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Extract from the Register of European Patents

EP About this file: EP2066816

EP2066816 - METHODS OF DETECTING AND MONITORING CANCER USING 3D ANALYSIS OF CENTROMERES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.09.2015
Database last updated on 14.03.2026
Most recent event   Tooltip27.10.2017Lapse of the patent in a contracting state
New state(s): BE		published on 29.11.2017  [2017/48]
Applicant(s)For all designated states
3D Signatures Inc
c/o 1700-360 Main Street
Winnipeg, MB R3C 3Z3 / CA
[2014/38]
Former [2009/24]For all designated states
Cancercare Manitoba
675 McDermot Avenue
Winnipeg MB R3E 0V9 / CA
Inventor(s)01 / MAI, Sabine
331 Beaverbrook Street
Winnipeg, Manitoba R3N 1M9 / CA
02 / GARINI, Yuval
Koranit
20181 D.N. Misgav / IL
03 / SARKAR, Rahul
6-460 Lindenwood Drive West
Winnipeg, Manitoba R3P 0Y1 / CA
04 / VERMOLEN, Bartholomeus J.
Jacob Catsstraat 56
NL-2613 HC Delft / NL
 [2009/32]
Former [2009/24]01 / MAI, Sabine
331 Beaverbrook Street
Winnipeg, Manitoba R3N 1M9 / CA
02 / GARINI, Yuval
Koranit
20181 D.N. Misgav / IL
03 / SARKAR, Rahul
10 Brigantine Bay
Winnipeg, Manitoba R3P 1R2 / CA
04 / VERMOLEN, Bartholomeus J.
Jacob Catsstraat 56
NL-2613 HC Delft / NL
Representative(s)Potter Clarkson
Chapel Quarter
Mount Street
Nottingham NG1 6HQ / GB
[N/P]
Former [2014/46]Potter Clarkson LLP
The Belgrave Centre
Talbot Street
Nottingham, NG1 5GG / GB
Former [2013/37]Potter Clarkson LLP
The Belgrave Centre
Talbot Street
Nottingham
NG1 5GG / GB
Former [2009/24]Wright, Andrew John
Potter Clarkson LLP Park View House 58 The Ropewalk
Nottingham NG1 5DD / GB
Application number, filing date07815918.328.09.2007
[2009/24]
WO2007CA01730
Priority number, dateUS20060848746P02.10.2006         Original published format: US 848746 P
[2009/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008040116
Date:10.04.2008
Language:EN
[2008/15]
Type: A1 Application with search report 
No.:EP2066816
Date:10.06.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 10.04.2008 takes the place of the publication of the European patent application.
[2009/24]
Type: B1 Patent specification 
No.:EP2066816
Date:12.11.2014
Language:EN
[2014/46]
Search report(s)International search report - published on:CA10.04.2008
(Supplementary) European search report - dispatched on:EP15.02.2010
ClassificationIPC:C12Q1/68, C12Q1/00, G01N15/10, G01N33/483, G01N21/84, G06K9/00, G01N33/574, G01N33/50, G01N15/14
[2014/15]
CPC:
G01N33/5035 (EP,US); G16H50/20 (EP,US); G01N33/5091 (EP,US);
G01N33/575 (EP,US); G01N33/57505 (EP,US); G06V20/695 (EP,US);
C12Q1/6886 (EP,US); G01N15/1433 (EP,US) (-)
Former IPC [2010/11]C12Q1/68, C12Q1/00, G01N15/10, G01N33/483, G01N21/84, G06K9/00
Former IPC [2009/24]C12Q1/68, C12Q1/00, G01N15/10, G01N33/483, G01N21/84
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/24]
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
MKNot yet paid
RSNot yet paid
TitleGerman:VERFAHREN ZUM NACHWEIS UND ZUR ÜBERWACHUNG EINER KREBSERKRANKUNG MITTELS 3D-ANALYSE VON ZENTROMEREN[2009/24]
English:METHODS OF DETECTING AND MONITORING CANCER USING 3D ANALYSIS OF CENTROMERES[2009/24]
French:MÉTHODES DE DÉTECTION ET DE SURVEILLANCE D'UN CANCER PAR ANALYSE TRIDIMENSIONNELLE DE CENTROMÈRES[2009/29]
Former [2009/24]METHODES DE DETECTION ET DE SURVEILLANCE D'UN CANCER PAR ANALYSE TRIDIMENSIONNELLE DE CENTROMERES
Entry into regional phase30.03.2009National basic fee paid 
30.03.2009Search fee paid 
30.03.2009Designation fee(s) paid 
30.03.2009Examination fee paid 
Examination procedure30.03.2009Examination requested  [2009/24]
04.06.2010Despatch of a communication from the examining division (Time limit: M06)
03.12.2010Reply to a communication from the examining division
24.09.2013Despatch of a communication from the examining division (Time limit: M04)
22.01.2014Reply to a communication from the examining division
09.04.2014Communication of intention to grant the patent
15.08.2014Fee for grant paid
