blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2067034

EP2067034 - EIF4E REGULON-BASED DIAGNOSTICS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.06.2019
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  06.07.2018
FormerGrant of patent is intended
Status updated on  28.02.2018
FormerExamination is in progress
Status updated on  12.01.2017
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): CY		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
Translational Therapeutics, Inc.
163 Scituate Street
Arlington, MA 02476 / US
[2009/24]
Inventor(s)01 / JAMIESON, Gordon A.
163 Scituate Street
Arlington, MA 02476 / US
02 / BORDEN, Katherine L. B.
2275 Rue Beaudet
St. Laurent Quebec H4M 1J6 / CA
03 / CULJKOVIC, Biljana
4870 Cote des Nieges, Apt. 110
Montreal Quebec H3V 1H3 / CA
04 / KENTSIS, Alex
255 Massachusetts Avenue, No. 914
Boston, MA 02115 / US
 [2010/31]
Former [2010/25]01 / JAMIESON, Gordon A.
163 Scituate Street
Arlington, MA 02476 / US
02 / BORDEN, Katherine L. B.
2275 Rue Beaudet
St. Laurent, Quebec, H4M 1J6 / CA
03 / CULJKOVIC, Biljana
4870 Cote des Nieges, Apt. 110
Montreal, Quebec, H3V 1H3 / CA
04 / KENTSIS, Alex
255 Massachusetts Avenue, No. 914
Boston, MA 02115 / US
Former [2009/24]01 / JAMIESON, Gordon A.
163 Scituate Street
Arlington, MA 02476 / US
02 / BORDEN, Katherine L. B.
2275 Rue Beaudet
St. Laurent, Quebec, H4M 1J6 / CA
Representative(s)Lee, Nicholas John, et al
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[2018/32]
Former [2009/24]Lee, Nicholas John, et al
Kilburn & Strode LLP 20 Red Lion Street
London WC1R 4PJ / GB
Application number, filing date07867193.001.10.2007
[2009/24]
WO2007US21167
Priority number, dateUS20060848583P29.09.2006         Original published format: US 848583 P
US20060854404P25.10.2006         Original published format: US 854404 P
US20070942884P08.06.2007         Original published format: US 942884 P
[2009/24]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008060369
Date:22.05.2008
Language:EN
[2008/21]
Type: A2 Application without search report 
No.:EP2067034
Date:10.06.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 22.05.2008 takes the place of the publication of the European patent application.
[2009/24]
Type: B1 Patent specification 
No.:EP2067034
Date:08.08.2018
Language:EN
[2018/32]
Search report(s)International search report - published on:US21.08.2008
(Supplementary) European search report - dispatched on:EP07.07.2010
ClassificationIPC:C12Q1/68, G01N33/574, G01N33/50
[2010/30]
CPC:
G01N33/57484 (EP); G01N33/5011 (EP); G01N2333/4703 (EP);
G01N2333/4739 (EP); G01N2510/00 (EP); G01N2800/32 (EP)
Former IPC [2009/24]G01N33/53
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/32]
Former [2009/24]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:AUF EIF4E-REGULON BASIERENDE DIAGNOSTIK[2009/24]
English:EIF4E REGULON-BASED DIAGNOSTICS[2009/24]
French:DIAGNOSTICS À BASE DE RÉGULON EIF4E[2009/28]
Former [2009/24]DIAGNOSTICS A BASE DE REGULON EIF4E
Entry into regional phase30.03.2009National basic fee paid 
30.03.2009Search fee paid 
30.03.2009Designation fee(s) paid 
30.03.2009Examination fee paid 
Examination procedure30.03.2009Examination requested  [2009/24]
06.06.2011Amendment by applicant (claims and/or description)
18.11.2011Despatch of a communication from the examining division (Time limit: M06)
28.05.2012Reply to a communication from the examining division
11.06.2014Despatch of a communication from the examining division (Time limit: M06)
19.12.2014Reply to a communication from the examining division
10.06.2016Despatch of a communication from the examining division (Time limit: M06)
13.01.2017Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
22.03.2017Reply to a communication from the examining division
01.03.2018Communication of intention to grant the patent
02.07.2018Fee for grant paid
02.07.2018Fee for publishing/printing paid
02.07.2018Receipt of the translation of the claim(s)
Divisional application(s)EP13194721.0  / EP2762886
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.11.2011
Opposition(s)09.05.2019No opposition filed within time limit [2019/29]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
22.03.2017Request for further processing filed
22.03.2017Full payment received (date of receipt of payment)
Request granted
31.03.2017Decision despatched
The application is deemed to be withdrawn due to failure to indicate the wish to proceed further with the application
06.06.2011Request for further processing filed
06.06.2011Full payment received (date of receipt of payment)
Request granted
11.08.2011Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
06.06.2011Request for further processing filed
06.06.2011Full payment received (date of receipt of payment)
Request granted
11.08.2011Decision despatched
Fees paidRenewal fee
13.10.2009Renewal fee patent year 03
12.10.2010Renewal fee patent year 04
11.10.2011Renewal fee patent year 05
11.10.2012Renewal fee patent year 06
14.10.2013Renewal fee patent year 07
