blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2004668

EP2004668 - AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.01.2014
Database last updated on 03.09.2024
Most recent event   Tooltip23.03.2018Lapse of the patent in a contracting statepublished on 25.04.2018  [2018/17]
Applicant(s)For all designated states
SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.
Viale Shakespeare 47
00144 Roma / IT
[2008/52]
Inventor(s)01 / CERRI, Alberto
Via Barnaba Oriani, 55
20156 Milano / IT
02 / TORRI, Marco
Via MOnte Grappa, 20
20017 Rho / IT
03 / ARMAROLI, Silvia
Via della Chiesa, 24
44020 Gallo Poggio Renatico / IT
04 / BANFI, Leonardo
via 1· Maggio 6/8
20026 Novate Milanese (MI) / IT
05 / BIANCHI, Giuseppe
Iazza Adigrat, 4
20133 Milano / IT
06 / CARZANA, Giulio
Largo Cavalieri di Malta, 16
20146 Milano / IT
07 / FERRARI, Patrizia
Via Gasparotto 57/A
21100 Varese / IT
08 / MICHELETTI, Rosamaria
Via Savona, 52
20144 Milano / IT
09 / SPUTORE, Simona
Via Pace, 14
20036 Meda / IT
10 / ZAPPAVIGNA, Maria Pia
Via Radice, 22
20013 Magenta / IT
 [2008/52]
Representative(s)Spadaro, Marco, et al
Cantaluppi & Partners S.r.l.
Viale della Tecnica, 205
00144 Roma / IT
[N/P]
Former [2011/50]Spadaro, Marco, et al
Cantaluppi & Partners Viale della Tecnica, 205
00144 Roma / IT
Former [2008/52]Spadaro, Marco, et al
Studio Associato Leone & Spadaro Viale Europa, 15
I-00144 Roma / IT
Application number, filing date07727992.511.04.2007
[2008/52]
WO2007EP53524
Priority number, dateEP2006011259813.04.2006         Original published format: EP 06112598
[2008/52]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2007118832
Date:25.10.2007
Language:EN
[2007/43]
Type: A2 Application without search report 
No.:EP2004668
Date:24.12.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 25.10.2007 takes the place of the publication of the European patent application.
[2008/52]
Type: B1 Patent specification 
No.:EP2004668
Date:13.03.2013
Language:EN
[2013/11]
Search report(s)International search report - published on:EP17.04.2008
ClassificationIPC:C07J41/00, C07J43/00, A61K31/58, A61K31/565, A61P9/04
[2008/52]
CPC:
C07J41/0038 (EP,US); C07J41/00 (KR); A61K31/565 (EP,KR);
A61K31/58 (KR); A61P13/12 (EP); A61P35/00 (EP);
A61P43/00 (EP); A61P9/00 (EP); A61P9/04 (EP);
A61P9/12 (EP); C07J41/0016 (EP,US); C07J43/00 (KR);
C07J43/003 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2008/52]
Extension statesAL05.11.2008
BA05.11.2008
HR05.11.2008
MK05.11.2008
RS05.11.2008
TitleGerman:AMINODERIVATE VON ANDROSTANEN UND ANDROSTENEN ALS MEDIKAMENTE GEGEN HERZKREISLAUFERKRANKUNGEN[2008/52]
English:AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS[2008/52]
French:DERIVÉS AMINÉS DE ANDROSTANE ET DE ANDROSTÈNE POUR LE TRAITEMENT DES CONDITIONS CARDIOVASCULAIRES[2008/52]
Entry into regional phase05.11.2008National basic fee paid 
05.11.2008Designation fee(s) paid 
05.11.2008Examination fee paid 
Examination procedure05.11.2008Examination requested  [2008/52]
22.12.2008Amendment by applicant (claims and/or description)
14.09.2011Despatch of a communication from the examining division (Time limit: M04)
11.01.2012Reply to a communication from the examining division
25.09.2012Communication of intention to grant the patent
30.01.2013Fee for grant paid
30.01.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  14.09.2011
Opposition(s)16.12.2013No opposition filed within time limit [2014/08]
Fees paidRenewal fee
29.04.2009Renewal fee patent year 03
26.04.2010Renewal fee patent year 04
25.04.2011Renewal fee patent year 05
25.04.2012Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT13.03.2013
CY13.03.2013
DK13.03.2013
EE13.03.2013
FI13.03.2013
LT13.03.2013
LV13.03.2013
MT13.03.2013
SE13.03.2013
SI13.03.2013
SK13.03.2013
TR13.03.2013
BG13.06.2013
IS13.07.2013
[2016/41]
Former [2015/32]AT13.03.2013
CY13.03.2013
DK13.03.2013
EE13.03.2013
FI13.03.2013
LT13.03.2013
LV13.03.2013
MT13.03.2013
SE13.03.2013
SI13.03.2013
SK13.03.2013
TR13.03.2013
BG13.06.2013
IS13.07.2013
Former [2015/13]AT13.03.2013
CY13.03.2013
DK13.03.2013
EE13.03.2013
FI13.03.2013
LT13.03.2013
LV13.03.2013
MT13.03.2013
SE13.03.2013
SI13.03.2013
SK13.03.2013
BG13.06.2013
IS13.07.2013
Former [2014/09]AT13.03.2013
CY13.03.2013
DK13.03.2013
EE13.03.2013
FI13.03.2013
LT13.03.2013
LV13.03.2013
SE13.03.2013
SI13.03.2013
SK13.03.2013
BG13.06.2013
IS13.07.2013
Former [2013/52]AT13.03.2013
CY13.03.2013
EE13.03.2013
FI13.03.2013
LT13.03.2013
LV13.03.2013
SE13.03.2013
SI13.03.2013
SK13.03.2013
BG13.06.2013
IS13.07.2013
Former [2013/49]AT13.03.2013
EE13.03.2013
FI13.03.2013
LT13.03.2013
LV13.03.2013
SE13.03.2013
SI13.03.2013
SK13.03.2013
BG13.06.2013
IS13.07.2013
Former [2013/48]AT13.03.2013
EE13.03.2013
FI13.03.2013
LT13.03.2013
LV13.03.2013
SE13.03.2013
SI13.03.2013
BG13.06.2013
IS13.07.2013
Former [2013/38]FI13.03.2013
LT13.03.2013
LV13.03.2013
SE13.03.2013
SI13.03.2013
BG13.06.2013
Former [2013/37]FI13.03.2013
LT13.03.2013
SE13.03.2013
SI13.03.2013
BG13.06.2013
Former [2013/34]LT13.03.2013
SE13.03.2013
BG13.06.2013
Former [2013/33]LT13.03.2013
Cited inInternational search[Y]GB868303  (SYNTEX SA) [Y] 1-7,18-47 * page 1, column 1, paragraph 3; examples IV,V *;
 [A]US3013009  (MARSHALL CHARLES W) [A] 1,8-15,18-47 * column 2, lines 55-62; example 2 *;
 [A]US3120515  (CHRISTIANSEN ROBERT G) [A] 1,16-33,39-47 * column 4, lines 13-23; examples 22,23 *;
 [A]GB1042292  (ORGANON LABOR LTD) [A] 1,16-33,39-47* page 1, column 2; examples 8,9 *;
 [Y]US5144017  (LABELLA FRANK S [CA], et al) [Y] 1-7,18-47 * column 1, paragraphs 3,7; figures 3,4 *;
 [DY]EP0825197  (SIGMA TAU IND FARMACEUTI [IT]) [DY] 1-7,18-47 * page 6; examples 1-18; table 1 *;
 [DY]  - DE MUNARI SERGIO ET AL, "Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.", JOURNAL OF MEDICINAL CHEMISTRY. 14 AUG 2003, (20030814), vol. 46, no. 17, ISSN 0022-2623, pages 3644 - 3654, XP002406552 [DY] 1-7,18-47 * page 3646, column 1; table 1 *

