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Extract from the Register of European Patents

EP About this file: EP2357229

EP2357229 - HYDROXYLASE GENE AND USE THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.05.2017
Database last updated on 18.01.2025
Most recent event   Tooltip06.03.2020Lapse of the patent in a contracting state
New state(s): TR		published on 08.04.2020  [2020/15]
Applicant(s)For all designated states
MicroBiopharm Japan Co., Ltd.
1-3-1 Kyobashi
Chuo-ku
Tokyo 104-0031 / JP
For all designated states
National Institute of Advanced Industrial Science and Technology
3-1, Kasumigaseki 1-chome Chiyoda-ku
Tokyo 100-8921 / JP
[2014/26]
Former [2012/28]For all designated states
MicroBiopharm Japan Co., Ltd.
3-3-6, Nihonbashihoncho
Chuo-ku
Tokyo 103-0023 / JP
For all designated states
National Institute of Advanced Industrial Science and Technology
3-1, Kasumigaseki 1-chome Chiyoda-ku
Tokyo 100-8921 / JP
Former [2011/33]For all designated states
MERCIAN CORPORATION
5-8, Kyobashi 1-chome Chuo-ku
Tokyo 104-8305 / JP
For all designated states
National Institute of Advanced Industrial Science and Technology
3-1, Kasumigaseki 1-chome Chiyoda-ku
Tokyo 100-8921 / JP
Inventor(s)01 / FUJII, Yoshikazu
Pretty Villa A-202
721-1, Ebitsuka
Iwata-shi Shizuoka 438-0812 / JP
02 / TAMURA, Tomohiro
Hokkaido Center
2-1, Tsukisamu-Higashi 2-jo 17-chome
Toyohira-ku
Sapporo-shi Hokkaido 062-8517 / JP
 [2016/29]
Former [2011/33]01 / FUJII, Yoshikazu
Pretty Villa A-202 721-1, Ebitsuka
Iwata-shi, Shizuoka 438-0812 / JP
02 / TAMURA, Tomohiro
Hokkaido Center 2-1, Tsukisamu-Higashi 2-jo 17-chome Toyohira-ku
Sapporo-shi, Hokkaido 062-8517 / JP
Representative(s)Chapman, Paul Gilmour, et al
Marks & Clerk LLP
Atholl Exchange
6 Canning Street
Edinburgh EH3 8EG / GB
[2013/42]
Former [2011/33]Chapman, Paul Gilmour
Marks & Clerk LLP Aurora 120 Bothwell Street
Glasgow G2 7JS / GB
Application number, filing date07743689.718.05.2007
[2011/33]
WO2007JP60254
Priority number, dateJP2006015084331.05.2006         Original published format: JP 2006150843
[2011/33]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2007138894
Date:06.12.2007
Language:JA
[2007/49]
Type: A1 Application with search report 
No.:EP2357229
Date:17.08.2011
Language:EN
[2011/33]
Type: B1 Patent specification 
No.:EP2357229
Date:20.07.2016
Language:EN
[2016/29]
Search report(s)International search report - published on:JP06.12.2007
(Supplementary) European search report - dispatched on:EP20.10.2009
ClassificationIPC:C12N15/09, C12N1/21, C12N9/04, C12P7/02, C12P33/06
[2011/33]
CPC:
C12P7/22 (EP,US); C12N9/0071 (EP,US); C12P7/02 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/29]
Former [2011/33]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:HYDROXYLASE-GEN UND VERWENDUNG DAVON[2011/33]
English:HYDROXYLASE GENE AND USE THEREOF[2011/33]
French:GENE D'HYDROXYLASE ET SON UTILISATION[2011/33]
Entry into regional phase19.01.2009Translation filed 
23.12.2008National basic fee paid 
23.12.2008Search fee paid 
23.12.2008Designation fee(s) paid 
23.12.2008Examination fee paid 
Examination procedure23.12.2008Examination requested  [2011/33]
07.03.2012Despatch of a communication from the examining division (Time limit: M04)
06.07.2012Reply to a communication from the examining division
26.08.2014Despatch of a communication from the examining division (Time limit: M04)
05.01.2015Reply to a communication from the examining division
18.01.2016Communication of intention to grant the patent
17.05.2016Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
17.05.2016Fee for grant paid
17.05.2016Fee for publishing/printing paid
13.06.2016Information about intention to grant a patent
13.06.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  07.03.2012
Opposition(s)21.04.2017No opposition filed within time limit [2017/26]
Request for further processing for:The application is deemed to be withdrawn due to failure to file the translation
19.01.2009Request for further processing filed
19.01.2009Full payment received (date of receipt of payment)
Request granted
10.02.2009Decision despatched
Fees paidRenewal fee
23.12.2008Renewal fee patent year 03
31.03.2010Renewal fee patent year 04
11.05.2011Renewal fee patent year 05
29.03.2012Renewal fee patent year 06
10.05.2013Renewal fee patent year 07
27.03.2014Renewal fee patent year 08
12.05.2015Renewal fee patent year 09
10.05.2016Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.05.2007
AT20.07.2016
BE20.07.2016
CY20.07.2016
CZ20.07.2016
DK20.07.2016
EE20.07.2016
ES20.07.2016
FI20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
SE20.07.2016
SI20.07.2016
SK20.07.2016
TR20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
[2020/15]
Former [2019/46]HU18.05.2007
AT20.07.2016
BE20.07.2016
CY20.07.2016
CZ20.07.2016
DK20.07.2016
EE20.07.2016
ES20.07.2016
FI20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
SE20.07.2016
SI20.07.2016
SK20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2019/31]HU18.05.2007
AT20.07.2016
BE20.07.2016
CZ20.07.2016
DK20.07.2016
EE20.07.2016
ES20.07.2016
FI20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
SE20.07.2016
SI20.07.2016
SK20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2018/06]AT20.07.2016
BE20.07.2016
CZ20.07.2016
DK20.07.2016
EE20.07.2016
ES20.07.2016
FI20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
SE20.07.2016
SI20.07.2016
SK20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/37]AT20.07.2016
BE20.07.2016
CZ20.07.2016
DK20.07.2016
EE20.07.2016
ES20.07.2016
FI20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
PL20.07.2016
RO20.07.2016
SE20.07.2016
SI20.07.2016
SK20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/31]AT20.07.2016
BE20.07.2016
CZ20.07.2016
DK20.07.2016
EE20.07.2016
ES20.07.2016
FI20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
PL20.07.2016
RO20.07.2016
SE20.07.2016
SK20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/13]AT20.07.2016
BE20.07.2016
ES20.07.2016
FI20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
PL20.07.2016
SE20.07.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/11]AT20.07.2016
BE20.07.2016
ES20.07.2016
FI20.07.2016
IT20.07.2016
LT20.07.2016
PL20.07.2016
SE20.07.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/10]BE20.07.2016
FI20.07.2016
IT20.07.2016
LT20.07.2016
PL20.07.2016
SE20.07.2016
IS20.11.2016
Former [2017/09]FI20.07.2016
IT20.07.2016
LT20.07.2016
Former [2017/07]LT20.07.2016
Documents cited:Search[Y]KR20030076027  ;
 [XY]  - KAWAUCHI H ET AL, "Cloning and nucleotide sequence of a bacterial cytochrome P-450VD25 gene encoding vitamin D-3 25-hydroxylase.", BIOCHIMICA ET BIOPHYSICA ACTA 13 SEP 1994, (19940913), vol. 1219, no. 1, ISSN 0006-3002, pages 179 - 183, XP002549241 [X] 1,2,7,9-12,14-16 * abstract * [Y] 3-6,8,13

