4 20133 Milano / IT | 06 /
CARZANA, Giulio Largo Cavalieri di Malta, 16 20146 Milano / IT | 07 /
FERRARI, Patrizia Via Gasparotto 57/A 21100 Varese / IT | 08 /
MICHELETTI, Rosamaria Via Savona, 52 20144 Milano / IT | 09 /
SPUTORE, Simona Via Pace, 14 20036 Meda / IT | 10 /
ZAPPAVIGNA, Maria Pia Via Radice, 22 20013 Magenta / IT | [2008/52] | Representative(s) | Spadaro, Marco, et al Cantaluppi & Partners S.r.l. Viale della Tecnica, 205 00144 Roma / IT | [N/P] |
Former [2011/50] | Spadaro, Marco, et al Cantaluppi & Partners Viale della Tecnica, 205 00144 Roma / IT | ||
Former [2008/52] | Spadaro, Marco, et al Studio Associato Leone & Spadaro Viale Europa, 15 I-00144 Roma / IT | Application number, filing date | 07727992.5 | 11.04.2007 | [2008/52] | WO2007EP53524 | Priority number, date | EP20060112598 | 13.04.2006 Original published format: EP 06112598 | [2008/52] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2007118832 | Date: | 25.10.2007 | Language: | EN | [2007/43] | Type: | A2 Application without search report | No.: | EP2004668 | Date: | 24.12.2008 | Language: | EN | The application published by WIPO in one of the EPO official languages on 25.10.2007 takes the place of the publication of the European patent application. | [2008/52] | Type: | B1 Patent specification | No.: | EP2004668 | Date: | 13.03.2013 | Language: | EN | [2013/11] | Search report(s) | International search report - published on: | EP | 17.04.2008 | Classification | IPC: | C07J41/00, C07J43/00, A61K31/58, A61K31/565, A61P9/04 | [2008/52] | CPC: |
C07J41/0038 (EP,US);
C07J41/00 (KR);
A61K31/565 (EP,KR);
A61K31/58 (KR);
A61P13/12 (EP);
A61P35/00 (EP);
A61P43/00 (EP);
A61P9/00 (EP);
A61P9/04 (EP);
A61P9/12 (EP);
C07J41/0016 (EP,US);
C07J43/00 (KR);
C07J43/003 (EP,US)
(-)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR [2008/52] | Extension states | AL | 05.11.2008 | BA | 05.11.2008 | HR | 05.11.2008 | MK | 05.11.2008 | RS | 05.11.2008 | Title | German: | AMINODERIVATE VON ANDROSTANEN UND ANDROSTENEN ALS MEDIKAMENTE GEGEN HERZKREISLAUFERKRANKUNGEN | [2008/52] | English: | AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS | [2008/52] | French: | DERIVÉS AMINÉS DE ANDROSTANE ET DE ANDROSTÈNE POUR LE TRAITEMENT DES CONDITIONS CARDIOVASCULAIRES | [2008/52] | Entry into regional phase | 05.11.2008 | National basic fee paid | 05.11.2008 | Designation fee(s) paid | 05.11.2008 | Examination fee paid | Examination procedure | 05.11.2008 | Examination requested [2008/52] | 22.12.2008 | Amendment by applicant (claims and/or description) | 14.09.2011 | Despatch of a communication from the examining division (Time limit: M04) | 11.01.2012 | Reply to a communication from the examining division | 25.09.2012 | Communication of intention to grant the patent | 30.01.2013 | Fee for grant paid | 30.01.2013 | Fee for publishing/printing paid | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 14.09.2011 | Opposition(s) | 16.12.2013 | No opposition filed within time limit [2014/08] | Fees paid | Renewal fee | 29.04.2009 | Renewal fee patent year 03 | 26.04.2010 | Renewal fee patent year 04 | 25.04.2011 | Renewal fee patent year 05 | 25.04.2012 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 13.03.2013 | CY | 13.03.2013 | DK | 13.03.2013 | EE | 13.03.2013 | FI | 13.03.2013 | LT | 13.03.2013 | LV | 13.03.2013 | MT | 13.03.2013 | SE | 13.03.2013 | SI | 13.03.2013 | SK | 13.03.2013 | TR | 13.03.2013 | BG | 13.06.2013 | IS | 13.07.2013 | [2016/41] |
Former [2015/32] | AT | 13.03.2013 | |
CY | 13.03.2013 | ||
DK | 13.03.2013 | ||
EE | 13.03.2013 | ||
FI | 13.03.2013 | ||
LT | 13.03.2013 | ||
LV | 13.03.2013 | ||
MT | 13.03.2013 | ||
SE | 13.03.2013 | ||
SI | 13.03.2013 | ||
SK | 13.03.2013 | ||
TR | 13.03.2013 | ||
BG | 13.06.2013 | ||
IS | 13.07.2013 | ||
Former [2015/13] | AT | 13.03.2013 | |
CY | 13.03.2013 | ||
DK | 13.03.2013 | ||
EE | 13.03.2013 | ||
FI | 13.03.2013 | ||