DOI:   http://dx.doi.org/10.1021/jm030830y
 [Y]  - TEMMA, KYOSUKE ET AL, "Effects of progesterone derivatives on sodium pump activity and force of myocardial contraction in isolated guinea pig heart", RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY , 41(1), 51-63 CODEN: RCOCB8; ISSN: 0034-5164, (1983), XP002406556 [Y] 1-7,18-47 * page 56; table 1 * * page 57; table 2 *
 [A]  - ULUBELEN A ET AL, "Cardioactive terpenoids and a new rearranged diterpene from Salvia syriaca", PLANTA MEDICA, THIEME, STUTTGART, DE, (2000), vol. 66, no. 7, ISSN 0032-0943, pages 627 - 629, XP003014892 [A] 1,8-15,18-47 * page 627, column 1, paragraph 3; compound 7 * * page 628, column 2, paragraph L *

DOI:   http://dx.doi.org/10.1055/s-2000-8629
 [A]  - LE MEN J ET AL, "CHEMISTRY AND PHARMACOLOGY OF HEMI SYNTHETIC COMPOUNDS FOR CARDIO VASCULAR ACTIVITY DERIVATIVES OF PARAVALLARINE A NATURALLY OCCURRING STEROID", CHIMICA THERAPEUTICA, (1970), vol. 5, no. 1, ISSN 0009-4374, pages 41 - 54, XP008088843 [A] 1,16-33,39-47 * page 45; compound 33 *
 [A]  - KAMERNITSKII, A. V. ET AL, "A new class of cardiotonic steroids", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 1991:199372, URL: STN, XP002469943 [A] 1,16-33,39-47 * abstract *
Examination   - SORENSEN MORTEN B ET AL, "Long-term use of contraceptive depot medroxyprogesterone acetate in young women impairs arterial endothelial function assessed by cardiovascular magnetic resonance.", CIRCULATION 24 SEP 2002 LNKD- PUBMED:12270857, (20020924), vol. 106, no. 13, ISSN 1524-4539, pages 1646 - 1651
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.