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Extract from the Register of European Patents

EP About this file: EP2069535

EP2069535 - CONSENSUS CODING SEQUENCES OF HUMAN BREAST AND COLORECTAL CANCERS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.02.2014
Database last updated on 28.03.2026
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU, LU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
Johns Hopkins University
100 North Charles Street, 5th Floor
Baltimore, MD 21201 / US
[2009/25]
Inventor(s)01 / SJOBLOM, Tobias
John Hopkins University
100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
02 / JONES, Sian
Johns Hopkins University
100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
03 / PARSONS, D. Williams
Johns Hopkins University
100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
04 / WOOD, Laura D.
Johns Hopkins University
100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
05 / LIN, Jimmy
Johns Hopkins University
100 N . Charles Street, 5th Floor
Baltimore, MD 21201 / US
06 / BARBER, Thomas
Johns Hopkins University
100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
07 / MANDELKER, Diana
Johns Hopkins University
100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
08 / VOGELSTEIN, Bert
Johns Hopkins University
100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
09 / KINZLER, Kenneth W.
Johns Hopkins University
100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
10 / VELCULESU, Victor E.
Johns Hopkins University
100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
 [2013/15]
Former [2009/25]01 / SJOBLOM, Tobias
John Hopkins University 100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
02 / JONES, Sian
Johns Hopkins University 100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
03 / PARSONS, D. Williams
Johns Hopkins University 100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
04 / WOOD, Laura D.
Johns Hopkins University 100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
05 / LIN, Jimmy
Johns Hopkins University 100 N . Charles Street, 5th Floor
Baltimore, MD 21201 / US
06 / BARBER, Thomas
Johns Hopkins University 100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
07 / MANDELKER, Diana
Johns Hopkins University 100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
08 / VOGELSTEIN, Bert
Johns Hopkins University 100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
09 / KINZLER, Kenneth W.
Johns Hopkins University 100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
10 / VELCULESU, Victor E.
Johns Hopkins University 100 N. Charles Street, 5th Floor
Baltimore, MD 21201 / US
Representative(s)Tombling, Adrian George, et al
Withers & Rogers LLP
2 London Bridge
London SE1 9RA / GB
[N/P]
Former [2013/15]Tombling, Adrian George, et al
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
Former [2009/25]Tombling, Adrian George, et al
Withers & Rogers LLP Goldings House 2 Hays Lane London
SE1 2HW / GB
Application number, filing date07811279.413.08.2007
[2009/25]
WO2007US17866
Priority number, dateUS20060836944P11.08.2006         Original published format: US 836944 P
US20060842363P06.09.2006         Original published format: US 842363 P
[2009/25]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008021288
Date:21.02.2008
Language:EN
[2008/08]
Type: A2 Application without search report 
No.:EP2069535
Date:17.06.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 21.02.2008 takes the place of the publication of the European patent application.
[2009/25]
Type: B1 Patent specification 
No.:EP2069535
Date:10.04.2013
Language:EN
[2013/15]
Search report(s)International search report - published on:US13.11.2008
(Supplementary) European search report - dispatched on:EP23.03.2010
ClassificationIPC:C12Q1/68
[2009/25]
CPC:
C12Q1/6886 (EP,US); C12Q2600/106 (EP,US); C12Q2600/156 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/25]
TitleGerman:CODIERENDE KONSENSUSSEQUENZEN MENSCHLICHER BRUST- UND KOLOREKTALKARZINOME[2009/25]
English:CONSENSUS CODING SEQUENCES OF HUMAN BREAST AND COLORECTAL CANCERS[2009/25]
French:SÉQUENCES CODANTES CONSENSUS DE CANCERS DU SEIN ET COLORECTAUX HUMAINS[2009/25]