14.10.2014Renewal fee patent year 08
12.10.2015Renewal fee patent year 09
11.10.2016Renewal fee patent year 10
11.10.2017Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.10.2007
AT08.08.2018
CY08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
PT08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
TR08.08.2018
LU01.10.2018
MT01.10.2018
BE31.10.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
[2020/32]
Former [2020/30]HU01.10.2007
AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
PT08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
TR08.08.2018
LU01.10.2018
MT01.10.2018
BE31.10.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2020/27]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
PT08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
TR08.08.2018
LU01.10.2018
MT01.10.2018
BE31.10.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2020/16]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
TR08.08.2018
LU01.10.2018
MT01.10.2018
BE31.10.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2020/08]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
LU01.10.2018
MT01.10.2018
BE31.10.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/38]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
LU01.10.2018
BE31.10.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/37]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
LU01.10.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/30]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SK08.08.2018
LU01.10.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/28]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SK08.08.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/26]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SK08.08.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/24]AT08.08.2018
CZ08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SK08.08.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/22]AT08.08.2018
CZ08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/21]AT08.08.2018
ES08.08.2018
FI08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
SE08.08.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/13]AT08.08.2018
ES08.08.2018
FI08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
SE08.08.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/10]AT08.08.2018
FI08.08.2018
LT08.08.2018
NL08.08.2018
PL08.08.2018
SE08.08.2018
BG08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/09]FI08.08.2018
LT08.08.2018
NL08.08.2018
IS08.12.2018
Former [2019/08]FI08.08.2018
LT08.08.2018
IS08.12.2018
Former [2019/07]LT08.08.2018
Documents cited:Search[X]  - KENTSIS A. ET AL., "Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap", PROC. NATL. ACAD. SCI. USA, (20041228), vol. 101, no. 52, pages 18105 - 18110, XP002587696 [X] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1073/PNAS.0406927102
 [X]  - KENTSIS A. ET AL., "Further evidence that ribavirin interacts with eIF4E", RNA, (200512), vol. 11, no. 12, pages 1762 - 1766, XP002587697 [X] 1-15 * the whole document *
 [X]  - CULJKOVIC B. ET AL., "eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3 ' UTR", J. CELL BIOL., (20050425), vol. 169, no. 2, pages 245 - 256, XP002587698 [X] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1083/JCB.200501019
 [XP]  - CULJKOVIC B. ET AL., "eIF4E is a central node of an RNA regulon that governs cellular proliferation", J. CELL BIOL., (20061106), vol. 175, no. 3, pages 415 - 426, XP002587699 [XP] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1083/JCB.200607020
 [T]  - CULJKOVIC B. ET AL., "The eIF4E RNA regulon promotes the Akt signaling pathway", J. CELL BIOL., (20080407), vol. 181, no. 1, pages 51 - 63, XP002587700 [T] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1083/JCB.200707018
 [XP]  - CULJKOVIC B. ET AL., "Controlling gene expression through RNA regulons - The role of the eukaryotic translation initiation factor eIF4E", CELL CYCLE, (20070101), vol. 6, no. 1, pages 65 - 69, XP002587701 [XP] 1-15 * the whole document *
 [X]  - FAIVRE S. ET AL., "Current development of mTOR inhibitors as anticancer agents.", NATURE REVIEWS - DRUG DISCOVERY, (200608), vol. 5, no. 8, pages 671 - 688, XP002587702 [X] 1-15 * abstract * * page 672, column 2 * * figure 1 *

DOI:   http://dx.doi.org/10.1038/NRD2062
 [X]  - WENDEL H.-G. ET AL., "Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy", NATURE, (20040318), vol. 428, pages 332 - 337, XP002996035 [X] 8-15 * abstract * * page 334, column 2 - page 335, column 1 * * figure 5 *

DOI:   http://dx.doi.org/10.1038/nature02369
International search[X]  - BENEDETTI ET AL., "eIF-4E expression and its role in malignancies and metastases", ONCOGENE, (2004), vol. 23, pages 3189 - 3199, XP008105358

DOI:   http://dx.doi.org/10.1038/sj.onc.1207545
 [Y]  - HIDALGO A. ET AL., "Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma", BMC CANCER, (2005), vol. 5, no. 77, pages 1 - 7, XP021004841

DOI:   http://dx.doi.org/10.1186/1471-2407-5-77
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.