15.08.2014Fee for publishing/printing paid
15.08.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.06.2010
Opposition(s)13.08.2015No opposition filed within time limit [2015/43]
Fees paidRenewal fee
25.09.2009Renewal fee patent year 03
27.09.2010Renewal fee patent year 04
29.09.2011Renewal fee patent year 05
28.09.2012Renewal fee patent year 06
30.09.2013Renewal fee patent year 07
30.09.2014Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.09.2007
AT12.11.2014
BE12.11.2014
BG12.11.2014
CY12.11.2014
CZ12.11.2014
DK12.11.2014
EE12.11.2014
ES12.11.2014
FI12.11.2014
IT12.11.2014
LT12.11.2014
LV12.11.2014
MC12.11.2014
MT12.11.2014
NL12.11.2014
PL12.11.2014
RO12.11.2014
SE12.11.2014
SI12.11.2014
SK12.11.2014
TR12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
[2017/46]
Former [2017/39]HU28.09.2007
AT12.11.2014
BG12.11.2014
CY12.11.2014
CZ12.11.2014
DK12.11.2014
EE12.11.2014
ES12.11.2014
FI12.11.2014
IT12.11.2014
LT12.11.2014
LV12.11.2014
MC12.11.2014
MT12.11.2014
NL12.11.2014
PL12.11.2014
RO12.11.2014
SE12.11.2014
SI12.11.2014
SK12.11.2014
TR12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2017/22]AT12.11.2014
CY12.11.2014
CZ12.11.2014
DK12.11.2014
EE12.11.2014
ES12.11.2014
FI12.11.2014
IT12.11.2014
LT12.11.2014
LV12.11.2014
MC12.11.2014
MT12.11.2014
NL12.11.2014
PL12.11.2014
RO12.11.2014
SE12.11.2014
SI12.11.2014
SK12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2016/23]AT12.11.2014
CY12.11.2014
CZ12.11.2014
DK12.11.2014
EE12.11.2014
ES12.11.2014
FI12.11.2014
IT12.11.2014
LT12.11.2014
LV12.11.2014
MC12.11.2014
NL12.11.2014
PL12.11.2014
RO12.11.2014
SE12.11.2014
SI12.11.2014
SK12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2016/12]AT12.11.2014
CY12.11.2014
CZ12.11.2014
DK12.11.2014
EE12.11.2014
ES12.11.2014
FI12.11.2014
IT12.11.2014
LT12.11.2014
LV12.11.2014
NL12.11.2014
PL12.11.2014
RO12.11.2014
SE12.11.2014
SI12.11.2014
SK12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2016/03]AT12.11.2014
CY12.11.2014
CZ12.11.2014
DK12.11.2014
EE12.11.2014
ES12.11.2014
FI12.11.2014
IT12.11.2014
LT12.11.2014
LV12.11.2014
NL12.11.2014
PL12.11.2014
RO12.11.2014
SE12.11.2014
SK12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2015/37]AT12.11.2014
CY12.11.2014
CZ12.11.2014
DK12.11.2014
EE12.11.2014
ES12.11.2014
FI12.11.2014
LT12.11.2014
LV12.11.2014
NL12.11.2014
PL12.11.2014
RO12.11.2014
SE12.11.2014
SK12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2015/36]AT12.11.2014
CY12.11.2014
CZ12.11.2014
DK12.11.2014
EE12.11.2014
ES12.11.2014
FI12.11.2014
LT12.11.2014
LV12.11.2014
NL12.11.2014
PL12.11.2014
RO12.11.2014
SE12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2015/35]AT12.11.2014
CY12.11.2014
DK12.11.2014
EE12.11.2014
ES12.11.2014
FI12.11.2014
LT12.11.2014
LV12.11.2014
NL12.11.2014
PL12.11.2014
SE12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2015/26]AT12.11.2014
CY12.11.2014
ES12.11.2014
FI12.11.2014
LT12.11.2014
LV12.11.2014
NL12.11.2014
PL12.11.2014
SE12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2015/25]AT12.11.2014
ES12.11.2014
FI12.11.2014
LT12.11.2014
LV12.11.2014
NL12.11.2014
PL12.11.2014
SE12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2015/24]ES12.11.2014
FI12.11.2014
LT12.11.2014
LV12.11.2014
NL12.11.2014
PL12.11.2014
SE12.11.2014
GR13.02.2015
IS12.03.2015
PT12.03.2015
Former [2015/23]ES12.11.2014
FI12.11.2014
LT12.11.2014
NL12.11.2014
IS12.03.2015
PT12.03.2015
Former [2015/22]LT12.11.2014
PT12.03.2015
Former [2015/20]LT12.11.2014
Documents cited:Search[XI]   TAGAWA Y ET AL: "Differences in spatial localization and chromatin pattern during different phases of cell cycle between normal and cancer cells", CYTOMETRY, ALAN LISS, NEW YORK, US, vol. 27, no. 4, 1 April 1997 (1997-04-01), pages 327 - 335, XP008105606, ISSN: 0196-4763, [retrieved on 19981206] [X] 1-3,5-7 * the whole document * * abstract * * page 329, column r, paragraph last - page 330, column l, paragraph first * * page 330, column l, paragraph last - column r, paragraph 2 * * page 334, column r, paragraph l * [I] 4,8-14

