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Extract from the Register of European Patents

EP About this file: EP1994043

EP1994043 - PHOSPHATASE INHIBITOR PROTEIN-1 AS A REGULATOR OF CARDIAC FUNCTION [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  25.10.2013
Database last updated on 28.06.2024
Most recent event   Tooltip25.10.2013Application deemed to be withdrawnpublished on 27.11.2013  [2013/48]
Applicant(s)For all designated states
The University of Cincinnati
Dept. of Pharmacology and Cell Biophysics University of Cincinnati College of Medicine
Cincinnati OH 45267-0575 / US
[2008/48]
Inventor(s)01 / KRANIAS, Evangelia
5890 Park Road
Cincinnati, OH 45243 / US
02 / RODRIGUEZ, Patricia
236 Loraine Avenue 1
Cincinnati, OH 45220 / US
03 / MITTON, Bryan
765 Weyburn Place No.67
Los Angeles, CA 90024 / US
 [2009/02]
Former [2008/48]01 / KRANIAS, Evangelia
5890 Park Road
Cincinnati, OH 45243 / US
02 / RODRIGUEZ, Patricia
236 Loraine Avenue 1
Cincinnati, OH 45220 / US
03 / MITTON, Bryan
3827 Paxton Avenue 235
Cincinnati, OH 45209 / US
Representative(s)Reitstötter Kinzebach
Patentanwälte
Sternwartstraße 4
81679 München / DE
[N/P]
Former [2008/48]Reitstötter - Kinzebach
Patentanwälte Sternwartstrasse 4
81679 München / DE
Application number, filing date07750317.509.02.2007
[2008/48]
WO2007US03470
Priority number, dateUS20060772327P10.02.2006         Original published format: US 772327 P
[2008/48]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2007100465
Date:07.09.2007
Language:EN
[2007/36]
Type: A2 Application without search report 
No.:EP1994043
Date:26.11.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 07.09.2007 takes the place of the publication of the European patent application.
[2008/48]
Search report(s)International search report - published on:US31.07.2008
(Supplementary) European search report - dispatched on:EP22.04.2009
ClassificationIPC:C07H21/02
[2008/48]
CPC:
C07K14/4703 (EP,US); A61P9/00 (EP); A61P9/04 (EP);
A61K38/00 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2008/48]
TitleGerman:PHOSPHATASEHEMMER-PROTEIN 1 ALS REGULATOR DER HERZFUNKTION[2008/48]
English:PHOSPHATASE INHIBITOR PROTEIN-1 AS A REGULATOR OF CARDIAC FUNCTION[2008/48]
French:PROTÉINE-A INHIBITEUR DE PHOSPHATASE EN TANT QUE RÉGULATEUR DE LA FONCTION CARDIAQUE[2008/48]
Entry into regional phase08.08.2008National basic fee paid 
08.08.2008Search fee paid 
08.08.2008Designation fee(s) paid 
08.08.2008Examination fee paid 
Examination procedure08.08.2008Examination requested  [2008/48]
23.12.2008Amendment by applicant (claims and/or description)
08.09.2009Despatch of a communication from the examining division (Time limit: M06)
08.02.2010Reply to a communication from the examining division
01.12.2010Despatch of a communication from the examining division (Time limit: M06)
10.06.2011Reply to a communication from the examining division
02.08.2011Despatch of a communication from the examining division (Time limit: M06)
25.05.2012Reply to a communication from the examining division
19.06.2012Despatch of a communication from the examining division (Time limit: M06)
20.12.2012Reply to a communication from the examining division
05.02.2013Despatch of a communication from the examining division (Time limit: M04)
18.06.2013Application deemed to be withdrawn, date of legal effect  [2013/48]
19.07.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2013/48]
Divisional application(s)EP11181884.5  / EP2441770
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.09.2009
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
25.05.2012Request for further processing filed
25.05.2012Full payment received (date of receipt of payment)
Request granted
13.06.2012Decision despatched
02.02.2009Request for further processing filed
05.03.2009Decision despatched
Fees paidRenewal fee
26.02.2009Renewal fee patent year 03
24.02.2010Renewal fee patent year 04
23.02.2011Renewal fee patent year 05
24.02.2012Renewal fee patent year 06
27.02.2013Renewal fee patent year 07
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Documents cited:Search[X]  - BIBB J A ET AL, "Phosphorylation of Protein Phosphatase Inhibitor-1 by Cdk5", JOURNAL OF BIOLOGICAL CHEMISTRY 20010427 AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY INC. US, (20010427), vol. 276, no. 17, pages 14490 - 14497, XP002522737 [X] 11,12 * page 14493 *

DOI:   http://dx.doi.org/10.1074/jbc.M007197200
 [A]  - HUANG KE-XUE ET AL, "Ser67-phosphorylated inhibitor 1 is a potent protein phosphatase 1 inhibitor", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20000523), vol. 97, no. 11, ISSN 0027-8424, pages 5824 - 5829, XP002522738 [A] * the whole document *

DOI:   http://dx.doi.org/10.1073/PNAS.100460897
 [A]  - BRAZ J C ET AL, "PKC-ALPHA REGULATES CARDIAC CONTRACTILITY AND PROPENSITY TOWARD HEART FAILURE", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20040301), vol. 10, no. 3, ISSN 1078-8956, pages 248 - 254, XP008049092 [A] * the whole document *

DOI:   http://dx.doi.org/10.1038/nm1000
 [T]  - RODRIGUEZ P ET AL, "Identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function", JOURNAL OF BIOLOGICAL CHEMISTRY 20061215 AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY INC. US, (20061215), vol. 281, no. 50, pages 38599 - 38608, XP002522739 [T] * the whole document *

DOI:   http://dx.doi.org/10.1074/JBC.M604139200
 [T]  - RODRIGUEZ PATRICIA ET AL, "Phosphorylation of human inhibitor-1 at Ser67 and/or Thr75 attenuates stimulatory effects of protein kinase A signaling in cardiac myocytes", AMERICAN JOURNAL OF PHYSIOLOGY - HEART AND CIRCULATORY PHYSIOLOGY, (200707), vol. 293, no. 1, ISSN 0363-6135, pages H762 - H769, XP002522740 [T] * the whole document *

DOI:   http://dx.doi.org/10.1152/AJPHEART.00104.2007
International search[X]  - ENDO ET AL., "Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor", GENBANK, Database accession no. (HSU48707), XP003023456
    [ ] - BIOCHEMISTRY, (19960423), vol. 35, no. 16, pages 5220 - 5228
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.