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Extract from the Register of European Patents

EP About this file: EP2117544

EP2117544 - BIOMARKER IDENTIFYING THE REACTIVATION OF STAT3 AFTER SRC INHIBITION [Right-click to bookmark this link]
StatusThe application has been refused
Status updated on  04.01.2013
Database last updated on 02.09.2024
Most recent event   Tooltip04.01.2013Refusal of applicationpublished on 06.02.2013  [2013/06]
Applicant(s)For all designated states
Board of Regents of the University of Texas System
201 West 7th Street
Austin, TX 78701 / US
For all designated states
Bristol-Myers Squibb Company
Route 206 and Province Line Road
Princeton, NJ 08543 / US
[N/P]
Former [2009/47]For all designated states
Board of Regents of the University of Texas System
201 West 7th Street
Austin, TX 78701 / US
For all designated states
Bristol-Myers Squibb Company
Lawrenceville-Princeton Road
Princeton NJ 08543-4000 / US
Former [2008/37]For all designated states
Bristol-Myers Squibb Company
Lawrenceville-Princeton Road
Princeton, VT 08543 / US
Inventor(s)01 / JOHNSON, Faye M.
235 Angel Leaf Road
The Woodlands, TX 77380 / US
02 / DONATO, Nicholas J.
815 Sandpiper Drive
Sugarland, TX 77478 / US
03 / LEE, Francis Y.
363 Lang Court
Yardley, PA 19067 / US
 [2009/47]
Representative(s)Hiebl, Inge Elisabeth
Kraus & Weisert
Patentanwälte PartGmbB
Thomas-Wimmer-Ring 15
80539 München / DE
[N/P]
Former [2009/47]Hiebl, Inge Elisabeth
Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15
80539 München / DE
Application number, filing date07865826.718.12.2007
[2009/47]
WO2007US87982
Priority number, dateUS20060870737P19.12.2006         Original published format: US 870737 P
[2009/47]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008077064
Date:26.06.2008
Language:EN
[2008/26]
Type: A2 Application without search report 
No.:EP2117544
Date:18.11.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 26.06.2008 takes the place of the publication of the European patent application.
[2009/47]
Search report(s)International search report - published on:US07.08.2008
(Supplementary) European search report - dispatched on:EP01.02.2010
ClassificationIPC:A61K31/44, A61K31/277, C07D213/57, C07C255/41
[2009/47]
CPC:
G01N33/574 (EP,US); A61P35/00 (EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/47]
Extension statesAL20.07.2009
BA20.07.2009
HR20.07.2009
MK20.07.2009
RS20.07.2009
TitleGerman:BIOMARKER ZUR IDENTIFIZIERUNG DER REAKTIVIERUNG VON STAT3 NACH SRC-HEMMUNG[2009/47]
English:BIOMARKER IDENTIFYING THE REACTIVATION OF STAT3 AFTER SRC INHIBITION[2009/47]
French:BIOMARQUEUR PERMETTANT D'IDENTIFIER LA REACTIVATION DE LA STAT3 APRES INHIBITION DE SRC[2009/47]
Entry into regional phase20.07.2009National basic fee paid 
20.07.2009Search fee paid 
20.07.2009Designation fee(s) paid 
20.07.2009Examination fee paid 
Examination procedure20.07.2009Examination requested  [2009/47]
06.05.2010Despatch of a communication from the examining division (Time limit: M06)
09.11.2010Reply to a communication from the examining division
28.02.2011Despatch of a communication from the examining division (Time limit: M04)
24.06.2011Reply to a communication from the examining division
15.07.2011Despatch of a communication from the examining division (Time limit: M04)
04.11.2011Reply to a communication from the examining division
18.07.2012Cancellation of oral proceeding that was planned for 19.07.2012
19.07.2012Date of oral proceedings (cancelled)
17.09.2012Despatch of communication that the application is refused, reason: substantive examination [2013/06]
27.09.2012Application refused, date of legal effect [2013/06]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  06.05.2010
Fees paidRenewal fee
22.10.2009Renewal fee patent year 03
22.10.2010Renewal fee patent year 04
19.12.2011Renewal fee patent year 05
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Documents cited:Search[XI]  - JOHNSON FAYE M ET AL, "Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 OCT 2005, (20051001), vol. 11, no. 19 Pt 1, ISSN 1078-0432, pages 6924 - 6932, XP002558632 [X] 3 * materials and methods; p.6928 col.2, p.6931 col.2; figure 8 * [I] 1-2

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-05-0757
 [A]  - HAURA ERIC B, "SRC and STAT pathways.", JOURNAL OF THORACIC ONCOLOGY : OFFICIAL PUBLICATION OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER JUN 2006, (200606), vol. 1, no. 5, ISSN 1556-1380, pages 403 - 405, XP009126668 [A] 1-3

DOI:   http://dx.doi.org/10.1097/01243894-200606000-00003
International search[P]  - JOHNSON F.M. ET AL., "Abrogation of signal transducer and activator of transcription 3 reactivation after src kinase inhibition results in synergistic antitumor effects", CLIN. CANCER RES., (20070715), vol. 13, no. 14, pages 4233 - 4244, XP008112271

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-06-2981
Examination   - QUINTAS-CARDAMA A ET AL, "Targeting ABL and SRC kinases in chronic myeloid leukemia: experience with dasatinib", FUTURE ONCOLOGY, FUTURE MEDICINE LTD., LONDON, GB, (20061201), vol. 2, doi:10.2217/14796694.2.6.655, ISSN 1479-6694, pages 655 - 665, XP009086262

DOI:   http://dx.doi.org/10.2217/14796694.2.6.655
    - L. Pedranzini ET AL, "Pyridone 6, A Pan-Janus-Activated Kinase Inhibitor, Induces Growth Inhibition of Multiple Myeloma Cells", Cancer research, (20061001), vol. 66, no. 19, doi:10.1158/0008-5472.CAN-05-4280, ISSN 0008-5472, pages 9714 - 9721, XP055012563

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-05-4280
    - DUHE R J ET AL, "NEGATIVE REGULATION OF JANUS KINASES", CELL BIOCHEMISTRY AND BIOPHYSICS, TOTOWA, NJ, US, (20010101), vol. 34, no. 1, doi:10.1385/CBB:34:1:17, ISSN 1085-9195, pages 17 - 59, XP008052128

DOI:   http://dx.doi.org/10.1385/CBB:34:1:17
    - JING NAIJIE ET AL, "Targeting Stat3 in cancer therapy", ANTI-CANCER DRUGS, LIPPINCOTT WILLIAMS & WILKINS, US; NL, (20050701), vol. 16, no. 6, ISSN 0959-4973, pages 601 - 607, XP009154227

DOI:   http://dx.doi.org/10.1097/00001813-200507000-00002
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