LT | 13.03.2013 | ||
LV | 13.03.2013 | ||
MT | 13.03.2013 | ||
SE | 13.03.2013 | ||
SI | 13.03.2013 | ||
SK | 13.03.2013 | ||
BG | 13.06.2013 | ||
IS | 13.07.2013 | ||
Former [2014/09] | AT | 13.03.2013 | |
CY | 13.03.2013 | ||
DK | 13.03.2013 | ||
EE | 13.03.2013 | ||
FI | 13.03.2013 | ||
LT | 13.03.2013 | ||
LV | 13.03.2013 | ||
SE | 13.03.2013 | ||
SI | 13.03.2013 | ||
SK | 13.03.2013 | ||
BG | 13.06.2013 | ||
IS | 13.07.2013 | ||
Former [2013/52] | AT | 13.03.2013 | |
CY | 13.03.2013 | ||
EE | 13.03.2013 | ||
FI | 13.03.2013 | ||
LT | 13.03.2013 | ||
LV | 13.03.2013 | ||
SE | 13.03.2013 | ||
SI | 13.03.2013 | ||
SK | 13.03.2013 | ||
BG | 13.06.2013 | ||
IS | 13.07.2013 | ||
Former [2013/49] | AT | 13.03.2013 | |
EE | 13.03.2013 | ||
FI | 13.03.2013 | ||
LT | 13.03.2013 | ||
LV | 13.03.2013 | ||
SE | 13.03.2013 | ||
SI | 13.03.2013 | ||
SK | 13.03.2013 | ||
BG | 13.06.2013 | ||
IS | 13.07.2013 | ||
Former [2013/48] | AT | 13.03.2013 | |
EE | 13.03.2013 | ||
FI | 13.03.2013 | ||
LT | 13.03.2013 | ||
LV | 13.03.2013 | ||
SE | 13.03.2013 | ||
SI | 13.03.2013 | ||
BG | 13.06.2013 | ||
IS | 13.07.2013 | ||
Former [2013/38] | FI | 13.03.2013 | |
LT | 13.03.2013 | ||
LV | 13.03.2013 | ||
SE | 13.03.2013 | ||
SI | 13.03.2013 | ||
BG | 13.06.2013 | ||
Former [2013/37] | FI | 13.03.2013 | |
LT | 13.03.2013 | ||
SE | 13.03.2013 | ||
SI | 13.03.2013 | ||
BG | 13.06.2013 | ||
Former [2013/34] | LT | 13.03.2013 | |
SE | 13.03.2013 | ||
BG | 13.06.2013 | ||
Former [2013/33] | LT | 13.03.2013 | Cited in | International search | [Y]GB868303 (SYNTEX SA) [Y] 1-7,18-47 * page 1, column 1, paragraph 3; examples IV,V *; | [A]US3013009 (MARSHALL CHARLES W) [A] 1,8-15,18-47 * column 2, lines 55-62; example 2 *; | [A]US3120515 (CHRISTIANSEN ROBERT G) [A] 1,16-33,39-47 * column 4, lines 13-23; examples 22,23 *; | [A]GB1042292 (ORGANON LABOR LTD) [A] 1,16-33,39-47* page 1, column 2; examples 8,9 *; | [Y]US5144017 (LABELLA FRANK S [CA], et al) [Y] 1-7,18-47 * column 1, paragraphs 3,7; figures 3,4 *; | [DY]EP0825197 (SIGMA TAU IND FARMACEUTI [IT]) [DY] 1-7,18-47 * page 6; examples 1-18; table 1 *; | [DY] - DE MUNARI SERGIO ET AL, "Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.", JOURNAL OF MEDICINAL CHEMISTRY. 14 AUG 2003, (20030814), vol. 46, no. 17, ISSN 0022-2623, pages 3644 - 3654, XP002406552 [DY] 1-7,18-47 * page 3646, column 1; table 1 * DOI: http://dx.doi.org/10.1021/jm030830y | [Y] - TEMMA, KYOSUKE ET AL, "Effects of progesterone derivatives on sodium pump activity and force of myocardial contraction in isolated guinea pig heart", RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY , 41(1), 51-63 CODEN: RCOCB8; ISSN: 0034-5164, (1983), XP002406556 [Y] 1-7,18-47 * page 56; table 1 * * page 57; table 2 * | [A] - ULUBELEN A ET AL, "Cardioactive terpenoids and a new rearranged diterpene from Salvia syriaca", PLANTA MEDICA, THIEME, STUTTGART, DE, (2000), vol. 66, no. 7, ISSN 0032-0943, pages 627 - 629, XP003014892 [A] 1,8-15,18-47 * page 627, column 1, paragraph 3; compound 7 * * page 628, column 2, paragraph L * DOI: http://dx.doi.org/10.1055/s-2000-8629 | [A] - LE MEN J ET AL, "CHEMISTRY AND PHARMACOLOGY OF HEMI SYNTHETIC COMPOUNDS FOR CARDIO VASCULAR ACTIVITY DERIVATIVES OF PARAVALLARINE A NATURALLY OCCURRING STEROID", CHIMICA THERAPEUTICA, (1970), vol. 5, no. 1, ISSN 0009-4374, pages 41 - 54, XP008088843 [A] 1,16-33,39-47 * page 45; compound 33 * | [A] - KAMERNITSKII, A. V. ET AL, "A new class of cardiotonic steroids", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 1991:199372, URL: STN, XP002469943 [A] 1,16-33,39-47 * abstract * | Examination | - SORENSEN MORTEN B ET AL, "Long-term use of contraceptive depot medroxyprogesterone acetate in young women impairs arterial endothelial function assessed by cardiovascular magnetic resonance.", CIRCULATION 24 SEP 2002 LNKD- PUBMED:12270857, (20020924), vol. 106, no. 13, ISSN 1524-4539, pages 1646 - 1651 |