DOI:   http://dx.doi.org/10.1016/0167-4781(94)90266-6
 [Y]  - DATABASE WPI, 0, Derwent World Patents Index, vol. 2004, no. 11, Database accession no. 2004-105188, XP002549245 & KR20030076027 A 20030926 (IL-DONG PHARM CO LTD) [Y] 3-6,8 * abstract *
 [DY]  - NAGY I ET AL, "Degradation of the thiocarbamate herbicide EPTC (S-ethyl dipropylcarbamothioate) and biosafening by Rhodococcus sp. strain NI86/21 involve an inducible cytochrome P-450 system and aldehyde dehydrogenase.", JOURNAL OF BACTERIOLOGY FEB 1995, (199502), vol. 177, no. 3, ISSN 0021-9193, pages 676 - 687, XP002549242 [DY] 13 * abstract *
 [Y]  - WARWICK S ET AL, "A phylogenetic analysis of the family Pseudonocardiaceae and the genera Actinokineospora and Saccharothrix with 16S rRNA sequences and a proposal to combine the genera Amycolata and Pseudonocardia in an emended genus Pseudonocardia.", INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY APR 1994, (199404), vol. 44, no. 2, ISSN 0020-7713, pages 293 - 299, XP002549243 [Y] 3-6,8 * abstract *

DOI:   http://dx.doi.org/10.1099/00207713-44-2-293
 [T]  - FUJII YOSHIKAZU ET AL, "Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 24 JUL 2009, (20090724), vol. 385, no. 2, ISSN 1090-2104, pages 170 - 175, XP002549244 [T] 1-12,14-17

DOI:   http://dx.doi.org/10.1016/j.bbrc.2009.05.033
International search[A]JPH02231089  (TAISHO PHARMA CO LTD);
 [A]JP4064678B  ;
 [X]  - SAWADA N. ET AL., "Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (2004), vol. 320, pages 156 - 164, XP004519078

DOI:   http://dx.doi.org/10.1016/j.bbrc.2004.05.140
 [Y]  - SASAKI J. ET AL., "Transformation of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 via 25-hydroxyl vitamin D3 using Amycolata sp. strains", APPL. MICROBIOL. BIOTECHNOL., (1992), vol. 38, no. 2, pages 152 - 157, XP003019722

DOI:   http://dx.doi.org/10.1007/BF00174460
 [Y]  - TAKEDA K. ET AL., "Application of cyclodextrin to microbial transformation of vitamin D3 to 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3", J. FERMENT. BIOENG., (1994), vol. 78, pages 380 - 382, XP001053545

DOI:   http://dx.doi.org/10.1016/0922-338X(94)90285-2
by applicantJPH02469
 JPH02231089
 JP2003325175
    - KAWAUCHI H ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, (1994), vol. 1219, pages 179 - 183
    - SAWADA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (2004), vol. 320, pages 156 - 164
    - UCHIDA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (2004), vol. 320, pages 156 - 164
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.