Entry into regional phase10.03.2009National basic fee paid 
10.03.2009Search fee paid 
10.03.2009Designation fee(s) paid 
10.03.2009Examination fee paid 
Examination procedure10.03.2009Amendment by applicant (claims and/or description)
11.03.2009Examination requested  [2009/25]
05.07.2010Despatch of a communication from the examining division (Time limit: M06)
11.01.2011Reply to a communication from the examining division
25.10.2012Communication of intention to grant the patent
25.02.2013Fee for grant paid
25.02.2013Fee for publishing/printing paid
Divisional application(s)EP12176466.6  / EP2543739
EP12176467.4  / EP2543740
EP15175950.3  / EP2949763
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  05.07.2010
Opposition(s)13.01.2014No opposition filed within time limit [2014/12]
Fees paidRenewal fee
10.03.2009Renewal fee patent year 03
25.08.2010Renewal fee patent year 04
25.10.2011Renewal fee patent year 05
27.08.2012Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
31.08.201105   M06   Fee paid on   25.10.2011
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU13.08.2007
AT10.04.2013
CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
LV10.04.2013
MC10.04.2013
MT10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
TR10.04.2013
BG10.07.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
IE13.08.2013
LU13.08.2013
CH31.08.2013
LI31.08.2013
[2015/34]
Former [2015/32]AT10.04.2013
CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
LV10.04.2013
MC10.04.2013
MT10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
TR10.04.2013
BG10.07.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
IE13.08.2013
CH31.08.2013
LI31.08.2013
Former [2014/33]AT10.04.2013
CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
LV10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
IE13.08.2013
CH31.08.2013
LI31.08.2013
Former [2014/20]AT10.04.2013
CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
LV10.04.2013
MC10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
CH31.08.2013
LI31.08.2013
Former [2014/11]AT10.04.2013
CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
IT10.04.2013
LT10.04.2013
LV10.04.2013
NL10.04.2013
PL10.04.2013
RO10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
Former [2014/10]AT10.04.2013
CY10.04.2013
CZ10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
LT10.04.2013
LV10.04.2013
NL10.04.2013
PL10.04.2013
SE10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
Former [2014/09]AT10.04.2013
CY10.04.2013
DK10.04.2013
EE10.04.2013
FI10.04.2013
LT10.04.2013
LV10.04.2013
NL10.04.2013
PL10.04.2013
SE10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
Former [2013/52]AT10.04.2013
CY10.04.2013
FI10.04.2013
LT10.04.2013
LV10.04.2013
NL10.04.2013
PL10.04.2013
SE10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
Former [2013/50]AT10.04.2013
FI10.04.2013
LT10.04.2013
LV10.04.2013
NL10.04.2013
PL10.04.2013
SE10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
Former [2013/49]AT10.04.2013
FI10.04.2013
LT10.04.2013
NL10.04.2013
SE10.04.2013
SI10.04.2013
GR11.07.2013
IS10.08.2013
PT12.08.2013
Former [2013/48]AT10.04.2013
LT10.04.2013
NL10.04.2013
SI10.04.2013
IS10.08.2013
PT12.08.2013
Former [2013/47]LT10.04.2013
SI10.04.2013
PT12.08.2013
Former [2013/37]SI10.04.2013
Documents cited:Search[I] WO9213103  (UNIV JOHNS HOPKINS et al.) [I] 1,5,7,15 * page 3, paragraph 7; claims 1-54 * * example 3 *
 [I] WO0042436  (CA TX INC et al.) [I] 1,5,7,15 * claims 1-22 *
 [I] EP0785216  (MYRIAD GENETICS INC et al.) [I] 1,5,7,15 * pages 1-5 * * example 11 * * claims 42-47 *
 [I] US2001021502  (SWIFT MICHAEL R et al.) [I] 1,5,7,15 * paragraphs [0003] , [0013] - [0020] - [0027] - [0028] * * claims 1-6 *
 [I] US5605799  (WHITE RAYMOND L et al.) [I] 1,5,7,15 * column 5, paragraph 5 - column 6, paragraph 3 * * example 6 *
 [XP]   TOBIAS SJBLOM ET AL: "The Consensus Coding Sequences of Human Breast and Colorectal Cancers", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 314, 13 October 2006 (2006-10-13), pages 268 - 274, XP007901261, ISSN: 0036-8075 [XP] 1-5,7,15-16 * the whole document *