DOI:   http://dx.doi.org/10.1002/(SICI)1097-0320(19970401)27:4<327::AID-CYTO3>3.0.CO;2-9
 [XI]   TOLAND C F ET AL: "3D organisation of chromosome 11 centromeres in prostate cancer cell lines", CELLULAR ONCOLOGY, vol. 27, no. 2, 2005, & MEETING OF THE INTERNATIONAL-SOCIETY-FOR-CELLULAR-ONCOLOGY (ISCO 2005); BELFAST, NORTH IRELAND; APRIL 05 -08, 2005, pages 158, XP008117687, ISSN: 1570-5870 [X] 1-3,6-7 * poster P53 *[I] 4-5,9-14
 [XI]   AUBELE M ET AL: "COMPARATIVE FISH ANALYSIS OF NUMERICAL CHROMOSOME 7 ABNORMALITIES IN 5-MUM AND 15-MUM PARAFFIN-EMBEDDED TISSUE SECTIONS FROM PROSTATIC CARCINOMA", HISTOCHEMISTRY AND CELL BIOLOGY, SPRINGER, BERLIN, DE, vol. 107, no. 2, 1 January 1997 (1997-01-01), pages 121 - 126, XP001024090, ISSN: 0948-6143 [X] 1-2,5,7 * the whole document * * abstract * * page 122, column l, paragraph l * * page 122, column r, paragraph 1 * * page 123, column r, paragraph 3 * * Discussion; page 125 - page 126 * [I] 8-10,13-14

DOI:   http://dx.doi.org/10.1007/s004180050096
 [L]   KOUTN I ET AL: "Topography of genetic loci in tissue samples: towards new diagnostic tool using interphase FISH and high-resolution image analysis techniques.", ANALYTICAL CELLULAR PATHOLOGY : THE JOURNAL OF THE EUROPEAN SOCIETY FOR ANALYTICAL CELLULAR PATHOLOGY 2000, vol. 20, no. 4, 2000, pages 173 - 185, XP008117839, ISSN: 0921-8912 [L] 1-14 * the whole document * * abstract * * page 175, column r, paragraph 1 * * page 183, column r, paragraph 4 * * page 184, column l, paragraph 2 *
 [L]   SOLOVEI IRINA ET AL: "Differences in centromere positioning of cycling and postmitotic human cell types", CHROMOSOMA (BERLIN), vol. 112, no. 8, June 2004 (2004-06-01), pages 410 - 423, XP002566098, ISSN: 0009-5915 [L] 1-14 * the whole document * * abstract * * page 411, column r, paragraph l * * page 419, column r, paragraph l; figure 8 *

DOI:   http://dx.doi.org/10.1007/s00412-004-0287-3
 [A]   BAYANI JANE ET AL: "Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas.", GENES CHROMOSOMES AND CANCER, vol. 36, no. 1, January 2003 (2003-01-01), pages 7 - 16, XP002566099, ISSN: 1045-2257 [A] 1-8 * the whole document * * abstract *