DOI:   http://dx.doi.org/10.1126/science.1133427
 [I]   MERAJVER S D ET AL: "SOMATIC MUTATIONS IN THE BRCA1 GENE IN SPORADIC OVARIAN TUMOURS", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, vol. 9, no. 4, 1 April 1995 (1995-04-01), pages 439 - 443, XP009055785, ISSN: 1061-4036 [I] 1,5,7,15 * the whole document *

DOI:   http://dx.doi.org/10.1038/ng0495-439
 [I]   WU GUOJUN ET AL: "Somatic mutation and gain of copy number of PIK3CA in human breast cancer", BREAST CANCER RESEARCH, CURRENT SCIENCE, LONDON, GB, vol. 7, no. 5, 31 May 2005 (2005-05-31), pages R609 - R616, XP021011863, ISSN: 1465-5411 [I] 1,5,7,15 * the whole document *

DOI:   http://dx.doi.org/10.1186/bcr1262
 [I]   LIN CHIN-YO ET AL: "Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells.", GENOME BIOLOGY 2004, vol. 5, no. 9, 2004, pages R66, XP002572575, ISSN: 1465-6914 [I] 1,5,7,15 * the whole document *

DOI:   http://dx.doi.org/10.1186/gb-2004-5-9-r66
 [Y]   STEINBACH DANIEL ET AL: "ABCA3 as a possible cause of drug resistance in childhood acute myeloid leukemia.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 15 JUL 2006, vol. 12, no. 14 Pt 1, 15 July 2006 (2006-07-15), pages 4357 - 4363, XP002572576, ISSN: 1078-0432 [Y] 2-4,16 * the whole document *

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-05-2587
 [Y]   HIRSCHMANN-JAX C ET AL: "A distinct side population of cells with high drug efflux capacity in human tumor cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 101, no. 39, 28 September 2004 (2004-09-28), pages 14228 - 14233, XP002390118, ISSN: 0027-8424 [Y] 2-4,16 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.0400067101
 [Y]   GILLET J-P ET AL: "Microarray-based detection of multidrug resistance n human tumor cells by expression profiling of ATP-binding cassette transporter genes", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD., US, vol. 64, 1 January 2004 (2004-01-01), pages 8987 - 8993, XP002497763, ISSN: 0008-5472 [Y] 2-4,16 * the whole document *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-04-1978
 [Y]   WAJAPEYEE NARENDRA ET AL: "Pharmacogenomics in breast cancer: current trends and future directions.", CURRENT OPINION IN MOLECULAR THERAPEUTICS JUN 2004, vol. 6, no. 3, June 2004 (2004-06-01), pages 296 - 301, XP002572577, ISSN: 1464-8431 [Y] 2-4,16 * the whole document *
 [Y]   PUSZTAI LAJOS ET AL: "Development of pharmacogenomic markers to select preoperative chemotherapy for breast cancer.", BREAST CANCER (TOKYO, JAPAN) 2005, vol. 12, no. 2, 2005, pages 73 - 85, XP002572578, ISSN: 1340-6868 [Y] 2-4,16 * the whole document *
 [A]   VAN PUTTEN ET AL: "Of tumours in mice and men, the different roles of somatic mutation in treatment failure", EUROPEAN JOURNAL OF CANCER AND CLINICAL ONCOLOGY, OXFORD, GB, vol. 22, no. 7, 1 July 1986 (1986-07-01), pages 753 - 755, XP026201020, ISSN: 0277-5379, [retrieved on 19860701] [A] 2-4 * the whole document *

DOI:   http://dx.doi.org/10.1016/0277-5379(86)90358-5
 [A]   FORBES S ET AL: "COSMIC 2005", BRITISH JOURNAL OF CANCER, vol. 94, no. 2, January 2006 (2006-01-01), pages 318 - 322, XP002572579, ISSN: 0007-0920 [A] 1-5,7,15-16 * the whole document *

DOI:   http://dx.doi.org/10.1038/sj.bjc.6602928
 [A]   BAMFORD S ET AL: "The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website.", BRITISH JOURNAL OF CANCER, vol. 91, no. 2, 19 July 2004 (2004-07-19), pages 355 - 358, XP002572580, ISSN: 0007-0920 [A] 1-5,7,15-16 * the whole document *

DOI:   http://dx.doi.org/10.1038/SJ.BJC.6601894
International search[XA] WO2005113824  (WANG ZHENGHE et al.) [X] 1-2, 5-8, 11-14, 17- 26, 29-38, 41-44, 47-48 * , see entire reference, particularly pages 2-3, 5-8; claims 1-9, 43-72; Figures 5-6). *[A] 3-4, 9-10, 15-16, 27- 28, 39-40, 45-46
 [AP]   SJOBLOM, T. ET AL.: "The consensus coding sequences of human breast and colorectal cancers.", SCIENCE, vol. 314, 7 September 2006 (2006-09-07), pages 268 - 274, XP055343517 [AP] 1-48 * , see entire reference, particularly page 270, right column-page 271, left column. *

DOI:   http://dx.doi.org/10.1126/science.1133427
 [A]   STEPHENS ET AL.: "A screen of the complete protein kinase family identifies diverse patterns of somatic mutations in human breast cancer.", NATURE GENETICS., vol. 37, no. 6, June 2005 (2005-06-01), pages 590 - 592, XP002454639 [A] 1-6, 13-24, 37-42 * , see entire reference particularly page 590, right column, and Supplementary Table 1. *

DOI:   http://dx.doi.org/10.1038/ng1571
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.