DOI:   http://dx.doi.org/10.1002/gcc.10132
 [A]   BEHESHTI ET AL: "Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer cell lines by sequential Giemsa banding and spectral karyotyping", MOLECULAR DIAGNOSIS, NAPERVILLE, IL, US, vol. 5, no. 1, 1 January 2000 (2000-01-01), pages 23 - 32, XP005076102, ISSN: 1084-8592 [A] 1-8 * the whole document * * abstract *

DOI:   http://dx.doi.org/10.1016/S1084-8592(00)00007-2
 [T]   SARKAR RAHUL ET AL: "Alterations of centromere positions in nuclei of immortalized and malignant mouse lymphocytes.", CYTOMETRY. PART A : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR ANALYTICAL CYTOLOGY JUN 2007, vol. 71, no. 6, June 2007 (2007-06-01), pages 386 - 392, XP002565310, ISSN: 1552-4922 [T] 1-14 * the whole document * * abstract *

DOI:   http://dx.doi.org/10.1002/CYTO.A.20395
 [T]   GUFFEI AMANDA ET AL: "c-Myc-dependent formation of robertsonian translocation chromosomes in mouse cells", NEOPLASIA (NEW YORK), vol. 9, no. 7, July 2007 (2007-07-01), pages 578, XP002565311, ISSN: 1522-8002 [T] 1-14 * the whole document * * abstract *

DOI:   http://dx.doi.org/10.1593/NEO.07355
 [T]   GONALVES DOS SANTOS SILVA AMANDA ET AL: "Centromeres in cell division, evolution, nuclear organization and disease.", JOURNAL OF CELLULAR BIOCHEMISTRY 15 AUG 2008, vol. 104, no. 6, 15 August 2008 (2008-08-15), pages 2040 - 2058, XP002565312, ISSN: 1097-4644 [T] 1-14 * the whole document * * abstract *

DOI:   http://dx.doi.org/10.1002/jcb.21766
International search[X]   AUBELE M. ET AL.: "Comparative FISH analysis of numerical chromosome 7 abnormalities in 5-mum and 15-mum paraffin-embedded tissue sections from prostatic carcinoma", HISTOCHEM. CELL BIOL., vol. 107, no. 2, February 1997 (1997-02-01), pages 121 - 126, XP001024090

DOI:   http://dx.doi.org/10.1007/s004180050096
 [X]   TAGAWA Y. ET AL.: "Differences in spatial localization and chromatin pattern during different phases of cell cycle between normal and cancer cells", CYTOMETRY, vol. 27, no. 4, 1 April 1997 (1997-04-01), pages 327 - 335, XP008105606 [X]

DOI:   http://dx.doi.org/10.1002/(SICI)1097-0320(19970401)27:4<327::AID-CYTO3>3.0.CO;2-9
 [A]   BEIL M. ET AL.: "Spatial distribution patterns of interphase centromers during retinoic acid-induced differentiation of promyelocytic leukemia cells", CYTOMETRY, vol. 47, no. 4, 1 April 2002 (2002-04-01), pages 217 - 225, XP008105607

DOI:   http://dx.doi.org/10.1002/CYTO.10077
 [A]   BEIL M. ET AL.: "Statistical analysis of the three-dimensional structure of centromeric heterochromatin in interphase nuclei", J. MICROSC., vol. 217, no. PART 1, January 2005 (2005-01-01), pages 60 - 68, XP008105699 [A]

DOI:   http://dx.doi.org/10.1111/j.0022-2720.2005.01439.x
 [A]   GARAGNA S. ET AL.: "Three-dimensional localization and dynamics of centromeres in mouse oocytes during folliculogenesis", J. MOL. HISTOL., vol. 35, no. 6, August 2004 (2004-08-01), pages 631 - 638, XP008105608 [A]

DOI:   http://dx.doi.org/10.1007/s10735-004-2190-x
 [A]   KURODA M. ET AL.: "Alteration of chromosome positioning during adipocyte differentiation", J. CELL SCI., vol. 117, no. PART 24, 15 November 2004 (2004-11-15), pages 5897 - 5903, XP008105700 [A]

DOI:   http://dx.doi.org/10.1242/JCS.01508
 [A]   WIBLIN A.E. ET AL.: "Distinctive nuclear organisation of centromeres and regions involved in pluripotency in human embryonic stem cells", J. CELL SCI., vol. 118, no. PART 17, 1 September 2005 (2005-09-01), pages 3861 - 3868, XP008105701 [A]

DOI:   http://dx.doi.org/10.1242/JCS.02500
by applicant  J CELL SCI, vol. 118, 16 August 2005 (2005-08-16), pages 3861 - 3868
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.